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The map label for this gene is folP [H]

Identifier: 222110674

GI number: 222110674

Start: 1548041

End: 1548892

Strand: Direct

Name: folP [H]

Synonym: Dtpsy_1476

Alternate gene names: 222110674

Gene position: 1548041-1548892 (Clockwise)

Preceding gene: 222110673

Following gene: 222110675

Centisome position: 40.77

GC content: 66.67

Gene sequence:

>852_bases
ATGCGCTGGCAAACCACACGTTTCGACGTGGACCTCACGCGTCCCCAGGTCATGGGGATCGTCAACGTCACCCCAGATTC
CTTCTCAGACGGCGGCCGGCATGTTGATACGCGGGGAGCGTTGCGGCACTGCGAGCAGCTGATCAAGGATGGCGCGGATA
TCCTGGACATCGGCGGTGAATCCACGCGCCCGGGTAGCCCGGCGGTGCCGCTGGAGCAAGAGCTGGCGCGCGTCGTGCCG
CTGGTGGCGGAGGCGGTGCGCCTGGGGGTGCCAGTCTCGGTCGACACCTACAAGCCCCAGGTCATGCAGGCGGTGCTGGA
CCTGGGGGCGGACATCGTCAACGACATCTGGGCGTTGCGCCAGCCAGGGGCGGCCGGGATCGTCGCCGCCCATCCGCGCT
GCGGCGTGTGCCTGATGCATATGCACCGGGACCCGCAGACCATGCAGGCCACGCCCATGGAGGAAGATGTGGTGCCGTCA
GTGCTCTATTTTTTGGAGCGCTCAGCGCAGGAACTGCAAGCGCTGGGCGTGGAAAAGGCCCGCATCGTACTCGACTATGG
CATTGGGTTCGGCAAGACAGTCGAGCAAAATTTCGCCCTGCTGGCCCGCCAGCCCGAGCTCCTGGCCTTGGGCTACCCGT
TGCTGGCCGGCTGGTCGCGCAAATCGTCCATCGGTTCCGTCACTGGCCTACCTGTGCACGAACGCATGGCACCAAGCGTT
GCCGCGGCCGTGCTTGCCGTGGAGCGCGGTGCGCGGGTGGTGCGTGTGCATGACGTACGCGACACCGTGGCGGCGCTGGC
GGTGTGGAGCGCGATGCGGCAGCAGGACACCGGCGCCGCCATTTCCCAGTAA

Upstream 100 bases:

>100_bases
AGCCGGACCCGGCGCCCTCCGCCGCCTGACAGCGGTTTGGCATGAAGAACGGGGCCTCGCGCCCCGTTTTCTGTATTTCA
CGGCTCTCACTCACTCACGC

Downstream 100 bases:

>100_bases
TCAAGGAATTTCATGACCCGCAAGTATTTCGGCACCGATGGCATCCGCGGCACGGTGGGACAGTCGCCCATCACCCCCGA
CTTCGCGCTGCGCTTGGCAC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MRWQTTRFDVDLTRPQVMGIVNVTPDSFSDGGRHVDTRGALRHCEQLIKDGADILDIGGESTRPGSPAVPLEQELARVVP
LVAEAVRLGVPVSVDTYKPQVMQAVLDLGADIVNDIWALRQPGAAGIVAAHPRCGVCLMHMHRDPQTMQATPMEEDVVPS
VLYFLERSAQELQALGVEKARIVLDYGIGFGKTVEQNFALLARQPELLALGYPLLAGWSRKSSIGSVTGLPVHERMAPSV
AAAVLAVERGARVVRVHDVRDTVAALAVWSAMRQQDTGAAISQ

Sequences:

>Translated_283_residues
MRWQTTRFDVDLTRPQVMGIVNVTPDSFSDGGRHVDTRGALRHCEQLIKDGADILDIGGESTRPGSPAVPLEQELARVVP
LVAEAVRLGVPVSVDTYKPQVMQAVLDLGADIVNDIWALRQPGAAGIVAAHPRCGVCLMHMHRDPQTMQATPMEEDVVPS
VLYFLERSAQELQALGVEKARIVLDYGIGFGKTVEQNFALLARQPELLALGYPLLAGWSRKSSIGSVTGLPVHERMAPSV
AAAVLAVERGARVVRVHDVRDTVAALAVWSAMRQQDTGAAISQ
>Mature_283_residues
MRWQTTRFDVDLTRPQVMGIVNVTPDSFSDGGRHVDTRGALRHCEQLIKDGADILDIGGESTRPGSPAVPLEQELARVVP
LVAEAVRLGVPVSVDTYKPQVMQAVLDLGADIVNDIWALRQPGAAGIVAAHPRCGVCLMHMHRDPQTMQATPMEEDVVPS
VLYFLERSAQELQALGVEKARIVLDYGIGFGKTVEQNFALLARQPELLALGYPLLAGWSRKSSIGSVTGLPVHERMAPSV
AAAVLAVERGARVVRVHDVRDTVAALAVWSAMRQQDTGAAISQ

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=264, Percent_Identity=48.8636363636364, Blast_Score=237, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6324073, Length=328, Percent_Identity=28.9634146341463, Blast_Score=109, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30563; Mature: 30563

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWQTTRFDVDLTRPQVMGIVNVTPDSFSDGGRHVDTRGALRHCEQLIKDGADILDIGGE
CCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCC
STRPGSPAVPLEQELARVVPLVAEAVRLGVPVSVDTYKPQVMQAVLDLGADIVNDIWALR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHCHHHHHHHHHHC
QPGAAGIVAAHPRCGVCLMHMHRDPQTMQATPMEEDVVPSVLYFLERSAQELQALGVEKA
CCCCCCEEECCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCE
RIVLDYGIGFGKTVEQNFALLARQPELLALGYPLLAGWSRKSSIGSVTGLPVHERMAPSV
EEEEEECCCCCCHHHHHHHHHHCCCCCEEECCHHHHCCCCCCCCCCCCCCCCHHHHHHHH
AAAVLAVERGARVVRVHDVRDTVAALAVWSAMRQQDTGAAISQ
HHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRWQTTRFDVDLTRPQVMGIVNVTPDSFSDGGRHVDTRGALRHCEQLIKDGADILDIGGE
CCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCC
STRPGSPAVPLEQELARVVPLVAEAVRLGVPVSVDTYKPQVMQAVLDLGADIVNDIWALR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHCHHHHHHHHHHC
QPGAAGIVAAHPRCGVCLMHMHRDPQTMQATPMEEDVVPSVLYFLERSAQELQALGVEKA
CCCCCCEEECCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCE
RIVLDYGIGFGKTVEQNFALLARQPELLALGYPLLAGWSRKSSIGSVTGLPVHERMAPSV
EEEEEECCCCCCHHHHHHHHHHCCCCCEEECCHHHHCCCCCCCCCCCCCCCCHHHHHHHH
AAAVLAVERGARVVRVHDVRDTVAALAVWSAMRQQDTGAAISQ
HHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400191; 7642493; 10710307 [H]