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The map label for this gene is caiD [C]

Identifier: 222111134

GI number: 222111134

Start: 2077711

End: 2078478

Strand: Direct

Name: caiD [C]

Synonym: Dtpsy_1942

Alternate gene names: 222111134

Gene position: 2077711-2078478 (Clockwise)

Preceding gene: 222111133

Following gene: 222111135

Centisome position: 54.73

GC content: 69.53

Gene sequence:

>768_bases
ATGCCCGCCGAACTGCAAAGCACCAGCCAGGGCCAGACCCTGGTCCTGACCCTTCGCCACCCCGAGCTGCGCAATGCCCT
GGAGCCGGCCATCTGCGCGGCGGGCATCGAAGCCCTGAACGTGGCGGAGCGCAATCCCGATGTGCGCTGCGTGGTCATCA
CGGGCGCGGACGGCCTGTTCAGCGCCGGCAACAGCCCCCAGCGGCTGCAGGCGTTGCGGCATCAGAGCGCGCCAGCGCAG
GTGCATGGCCTGGATCTGCTGCACCACTGGATAGAGGCGATACGCACCCATCCCAAGCCCGTGATCGCCGCCGTGGAGGG
TGAAGCCAAGGGTGCGGGGTTTTCACTCGCGCTGGCATGCGACCTGATGGTGGCCGCGCGCAACGCGGTGTTTGCCATGA
ACCATGTCCACGCGGGCCTGTCGCCCGATGGCGGCGCCAGCTGGAGCCTGGCGCAAATGCTGCCCCGCGCGCTGGCGCAT
GAGATCCTGATGTGCGGCGACCGCATCGACGCCGCACGACTGCAGTCCCTGGGCATGGTCAACCGGCTGGCCGATCCCGG
GCGCGCCCTGCATGAGGCGCTGGCGCTGGCCCAGCGCCTGAACGATGGCCCGCCCCATGCGCTGGCGAGCATCAAGGAAC
TGGTGGGCGAGGCGCGGCACCACAGCTTCACCGAACAGCTCGCGCTGGAGCGCAGCCACTTCGTGCGCAACCTCCAGCAT
GCCCTGGCGGGCGAAACCCGGGCGGCTTCTGCCGACCCACGCGCTTAA

Upstream 100 bases:

>100_bases
GACCCGCGCTACCGCCCCAGCCCCTGGCTGCGCCGGCGCGGCGCCATCGGCCTGAGCCTGACGCACGAAGAACCCTGACC
CTGCCACCACCCGCGCCGCC

Downstream 100 bases:

>100_bases
AGCTACTATTTTTATAGCTGCTAGCGCTTGACGGTCAAGCGCCGGCGGCTTGTCTCATTCAAACCCATCCATGGCATTGC
TGGCTCCGCGGCAGCGGCGC

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MPAELQSTSQGQTLVLTLRHPELRNALEPAICAAGIEALNVAERNPDVRCVVITGADGLFSAGNSPQRLQALRHQSAPAQ
VHGLDLLHHWIEAIRTHPKPVIAAVEGEAKGAGFSLALACDLMVAARNAVFAMNHVHAGLSPDGGASWSLAQMLPRALAH
EILMCGDRIDAARLQSLGMVNRLADPGRALHEALALAQRLNDGPPHALASIKELVGEARHHSFTEQLALERSHFVRNLQH
ALAGETRAASADPRA

Sequences:

>Translated_255_residues
MPAELQSTSQGQTLVLTLRHPELRNALEPAICAAGIEALNVAERNPDVRCVVITGADGLFSAGNSPQRLQALRHQSAPAQ
VHGLDLLHHWIEAIRTHPKPVIAAVEGEAKGAGFSLALACDLMVAARNAVFAMNHVHAGLSPDGGASWSLAQMLPRALAH
EILMCGDRIDAARLQSLGMVNRLADPGRALHEALALAQRLNDGPPHALASIKELVGEARHHSFTEQLALERSHFVRNLQH
ALAGETRAASADPRA
>Mature_254_residues
PAELQSTSQGQTLVLTLRHPELRNALEPAICAAGIEALNVAERNPDVRCVVITGADGLFSAGNSPQRLQALRHQSAPAQV
HGLDLLHHWIEAIRTHPKPVIAAVEGEAKGAGFSLALACDLMVAARNAVFAMNHVHAGLSPDGGASWSLAQMLPRALAHE
ILMCGDRIDAARLQSLGMVNRLADPGRALHEALALAQRLNDGPPHALASIKELVGEARHHSFTEQLALERSHFVRNLQHA
LAGETRAASADPRA

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=224, Percent_Identity=30.8035714285714, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI70995211, Length=231, Percent_Identity=31.1688311688312, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI4757966, Length=203, Percent_Identity=28.0788177339901, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI51538581, Length=203, Percent_Identity=28.0788177339901, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI25453481, Length=203, Percent_Identity=28.0788177339901, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI51538573, Length=203, Percent_Identity=28.0788177339901, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4757968, Length=203, Percent_Identity=27.5862068965517, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI49355787, Length=203, Percent_Identity=27.5862068965517, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI68989263, Length=196, Percent_Identity=33.1632653061224, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI45643119, Length=212, Percent_Identity=25, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI260275230, Length=212, Percent_Identity=25, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI260274832, Length=212, Percent_Identity=25, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI31542718, Length=188, Percent_Identity=29.7872340425532, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI116235487, Length=186, Percent_Identity=25.8064516129032, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI157694516, Length=221, Percent_Identity=23.0769230769231, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI213417737, Length=221, Percent_Identity=23.0769230769231, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI221142681, Length=244, Percent_Identity=34.0163934426229, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1787659, Length=233, Percent_Identity=30.9012875536481, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787660, Length=224, Percent_Identity=33.0357142857143, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788597, Length=199, Percent_Identity=30.6532663316583, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI87082183, Length=209, Percent_Identity=25.8373205741627, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=241, Percent_Identity=28.6307053941909, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17554946, Length=239, Percent_Identity=28.0334728033473, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17540714, Length=241, Percent_Identity=26.1410788381743, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17560910, Length=226, Percent_Identity=23.0088495575221, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17535521, Length=215, Percent_Identity=24.1860465116279, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17536985, Length=210, Percent_Identity=24.2857142857143, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17549921, Length=213, Percent_Identity=26.2910798122066, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI20129971, Length=240, Percent_Identity=27.9166666666667, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24653477, Length=240, Percent_Identity=27.9166666666667, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24653139, Length=206, Percent_Identity=28.6407766990291, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19920382, Length=225, Percent_Identity=27.5555555555556, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19922422, Length=242, Percent_Identity=26.8595041322314, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 27153; Mature: 27022

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAELQSTSQGQTLVLTLRHPELRNALEPAICAAGIEALNVAERNPDVRCVVITGADGLF
CCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
SAGNSPQRLQALRHQSAPAQVHGLDLLHHWIEAIRTHPKPVIAAVEGEAKGAGFSLALAC
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHH
DLMVAARNAVFAMNHVHAGLSPDGGASWSLAQMLPRALAHEILMCGDRIDAARLQSLGMV
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
NRLADPGRALHEALALAQRLNDGPPHALASIKELVGEARHHSFTEQLALERSHFVRNLQH
HHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAGETRAASADPRA
HHCCCCCCCCCCCCC
>Mature Secondary Structure 
PAELQSTSQGQTLVLTLRHPELRNALEPAICAAGIEALNVAERNPDVRCVVITGADGLF
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
SAGNSPQRLQALRHQSAPAQVHGLDLLHHWIEAIRTHPKPVIAAVEGEAKGAGFSLALAC
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHH
DLMVAARNAVFAMNHVHAGLSPDGGASWSLAQMLPRALAHEILMCGDRIDAARLQSLGMV
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
NRLADPGRALHEALALAQRLNDGPPHALASIKELVGEARHHSFTEQLALERSHFVRNLQH
HHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAGETRAASADPRA
HHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA