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The map label for this gene is garR [H]

Identifier: 222110856

GI number: 222110856

Start: 1756591

End: 1757478

Strand: Direct

Name: garR [H]

Synonym: Dtpsy_1662

Alternate gene names: 222110856

Gene position: 1756591-1757478 (Clockwise)

Preceding gene: 222110855

Following gene: 222110859

Centisome position: 46.27

GC content: 70.38

Gene sequence:

>888_bases
ATGAACACCCCTCGCATCGGACTGATCGGCGTAGGCCTGATGGGCCACGGCATTGCCATGAATATCGCCCGCAAGGGCTA
TGCGCTGACGGTGCTGGAGCACCCTGGCAACCAGCCCCTGGATGCATTGCGCGCCCAGGGCGTGGCCAGCGCCGCATCGG
TGCATGAACTGATGCGACAGGTGCAGGTGCTCATCCTGTGCGTGACGGGATCGCCCCAGGTAGAGGCGGTGCTGCTGGGC
GAGGAGGGCGCCCTGGCCGCCCTGCAGCCCGGCACCGTGGTGATCGACTGCTCCACGGCCATTCCCTCGTCCACCGAACC
CGTCGCCCGCGCCGTGGCGGCGGCCGGCGGGCGGTTTCTGGATGCGCCGATGACCCGCACCCCCAAGGAGGCCGCCGAGG
GCCGGCTGAACCTGCTGGTGGGCGGCGAGGCCGCACTGCTCGACGAAGTGCGCCCGGTGCTGCAGTGCTTTGCCGAGAAC
ATCACGCATACCGGTGCCGTGGGCAGCGGCCACCGCATGAAGCTGCTGCACAACTATGTGTCGCTGGGCAGCGTGTCGCT
GATCGCGGAGGCTGCCGCGTGCGCGCTGGCGGCCGACGTGGCCCCGCAGGTGTTCCTGGATGTTCTCGCCAAGGGCGGCG
GCGGCGGCGTGGCGCTGGAGCGCCTGCGGCCCTACCTGCTGCAGCAGGACCCCTCCGGGCTGCGCTTCTTCATGTCCAAC
GCGCTCAAGGACATGGGCTACTACACCGCCATGGCGCACGACGGCGGTGCGGCCGATGGCATTGCCCAGGCCGTGCACGA
CACCTTTGCCGCCGCCGTTGCCGAGGGTGGGCCGCAGGCGCTGGTGCCGGAGCTGGTAGCGCTGCTGCGCGCCAAGGGGG
CGGGTTGA

Upstream 100 bases:

>100_bases
GGTACTGGTTTTCCGGGATACGGCGGCGGTGGGTTGAAGGGGCTCCGCGCGCCACAATGCGGTGGACACCGCTTCCCACC
CACCGGTTGAAACGCAGCAC

Downstream 100 bases:

>100_bases
TGAAGGTTGGACTTCTGGCGGGGATTCCCTCTTCCCGCCTCCAGTCCTCCCGCCTCCCGCCTCCCGCCTCCAGCCTCCAG
CCTCCAGCCTCCAGCCTCCA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MNTPRIGLIGVGLMGHGIAMNIARKGYALTVLEHPGNQPLDALRAQGVASAASVHELMRQVQVLILCVTGSPQVEAVLLG
EEGALAALQPGTVVIDCSTAIPSSTEPVARAVAAAGGRFLDAPMTRTPKEAAEGRLNLLVGGEAALLDEVRPVLQCFAEN
ITHTGAVGSGHRMKLLHNYVSLGSVSLIAEAAACALAADVAPQVFLDVLAKGGGGGVALERLRPYLLQQDPSGLRFFMSN
ALKDMGYYTAMAHDGGAADGIAQAVHDTFAAAVAEGGPQALVPELVALLRAKGAG

Sequences:

>Translated_295_residues
MNTPRIGLIGVGLMGHGIAMNIARKGYALTVLEHPGNQPLDALRAQGVASAASVHELMRQVQVLILCVTGSPQVEAVLLG
EEGALAALQPGTVVIDCSTAIPSSTEPVARAVAAAGGRFLDAPMTRTPKEAAEGRLNLLVGGEAALLDEVRPVLQCFAEN
ITHTGAVGSGHRMKLLHNYVSLGSVSLIAEAAACALAADVAPQVFLDVLAKGGGGGVALERLRPYLLQQDPSGLRFFMSN
ALKDMGYYTAMAHDGGAADGIAQAVHDTFAAAVAEGGPQALVPELVALLRAKGAG
>Mature_295_residues
MNTPRIGLIGVGLMGHGIAMNIARKGYALTVLEHPGNQPLDALRAQGVASAASVHELMRQVQVLILCVTGSPQVEAVLLG
EEGALAALQPGTVVIDCSTAIPSSTEPVARAVAAAGGRFLDAPMTRTPKEAAEGRLNLLVGGEAALLDEVRPVLQCFAEN
ITHTGAVGSGHRMKLLHNYVSLGSVSLIAEAAACALAADVAPQVFLDVLAKGGGGGVALERLRPYLLQQDPSGLRFFMSN
ALKDMGYYTAMAHDGGAADGIAQAVHDTFAAAVAEGGPQALVPELVALLRAKGAG

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=243, Percent_Identity=26.3374485596708, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI23308751, Length=225, Percent_Identity=28, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI145693186, Length=273, Percent_Identity=28.9377289377289, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1786719, Length=199, Percent_Identity=32.6633165829146, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790315, Length=241, Percent_Identity=29.045643153527, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789092, Length=248, Percent_Identity=27.8225806451613, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788341, Length=211, Percent_Identity=24.1706161137441, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17557316, Length=173, Percent_Identity=31.7919075144509, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24655230, Length=221, Percent_Identity=29.4117647058824, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI19922568, Length=221, Percent_Identity=29.4117647058824, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI28574115, Length=196, Percent_Identity=26.530612244898, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30163; Mature: 30163

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPRIGLIGVGLMGHGIAMNIARKGYALTVLEHPGNQPLDALRAQGVASAASVHELMRQ
CCCCCEEEEEECHHCCCCEEEEECCCEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHH
VQVLILCVTGSPQVEAVLLGEEGALAALQPGTVVIDCSTAIPSSTEPVARAVAAAGGRFL
HHEEEEEECCCCCEEEEEECCCCCEEEECCCEEEEECCCCCCCCCHHHHHHHHHCCCCEE
DAPMTRTPKEAAEGRLNLLVGGEAALLDEVRPVLQCFAENITHTGAVGSGHRMKLLHNYV
CCCCCCCCHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
SLGSVSLIAEAAACALAADVAPQVFLDVLAKGGGGGVALERLRPYLLQQDPSGLRFFMSN
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHH
ALKDMGYYTAMAHDGGAADGIAQAVHDTFAAAVAEGGPQALVPELVALLRAKGAG
HHHHCCHHEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNTPRIGLIGVGLMGHGIAMNIARKGYALTVLEHPGNQPLDALRAQGVASAASVHELMRQ
CCCCCEEEEEECHHCCCCEEEEECCCEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHH
VQVLILCVTGSPQVEAVLLGEEGALAALQPGTVVIDCSTAIPSSTEPVARAVAAAGGRFL
HHEEEEEECCCCCEEEEEECCCCCEEEECCCEEEEECCCCCCCCCHHHHHHHHHCCCCEE
DAPMTRTPKEAAEGRLNLLVGGEAALLDEVRPVLQCFAENITHTGAVGSGHRMKLLHNYV
CCCCCCCCHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
SLGSVSLIAEAAACALAADVAPQVFLDVLAKGGGGGVALERLRPYLLQQDPSGLRFFMSN
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHH
ALKDMGYYTAMAHDGGAADGIAQAVHDTFAAAVAEGGPQALVPELVALLRAKGAG
HHHHCCHHEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]