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The map label for this gene is pepA

Identifier: 222110918

GI number: 222110918

Start: 1831645

End: 1833135

Strand: Direct

Name: pepA

Synonym: Dtpsy_1725

Alternate gene names: 222110918

Gene position: 1831645-1833135 (Clockwise)

Preceding gene: 222110912

Following gene: 222110919

Centisome position: 48.24

GC content: 65.79

Gene sequence:

>1491_bases
ATGAACTTCGAACTGAAGACGCTTTCGCTGGCTGCCGCTGCTGCGTACAAATGCGACCTGCTGGTGGTGTTGGTGCCTGA
AGGCTTCCTGCCGGGCAGCGACGTGTTGTCTACCCTGACGGCGCATGCGCTCAAGCAAGGCGATCTGGAGGTTAAACCGG
GCAAGCTCCTGCAGTGCTATGCCCCCGCCGGTGTTGCGGCGCGTCGGGTTGTGCTGCTGGGGTGCGGTGCGGCCGATGCA
CATGCGGTGCGCCAGGCCATGCAAGCCTTGGCCCCCTCGTTCAAGTTGCCGTCGGTCAAGCGCGTGGCGCTGGTGTTTGG
AACCTCGGCCCAGCGGGGCGCCATCGGCGCTGCGGTGCGTGCGGTGTCCGATGGGAGCTATGTCTATACGGCCACCAAGA
CCAAGGCTGAGCCGCGTGCCCTGCTGCGTGTCACCCTGGGCGTGCCCGATGCGGGTGCAGCGCAGCCGGAGTTCGCCACG
GCCACGGCCGTGGCGGCCGGTGTAGAGTTTGCGCGCGAGTGGGCCAATCGCCCTGCCAACCATGCGACCCCCACGCTGGT
GGCCAATGCCGCCAAGACGCTTGCGAAATACCCCGGCGTCCAGTGCCAGGTGCTGGGCCCTACTGAGGTGGCCAAGCTGG
GCATGGGGGCGTTTCTGGCGGTGGCTCAAGGATCCGATCAGCCGCTTCGCCTGGTGGAATTGCGCTACAACGGCGCGGCC
CGCACGCAGGCTCCCGTGGTGCTGGTGGGCAAGGGCATCACGTTCGACACTGGGGGGATCTCGCTGAAACCCGCGGCGGA
GATGGACGAGATGAAGTTCGACATGGGCGGGGCGGCGAGCGTCCTGGGCGTGTTCCGGGCGCTGGCGGAACTCCGGCCGG
CGATCAACGTGGTGGGCCTCATTCCTGCGTGCGAAAACATGCCCGATGGTAAAGCGGTCAAGCCGGGCGATGTCGTGACG
AGCATGAGCGGCCAGACTATCGAAATCCTCAACACAGACGCAGAAGGGCGTCTGGTCCTGTGCGACGCGCTGACCTACGC
GGCACGCTTCAAGCCAGCCGCCGTGGTGGACATTGCCACATTGACAGGCGCTTGTGTGGTGGCGCTTGGTGGCCTGCGCA
GCGGACTGTTTGCCTCCGATGACCTATTGGCGGAACAGCTCCTATCGGCAGGCGATGCCGCGCTTGACCCCTGTTGGCGT
ATGCCCTTGGATGACGAGTACGCAGAAGGGCTCAAGAGCAATTTTGCCGACATGGCCAATGTCGCAGGCCGGGCCGGTGG
TTCGATCACCGCCGCGAAGTTCCTGCAGCGCTTCGTCGGGGACACGCCGTGGGCACACCTGGACATTGCCGGGACGGCTT
GGAAGGGCGGCGCCGCCAAGGGCGCCACCGGCCGGCCTGTGGGACTGCTGGTGCACTATCTGCTGGAGCGGGCGACGGTG
AGTACCGTGAAACCCAAGCAAAAGACGCGCAGCCGCAAGTCGGTGGCTTGA

Upstream 100 bases:

>100_bases
ACGACGGTGACCAGAACCACCAGGGTCGCGCCGAAGGTGCGGGCCAGCTCCTTGCGAATGGATGAATCGAATAACATTGG
CTCGAAGGAAAACGCTGATT

Downstream 100 bases:

