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The map label for this gene is ansA [H]

Identifier: 222110747

GI number: 222110747

Start: 1635881

End: 1636852

Strand: Direct

Name: ansA [H]

Synonym: Dtpsy_1550

Alternate gene names: 222110747

Gene position: 1635881-1636852 (Clockwise)

Preceding gene: 222110743

Following gene: 222110754

Centisome position: 43.09

GC content: 70.58

Gene sequence:

>972_bases
ATGCAAGTGGCAGCTGCAAGAAAAATCGTCGTTATGGGCACCGGCGGCACGATTGCGGGCTCTTCCGCGGTGCAAGGTGC
GAACGTGGGCTACACGGCCGGGCAGATCGGCGTGGAGCAATTGCTGGCCGCGGTGCCCGGCCTGGTGCAGGCCGCGGGCG
GTGCGCTGGTGGCCGAACAGGTGGCGCAGCTGGACAGCAAGGACATGGGCTTTGACGTGTGGGCGCGCCTGGCCGGTCGT
TGCGCCGCACACCTGGCCGACCCGGCCGTGGCCGGCGTCGTCATCACCCACGGCACGGATACGCTGGAGGAAACCGCATG
GCTGCTGCACAACCTGCTCGATACCACCGCCAAGCCGGTGGTACTGACCTGTGCCATGCGTCCGGCCACGGCGCTCGCGC
CGGACGGGCCGCAGAACCTGCTGGATGCCGTCACGCTGGCGGCCGATCCCTCAGCGCGGGGGGTTCTGATGGCGGCCGCT
GGCGTGGTGCACGGGGCACGCGAGGTGAGCAAGGTGCACCCGCTGCGGCTGGACGCGTTCGACTCCGGCGATGCTGGGCC
TCTGGGCTGGATGGAAGCGGGGCGCGTGCGCTGGGCCCGCGGCCTTGCGCCGCAGGTGGAACAGCCCGCGCATGGCGCGC
TGGTGCCGATCCTGCCAGATGCCGCCTGGCCACGCGTGGAAATCGTCCTCAGCCACGCCGGCGCGGATGGCGCGTTGGTG
GACTGGCTGGTGGAGAAGGGCGTGCACGGCCTCGTGGTGGCCGCCACCGGCAATGGCACGCTGCACCATGCGCTGGAGGC
CGCGCTCGCGCGTGCCGTGACGGCTGGGGTGCAGGTGCGCGTGGCTTCGCGCTGCCTGCAGGGGCGGATGATGGACCTGA
CGGGCACGCCCTGGCGCGATGCGGATGGGCTGAGCCCTGTGAAGGCACGGGTCAGCCTGCTGCTGGAGCTGATGCAGTCC
GCTAATTCATAA

Upstream 100 bases:

>100_bases
CTTGGGACTGTCGAGCATGGTGCGATCCAATGCGGTCGGTGGTTGAGTGGGTTACTGTTTTTTAATCCAGTATCTGTATT
TTTGAACAGTTTTTGGAGGG

Downstream 100 bases:

>100_bases
GCACCGTCATGGGCCGAGGCGCTTGCCTGGGCACACAGCACAACGCCCCGCATTGCGGGGCGTTGGCGGGGGCCGGCGGC
GGGTTCGTCAGCTTGACAGT

Product: asparaginase

Products: NA

Alternate protein names: L-ASNase; L-asparagine amidohydrolase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MQVAAARKIVVMGTGGTIAGSSAVQGANVGYTAGQIGVEQLLAAVPGLVQAAGGALVAEQVAQLDSKDMGFDVWARLAGR
CAAHLADPAVAGVVITHGTDTLEETAWLLHNLLDTTAKPVVLTCAMRPATALAPDGPQNLLDAVTLAADPSARGVLMAAA
GVVHGAREVSKVHPLRLDAFDSGDAGPLGWMEAGRVRWARGLAPQVEQPAHGALVPILPDAAWPRVEIVLSHAGADGALV
DWLVEKGVHGLVVAATGNGTLHHALEAALARAVTAGVQVRVASRCLQGRMMDLTGTPWRDADGLSPVKARVSLLLELMQS
ANS

Sequences:

>Translated_323_residues
MQVAAARKIVVMGTGGTIAGSSAVQGANVGYTAGQIGVEQLLAAVPGLVQAAGGALVAEQVAQLDSKDMGFDVWARLAGR
CAAHLADPAVAGVVITHGTDTLEETAWLLHNLLDTTAKPVVLTCAMRPATALAPDGPQNLLDAVTLAADPSARGVLMAAA
GVVHGAREVSKVHPLRLDAFDSGDAGPLGWMEAGRVRWARGLAPQVEQPAHGALVPILPDAAWPRVEIVLSHAGADGALV
DWLVEKGVHGLVVAATGNGTLHHALEAALARAVTAGVQVRVASRCLQGRMMDLTGTPWRDADGLSPVKARVSLLLELMQS
ANS
>Mature_323_residues
MQVAAARKIVVMGTGGTIAGSSAVQGANVGYTAGQIGVEQLLAAVPGLVQAAGGALVAEQVAQLDSKDMGFDVWARLAGR
CAAHLADPAVAGVVITHGTDTLEETAWLLHNLLDTTAKPVVLTCAMRPATALAPDGPQNLLDAVTLAADPSARGVLMAAA
GVVHGAREVSKVHPLRLDAFDSGDAGPLGWMEAGRVRWARGLAPQVEQPAHGALVPILPDAAWPRVEIVLSHAGADGALV
DWLVEKGVHGLVVAATGNGTLHHALEAALARAVTAGVQVRVASRCLQGRMMDLTGTPWRDADGLSPVKARVSLLLELMQS
ANS

Specific function: Unknown

COG id: COG0252

COG function: function code EJ; L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the asparaginase 1 family [H]

Homologues:

Organism=Homo sapiens, GI122937331, Length=227, Percent_Identity=28.6343612334802, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1789327, Length=304, Percent_Identity=36.5131578947368, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1788065, Length=289, Percent_Identity=28.3737024221453, Blast_Score=88, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI193207372, Length=240, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17558280, Length=240, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17558278, Length=240, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193207374, Length=240, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320527, Length=326, Percent_Identity=27.9141104294479, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6323189, Length=259, Percent_Identity=33.976833976834, Blast_Score=112, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6323187, Length=259, Percent_Identity=33.976833976834, Blast_Score=112, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6323186, Length=259, Percent_Identity=33.976833976834, Blast_Score=112, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6323184, Length=259, Percent_Identity=33.976833976834, Blast_Score=112, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004550
- InterPro:   IPR006034
- InterPro:   IPR020827 [H]

Pfam domain/function: PF00710 Asparaginase [H]

EC number: =3.5.1.1 [H]

Molecular weight: Translated: 33047; Mature: 33047

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00144 ASN_GLN_ASE_1 ; PS00917 ASN_GLN_ASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVAAARKIVVMGTGGTIAGSSAVQGANVGYTAGQIGVEQLLAAVPGLVQAAGGALVAEQ
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCHHHHHH
VAQLDSKDMGFDVWARLAGRCAAHLADPAVAGVVITHGTDTLEETAWLLHNLLDTTAKPV
HHHCCCCCCCHHHHHHHHHHHHHHHCCCHHEEEEEECCCCHHHHHHHHHHHHHHCCCCCE
VLTCAMRPATALAPDGPQNLLDAVTLAADPSARGVLMAAAGVVHGAREVSKVHPLRLDAF
EEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECC
DSGDAGPLGWMEAGRVRWARGLAPQVEQPAHGALVPILPDAAWPRVEIVLSHAGADGALV
CCCCCCCCCHHHHCHHHHHHCCCCCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCHHHH
DWLVEKGVHGLVVAATGNGTLHHALEAALARAVTAGVQVRVASRCLQGRMMDLTGTPWRD
HHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCEECCCCCCCCC
ADGLSPVKARVSLLLELMQSANS
CCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQVAAARKIVVMGTGGTIAGSSAVQGANVGYTAGQIGVEQLLAAVPGLVQAAGGALVAEQ
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCHHHHHH
VAQLDSKDMGFDVWARLAGRCAAHLADPAVAGVVITHGTDTLEETAWLLHNLLDTTAKPV
HHHCCCCCCCHHHHHHHHHHHHHHHCCCHHEEEEEECCCCHHHHHHHHHHHHHHCCCCCE
VLTCAMRPATALAPDGPQNLLDAVTLAADPSARGVLMAAAGVVHGAREVSKVHPLRLDAF
EEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECC
DSGDAGPLGWMEAGRVRWARGLAPQVEQPAHGALVPILPDAAWPRVEIVLSHAGADGALV
CCCCCCCCCHHHHCHHHHHHCCCCCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCHHHH
DWLVEKGVHGLVVAATGNGTLHHALEAALARAVTAGVQVRVASRCLQGRMMDLTGTPWRD
HHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCEECCCCCCCCC
ADGLSPVKARVSLLLELMQSANS
CCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]