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The map label for this gene is paaH [H]

Identifier: 222111133

GI number: 222111133

Start: 2076168

End: 2077688

Strand: Direct

Name: paaH [H]

Synonym: Dtpsy_1941

Alternate gene names: 222111133

Gene position: 2076168-2077688 (Clockwise)

Preceding gene: 222111131

Following gene: 222111134

Centisome position: 54.69

GC content: 69.56

Gene sequence:

>1521_bases
ATGCAAACGGTCTTCACTTCAATCGGCATCGTGGGCACTGGCGCCATGGGCCGCGGCATCGCGCAGATCGCCGCCCAGGC
AGGCAGCACGGTCTACCTCTATGACACCCATGGCGGCGCCGCCGACGCCGCCCGCACCCACATCCACCAGCAGTGGCAGC
GTCTGGTGGACAAGGGTCGGCTGGACGAGAGCCTGTTGCCGGCTCTGGTGCAGCGGCTGGTTCCCGTCACGTCGCTGCAC
GACTTCGCGGCTTGCGAATTGGTGGTGGAAGCCATCGTCGAGCGACTGGATTCCAAGCAGGAACTGCTCAAACAGCTCGA
AGCCATCGTCTCGCCCGAAGCCGTGCTGGCCAGCAACACGTCATCGCTGTCCATCACCGCCGTGGCCGCACCGCTGCAGC
GGCCGCAGCGCATGGCAGGCTTTCACTTCTTCAACCCGGTGCCGCTGATGAAGGTGGTCGAGGTCGTGGCCGGCCTGCGC
ACGGACCCCCATGTCTGCACCCGCCTGGCCGGCTATGCGCGCGCCATGGGCCACACCCCGGTGATGGCGCAGGACACGCC
GGGCTTCATCGTCAACCACGCAGGGCGGGGCTACGGCACCGAGGCGCTGCGCATCGTGAGCGAGGGCGTGGCCGATTTCG
CCACCGTGGACCGCATCCTGCGCGACCAGGTGGGCTTCAAGCTCGGCCCCTTCGAGTTGCTGGACCTCACCGCGCTCGAT
GTGTCGCACCCGGTCATGGAGTCGATCTACCGCCAGTACTACGACGAGCCGCGCTTTCGCCCCAGCGTGATCACGGCGCA
GCGCTTGAGCGGCGGCCTGCTGGGCCGCAAGTCCGGCGAGGGCTTTTACCGCTACGTGGACGGTGCGCCCGAGCTGCCGG
CCGAGCCGCCGGTGCCCGAGGTATCGGGCCTGCCGCCGGTCTGGGTCTCCACGCGCGCCGCCCGCCGCGCCGAGCTGTAC
CAGTTGCTCAAGGACCTGGGGGCAACGATCGAGACGGGCACCTCGCCCTCGGCCCAGGCGCTCACGCTGGTCGCGCCACT
CGGCTTTGACGTGACCACCGTGGCCGTGGTGGAGCGCCTGGACCCCGCACGCACCATCGGCATCGACATGCTGATCGACG
ACGCGGCCACCCGCCGGCGCGTGCTGGCGACCAACCCCGCCACACGCGAAGACATGCGCGACGCCGCGCACGCGCTGTTC
GCGCGCGACGGCAAGCCAGTGAGCGTGATCCGCGACAGCGGCGGCTTCGTCACGCAGCGCGTCGTGGCCAACATCGTCAA
CATCGCCGCGGACATCTGCCAGCAGCGCATCTGCAGCCCCAAGGACCTGGAGACCGCCGTGACCCTGGGCCTGGGCTACC
CGCTGGGCCCGCTGGCCATGGGCGACCGCTGGGGCCCCACCAACATCCTGGAAGTGCTCTTCAACATGCAGACCGTGTAC
GGCGACCCGCGCTACCGCCCCAGCCCCTGGCTGCGCCGGCGCGGCGCCATCGGCCTGAGCCTGACGCACGAAGAACCCTG
A

Upstream 100 bases:

>100_bases
GGCGCCGACAAGTAGGTTACGCATAAACACAATGGTTTCAATTTGTTTATAAATTTTGCCATAACCCTGCCGCATCCGAT
AGCGCTAGATAATTGCCGCC

Downstream 100 bases:

>100_bases
CCCTGCCACCACCCGCGCCGCCATGCCCGCCGAACTGCAAAGCACCAGCCAGGGCCAGACCCTGGTCCTGACCCTTCGCC
ACCCCGAGCTGCGCAATGCC

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MQTVFTSIGIVGTGAMGRGIAQIAAQAGSTVYLYDTHGGAADAARTHIHQQWQRLVDKGRLDESLLPALVQRLVPVTSLH
DFAACELVVEAIVERLDSKQELLKQLEAIVSPEAVLASNTSSLSITAVAAPLQRPQRMAGFHFFNPVPLMKVVEVVAGLR
TDPHVCTRLAGYARAMGHTPVMAQDTPGFIVNHAGRGYGTEALRIVSEGVADFATVDRILRDQVGFKLGPFELLDLTALD
VSHPVMESIYRQYYDEPRFRPSVITAQRLSGGLLGRKSGEGFYRYVDGAPELPAEPPVPEVSGLPPVWVSTRAARRAELY
QLLKDLGATIETGTSPSAQALTLVAPLGFDVTTVAVVERLDPARTIGIDMLIDDAATRRRVLATNPATREDMRDAAHALF
ARDGKPVSVIRDSGGFVTQRVVANIVNIAADICQQRICSPKDLETAVTLGLGYPLGPLAMGDRWGPTNILEVLFNMQTVY
GDPRYRPSPWLRRRGAIGLSLTHEEP

Sequences:

>Translated_506_residues
MQTVFTSIGIVGTGAMGRGIAQIAAQAGSTVYLYDTHGGAADAARTHIHQQWQRLVDKGRLDESLLPALVQRLVPVTSLH
DFAACELVVEAIVERLDSKQELLKQLEAIVSPEAVLASNTSSLSITAVAAPLQRPQRMAGFHFFNPVPLMKVVEVVAGLR
TDPHVCTRLAGYARAMGHTPVMAQDTPGFIVNHAGRGYGTEALRIVSEGVADFATVDRILRDQVGFKLGPFELLDLTALD
VSHPVMESIYRQYYDEPRFRPSVITAQRLSGGLLGRKSGEGFYRYVDGAPELPAEPPVPEVSGLPPVWVSTRAARRAELY
QLLKDLGATIETGTSPSAQALTLVAPLGFDVTTVAVVERLDPARTIGIDMLIDDAATRRRVLATNPATREDMRDAAHALF
ARDGKPVSVIRDSGGFVTQRVVANIVNIAADICQQRICSPKDLETAVTLGLGYPLGPLAMGDRWGPTNILEVLFNMQTVY
GDPRYRPSPWLRRRGAIGLSLTHEEP
>Mature_506_residues
MQTVFTSIGIVGTGAMGRGIAQIAAQAGSTVYLYDTHGGAADAARTHIHQQWQRLVDKGRLDESLLPALVQRLVPVTSLH
DFAACELVVEAIVERLDSKQELLKQLEAIVSPEAVLASNTSSLSITAVAAPLQRPQRMAGFHFFNPVPLMKVVEVVAGLR
TDPHVCTRLAGYARAMGHTPVMAQDTPGFIVNHAGRGYGTEALRIVSEGVADFATVDRILRDQVGFKLGPFELLDLTALD
VSHPVMESIYRQYYDEPRFRPSVITAQRLSGGLLGRKSGEGFYRYVDGAPELPAEPPVPEVSGLPPVWVSTRAARRAELY
QLLKDLGATIETGTSPSAQALTLVAPLGFDVTTVAVVERLDPARTIGIDMLIDDAATRRRVLATNPATREDMRDAAHALF
ARDGKPVSVIRDSGGFVTQRVVANIVNIAADICQQRICSPKDLETAVTLGLGYPLGPLAMGDRWGPTNILEVLFNMQTVY
GDPRYRPSPWLRRRGAIGLSLTHEEP

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=293, Percent_Identity=34.8122866894198, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI296179427, Length=310, Percent_Identity=32.9032258064516, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI20127408, Length=284, Percent_Identity=31.3380281690141, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI261878539, Length=292, Percent_Identity=28.0821917808219, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI68989263, Length=292, Percent_Identity=28.0821917808219, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI115430219, Length=237, Percent_Identity=27.4261603375527, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1787661, Length=498, Percent_Identity=37.9518072289157, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1790281, Length=283, Percent_Identity=29.3286219081272, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1788682, Length=265, Percent_Identity=30.5660377358491, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=36.2369337979094, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17553560, Length=292, Percent_Identity=34.9315068493151, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=33.4494773519164, Blast_Score=165, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71985923, Length=280, Percent_Identity=28.9285714285714, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17508951, Length=285, Percent_Identity=29.4736842105263, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17508953, Length=285, Percent_Identity=29.4736842105263, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI25144276, Length=285, Percent_Identity=29.4736842105263, Blast_Score=132, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17558304, Length=342, Percent_Identity=27.1929824561404, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI71985930, Length=282, Percent_Identity=25.177304964539, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24583077, Length=281, Percent_Identity=27.0462633451957, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24583079, Length=281, Percent_Identity=27.0462633451957, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19921000, Length=281, Percent_Identity=27.0462633451957, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=29.5833333333333, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI20129993, Length=238, Percent_Identity=29.8319327731092, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 54835; Mature: 54835

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTVFTSIGIVGTGAMGRGIAQIAAQAGSTVYLYDTHGGAADAARTHIHQQWQRLVDKGR
CCCHHHHCCCEECCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
LDESLLPALVQRLVPVTSLHDFAACELVVEAIVERLDSKQELLKQLEAIVSPEAVLASNT
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHEECCC
SSLSITAVAAPLQRPQRMAGFHFFNPVPLMKVVEVVAGLRTDPHVCTRLAGYARAMGHTP
CCEEEEEEHHHHHCHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
VMAQDTPGFIVNHAGRGYGTEALRIVSEGVADFATVDRILRDQVGFKLGPFELLDLTALD
EEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VSHPVMESIYRQYYDEPRFRPSVITAQRLSGGLLGRKSGEGFYRYVDGAPELPAEPPVPE
HCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
VSGLPPVWVSTRAARRAELYQLLKDLGATIETGTSPSAQALTLVAPLGFDVTTVAVVERL
CCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEECCCCCHHHHHHHHHC
DPARTIGIDMLIDDAATRRRVLATNPATREDMRDAAHALFARDGKPVSVIRDSGGFVTQR
CCHHHHCHHHEECCHHHHCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
VVANIVNIAADICQQRICSPKDLETAVTLGLGYPLGPLAMGDRWGPTNILEVLFNMQTVY
HHHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
GDPRYRPSPWLRRRGAIGLSLTHEEP
CCCCCCCCHHHHHCCCCEEEECCCCC
>Mature Secondary Structure
MQTVFTSIGIVGTGAMGRGIAQIAAQAGSTVYLYDTHGGAADAARTHIHQQWQRLVDKGR
CCCHHHHCCCEECCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
LDESLLPALVQRLVPVTSLHDFAACELVVEAIVERLDSKQELLKQLEAIVSPEAVLASNT
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHEECCC
SSLSITAVAAPLQRPQRMAGFHFFNPVPLMKVVEVVAGLRTDPHVCTRLAGYARAMGHTP
CCEEEEEEHHHHHCHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
VMAQDTPGFIVNHAGRGYGTEALRIVSEGVADFATVDRILRDQVGFKLGPFELLDLTALD
EEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VSHPVMESIYRQYYDEPRFRPSVITAQRLSGGLLGRKSGEGFYRYVDGAPELPAEPPVPE
HCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
VSGLPPVWVSTRAARRAELYQLLKDLGATIETGTSPSAQALTLVAPLGFDVTTVAVVERL
CCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEECCCCCHHHHHHHHHC
DPARTIGIDMLIDDAATRRRVLATNPATREDMRDAAHALFARDGKPVSVIRDSGGFVTQR
CCHHHHCHHHEECCHHHHCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
VVANIVNIAADICQQRICSPKDLETAVTLGLGYPLGPLAMGDRWGPTNILEVLFNMQTVY
HHHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
GDPRYRPSPWLRRRGAIGLSLTHEEP
CCCCCCCCHHHHHCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]