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The map label for this gene is mdtD [H]

Identifier: 222110859

GI number: 222110859

Start: 1759127

End: 1760563

Strand: Direct

Name: mdtD [H]

Synonym: Dtpsy_1665

Alternate gene names: 222110859

Gene position: 1759127-1760563 (Clockwise)

Preceding gene: 222110856

Following gene: 222110861

Centisome position: 46.33

GC content: 68.48

Gene sequence:

>1437_bases
ATGGGCGATTTCATGACGCGTGGACCTGTTTCCCCCACTTCGCGCCAGCCGCTGCTGTGGGTGGTCGCGCTGGGCTTCTT
CATGCAGACGCTGGACGCCACCATCGTCAACACGGCCTTGCCGGCCATGGCGCGCGACCTGGGCGAGAGCCCGCTGCAGA
TGCACTCGGTGATCGTGGCGTATTCGCTGGCCATGGCGGTGCTGATTCCGGCGTCGGGCTGGCTGGCGGACCGTTTCGGC
ACGCGGCGGGTGTTCATGTCGGCGATCGCGTTGTTCGTGCTCGGCTCAGTGTTGTGCGCGCTGTCGTCCACGCTGCCGCT
GCTGGTGGGCGCGCGCGTGGTCCAGGGGCTGGGCGGTGCGCTGCTGCTGCCCGTGGGGCGGCTGGCGGTGCTGCGGGCGT
TTCCGCGCGACGAGTTCATCCGCGCCATGAGCTTCGTGGCGATTCCCGGGCTGGTGGGGCCGCTGATCGGGCCGACCCTG
GGCGGCTGGATGGTGGAGTACGCCTCCTGGCATTGGATCTTCTGGGTCAATGTGCCCGTGGGGCTGGTGGGCTTGATGGC
CGCGCGGCGCTTCATGGCGGCGGGAGAGGTGCTGGCCGTGCGTGGATTCGACGCCGTGGGTTATGGCCTGCTGGCCTTTG
GCATGGCGGCCGTGTCGCTGGCGGTGGAGGGCATGGCCGGCGGTGGTGCGCGCAGCGCGTCGTCGCTAGTGATGATGATC
TTTGGCCTGGCCAGTCTGGCGGCCTACTGGCTGCATGCGCTGCGCAGCGATGCGCCGCTGTTTGTGCCGGGGTTGTTCGC
GGTGCGCACGCTGCGCGTGGGGCTGCTGGGCAACTTGTTTTCGCGGCTGGGCAGCTCGTGCATGCCCTTCATGATCCCGC
TGGTGCTGCAGGTCAGCCTGGGCTACGCACCCATGCAGGCGGGCATGATGATGCTGCCCACGGTGCTGGGCAGCATGGCC
GTGAAACCTGTGGTCACCTTCATGGTGCGGCGCTGGGGCTATCGCGAGGTGCTGGTGGTCAATACCTGCGCGCTGGCGTT
GCTCATCGCCAGCTTCTGCCTGATCACGCCCGGCCAGCCCCCGTGGCTGCTGATGGTGCAGCTGGCGGCGTTTGGCGGCG
TGAACTCCATGCAGTTCTCGGCCATGAACACGGTCACGCTCAAGGACCTGGACACGGGTCATGCCAGTAGCGGCAACAGC
CTGCTGTCCATGGTGCAGATGCTGGCCATGGGCATGGGGGTGGCGGCTGCCGGGGCGGTGCTGGCGAGCTTCCAGGGCTA
CTTTGGCGCCGCAGATGCGCAGGACACGCTCCACGCGTTCCGCGCCACGTTTGCCTGCATGGGTGTGCTGACGCTGGCGG
CCACGGCGCTGTTCCTGCAGTTGCCGCCGCACGAGCCGCCGCGCCCCCATCCCCTGGGCCCCGAGGAGCAGAGCTGA

Upstream 100 bases:

>100_bases
TGGTGAACAGGGCCCAACATCGTTTTGACGGATATGACCAGCGCATTAGTCCGCAAACGGGCCCCAATGGCACACTTTGG
CCTTCTTTTCTGAGCCCGCC

Downstream 100 bases:

>100_bases
ACCGGGACTCTTCAGTCTCTTGTGCTATTGTTATAAGAGCTGTTGGCGCTTGTCAGTATTGCCTCGGAGGCCTATTTCTG
TCTCGATTGCCATGATCGTG

Product: EmrB/QacA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MGDFMTRGPVSPTSRQPLLWVVALGFFMQTLDATIVNTALPAMARDLGESPLQMHSVIVAYSLAMAVLIPASGWLADRFG
TRRVFMSAIALFVLGSVLCALSSTLPLLVGARVVQGLGGALLLPVGRLAVLRAFPRDEFIRAMSFVAIPGLVGPLIGPTL
GGWMVEYASWHWIFWVNVPVGLVGLMAARRFMAAGEVLAVRGFDAVGYGLLAFGMAAVSLAVEGMAGGGARSASSLVMMI
FGLASLAAYWLHALRSDAPLFVPGLFAVRTLRVGLLGNLFSRLGSSCMPFMIPLVLQVSLGYAPMQAGMMMLPTVLGSMA
VKPVVTFMVRRWGYREVLVVNTCALALLIASFCLITPGQPPWLLMVQLAAFGGVNSMQFSAMNTVTLKDLDTGHASSGNS
LLSMVQMLAMGMGVAAAGAVLASFQGYFGAADAQDTLHAFRATFACMGVLTLAATALFLQLPPHEPPRPHPLGPEEQS