>100_bases
GGGCCATGTCGTTGGAGGTGCGCGCATGACACAGGTGGCATTCCACTTCAATGCACCCGACAAACTGGCGTATGTCTGTC
GCCTGGTGCGAAAAGCCACC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MNFELKTLSLAAAAAYKCDLLVVLVPEGFLPGSDVLSTLTAHALKQGDLEVKPGKLLQCYAPAGVAARRVVLLGCGAADA
HAVRQAMQALAPSFKLPSVKRVALVFGTSAQRGAIGAAVRAVSDGSYVYTATKTKAEPRALLRVTLGVPDAGAAQPEFAT
ATAVAAGVEFAREWANRPANHATPTLVANAAKTLAKYPGVQCQVLGPTEVAKLGMGAFLAVAQGSDQPLRLVELRYNGAA
RTQAPVVLVGKGITFDTGGISLKPAAEMDEMKFDMGGAASVLGVFRALAELRPAINVVGLIPACENMPDGKAVKPGDVVT
SMSGQTIEILNTDAEGRLVLCDALTYAARFKPAAVVDIATLTGACVVALGGLRSGLFASDDLLAEQLLSAGDAALDPCWR
MPLDDEYAEGLKSNFADMANVAGRAGGSITAAKFLQRFVGDTPWAHLDIAGTAWKGGAAKGATGRPVGLLVHYLLERATV
STVKPKQKTRSRKSVA

Sequences:

>Translated_496_residues
MNFELKTLSLAAAAAYKCDLLVVLVPEGFLPGSDVLSTLTAHALKQGDLEVKPGKLLQCYAPAGVAARRVVLLGCGAADA
HAVRQAMQALAPSFKLPSVKRVALVFGTSAQRGAIGAAVRAVSDGSYVYTATKTKAEPRALLRVTLGVPDAGAAQPEFAT
ATAVAAGVEFAREWANRPANHATPTLVANAAKTLAKYPGVQCQVLGPTEVAKLGMGAFLAVAQGSDQPLRLVELRYNGAA
RTQAPVVLVGKGITFDTGGISLKPAAEMDEMKFDMGGAASVLGVFRALAELRPAINVVGLIPACENMPDGKAVKPGDVVT
SMSGQTIEILNTDAEGRLVLCDALTYAARFKPAAVVDIATLTGACVVALGGLRSGLFASDDLLAEQLLSAGDAALDPCWR
MPLDDEYAEGLKSNFADMANVAGRAGGSITAAKFLQRFVGDTPWAHLDIAGTAWKGGAAKGATGRPVGLLVHYLLERATV
STVKPKQKTRSRKSVA
>Mature_496_residues
MNFELKTLSLAAAAAYKCDLLVVLVPEGFLPGSDVLSTLTAHALKQGDLEVKPGKLLQCYAPAGVAARRVVLLGCGAADA
HAVRQAMQALAPSFKLPSVKRVALVFGTSAQRGAIGAAVRAVSDGSYVYTATKTKAEPRALLRVTLGVPDAGAAQPEFAT
ATAVAAGVEFAREWANRPANHATPTLVANAAKTLAKYPGVQCQVLGPTEVAKLGMGAFLAVAQGSDQPLRLVELRYNGAA
RTQAPVVLVGKGITFDTGGISLKPAAEMDEMKFDMGGAASVLGVFRALAELRPAINVVGLIPACENMPDGKAVKPGDVVT
SMSGQTIEILNTDAEGRLVLCDALTYAARFKPAAVVDIATLTGACVVALGGLRSGLFASDDLLAEQLLSAGDAALDPCWR
MPLDDEYAEGLKSNFADMANVAGRAGGSITAAKFLQRFVGDTPWAHLDIAGTAWKGGAAKGATGRPVGLLVHYLLERATV
STVKPKQKTRSRKSVA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=330, Percent_Identity=43.6363636363636, Blast_Score=255, Evalue=7e-68,
Organism=Homo sapiens, GI47155554, Length=314, Percent_Identity=34.3949044585987, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1790710, Length=498, Percent_Identity=44.578313253012, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI87082123, Length=320, Percent_Identity=39.0625, Blast_Score=182, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=306, Percent_Identity=34.640522875817, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17565172, Length=146, Percent_Identity=41.7808219178082, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21355725, Length=318, Percent_Identity=37.7358490566038, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24661038, Length=318, Percent_Identity=37.4213836477987, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI20129969, Length=319, Percent_Identity=37.3040752351097, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24662227, Length=325, Percent_Identity=35.6923076923077, Blast_Score=185, Evalue=8e-47,
Organism=Drosophila melanogaster, GI161077148, Length=319, Percent_Identity=35.423197492163, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI20130057, Length=319, Percent_Identity=35.423197492163, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI21355645, Length=319, Percent_Identity=35.1097178683386, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI24662223, Length=319, Percent_Identity=35.1097178683386, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI20129963, Length=362, Percent_Identity=32.3204419889503, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI19922386, Length=365, Percent_Identity=32.0547945205479, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI21357381, Length=278, Percent_Identity=36.6906474820144, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI221379063, Length=278, Percent_Identity=36.6906474820144, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI221379062, Length=278, Percent_Identity=36.6906474820144, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24646701, Length=252, Percent_Identity=31.3492063492063, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24646703, Length=252, Percent_Identity=31.3492063492063, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21358201, Length=252, Percent_Identity=31.3492063492063, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_ACIET (B9MJ44)

Other databases:

- EMBL:   CP001392
- RefSeq:   YP_002553182.1
- MEROPS:   M17.003
- GeneID:   7385289
- GenomeReviews:   CP001392_GR
- KEGG:   dia:Dtpsy_1725
- ProtClustDB:   CLSK951414
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 51286; Mature: 51286

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 263-263 ACT_SITE 337-337

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFELKTLSLAAAAAYKCDLLVVLVPEGFLPGSDVLSTLTAHALKQGDLEVKPGKLLQCY
CCCEEEHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEECCCCEEEEE
APAGVAARRVVLLGCGAADAHAVRQAMQALAPSFKLPSVKRVALVFGTSAQRGAIGAAVR
CCCCHHHCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHE
AVSDGSYVYTATKTKAEPRALLRVTLGVPDAGAAQPEFATATAVAAGVEFAREWANRPAN
EECCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
HATPTLVANAAKTLAKYPGVQCQVLGPTEVAKLGMGAFLAVAQGSDQPLRLVELRYNGAA
CCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHCCCEEEEEECCCCCCEEEEEEEECCCC
RTQAPVVLVGKGITFDTGGISLKPAAEMDEMKFDMGGAASVLGVFRALAELRPAINVVGL
CCCCCEEEEECCEEECCCCEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEEEE
IPACENMPDGKAVKPGDVVTSMSGQTIEILNTDAEGRLVLCDALTYAARFKPAAVVDIAT
CCCCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCEEEEEHHHHHHHCCCCCEEEHHH
LTGACVVALGGLRSGLFASDDLLAEQLLSAGDAALDPCWRMPLDDEYAEGLKSNFADMAN
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHH
VAGRAGGSITAAKFLQRFVGDTPWAHLDIAGTAWKGGAAKGATGRPVGLLVHYLLERATV
HHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
STVKPKQKTRSRKSVA
HCCCCHHHHHHHCCCC
>Mature Secondary Structure
MNFELKTLSLAAAAAYKCDLLVVLVPEGFLPGSDVLSTLTAHALKQGDLEVKPGKLLQCY
CCCEEEHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEECCCCEEEEE
APAGVAARRVVLLGCGAADAHAVRQAMQALAPSFKLPSVKRVALVFGTSAQRGAIGAAVR
CCCCHHHCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHE
AVSDGSYVYTATKTKAEPRALLRVTLGVPDAGAAQPEFATATAVAAGVEFAREWANRPAN
EECCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
HATPTLVANAAKTLAKYPGVQCQVLGPTEVAKLGMGAFLAVAQGSDQPLRLVELRYNGAA
CCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHCCCEEEEEECCCCCCEEEEEEEECCCC
RTQAPVVLVGKGITFDTGGISLKPAAEMDEMKFDMGGAASVLGVFRALAELRPAINVVGL
CCCCCEEEEECCEEECCCCEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEEEE
IPACENMPDGKAVKPGDVVTSMSGQTIEILNTDAEGRLVLCDALTYAARFKPAAVVDIAT
CCCCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCEEEEEHHHHHHHCCCCCEEEHHH
LTGACVVALGGLRSGLFASDDLLAEQLLSAGDAALDPCWRMPLDDEYAEGLKSNFADMAN
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHH
VAGRAGGSITAAKFLQRFVGDTPWAHLDIAGTAWKGGAAKGATGRPVGLLVHYLLERATV
HHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
STVKPKQKTRSRKSVA
HCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA