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The map label for this gene is pccB [H]

Identifier: 222111044

GI number: 222111044

Start: 1971471

End: 1973003

Strand: Direct

Name: pccB [H]

Synonym: Dtpsy_1851

Alternate gene names: 222111044

Gene position: 1971471-1973003 (Clockwise)

Preceding gene: 222111043

Following gene: 222111045

Centisome position: 51.93

GC content: 63.34

Gene sequence:

>1533_bases
ATGCAAGACATCCTGGATCAACTGGAGAAAAAGCGCGAACTCGCCCGCCTGGGCGGTGGCCAGAAGCGCATCGACGCCCA
GCACAAGAAGGGCAAGCTCACCGCGCGCGAGCGCATCGAACTGCTGCTGGACGACGGCACGTTCGAGGAATGGGACATGT
TCGTGGAGCACCGCTGCACGGACTTCGGCATGGAGAACACCAAGATCCCCGGTGACGGCGTGGTCACCGGCTACGGCATG
ATCAACGGCCGCCTGGTGTTCGTGTTCAGCCAGGACTTCACGGTGTTCGGCGGCGCGCTCTCCGAGACCCACGCCGAGAA
GATCTGCAAGGTCATGGACCAGGCCATGAAGGTCGGTGCGCCGGTGATCGGCCTGAACGACTCGGGCGGCGCGCGCATCC
AGGAGGGTGTGGCTTCCCTGGGTGGCTATGCCGACGTGTTCCAGAAGAATGTGCTGGCGTCCGGCGTGATCCCGCAGATC
AGCATGATCATGGGCCCCTGCGCGGGCGGTGCGGTGTACAGCCCGGCCATGACCGACTTCATCTTCATGGTCAAGGACAG
CTCGTACATGTTCGTGACCGGCCCCGAAGTGGTGAAGACCGTGACGCACGAAGAAGTCACGGCCGAAGAACTGGGCGGCG
CCATCACGCACACCACCAAGAGCGGCGTGGCCGACATGGCCTTCGAGAACGACGTGGAGGCGCTGATGATGCTGCGCCGC
CTGTACAACTACCTGCCGCTCAACAACAAGGAAAAGGCGCCCGTGCGCCCGAGCAACGACCCGGCCGACCGCGCCGACCT
GTCGCTGGACACGCTGGTGCCCGACAACCCCAACAAGCCGTATGACATGAAGGAGCTGATCGTCAAGACGGTGGACGACG
GTGACTTCTTTGAGCTGCAGCCCGACTACGCCAAGAACATTCTCATTGGCTTCGCGCGCATGGAAGGGCAGACCGTGGGC
ATCGTGGCCAACCAGCCGCTGGTACTGGCGGGTTGCCTGGACATCAAGAGCTCTATCAAGGCCGCACGCTTCGTGCGCTT
CTGCGATGCGTTCAACATCCCCGTCATCACCTTCGTGGACGTGCCCGGTTTCATGCCAGGCACCAGCCAGGAATACGGCG
GCATCATCAAGCACGGCGCCAAGCTGCTCTACGCATACGCCGAATGCACGGTGCCGAAGATCACCGTCATCACGCGCAAG
GCCTACGGCGGCGCGTACGACGTGATGAGCTCCAAGCATCTGCGCGGCGACGTGAACCTGGCCTGGCCGAACGCCGAGAT
CGCCGTGATGGGCGCCAAGGGCGCGGTGGAGATCATCTTCCGCGAGGACAAGAACGACCCCGCCAAGCTGGCCGCCCGCG
AGGCTGAGTACAAGGCGCGCTTTGCCAACCCGTTCGTCGCCGGCGCACGCGGCTTCATCGACGACGTGATCCTGCCGCAT
GAGACACGCAAGCGCATCTGCCGCAGCCTGGCCATGCTCAAGAACAAGCAGCTTGATAACCCGTGGCGCAAGCACGGGAA
CATTCCGCTGTAA

Upstream 100 bases:

>100_bases
CGCGTAGCGGCTTCCACTGCAGCACGAAATTTGCTTGCGGCGCAATCTGGACAAGCGCTGCAAGCTACTATTTAAATAGC
ACTTCACTGAAAGAGCGACC

Downstream 100 bases:

>100_bases
GCAGGCCAGGCCGGCAATGACGCACACCCGCCCCGTATTTTTCTCCCGGGTCGATGCCTGGATCCTGGCCATCGGCCCCG
TGACCGGCCTTGCCGCGGTC

Product: carboxyl transferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MQDILDQLEKKRELARLGGGQKRIDAQHKKGKLTARERIELLLDDGTFEEWDMFVEHRCTDFGMENTKIPGDGVVTGYGM
INGRLVFVFSQDFTVFGGALSETHAEKICKVMDQAMKVGAPVIGLNDSGGARIQEGVASLGGYADVFQKNVLASGVIPQI
SMIMGPCAGGAVYSPAMTDFIFMVKDSSYMFVTGPEVVKTVTHEEVTAEELGGAITHTTKSGVADMAFENDVEALMMLRR
LYNYLPLNNKEKAPVRPSNDPADRADLSLDTLVPDNPNKPYDMKELIVKTVDDGDFFELQPDYAKNILIGFARMEGQTVG
IVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVITFVDVPGFMPGTSQEYGGIIKHGAKLLYAYAECTVPKITVITRK
AYGGAYDVMSSKHLRGDVNLAWPNAEIAVMGAKGAVEIIFREDKNDPAKLAAREAEYKARFANPFVAGARGFIDDVILPH
ETRKRICRSLAMLKNKQLDNPWRKHGNIPL

Sequences:

>Translated_510_residues
MQDILDQLEKKRELARLGGGQKRIDAQHKKGKLTARERIELLLDDGTFEEWDMFVEHRCTDFGMENTKIPGDGVVTGYGM
INGRLVFVFSQDFTVFGGALSETHAEKICKVMDQAMKVGAPVIGLNDSGGARIQEGVASLGGYADVFQKNVLASGVIPQI
SMIMGPCAGGAVYSPAMTDFIFMVKDSSYMFVTGPEVVKTVTHEEVTAEELGGAITHTTKSGVADMAFENDVEALMMLRR
LYNYLPLNNKEKAPVRPSNDPADRADLSLDTLVPDNPNKPYDMKELIVKTVDDGDFFELQPDYAKNILIGFARMEGQTVG
IVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVITFVDVPGFMPGTSQEYGGIIKHGAKLLYAYAECTVPKITVITRK
AYGGAYDVMSSKHLRGDVNLAWPNAEIAVMGAKGAVEIIFREDKNDPAKLAAREAEYKARFANPFVAGARGFIDDVILPH
ETRKRICRSLAMLKNKQLDNPWRKHGNIPL
>Mature_510_residues
MQDILDQLEKKRELARLGGGQKRIDAQHKKGKLTARERIELLLDDGTFEEWDMFVEHRCTDFGMENTKIPGDGVVTGYGM
INGRLVFVFSQDFTVFGGALSETHAEKICKVMDQAMKVGAPVIGLNDSGGARIQEGVASLGGYADVFQKNVLASGVIPQI
SMIMGPCAGGAVYSPAMTDFIFMVKDSSYMFVTGPEVVKTVTHEEVTAEELGGAITHTTKSGVADMAFENDVEALMMLRR
LYNYLPLNNKEKAPVRPSNDPADRADLSLDTLVPDNPNKPYDMKELIVKTVDDGDFFELQPDYAKNILIGFARMEGQTVG
IVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVITFVDVPGFMPGTSQEYGGIIKHGAKLLYAYAECTVPKITVITRK
AYGGAYDVMSSKHLRGDVNLAWPNAEIAVMGAKGAVEIIFREDKNDPAKLAAREAEYKARFANPFVAGARGFIDDVILPH
ETRKRICRSLAMLKNKQLDNPWRKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=507, Percent_Identity=70.8086785009862, Blast_Score=753, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=527, Percent_Identity=68.1214421252372, Blast_Score=739, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=523, Percent_Identity=34.0344168260038, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI38679974, Length=389, Percent_Identity=23.9074550128535, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI38679960, Length=389, Percent_Identity=23.9074550128535, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI38679971, Length=389, Percent_Identity=23.9074550128535, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI38679977, Length=389, Percent_Identity=23.9074550128535, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI38679967, Length=389, Percent_Identity=23.9074550128535, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI134142062, Length=393, Percent_Identity=22.9007633587786, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=70.0197238658777, Blast_Score=761, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=70.0197238658777, Blast_Score=761, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=523, Percent_Identity=33.4608030592734, Blast_Score=254, Evalue=6e-68,
Organism=Drosophila melanogaster, GI24586065, Length=542, Percent_Identity=34.1328413284133, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56015; Mature: 56015

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDILDQLEKKRELARLGGGQKRIDAQHKKGKLTARERIELLLDDGTFEEWDMFVEHRCT
CHHHHHHHHHHHHHHHHCCCCHHHCCHHHCCCCCHHHHEEEEECCCCHHHHHHHHHHHHH
DFGMENTKIPGDGVVTGYGMINGRLVFVFSQDFTVFGGALSETHAEKICKVMDQAMKVGA
HCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHCCC
PVIGLNDSGGARIQEGVASLGGYADVFQKNVLASGVIPQISMIMGPCAGGAVYSPAMTDF
CEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHEE
IFMVKDSSYMFVTGPEVVKTVTHEEVTAEELGGAITHTTKSGVADMAFENDVEALMMLRR
EEEEECCCEEEEECHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHCCHHHHHHHHH
LYNYLPLNNKEKAPVRPSNDPADRADLSLDTLVPDNPNKPYDMKELIVKTVDDGDFFELQ
HHHHCCCCCCCCCCCCCCCCCCCHHCCEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEC
PDYAKNILIGFARMEGQTVGIVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVITFVD
CHHHHHHEEEEEEECCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
VPGFMPGTSQEYGGIIKHGAKLLYAYAECTVPKITVITRKAYGGAYDVMSSKHLRGDVNL
CCCCCCCCCHHHCHHHHHHHHHEEHHHHCCCCEEEEEEECCCCCHHHHHCCCCCCCCEEE
AWPNAEIAVMGAKGAVEIIFREDKNDPAKLAAREAEYKARFANPFVAGARGFIDDVILPH
ECCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHCCHHHHHHCCCCC
ETRKRICRSLAMLKNKQLDNPWRKHGNIPL
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCC
>Mature Secondary Structure
MQDILDQLEKKRELARLGGGQKRIDAQHKKGKLTARERIELLLDDGTFEEWDMFVEHRCT
CHHHHHHHHHHHHHHHHCCCCHHHCCHHHCCCCCHHHHEEEEECCCCHHHHHHHHHHHHH
DFGMENTKIPGDGVVTGYGMINGRLVFVFSQDFTVFGGALSETHAEKICKVMDQAMKVGA
HCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHCCC
PVIGLNDSGGARIQEGVASLGGYADVFQKNVLASGVIPQISMIMGPCAGGAVYSPAMTDF
CEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHEE
IFMVKDSSYMFVTGPEVVKTVTHEEVTAEELGGAITHTTKSGVADMAFENDVEALMMLRR
EEEEECCCEEEEECHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHCCHHHHHHHHH
LYNYLPLNNKEKAPVRPSNDPADRADLSLDTLVPDNPNKPYDMKELIVKTVDDGDFFELQ
HHHHCCCCCCCCCCCCCCCCCCCHHCCEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEC
PDYAKNILIGFARMEGQTVGIVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVITFVD
CHHHHHHEEEEEEECCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
VPGFMPGTSQEYGGIIKHGAKLLYAYAECTVPKITVITRKAYGGAYDVMSSKHLRGDVNL
CCCCCCCCCHHHCHHHHHHHHHEEHHHHCCCCEEEEEEECCCCCHHHHHCCCCCCCCEEE
AWPNAEIAVMGAKGAVEIIFREDKNDPAKLAAREAEYKARFANPFVAGARGFIDDVILPH
ECCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHCCHHHHHHCCCCC
ETRKRICRSLAMLKNKQLDNPWRKHGNIPL
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]