Sequences:

>Translated_478_residues
MGDFMTRGPVSPTSRQPLLWVVALGFFMQTLDATIVNTALPAMARDLGESPLQMHSVIVAYSLAMAVLIPASGWLADRFG
TRRVFMSAIALFVLGSVLCALSSTLPLLVGARVVQGLGGALLLPVGRLAVLRAFPRDEFIRAMSFVAIPGLVGPLIGPTL
GGWMVEYASWHWIFWVNVPVGLVGLMAARRFMAAGEVLAVRGFDAVGYGLLAFGMAAVSLAVEGMAGGGARSASSLVMMI
FGLASLAAYWLHALRSDAPLFVPGLFAVRTLRVGLLGNLFSRLGSSCMPFMIPLVLQVSLGYAPMQAGMMMLPTVLGSMA
VKPVVTFMVRRWGYREVLVVNTCALALLIASFCLITPGQPPWLLMVQLAAFGGVNSMQFSAMNTVTLKDLDTGHASSGNS
LLSMVQMLAMGMGVAAAGAVLASFQGYFGAADAQDTLHAFRATFACMGVLTLAATALFLQLPPHEPPRPHPLGPEEQS
>Mature_477_residues
GDFMTRGPVSPTSRQPLLWVVALGFFMQTLDATIVNTALPAMARDLGESPLQMHSVIVAYSLAMAVLIPASGWLADRFGT
RRVFMSAIALFVLGSVLCALSSTLPLLVGARVVQGLGGALLLPVGRLAVLRAFPRDEFIRAMSFVAIPGLVGPLIGPTLG
GWMVEYASWHWIFWVNVPVGLVGLMAARRFMAAGEVLAVRGFDAVGYGLLAFGMAAVSLAVEGMAGGGARSASSLVMMIF
GLASLAAYWLHALRSDAPLFVPGLFAVRTLRVGLLGNLFSRLGSSCMPFMIPLVLQVSLGYAPMQAGMMMLPTVLGSMAV
KPVVTFMVRRWGYREVLVVNTCALALLIASFCLITPGQPPWLLMVQLAAFGGVNSMQFSAMNTVTLKDLDTGHASSGNSL
LSMVQMLAMGMGVAAAGAVLASFQGYFGAADAQDTLHAFRATFACMGVLTLAATALFLQLPPHEPPRPHPLGPEEQS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=446, Percent_Identity=47.5336322869955, Blast_Score=410, Evalue=1e-115,
Organism=Escherichia coli, GI1788392, Length=469, Percent_Identity=46.908315565032, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1789042, Length=306, Percent_Identity=29.4117647058824, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI87081983, Length=316, Percent_Identity=30.0632911392405, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1788710, Length=323, Percent_Identity=29.1021671826625, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1788509, Length=141, Percent_Identity=31.2056737588652, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790146, Length=149, Percent_Identity=32.8859060402685, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325455, Length=144, Percent_Identity=31.9444444444444, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321663, Length=154, Percent_Identity=30.5194805194805, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322958, Length=187, Percent_Identity=28.8770053475936, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50483; Mature: 50352

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDFMTRGPVSPTSRQPLLWVVALGFFMQTLDATIVNTALPAMARDLGESPLQMHSVIVA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YSLAMAVLIPASGWLADRFGTRRVFMSAIALFVLGSVLCALSSTLPLLVGARVVQGLGGA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
LLLPVGRLAVLRAFPRDEFIRAMSFVAIPGLVGPLIGPTLGGWMVEYASWHWIFWVNVPV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEEEECHH
GLVGLMAARRFMAAGEVLAVRGFDAVGYGLLAFGMAAVSLAVEGMAGGGARSASSLVMMI
HHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
FGLASLAAYWLHALRSDAPLFVPGLFAVRTLRVGLLGNLFSRLGSSCMPFMIPLVLQVSL
HHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
GYAPMQAGMMMLPTVLGSMAVKPVVTFMVRRWGYREVLVVNTCALALLIASFCLITPGQP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
PWLLMVQLAAFGGVNSMQFSAMNTVTLKDLDTGHASSGNSLLSMVQMLAMGMGVAAAGAV
HHHHHHHHHHHCCCCCCEEHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHH
LASFQGYFGAADAQDTLHAFRATFACMGVLTLAATALFLQLPPHEPPRPHPLGPEEQS
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GDFMTRGPVSPTSRQPLLWVVALGFFMQTLDATIVNTALPAMARDLGESPLQMHSVIVA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YSLAMAVLIPASGWLADRFGTRRVFMSAIALFVLGSVLCALSSTLPLLVGARVVQGLGGA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
LLLPVGRLAVLRAFPRDEFIRAMSFVAIPGLVGPLIGPTLGGWMVEYASWHWIFWVNVPV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEEEECHH
GLVGLMAARRFMAAGEVLAVRGFDAVGYGLLAFGMAAVSLAVEGMAGGGARSASSLVMMI
HHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
FGLASLAAYWLHALRSDAPLFVPGLFAVRTLRVGLLGNLFSRLGSSCMPFMIPLVLQVSL
HHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
GYAPMQAGMMMLPTVLGSMAVKPVVTFMVRRWGYREVLVVNTCALALLIASFCLITPGQP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
PWLLMVQLAAFGGVNSMQFSAMNTVTLKDLDTGHASSGNSLLSMVQMLAMGMGVAAAGAV
HHHHHHHHHHHCCCCCCEEHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHH
LASFQGYFGAADAQDTLHAFRATFACMGVLTLAATALFLQLPPHEPPRPHPLGPEEQS
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA