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The map label for this gene is uvrA [H]

Identifier: 222150280

GI number: 222150280

Start: 34042

End: 36297

Strand: Direct

Name: uvrA [H]

Synonym: MCCL_0030

Alternate gene names: 222150280

Gene position: 34042-36297 (Clockwise)

Preceding gene: 222150278

Following gene: 222150281

Centisome position: 1.62

GC content: 36.7

Gene sequence:

>2256_bases
ATGAAAAATATCATCATCAAAGGTGCACGACAAAATAATTTAAAAAATGTTTCGTTAAGTCTTCCAAAGCATCAATTGAC
CGTTTTTACAGGAAAATCAGGATCTGGAAAATCTTCATTAGTATTTAGTACGATTGCAGCTGAATCTGAGCGTCTACTCA
ATGAAACTTATTCTACATATATACAGAATCAATTGACTCATTATGAGAAACCTGATGTAGATTCCATTCAAAATCTTCCT
GTTTCAATGGTCATTAGTCAGAAAAGACTTGGTGGTAACTCGCGCTCTACAGTAGGTACAATTTCCGACATTTATTCTGC
TGTTCGTCTACTATGGTCTCGTATTGGTCAACCATTTGTCGGATATTCAAATGAATTTTCATTCAATAATTCGGCAGGAA
TGTGTGAGAGATGCCAAGGCTTAGGATATGTCGAGGAAATTGATATCGATGAATTGCTGGATTATGACAAATCTTTAAAC
GAACATGGAATTAATTTTCCTACATTCGGACCAGATCACTGGCGTGGTAAAAGCTATACGCATTCGGGTCTATTTGATAA
TGATAAGAAGCTGAAAGATTATTCGAAGGAAGAGATGCATCAATTACTTTATTTAGAGCCGACCAAACTGACCAATCCTC
CTGAAGAATGGCCCCGTACTGCAAAATATGAAGGGGTCGTCTATCGATTCAGGCGACTGTTTATTATTAATGATGGCTAT
GAAAAGAGCAGGTGGCCGGATGAATATGAGCGTGTTGTAACGACAATGGTTTGTCCTAACTGTCACGGAAAACGTTTAAA
TCAACGTATTTTAAGCTGCAAAATTAACGGTGCAGATATTGCTGATTTTACAAATCAAACTATCGTAGAAAATATCCTGT
TTTTAGACCATCTTACTGATAAAACAGCTGCATATATTGTAAAGCCGCTTAAACAGCAACTTCAATCTCTAGTTGATATT
GGACTTGGTTATTTGACACTTGGTCGAGAAACACCTACCTTATCAGGTGGTGAATCTCAGCGTATTAAGCTTATTCGTCA
TCTAAGTAGCCCACTGACCGATCTCGTATACATTATCGATGAACCGAGTGTTGGACTGCATCCTGAAGATATTGAAAATA
TCAATCGCATAATTATGTCTATTCGGGATAAAGGAAATACAGTTATTGTGGTTGAACACGATCCTGATATTATTAAGATT
GCAGATCACATTGTTGACGTAGGACCAGGTGCCGGTAAAAATGGGGGTAGAATTACATTTGAAGGAACATACGATCAACT
TCTCGACTCCCACACTGCGACTGGACAAGAACTCAAAGAAAAACATCAACTAAAAGTTCCAAGGTCATCTCAAGAAATGA
TTCATATCGGTCCAGTTACAAAAAATAACGTCAAAAATGTTGAAGTGTATCTCCCTAAAAATGCTATTTCTGTTATTACA
GGGGTTGCTGGTTCTGGGAAGAGTACGCTCATAAAGACTGGGTTTAAACAGATTAAAAACGTTATATTCATCGATCAAAA
AGCTATTAATGCTTCAAATCGTTCAAATATATTAACTTATACCAATACATTTGATGAATTACGAGCATTTTTCAGTAAGG
AGACAGGGCTAAAGAAAAGTATGTTCAGCTATAATTCTGAAGGTGCTTGTCCAAACTGTAAAGGAAAAGGAATTCTTAAA
ACAGAACTTGCGTTTATGCCCGATTTTTCACAAGTTTGTGAAGTATGTCATGGAACACGTTATAGACAGGAAGTACTGGA
TGTTAAAGTAGATGGTTACTCTATTGCAGATGTATTACAATTAACGGTCGAAGAAGGAATAAATTACTTCAATACACATC
ATAAAATTCTGGAGATATTAAAATCCCTTGCTGCCACTGGTCTAGGCTATATGACACTTGGACAATCATTGGACACACTT
TCAGGTGGAGAAATTCAACGTGTAAAGCTCAGTGCGTATTTAATCAATCAAGTGACTGACCACATCTTTATTTTTGATGA
ACCAACAACAGGGTTACATGAAAGGGATATCCATGTGCTGATAGAATTATTTAATCAATTAGTGGATGAAGGTAATACCG
TCGTTCTAATCGAGCATAACTTGTCAATGATGACAGAAGCAGACTGGTTAATTGATATGGGACCAGCTGCTGGTCAACAA
GGAGGAAGATTATTATACAGTGGTTACCCAGAAGGTGTCCTTAGCATACAAGATAGCGTAACTGGGAAACATTTATCTAA
TTACATTCAAAAATAA

Upstream 100 bases:

>100_bases
AGCTAAAAATTTGGAACTTTAAAATTGATACTTATAAACTTATTTCTCGTTAGAAAGGTAAAAAATATAAATATATTTAA
TTATGGAGAGGAAGTTTGGG

Downstream 100 bases:

>100_bases
GGGGAGTGTATTTAGTAGTGAAAAAAGTAAGATATTTTTAGTGATGGTAAAGTAAAAGCAAGTATATGTAATAAGAAGAT
ATACTAAGCTGATACTTCGT

Product: daunorubicin resistance protein

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 751; Mature: 751

Protein sequence:

>751_residues
MKNIIIKGARQNNLKNVSLSLPKHQLTVFTGKSGSGKSSLVFSTIAAESERLLNETYSTYIQNQLTHYEKPDVDSIQNLP
VSMVISQKRLGGNSRSTVGTISDIYSAVRLLWSRIGQPFVGYSNEFSFNNSAGMCERCQGLGYVEEIDIDELLDYDKSLN
EHGINFPTFGPDHWRGKSYTHSGLFDNDKKLKDYSKEEMHQLLYLEPTKLTNPPEEWPRTAKYEGVVYRFRRLFIINDGY
EKSRWPDEYERVVTTMVCPNCHGKRLNQRILSCKINGADIADFTNQTIVENILFLDHLTDKTAAYIVKPLKQQLQSLVDI
GLGYLTLGRETPTLSGGESQRIKLIRHLSSPLTDLVYIIDEPSVGLHPEDIENINRIIMSIRDKGNTVIVVEHDPDIIKI
ADHIVDVGPGAGKNGGRITFEGTYDQLLDSHTATGQELKEKHQLKVPRSSQEMIHIGPVTKNNVKNVEVYLPKNAISVIT
GVAGSGKSTLIKTGFKQIKNVIFIDQKAINASNRSNILTYTNTFDELRAFFSKETGLKKSMFSYNSEGACPNCKGKGILK
TELAFMPDFSQVCEVCHGTRYRQEVLDVKVDGYSIADVLQLTVEEGINYFNTHHKILEILKSLAATGLGYMTLGQSLDTL
SGGEIQRVKLSAYLINQVTDHIFIFDEPTTGLHERDIHVLIELFNQLVDEGNTVVLIEHNLSMMTEADWLIDMGPAAGQQ
GGRLLYSGYPEGVLSIQDSVTGKHLSNYIQK

Sequences:

>Translated_751_residues
MKNIIIKGARQNNLKNVSLSLPKHQLTVFTGKSGSGKSSLVFSTIAAESERLLNETYSTYIQNQLTHYEKPDVDSIQNLP
VSMVISQKRLGGNSRSTVGTISDIYSAVRLLWSRIGQPFVGYSNEFSFNNSAGMCERCQGLGYVEEIDIDELLDYDKSLN
EHGINFPTFGPDHWRGKSYTHSGLFDNDKKLKDYSKEEMHQLLYLEPTKLTNPPEEWPRTAKYEGVVYRFRRLFIINDGY
EKSRWPDEYERVVTTMVCPNCHGKRLNQRILSCKINGADIADFTNQTIVENILFLDHLTDKTAAYIVKPLKQQLQSLVDI
GLGYLTLGRETPTLSGGESQRIKLIRHLSSPLTDLVYIIDEPSVGLHPEDIENINRIIMSIRDKGNTVIVVEHDPDIIKI
ADHIVDVGPGAGKNGGRITFEGTYDQLLDSHTATGQELKEKHQLKVPRSSQEMIHIGPVTKNNVKNVEVYLPKNAISVIT
GVAGSGKSTLIKTGFKQIKNVIFIDQKAINASNRSNILTYTNTFDELRAFFSKETGLKKSMFSYNSEGACPNCKGKGILK
TELAFMPDFSQVCEVCHGTRYRQEVLDVKVDGYSIADVLQLTVEEGINYFNTHHKILEILKSLAATGLGYMTLGQSLDTL
SGGEIQRVKLSAYLINQVTDHIFIFDEPTTGLHERDIHVLIELFNQLVDEGNTVVLIEHNLSMMTEADWLIDMGPAAGQQ
GGRLLYSGYPEGVLSIQDSVTGKHLSNYIQK
>Mature_751_residues
MKNIIIKGARQNNLKNVSLSLPKHQLTVFTGKSGSGKSSLVFSTIAAESERLLNETYSTYIQNQLTHYEKPDVDSIQNLP
VSMVISQKRLGGNSRSTVGTISDIYSAVRLLWSRIGQPFVGYSNEFSFNNSAGMCERCQGLGYVEEIDIDELLDYDKSLN
EHGINFPTFGPDHWRGKSYTHSGLFDNDKKLKDYSKEEMHQLLYLEPTKLTNPPEEWPRTAKYEGVVYRFRRLFIINDGY
EKSRWPDEYERVVTTMVCPNCHGKRLNQRILSCKINGADIADFTNQTIVENILFLDHLTDKTAAYIVKPLKQQLQSLVDI
GLGYLTLGRETPTLSGGESQRIKLIRHLSSPLTDLVYIIDEPSVGLHPEDIENINRIIMSIRDKGNTVIVVEHDPDIIKI
ADHIVDVGPGAGKNGGRITFEGTYDQLLDSHTATGQELKEKHQLKVPRSSQEMIHIGPVTKNNVKNVEVYLPKNAISVIT
GVAGSGKSTLIKTGFKQIKNVIFIDQKAINASNRSNILTYTNTFDELRAFFSKETGLKKSMFSYNSEGACPNCKGKGILK
TELAFMPDFSQVCEVCHGTRYRQEVLDVKVDGYSIADVLQLTVEEGINYFNTHHKILEILKSLAATGLGYMTLGQSLDTL
SGGEIQRVKLSAYLINQVTDHIFIFDEPTTGLHERDIHVLIELFNQLVDEGNTVVLIEHNLSMMTEADWLIDMGPAAGQQ
GGRLLYSGYPEGVLSIQDSVTGKHLSNYIQK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=739, Percent_Identity=33.5588633288227, Blast_Score=385, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 84097; Mature: 84097

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIIIKGARQNNLKNVSLSLPKHQLTVFTGKSGSGKSSLVFSTIAAESERLLNETYSTY
CCCEEEECCCCCCCCEEEEECCCEEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
IQNQLTHYEKPDVDSIQNLPVSMVISQKRLGGNSRSTVGTISDIYSAVRLLWSRIGQPFV
HHHHHHCCCCCCHHHHHCCCHHEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
GYSNEFSFNNSAGMCERCQGLGYVEEIDIDELLDYDKSLNEHGINFPTFGPDHWRGKSYT
CCCCCCCCCCCCCHHHHHHCCCCHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
HSGLFDNDKKLKDYSKEEMHQLLYLEPTKLTNPPEEWPRTAKYEGVVYRFRRLFIINDGY
CCCCCCCCHHHHHCCHHHHHHHEEECCCCCCCCHHHCCCCCCCCHHHEEEEEEEEEECCC
EKSRWPDEYERVVTTMVCPNCHGKRLNQRILSCKINGADIADFTNQTIVENILFLDHLTD
CCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHCC
KTAAYIVKPLKQQLQSLVDIGLGYLTLGRETPTLSGGESQRIKLIRHLSSPLTDLVYIID
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHEEEEEC
EPSVGLHPEDIENINRIIMSIRDKGNTVIVVEHDPDIIKIADHIVDVGPGAGKNGGRITF
CCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCEEEE
EGTYDQLLDSHTATGQELKEKHQLKVPRSSQEMIHIGPVTKNNVKNVEVYLPKNAISVIT
CCCHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCEEEEEECCCHHHHHH
GVAGSGKSTLIKTGFKQIKNVIFIDQKAINASNRSNILTYTNTFDELRAFFSKETGLKKS
CCCCCCCHHHHHHHHHHHHHEEEEEHHHCCCCCCCCEEEEECCHHHHHHHHHHHCCCHHH
MFSYNSEGACPNCKGKGILKTELAFMPDFSQVCEVCHGTRYRQEVLDVKVDGYSIADVLQ
HHCCCCCCCCCCCCCCCEEEEHHHCCCCHHHHHHHHCCCHHHHHHHEEEECCCHHHHHHH
LTVEEGINYFNTHHKILEILKSLAATGLGYMTLGQSLDTLSGGEIQRVKLSAYLINQVTD
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEEEHHHHHHHHHCC
HIFIFDEPTTGLHERDIHVLIELFNQLVDEGNTVVLIEHNLSMMTEADWLIDMGPAAGQQ
EEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHCCCCCEEECCCCCCCC
GGRLLYSGYPEGVLSIQDSVTGKHLSNYIQK
CCEEEECCCCCCEEEEHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNIIIKGARQNNLKNVSLSLPKHQLTVFTGKSGSGKSSLVFSTIAAESERLLNETYSTY
CCCEEEECCCCCCCCEEEEECCCEEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
IQNQLTHYEKPDVDSIQNLPVSMVISQKRLGGNSRSTVGTISDIYSAVRLLWSRIGQPFV
HHHHHHCCCCCCHHHHHCCCHHEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
GYSNEFSFNNSAGMCERCQGLGYVEEIDIDELLDYDKSLNEHGINFPTFGPDHWRGKSYT
CCCCCCCCCCCCCHHHHHHCCCCHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
HSGLFDNDKKLKDYSKEEMHQLLYLEPTKLTNPPEEWPRTAKYEGVVYRFRRLFIINDGY
CCCCCCCCHHHHHCCHHHHHHHEEECCCCCCCCHHHCCCCCCCCHHHEEEEEEEEEECCC
EKSRWPDEYERVVTTMVCPNCHGKRLNQRILSCKINGADIADFTNQTIVENILFLDHLTD
CCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHCC
KTAAYIVKPLKQQLQSLVDIGLGYLTLGRETPTLSGGESQRIKLIRHLSSPLTDLVYIID
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHEEEEEC
EPSVGLHPEDIENINRIIMSIRDKGNTVIVVEHDPDIIKIADHIVDVGPGAGKNGGRITF
CCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCEEEE
EGTYDQLLDSHTATGQELKEKHQLKVPRSSQEMIHIGPVTKNNVKNVEVYLPKNAISVIT
CCCHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCEEEEEECCCHHHHHH
GVAGSGKSTLIKTGFKQIKNVIFIDQKAINASNRSNILTYTNTFDELRAFFSKETGLKKS
CCCCCCCHHHHHHHHHHHHHEEEEEHHHCCCCCCCCEEEEECCHHHHHHHHHHHCCCHHH
MFSYNSEGACPNCKGKGILKTELAFMPDFSQVCEVCHGTRYRQEVLDVKVDGYSIADVLQ
HHCCCCCCCCCCCCCCCEEEEHHHCCCCHHHHHHHHCCCHHHHHHHEEEECCCHHHHHHH
LTVEEGINYFNTHHKILEILKSLAATGLGYMTLGQSLDTLSGGEIQRVKLSAYLINQVTD
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEEEHHHHHHHHHCC
HIFIFDEPTTGLHERDIHVLIELFNQLVDEGNTVVLIEHNLSMMTEADWLIDMGPAAGQQ
EEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHCCCCCEEECCCCCCCC
GGRLLYSGYPEGVLSIQDSVTGKHLSNYIQK
CCEEEECCCCCCEEEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]