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The map label for this gene is phoR [H]

Identifier: 222110689

GI number: 222110689

Start: 1565660

End: 1567057

Strand: Direct

Name: phoR [H]

Synonym: Dtpsy_1492

Alternate gene names: 222110689

Gene position: 1565660-1567057 (Clockwise)

Preceding gene: 222110688

Following gene: 222110699

Centisome position: 41.24

GC content: 68.45

Gene sequence:

>1398_bases
ATGCTCCTGCGCTTCTTTTTCTTTCTGCTGTGCCAACTGATCGGCGGTGCGCTGGGCTGGTGGCAGGCGGGCCCCTGGGG
TGCCGGCATCGGCGCCTGTTTCGCCGCATGGTTGTGGTTTGCCTGGGATCTGTGGCGCGGCGCGCGCGTGCTGAACTGGT
TGCGCCAGGGAGACCCCACGCAAACGCCACGCCTGAGTGGCCTGTGGGGAGAAGCAGCGGACCGCGCACGGCGCTTGGTG
CGCCAGGGCCAGCTGAAGGCGCAGGCCGGCGATGCGCGCCTGCAGGAAATCCTCCAGGCGCTGCAGGCATCGCCTAATGG
CGTGATGCTGCTGGATGCCGAAGGCCATATCGAATGGTGCAACCAGATGGCCGAGGAGCACTTTGGCCTGGATGCGGAGC
GTGATGCGCAGCAATCCATCGGCAACCTCGTGCGGGACCCGGACTTCAGTACCTACTACGCGTCCAAGGACTACACGCGC
GACGTGGTGCTGCCCGGACGCGCCAGCACGCCCTCGCGGCCGGTGCGCGTATCGGTGCACCTGCACCCGTATGGCGATGG
CCGCAAGCTGCTGCTGTCACGCGACGTGACGGCGCTGGAGCAGGCCGAGGCCATGCGGCGCGACTTCGTCGCCAACGTGT
CGCATGAGATCCGCACCCCGCTCACCGTGCTGATGGGCTTTGTCGAAACCCTGCAGACCCTGCAGCTCAGCAACGAGGAG
CGTGCGCGCTACCTGCGCATGATGTCGCAGCAGGCCGTGCGCATGCAGAACCTGGTGCAAGACCTGTTGACGCTGTCGCG
CCTGGAGGGAAGCCCTCCGCCCAGCATGCACGAATGGGTCGCGGTTTCGACGCTGCTGCGCCGCTGCGAGGACGAGGGGC
GCGCGCTCTCGGCCCTGCTGACGCAGAACCAGCCCGGCAAGCCTCACCAGATCACGTTCCCCACGGCCGAAGCAGCGCAG
GCGGCCGGGCAGGTGGCCGGCAATGCGGCCGAGCTGCAAAGCGCCCTGGCCAACCTGGTCAACAACGCTGTGCGCTACAC
GCCACCCGGAGGCAGTATCACCGTGGCGTGGGACGTAGAGCCTGATGGCAGCGCCCGTTTCATGGTGCGCGACTCAGGGC
CTGGCATTGAGCCGGAACACCTGCCGCGCATCACCGAGCGCTTTTACCGCGTGGACCGCAGCCGCTCGCGCGACACGGGC
GGCACGGGCCTCGGACTGGCCATCGTGAAGCATGTGGTGCAGCGCCATGGCGCAGCGCTGCAGGTGGCCAGCGTGGTGGG
GCAGGGCTCGACGTTCACGGTGGTGTTTCCGCCGTCGCGCCTGCGGACGCCGCCGCGCAGCCTCAGCGGTGGGGGTCCTG
CGGTAGCGGCGGAGCCGCCCGGCGTATCTGCAGCCTGA

Upstream 100 bases:

>100_bases
TCATGCGGGCGTGATGGCGGGTGCCCGACGCCTCCGTGTTTTTTCAGGCGCCCGGAGATGATGCGGGCGCTTTTTTGTTG
TTGACCTGAGCCCTGCGGCC

Downstream 100 bases:

>100_bases
GCACGCCCAGCAGCAGGGCCGTGAAAATCAACGCCGTCGCGCCTAGAGCGGCAGCGCTGGCGGCCCAAAAAGGCGAAGGG
GAATGCATCGGCCCCCAACC

Product: pas/pac sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MLLRFFFFLLCQLIGGALGWWQAGPWGAGIGACFAAWLWFAWDLWRGARVLNWLRQGDPTQTPRLSGLWGEAADRARRLV
RQGQLKAQAGDARLQEILQALQASPNGVMLLDAEGHIEWCNQMAEEHFGLDAERDAQQSIGNLVRDPDFSTYYASKDYTR
DVVLPGRASTPSRPVRVSVHLHPYGDGRKLLLSRDVTALEQAEAMRRDFVANVSHEIRTPLTVLMGFVETLQTLQLSNEE
RARYLRMMSQQAVRMQNLVQDLLTLSRLEGSPPPSMHEWVAVSTLLRRCEDEGRALSALLTQNQPGKPHQITFPTAEAAQ
AAGQVAGNAAELQSALANLVNNAVRYTPPGGSITVAWDVEPDGSARFMVRDSGPGIEPEHLPRITERFYRVDRSRSRDTG
GTGLGLAIVKHVVQRHGAALQVASVVGQGSTFTVVFPPSRLRTPPRSLSGGGPAVAAEPPGVSAA

Sequences:

>Translated_465_residues
MLLRFFFFLLCQLIGGALGWWQAGPWGAGIGACFAAWLWFAWDLWRGARVLNWLRQGDPTQTPRLSGLWGEAADRARRLV
RQGQLKAQAGDARLQEILQALQASPNGVMLLDAEGHIEWCNQMAEEHFGLDAERDAQQSIGNLVRDPDFSTYYASKDYTR
DVVLPGRASTPSRPVRVSVHLHPYGDGRKLLLSRDVTALEQAEAMRRDFVANVSHEIRTPLTVLMGFVETLQTLQLSNEE
RARYLRMMSQQAVRMQNLVQDLLTLSRLEGSPPPSMHEWVAVSTLLRRCEDEGRALSALLTQNQPGKPHQITFPTAEAAQ
AAGQVAGNAAELQSALANLVNNAVRYTPPGGSITVAWDVEPDGSARFMVRDSGPGIEPEHLPRITERFYRVDRSRSRDTG
GTGLGLAIVKHVVQRHGAALQVASVVGQGSTFTVVFPPSRLRTPPRSLSGGGPAVAAEPPGVSAA
>Mature_465_residues
MLLRFFFFLLCQLIGGALGWWQAGPWGAGIGACFAAWLWFAWDLWRGARVLNWLRQGDPTQTPRLSGLWGEAADRARRLV
RQGQLKAQAGDARLQEILQALQASPNGVMLLDAEGHIEWCNQMAEEHFGLDAERDAQQSIGNLVRDPDFSTYYASKDYTR
DVVLPGRASTPSRPVRVSVHLHPYGDGRKLLLSRDVTALEQAEAMRRDFVANVSHEIRTPLTVLMGFVETLQTLQLSNEE
RARYLRMMSQQAVRMQNLVQDLLTLSRLEGSPPPSMHEWVAVSTLLRRCEDEGRALSALLTQNQPGKPHQITFPTAEAAQ
AAGQVAGNAAELQSALANLVNNAVRYTPPGGSITVAWDVEPDGSARFMVRDSGPGIEPEHLPRITERFYRVDRSRSRDTG
GTGLGLAIVKHVVQRHGAALQVASVVGQGSTFTVVFPPSRLRTPPRSLSGGGPAVAAEPPGVSAA

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=421, Percent_Identity=38.7173396674584, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1786783, Length=239, Percent_Identity=31.7991631799163, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788393, Length=246, Percent_Identity=32.520325203252, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790346, Length=221, Percent_Identity=34.3891402714932, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI48994928, Length=255, Percent_Identity=30.9803921568627, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788713, Length=405, Percent_Identity=25.4320987654321, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1788549, Length=403, Percent_Identity=24.8138957816377, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789149, Length=282, Percent_Identity=27.3049645390071, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=29.0836653386454, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1790436, Length=312, Percent_Identity=26.6025641025641, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1789403, Length=218, Percent_Identity=31.1926605504587, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=239, Percent_Identity=29.2887029288703, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790861, Length=204, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787894, Length=240, Percent_Identity=29.5833333333333, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI87081816, Length=259, Percent_Identity=29.7297297297297, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790551, Length=227, Percent_Identity=33.0396475770925, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789808, Length=221, Percent_Identity=28.9592760180996, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790300, Length=374, Percent_Identity=24.8663101604278, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50929; Mature: 50929

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLRFFFFLLCQLIGGALGWWQAGPWGAGIGACFAAWLWFAWDLWRGARVLNWLRQGDPT
CHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QTPRLSGLWGEAADRARRLVRQGQLKAQAGDARLQEILQALQASPNGVMLLDAEGHIEWC
CCCCCCCCCHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHH
NQMAEEHFGLDAERDAQQSIGNLVRDPDFSTYYASKDYTRDVVLPGRASTPSRPVRVSVH
HHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCEEECCCCCCCCCCEEEEEE
LHPYGDGRKLLLSRDVTALEQAEAMRRDFVANVSHEIRTPLTVLMGFVETLQTLQLSNEE
EEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
RARYLRMMSQQAVRMQNLVQDLLTLSRLEGSPPPSMHEWVAVSTLLRRCEDEGRALSALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TQNQPGKPHQITFPTAEAAQAAGQVAGNAAELQSALANLVNNAVRYTPPGGSITVAWDVE
HCCCCCCCCEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEECCCCCEEEEEEECC
PDGSARFMVRDSGPGIEPEHLPRITERFYRVDRSRSRDTGGTGLGLAIVKHVVQRHGAAL
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHH
QVASVVGQGSTFTVVFPPSRLRTPPRSLSGGGPAVAAEPPGVSAA
HHHHHHCCCCEEEEEECHHHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLLRFFFFLLCQLIGGALGWWQAGPWGAGIGACFAAWLWFAWDLWRGARVLNWLRQGDPT
CHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QTPRLSGLWGEAADRARRLVRQGQLKAQAGDARLQEILQALQASPNGVMLLDAEGHIEWC
CCCCCCCCCHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHH
NQMAEEHFGLDAERDAQQSIGNLVRDPDFSTYYASKDYTRDVVLPGRASTPSRPVRVSVH
HHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCEEECCCCCCCCCCEEEEEE
LHPYGDGRKLLLSRDVTALEQAEAMRRDFVANVSHEIRTPLTVLMGFVETLQTLQLSNEE
EEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
RARYLRMMSQQAVRMQNLVQDLLTLSRLEGSPPPSMHEWVAVSTLLRRCEDEGRALSALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TQNQPGKPHQITFPTAEAAQAAGQVAGNAAELQSALANLVNNAVRYTPPGGSITVAWDVE
HCCCCCCCCEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEECCCCCEEEEEEECC
PDGSARFMVRDSGPGIEPEHLPRITERFYRVDRSRSRDTGGTGLGLAIVKHVVQRHGAAL
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHH
QVASVVGQGSTFTVVFPPSRLRTPPRSLSGGGPAVAAEPPGVSAA
HHHHHHCCCCEEEEEECHHHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043; 2115874 [H]