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The map label for this gene is dhaT [H]

Identifier: 222111185

GI number: 222111185

Start: 2128980

End: 2130116

Strand: Direct

Name: dhaT [H]

Synonym: Dtpsy_1993

Alternate gene names: 222111185

Gene position: 2128980-2130116 (Clockwise)

Preceding gene: 222111181

Following gene: 222111186

Centisome position: 56.08

GC content: 70.1

Gene sequence:

>1137_bases
ATGGCTTTCATCTACTACGTCACCCAGATCCAGTTCGAATTCGGCGCCGTGCGCCTGCTCAAAGCAGAATGCGAGCGCAT
CGGCATCACCCGCCCCCTGGTGGTCACCGACCCCGGCGTGAAGGCCGCCGGCGTGCTGCAGCAGGCACTGGACGCCCTGC
CCGGCCTGAACGTCGCCGTGTTCGACCAGACGCCCTCCAACCCCACCGAGGCGGCCGTGCGCGCGGCCGTGGAACTCTAC
AAGGCCCAGGGCTGCGACGGCCTGATCGCCGTGGGCGGTGGCAGCGCCATCGACTGCGCCAAGGGCATTGCCATCGCCGC
CACGCACGACGGCCCGCTCACGCACTACGCCACCATCGAGGGGGGTTCGCCGCGCATCACCGAGCGCGCCGCGCCGCTGA
TCGCCGTGCCCACCACCAGCGGCACGGGCAGCGAGGTGGCGCGCGGCGCCATCATCATCGTGGATGACCACCGCAAGCTG
GGCTTTCACTCCTGGCACCTGGTGCCCAAGGCCGCCATCTGCGACCCCGGCCTCACGCTGGGCCTGCCGCCCCTGCTGAC
GGCCGCCACAGGCATGGACGCCGTCGCGCACTGCATGGAAACTTTCATGTCCGCCGCCTTCAACCCGCCGGCGGACGGTA
TTGCTCTCGATGGTCTGGAGCGCGGCTGGCACCATATCGAGGCCGCCACGCGCGACGGCCAGGACCGCGACGCGCGCCTG
GCCATGATGAGCGCCAGCATGCAGGGCGCCATGGCCTTCCAGAAGGGCCTGGGCTGCGTGCACTCCCTGAGCCACAGCCT
GGGCGGGCTGAACCCGCGCCTGCACCACGGCACGCTGAACGCCGTGTTCCTGCCCGCCGTGGTGCGTTTCAACGCGCAAG
CCGAATCGGTGCGCAAGGAGCGCCGCCTGGAGCGCATGGCCCATGCCATGGGCCTGGCCTCCGCCAGCGACATCCCCGAT
GCCATCCGCGACATGAGCGCACGCCTGGGCCTGCCCACGGGGCTGGCCGCCATGGGCGTGACCGAGGCGGTGTTCGACGA
CGTGATCAAGGGCGCCCTGGCCGACCACTGCCACAAGACCAATCCCCGCCTGGCCACGCCAGATGACTACCGGGAGATGC
TGATCGAGTCGCTCTGA

Upstream 100 bases:

>100_bases
CCCGCGCACAGGGCGATGAGGGTTTGCTTCATGGTCATGCGTGTCTCCTGGTTGTAGTGTGTCGGGCGATCCTACTGGCA
CTCCCTCTCTTTCGCACACC

Downstream 100 bases:

>100_bases
CCCGCGGCAGCGTCCGCCGAGCAGGCGCCCGGCGGCCTCGCTACACTGGTGCGCTTAACATTTATTAACACGCATTCCGC
CGGTTCGGCGGGGCCGCGTA

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MAFIYYVTQIQFEFGAVRLLKAECERIGITRPLVVTDPGVKAAGVLQQALDALPGLNVAVFDQTPSNPTEAAVRAAVELY
KAQGCDGLIAVGGGSAIDCAKGIAIAATHDGPLTHYATIEGGSPRITERAAPLIAVPTTSGTGSEVARGAIIIVDDHRKL
GFHSWHLVPKAAICDPGLTLGLPPLLTAATGMDAVAHCMETFMSAAFNPPADGIALDGLERGWHHIEAATRDGQDRDARL
AMMSASMQGAMAFQKGLGCVHSLSHSLGGLNPRLHHGTLNAVFLPAVVRFNAQAESVRKERRLERMAHAMGLASASDIPD
AIRDMSARLGLPTGLAAMGVTEAVFDDVIKGALADHCHKTNPRLATPDDYREMLIESL

Sequences:

