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The map label for this gene is hssS [H]

Identifier: 222150339

GI number: 222150339

Start: 92220

End: 93557

Strand: Direct

Name: hssS [H]

Synonym: MCCL_0089

Alternate gene names: 222150339

Gene position: 92220-93557 (Clockwise)

Preceding gene: 222150338

Following gene: 222150340

Centisome position: 4.39

GC content: 33.26

Gene sequence:

>1338_bases
ATGTTTAAAAGACTATCTACTCGATTTATAATTGGCACCTTTCATGTTATTCTCGTCAGCTCATTACTTTCATTTATCAT
CGCAAACATTTATTATCACTTAACGCTAAAAGAACAGAACGACACACGTATAACGAACACTTTAATAACACAGAAGAAAT
ATATCGAAGCACACCCAGAAATAAAACCGGAAGCATTTTTCACACAACTTGCAAATTTAAATTTTCAAGTAGTAACAGTT
AAGGATGGTAAGAAAGCTTTCTATGGTACATCATTTAGAGTGAAAAATTTACCGAATAATGGCCCGTTAACGGAAACGTA
TCATGGAATTAAAGAACGGCCATTTAATGTATTTATTACGGGATTCTTTGATAATGAGACTAGAAATACAGTCGGTATGC
CGATAAAAGTTAATAATGAAATATACGATGTTTACATTAGACCAGATGTCGGAGAGAGTATGCATGAATTTAGAATTTTT
CTTGCGATACTGTTTCTATGTATTATTGTCTTTTCAATCTTATTTGTGTTTATTTCATCTAAATATATCGTGCGTCCTGT
TGTTCAACTAAAGGAAGCAGCCCGCAAAATTGGAGATCAGAGTGGTTATCAGACACAAGTAAAACGTAAGGATGAACTCG
GTGTATTAGCACATGAGATGAACATAATGAGTGCTAAGATACTGCATCACGAAGAAATGAATCAACGTTTTGTTGCTAAT
GTCAGTCATGAAATTCAGTCTCCTATAACCAATTTACTTGGACAAATTAAACAACTCAGACAAACAAAAGACTTTAGTTT
GTTAGATGACATTGAACACCAGTCACAACGGTTAAGTGGACTAACGAAACAGTTGCTGATGCTTGCGTCACTTGAGAAGA
CAGGTACTGCAATCGACAAAGAACATTTCAATGGAAAAACACTCATTCAGGAAGTTATACGTAATCATATGTATGCTCTT
GATCAAAAAGAAATTTTTGTTACAACGAAACTTAAAGATATTGAAATACTTGGTCATCGAGATTTATGTTATCAAATGAT
AAGTAATCTACTTTCTAATGCGATTAAATATAGCCCTGAAGAAACTCAAATTAAGTTTGAATTAGGAGAGGACGCACACA
AGTATATTAAGATTTCAGATGAAGGTTACGGAATGTCTGATAAAACTAAGGAACTGTTGTTTGAAAGGTTTTATAAAGCT
GAAGTACATGAAGATAAAGCACCGTCTAATGGCCTTGGGATGGCAATTGTTAAAGAAATTGTTGATCTGCATGGTTTTGA
AATAGAAGTAGAAAGTGAATTAAACAAAGGAACGATAATTACTATTAAGTTCACATAA

Upstream 100 bases:

>100_bases
ACAGTGGATGTACATGTGAAACGAATTCGTAAAAGGCTAGATGCATTTGACAGTGGTGTAGAGATTCAGACTGTACGCGG
TGTAGGATATAAGGTGCATC

Downstream 100 bases:

>100_bases
GAAGTATCAGATTAATCATTAATCTGGTACTCTCTCTATCTCTTTGATGTATAGTTTTATACCCTGGATAATTAAACAAG
CAACGATAGGGTATTGTTAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MFKRLSTRFIIGTFHVILVSSLLSFIIANIYYHLTLKEQNDTRITNTLITQKKYIEAHPEIKPEAFFTQLANLNFQVVTV
KDGKKAFYGTSFRVKNLPNNGPLTETYHGIKERPFNVFITGFFDNETRNTVGMPIKVNNEIYDVYIRPDVGESMHEFRIF
LAILFLCIIVFSILFVFISSKYIVRPVVQLKEAARKIGDQSGYQTQVKRKDELGVLAHEMNIMSAKILHHEEMNQRFVAN
VSHEIQSPITNLLGQIKQLRQTKDFSLLDDIEHQSQRLSGLTKQLLMLASLEKTGTAIDKEHFNGKTLIQEVIRNHMYAL
DQKEIFVTTKLKDIEILGHRDLCYQMISNLLSNAIKYSPEETQIKFELGEDAHKYIKISDEGYGMSDKTKELLFERFYKA
EVHEDKAPSNGLGMAIVKEIVDLHGFEIEVESELNKGTIITIKFT

Sequences:

>Translated_445_residues
MFKRLSTRFIIGTFHVILVSSLLSFIIANIYYHLTLKEQNDTRITNTLITQKKYIEAHPEIKPEAFFTQLANLNFQVVTV
KDGKKAFYGTSFRVKNLPNNGPLTETYHGIKERPFNVFITGFFDNETRNTVGMPIKVNNEIYDVYIRPDVGESMHEFRIF
LAILFLCIIVFSILFVFISSKYIVRPVVQLKEAARKIGDQSGYQTQVKRKDELGVLAHEMNIMSAKILHHEEMNQRFVAN
VSHEIQSPITNLLGQIKQLRQTKDFSLLDDIEHQSQRLSGLTKQLLMLASLEKTGTAIDKEHFNGKTLIQEVIRNHMYAL
DQKEIFVTTKLKDIEILGHRDLCYQMISNLLSNAIKYSPEETQIKFELGEDAHKYIKISDEGYGMSDKTKELLFERFYKA
EVHEDKAPSNGLGMAIVKEIVDLHGFEIEVESELNKGTIITIKFT
>Mature_445_residues
MFKRLSTRFIIGTFHVILVSSLLSFIIANIYYHLTLKEQNDTRITNTLITQKKYIEAHPEIKPEAFFTQLANLNFQVVTV
KDGKKAFYGTSFRVKNLPNNGPLTETYHGIKERPFNVFITGFFDNETRNTVGMPIKVNNEIYDVYIRPDVGESMHEFRIF
LAILFLCIIVFSILFVFISSKYIVRPVVQLKEAARKIGDQSGYQTQVKRKDELGVLAHEMNIMSAKILHHEEMNQRFVAN
VSHEIQSPITNLLGQIKQLRQTKDFSLLDDIEHQSQRLSGLTKQLLMLASLEKTGTAIDKEHFNGKTLIQEVIRNHMYAL
DQKEIFVTTKLKDIEILGHRDLCYQMISNLLSNAIKYSPEETQIKFELGEDAHKYIKISDEGYGMSDKTKELLFERFYKA
EVHEDKAPSNGLGMAIVKEIVDLHGFEIEVESELNKGTIITIKFT

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=30.5936073059361, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788279, Length=275, Percent_Identity=26.1818181818182, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788393, Length=280, Percent_Identity=26.4285714285714, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790861, Length=293, Percent_Identity=25.938566552901, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790346, Length=258, Percent_Identity=25.5813953488372, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786783, Length=317, Percent_Identity=24.2902208201893, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788713, Length=260, Percent_Identity=27.3076923076923, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790551, Length=281, Percent_Identity=23.1316725978648, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI145693157, Length=217, Percent_Identity=24.4239631336406, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789808, Length=288, Percent_Identity=24.3055555555556, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786912, Length=215, Percent_Identity=26.9767441860465, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789403, Length=226, Percent_Identity=28.3185840707965, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787374, Length=258, Percent_Identity=20.5426356589147, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1789149, Length=234, Percent_Identity=23.0769230769231, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51252; Mature: 51252

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKRLSTRFIIGTFHVILVSSLLSFIIANIYYHLTLKEQNDTRITNTLITQKKYIEAHPE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCCC
IKPEAFFTQLANLNFQVVTVKDGKKAFYGTSFRVKNLPNNGPLTETYHGIKERPFNVFIT
CCHHHHHHHHHCCCEEEEEEECCCEEEECCCEEECCCCCCCCCCHHHHHHHCCCCEEEEE
GFFDNETRNTVGMPIKVNNEIYDVYIRPDVGESMHEFRIFLAILFLCIIVFSILFVFISS
EEECCCCCCCCCCEEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KYIVRPVVQLKEAARKIGDQSGYQTQVKRKDELGVLAHEMNIMSAKILHHEEMNQRFVAN
CHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSHEIQSPITNLLGQIKQLRQTKDFSLLDDIEHQSQRLSGLTKQLLMLASLEKTGTAIDK
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
EHFNGKTLIQEVIRNHMYALDQKEIFVTTKLKDIEILGHRDLCYQMISNLLSNAIKYSPE
HHCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCC
ETQIKFELGEDAHKYIKISDEGYGMSDKTKELLFERFYKAEVHEDKAPSNGLGMAIVKEI
CCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
VDLHGFEIEVESELNKGTIITIKFT
HHHCCCEEEECCCCCCCEEEEEEEC
>Mature Secondary Structure
MFKRLSTRFIIGTFHVILVSSLLSFIIANIYYHLTLKEQNDTRITNTLITQKKYIEAHPE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCCC
IKPEAFFTQLANLNFQVVTVKDGKKAFYGTSFRVKNLPNNGPLTETYHGIKERPFNVFIT
CCHHHHHHHHHCCCEEEEEEECCCEEEECCCEEECCCCCCCCCCHHHHHHHCCCCEEEEE
GFFDNETRNTVGMPIKVNNEIYDVYIRPDVGESMHEFRIFLAILFLCIIVFSILFVFISS
EEECCCCCCCCCCEEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KYIVRPVVQLKEAARKIGDQSGYQTQVKRKDELGVLAHEMNIMSAKILHHEEMNQRFVAN
CHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSHEIQSPITNLLGQIKQLRQTKDFSLLDDIEHQSQRLSGLTKQLLMLASLEKTGTAIDK
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
EHFNGKTLIQEVIRNHMYALDQKEIFVTTKLKDIEILGHRDLCYQMISNLLSNAIKYSPE
HHCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCC
ETQIKFELGEDAHKYIKISDEGYGMSDKTKELLFERFYKAEVHEDKAPSNGLGMAIVKEI
CCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
VDLHGFEIEVESELNKGTIITIKFT
HHHCCCEEEECCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA