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The map label for this gene is ppiD [C]

Identifier: 222111223

GI number: 222111223

Start: 2172550

End: 2173335

Strand: Direct

Name: ppiD [C]

Synonym: Dtpsy_2031

Alternate gene names: 222111223

Gene position: 2172550-2173335 (Clockwise)

Preceding gene: 222111222

Following gene: 222111228

Centisome position: 57.22

GC content: 59.8

Gene sequence:

>786_bases
ATGAAGAAAAAGCTCTTGTCCGGCCTCGTGGCCGCAGCCGTGCTGGGCACGATGGCATTGCCCGTTGCCGCGCAAAACCT
CGCCATCGTCAATGGCAAGGCGGTTCCCAAGGAACGTGCCGAAGTCCTGAAGCAGCAGGTGGAGCGCTCGGGCCGCCCGG
TCACGCCCGAACTGGAAAACCAGATCAAGGAAGAAGTGATCGCCCGCGAGATCTTCATGCAGGAAGCGCAAAAGCGCGGC
CTGGAAGGCTCTGCCGATTACAAGGCCCAGATGGAGTTGGCACGCCAGACCATTCTGATCCGTGAACTGTTCGTGGATTT
CCAGAAGAACAATGCCGTGACCGATGCCGAGATCCAGGCCGAGTACGACAAGTTCGTGGCCGCCAACGCTGGCAAAGAAT
ATAAGGCCAGCCACATCCTGGTCGAAAAGGAAGACGAGGCCAAGGCCATCATTGCTTCCATCAAGAAGGGTGGCAAGTTC
GAGGACATTGCGAAGAAGCAATCCAAGGACCCCGGATCCGGCGCCCGCGGTGGCGACCTAGACTGGGCCAGCCCGAGCAG
CTACGTGGCTGAGTTCACGGAAGCGCTGGTGAAGCTGGAGAAAGGCAAGATGACCCAGACCCCCGTGAAGAGCCAGTTCG
GCTGGCACGTCATCCGCCTAGACGATGTGCGCGAAGCCCAGCTGCCGAAGCTGGAAGAGGTCAAGCCCCAGATCGCCCAG
CAACTGCAGCAGCAGAAACTGGCGAAGTTCCAGGAAGACCTGCGCGCCAAGGCCAAGGTGGAGTAA

Upstream 100 bases:

>100_bases
GGCGCCCACGCCATTGCCATTGAAACTCTCTGAAACAACCCCGCTCCAAGGGCGTTGCAGCCAGTCGGCTGCAGCCTATT
TCCCAATCAGTGGATTCTCA

Downstream 100 bases:

>100_bases
CCACTACAGGCGCCTCGCGCACGGCAACGCGGCCTTCGGGCCGCGTTTTTTTTTATGCCCGCCCCGCCAGCCAGCCTGCC
AGCAACAGTCCTCCGATCAG

Product: ppic-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MKKKLLSGLVAAAVLGTMALPVAAQNLAIVNGKAVPKERAEVLKQQVERSGRPVTPELENQIKEEVIAREIFMQEAQKRG
LEGSADYKAQMELARQTILIRELFVDFQKNNAVTDAEIQAEYDKFVAANAGKEYKASHILVEKEDEAKAIIASIKKGGKF
EDIAKKQSKDPGSGARGGDLDWASPSSYVAEFTEALVKLEKGKMTQTPVKSQFGWHVIRLDDVREAQLPKLEEVKPQIAQ
QLQQQKLAKFQEDLRAKAKVE

Sequences:

>Translated_261_residues
MKKKLLSGLVAAAVLGTMALPVAAQNLAIVNGKAVPKERAEVLKQQVERSGRPVTPELENQIKEEVIAREIFMQEAQKRG
LEGSADYKAQMELARQTILIRELFVDFQKNNAVTDAEIQAEYDKFVAANAGKEYKASHILVEKEDEAKAIIASIKKGGKF
EDIAKKQSKDPGSGARGGDLDWASPSSYVAEFTEALVKLEKGKMTQTPVKSQFGWHVIRLDDVREAQLPKLEEVKPQIAQ
QLQQQKLAKFQEDLRAKAKVE
>Mature_261_residues
MKKKLLSGLVAAAVLGTMALPVAAQNLAIVNGKAVPKERAEVLKQQVERSGRPVTPELENQIKEEVIAREIFMQEAQKRG
LEGSADYKAQMELARQTILIRELFVDFQKNNAVTDAEIQAEYDKFVAANAGKEYKASHILVEKEDEAKAIIASIKKGGKF
EDIAKKQSKDPGSGARGGDLDWASPSSYVAEFTEALVKLEKGKMTQTPVKSQFGWHVIRLDDVREAQLPKLEEVKPQIAQ
QLQQQKLAKFQEDLRAKAKVE

Specific function: Ppiases Accelerate The Folding Of Proteins. Seems To Be Involved In The Folding Of Outer Membrane Proteins. Its Preference At The P1 Position Of The Peptide Substrate Is Glu > Leu > Ala > His > Val > Phe > Ile > Gly > Lys > Thr. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Type II Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=138, Percent_Identity=35.5072463768116, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786238, Length=103, Percent_Identity=42.7184466019417, Blast_Score=78, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 28954; Mature: 28954

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKLLSGLVAAAVLGTMALPVAAQNLAIVNGKAVPKERAEVLKQQVERSGRPVTPELEN
CCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHH
QIKEEVIAREIFMQEAQKRGLEGSADYKAQMELARQTILIRELFVDFQKNNAVTDAEIQA
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
EYDKFVAANAGKEYKASHILVEKEDEAKAIIASIKKGGKFEDIAKKQSKDPGSGARGGDL
HHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCC
DWASPSSYVAEFTEALVKLEKGKMTQTPVKSQFGWHVIRLDDVREAQLPKLEEVKPQIAQ
CCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEEECCCCHHCCCCHHHHHHHHHH
QLQQQKLAKFQEDLRAKAKVE
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKKLLSGLVAAAVLGTMALPVAAQNLAIVNGKAVPKERAEVLKQQVERSGRPVTPELEN
CCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHH
QIKEEVIAREIFMQEAQKRGLEGSADYKAQMELARQTILIRELFVDFQKNNAVTDAEIQA
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
EYDKFVAANAGKEYKASHILVEKEDEAKAIIASIKKGGKFEDIAKKQSKDPGSGARGGDL
HHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCC
DWASPSSYVAEFTEALVKLEKGKMTQTPVKSQFGWHVIRLDDVREAQLPKLEEVKPQIAQ
CCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEEECCCCHHCCCCHHHHHHHHHH
QLQQQKLAKFQEDLRAKAKVE
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]