>Translated_378_residues
MAFIYYVTQIQFEFGAVRLLKAECERIGITRPLVVTDPGVKAAGVLQQALDALPGLNVAVFDQTPSNPTEAAVRAAVELY
KAQGCDGLIAVGGGSAIDCAKGIAIAATHDGPLTHYATIEGGSPRITERAAPLIAVPTTSGTGSEVARGAIIIVDDHRKL
GFHSWHLVPKAAICDPGLTLGLPPLLTAATGMDAVAHCMETFMSAAFNPPADGIALDGLERGWHHIEAATRDGQDRDARL
AMMSASMQGAMAFQKGLGCVHSLSHSLGGLNPRLHHGTLNAVFLPAVVRFNAQAESVRKERRLERMAHAMGLASASDIPD
AIRDMSARLGLPTGLAAMGVTEAVFDDVIKGALADHCHKTNPRLATPDDYREMLIESL
>Mature_377_residues
AFIYYVTQIQFEFGAVRLLKAECERIGITRPLVVTDPGVKAAGVLQQALDALPGLNVAVFDQTPSNPTEAAVRAAVELYK
AQGCDGLIAVGGGSAIDCAKGIAIAATHDGPLTHYATIEGGSPRITERAAPLIAVPTTSGTGSEVARGAIIIVDDHRKLG
FHSWHLVPKAAICDPGLTLGLPPLLTAATGMDAVAHCMETFMSAAFNPPADGIALDGLERGWHHIEAATRDGQDRDARLA
MMSASMQGAMAFQKGLGCVHSLSHSLGGLNPRLHHGTLNAVFLPAVVRFNAQAESVRKERRLERMAHAMGLASASDIPDA
IRDMSARLGLPTGLAAMGVTEAVFDDVIKGALADHCHKTNPRLATPDDYREMLIESL

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=397, Percent_Identity=27.7078085642317, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI48994951, Length=354, Percent_Identity=37.0056497175141, Blast_Score=194, Evalue=6e-51,
Organism=Escherichia coli, GI1789163, Length=373, Percent_Identity=32.171581769437, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1787493, Length=407, Percent_Identity=30.7125307125307, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI87082107, Length=363, Percent_Identity=32.2314049586777, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI1789386, Length=352, Percent_Identity=32.1022727272727, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17537053, Length=291, Percent_Identity=27.8350515463918, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321181, Length=340, Percent_Identity=38.8235294117647, Blast_Score=209, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24657991, Length=419, Percent_Identity=27.4463007159904, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 39813; Mature: 39682

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFIYYVTQIQFEFGAVRLLKAECERIGITRPLVVTDPGVKAAGVLQQALDALPGLNVAV
CEEEEEEEEEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCEEEE
FDQTPSNPTEAAVRAAVELYKAQGCDGLIAVGGGSAIDCAKGIAIAATHDGPLTHYATIE
ECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCEEEEEECCCCCEEEEEEC
GGSPRITERAAPLIAVPTTSGTGSEVARGAIIIVDDHRKLGFHSWHLVPKAAICDPGLTL
CCCCCCHHHCCCEEEEECCCCCCHHHHCCEEEEEECCCCCCCCEEECCCCHHHCCCCCCC
GLPPLLTAATGMDAVAHCMETFMSAAFNPPADGIALDGLERGWHHIEAATRDGQDRDARL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHCCCCCHHHHH
AMMSASMQGAMAFQKGLGCVHSLSHSLGGLNPRLHHGTLNAVFLPAVVRFNAQAESVRKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHCCCHHHHHHHH
RRLERMAHAMGLASASDIPDAIRDMSARLGLPTGLAAMGVTEAVFDDVIKGALADHCHKT
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
NPRLATPDDYREMLIESL
CCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
AFIYYVTQIQFEFGAVRLLKAECERIGITRPLVVTDPGVKAAGVLQQALDALPGLNVAV
EEEEEEEEEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCEEEE
FDQTPSNPTEAAVRAAVELYKAQGCDGLIAVGGGSAIDCAKGIAIAATHDGPLTHYATIE
ECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCEEEEEECCCCCEEEEEEC
GGSPRITERAAPLIAVPTTSGTGSEVARGAIIIVDDHRKLGFHSWHLVPKAAICDPGLTL
CCCCCCHHHCCCEEEEECCCCCCHHHHCCEEEEEECCCCCCCCEEECCCCHHHCCCCCCC
GLPPLLTAATGMDAVAHCMETFMSAAFNPPADGIALDGLERGWHHIEAATRDGQDRDARL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHCCCCCHHHHH
AMMSASMQGAMAFQKGLGCVHSLSHSLGGLNPRLHHGTLNAVFLPAVVRFNAQAESVRKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHCCCHHHHHHHH
RRLERMAHAMGLASASDIPDAIRDMSARLGLPTGLAAMGVTEAVFDDVIKGALADHCHKT
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
NPRLATPDDYREMLIESL
CCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]