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The map label for this gene is hssR [H]

Identifier: 222150338

GI number: 222150338

Start: 91556

End: 92227

Strand: Direct

Name: hssR [H]

Synonym: MCCL_0088

Alternate gene names: 222150338

Gene position: 91556-92227 (Clockwise)

Preceding gene: 222150335

Following gene: 222150339

Centisome position: 4.35

GC content: 38.54

Gene sequence:

>672_bases
GTGCAAAATAATATATTAGTTGTTGATGATGAAGCGGCTATTCGTTGTGAAGTTAAAGAAGGTTTTTTGCGTCACAGTTT
TCAAGTGTATGTTGCAAGCAACGGTGATGAAGCGATTAATCTGCTGGATAATGAAAGTATCGATTTATGTATCGTCGATA
TTATGATGCCAGGCATTGACGGGTTCCAGCTGTGCGAGCAAATTAAACAGGACTATCAACTACCTGTTATAATGCTAACT
GCACGAGATGCACTCGGAGATAAGAGGATTGCGTTTCAAGCAGGAAGTGATGATTATGTTACTAAACCATTTGAGATAGA
AGAAGTTATCTTTAGAGCACAAGCAATATTAAAGCGTTATGAGAAGGCGGTAGAGAAGGTTGAATTCGGAAAGCTGATAA
TTGATGCAGATAGTTATGAGGTGACGATGGAAGACGAGTCTTTATATCTTCCCAGAAAAGAATTTGAACTTCTATATTAT
TTAGTGAGGCATTATCCGAAAGTTGCAACGAGAGAACAGCTTATAGAAGAGATATGGGGATATGACTTTGATGGAGATGA
ACGAACAGTGGATGTACATGTGAAACGAATTCGTAAAAGGCTAGATGCATTTGACAGTGGTGTAGAGATTCAGACTGTAC
GCGGTGTAGGATATAAGGTGCATCATGTTTAA

Upstream 100 bases:

>100_bases
TTTCTTTTAGTGCTAAGTTCATAATGATCAACCTTTCGCTTTGTTTGTAATACATATATTAAAGGTTGAATATGAACGGA
ATATGAACGGAGGACATATT

Downstream 100 bases:

>100_bases
AAGACTATCTACTCGATTTATAATTGGCACCTTTCATGTTATTCTCGTCAGCTCATTACTTTCATTTATCATCGCAAACA
TTTATTATCACTTAACGCTA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MQNNILVVDDEAAIRCEVKEGFLRHSFQVYVASNGDEAINLLDNESIDLCIVDIMMPGIDGFQLCEQIKQDYQLPVIMLT
ARDALGDKRIAFQAGSDDYVTKPFEIEEVIFRAQAILKRYEKAVEKVEFGKLIIDADSYEVTMEDESLYLPRKEFELLYY
LVRHYPKVATREQLIEEIWGYDFDGDERTVDVHVKRIRKRLDAFDSGVEIQTVRGVGYKVHHV

Sequences:

>Translated_223_residues
MQNNILVVDDEAAIRCEVKEGFLRHSFQVYVASNGDEAINLLDNESIDLCIVDIMMPGIDGFQLCEQIKQDYQLPVIMLT
ARDALGDKRIAFQAGSDDYVTKPFEIEEVIFRAQAILKRYEKAVEKVEFGKLIIDADSYEVTMEDESLYLPRKEFELLYY
LVRHYPKVATREQLIEEIWGYDFDGDERTVDVHVKRIRKRLDAFDSGVEIQTVRGVGYKVHHV
>Mature_223_residues
MQNNILVVDDEAAIRCEVKEGFLRHSFQVYVASNGDEAINLLDNESIDLCIVDIMMPGIDGFQLCEQIKQDYQLPVIMLT
ARDALGDKRIAFQAGSDDYVTKPFEIEEVIFRAQAILKRYEKAVEKVEFGKLIIDADSYEVTMEDESLYLPRKEFELLYY
LVRHYPKVATREQLIEEIWGYDFDGDERTVDVHVKRIRKRLDAFDSGVEIQTVRGVGYKVHHV

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated hssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=38.8392857142857, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI87082012, Length=215, Percent_Identity=33.953488372093, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=33.6206896551724, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1786784, Length=217, Percent_Identity=32.258064516129, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=31.7180616740088, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=33.6283185840708, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=31.3636363636364, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=31.5555555555556, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=30.6034482758621, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=31.9634703196347, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1787375, Length=216, Percent_Identity=34.2592592592593, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790552, Length=173, Percent_Identity=35.2601156069364, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787229, Length=212, Percent_Identity=26.8867924528302, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=28.5067873303167, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1790299, Length=124, Percent_Identity=35.4838709677419, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788550, Length=117, Percent_Identity=32.4786324786325, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI145693157, Length=104, Percent_Identity=32.6923076923077, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25834; Mature: 25834

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNNILVVDDEAAIRCEVKEGFLRHSFQVYVASNGDEAINLLDNESIDLCIVDIMMPGID
CCCCEEEEECCCEEEEEHHHHHHHCEEEEEEECCCCCEEEECCCCCCCEEEEEECCCCCC
GFQLCEQIKQDYQLPVIMLTARDALGDKRIAFQAGSDDYVTKPFEIEEVIFRAQAILKRY
HHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
EKAVEKVEFGKLIIDADSYEVTMEDESLYLPRKEFELLYYLVRHYPKVATREQLIEEIWG
HHHHHHHHHCEEEEECCCEEEEECCCEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
YDFDGDERTVDVHVKRIRKRLDAFDSGVEIQTVRGVGYKVHHV
CCCCCCCEEEHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECC
>Mature Secondary Structure
MQNNILVVDDEAAIRCEVKEGFLRHSFQVYVASNGDEAINLLDNESIDLCIVDIMMPGID
CCCCEEEEECCCEEEEEHHHHHHHCEEEEEEECCCCCEEEECCCCCCCEEEEEECCCCCC
GFQLCEQIKQDYQLPVIMLTARDALGDKRIAFQAGSDDYVTKPFEIEEVIFRAQAILKRY
HHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
EKAVEKVEFGKLIIDADSYEVTMEDESLYLPRKEFELLYYLVRHYPKVATREQLIEEIWG
HHHHHHHHHCEEEEECCCEEEEECCCEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
YDFDGDERTVDVHVKRIRKRLDAFDSGVEIQTVRGVGYKVHHV
CCCCCCCEEEHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA