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The map label for this gene is aspA [H]

Identifier: 222110565

GI number: 222110565

Start: 1426606

End: 1428060

Strand: Direct

Name: aspA [H]

Synonym: Dtpsy_1365

Alternate gene names: 222110565

Gene position: 1426606-1428060 (Clockwise)

Preceding gene: 222110561

Following gene: 222110567

Centisome position: 37.58

GC content: 64.19

Gene sequence:

>1455_bases
TTGTTCCCCTTTTGTTTATTCCATTTCGCTAGAAAGCAGATCGACCATGCGTCAAGAACAGAACATGACTTCATCGGTAT
CAAGACCATTCCCCCGGACGCGTATTGGGGCGTCCACACCGCTCGTGCCGTAGAAAACTTTCCCATCACCGGCCACACCG
TGGCCCACATGCCCGAGTTGATCCGGGCCTTTGTCTTCGTCAAGAAGGCCGCCGCCCACGCCAATCTGCAGCTGGGCGCG
ATCAACGCAACCCAAGCCCGCGCCATTGCCCAAGCCTGCGACGACCTGATCGCCGGACAGTTGCACGACCAGTTCGTCGT
GGACGTGATCCAGGGCGGTGCCGGCACCTCCACGAACATGAACGCCAATGAGGTGATCGCCAACCGTGCCCTGGAGCACC
TGGGATTGCCCAAAGGCCGCTATGACACGATCCACCCGAACGATCACGTCAACGCATCGCAAAGCACCAACGATGCCTAT
CCCACGGCGCTGAAGATCGCCACCTATTTCGGTATCGAGACGCTGCTCAAGGCCCTGTCGGCCCTGCGCGGCGCGTTCGA
GGCCAAGGCCGAGGAATTCAAGGGCATCCTGAAGATCGGCCGCACCCAATTGCAAGATGCCGTGCCCATGACGCTGGGCC
AGGAGTTTGCCGCCTTCGCCGCCATGATTGCCGACGATGAGCGCCGCCTGCGCGAGTCCGCCTACCTGATGACCGAGGTG
AACATGGGCGGCACCGCCATCGGCACCGGCATCAACGCGCCCGTCGGCTACGTGGACGTGGTCATCCCTGAGCTGGCGCG
GCTGTCGGGCGTGCCGGTCAAGGCTGCGGCCAACCTGATCGCCGCCACGTCGGACACGGGGGCCTTCGTTGACATCTCGG
GCGTGCTCAAGCGCATCGCCGCCAAGCTCTCCAAGATCAGCAACGACCTGCGCCTGCTGTCCTCGGGCCCGCAGGCCGGT
GTGGGCGACATCCAGCTGCCCGCGCGCCAGGCGGGCTCGTCCATCATGCCCGGCAAGGTCAACCCCGTTATTCCCGAGGT
GATGAACCAGGTGTGCTTCGAAGTGATCGGCAACGACGCCGCCATCACCATGGCTGCCGAAGCCGGGCAATTGCAGCTCA
ACGCTTTTGAACCGCTGATGGGCTGGGCGCTGCACAAGAGCCTGCACCACCTGGCCAAGGCCTGCCACACCCTGCAGGTG
AACTGCGTGGAGGGCATCGTGGCCAACCAGGGGCTGCTGACGGAACGCATCGCCGCGTCGGTGACGCTGGTGACCGCGCT
CAACCCGCTGATCGGTTACGAGGAGGCGGCCGCCATCGCCAAGTCGGCCATTGCCACGGGCAAGCCGATTGCCGTGGTGG
CCGAGGACCTGGGCATCATGACCCAGGCCGAGATGCACAAGCTGCTGGTGGCCGAGCGCCTCACGCAGGCGGGCGCCATC
CAGGCCGCTGATTGA

Upstream 100 bases:

>100_bases
TTGCGCCCACAAGGTGCGCGCCCGGCTCCAGGGCGCTCCACGGCTGCACCCACCAAGCACCGCCTGCACCTCAGGCGGTG
TTTTCACTTGGGGCCTGGCT

Downstream 100 bases:

>100_bases
CGGGCGCTGCCGGAGCCTCGGCTGCTGCCGAAGGCGCCGGTAGGCCGCGGCGGTCATCCGCCCAAAAAAAAGCCCAGTCA
GGGACTGGGCTTGAAGGGAT

Product: fumarate lyase

Products: NA

Alternate protein names: Aspartase [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MFPFCLFHFARKQIDHASRTEHDFIGIKTIPPDAYWGVHTARAVENFPITGHTVAHMPELIRAFVFVKKAAAHANLQLGA
INATQARAIAQACDDLIAGQLHDQFVVDVIQGGAGTSTNMNANEVIANRALEHLGLPKGRYDTIHPNDHVNASQSTNDAY
PTALKIATYFGIETLLKALSALRGAFEAKAEEFKGILKIGRTQLQDAVPMTLGQEFAAFAAMIADDERRLRESAYLMTEV
NMGGTAIGTGINAPVGYVDVVIPELARLSGVPVKAAANLIAATSDTGAFVDISGVLKRIAAKLSKISNDLRLLSSGPQAG
VGDIQLPARQAGSSIMPGKVNPVIPEVMNQVCFEVIGNDAAITMAAEAGQLQLNAFEPLMGWALHKSLHHLAKACHTLQV
NCVEGIVANQGLLTERIAASVTLVTALNPLIGYEEAAAIAKSAIATGKPIAVVAEDLGIMTQAEMHKLLVAERLTQAGAI
QAAD

Sequences:

>Translated_484_residues
MFPFCLFHFARKQIDHASRTEHDFIGIKTIPPDAYWGVHTARAVENFPITGHTVAHMPELIRAFVFVKKAAAHANLQLGA
INATQARAIAQACDDLIAGQLHDQFVVDVIQGGAGTSTNMNANEVIANRALEHLGLPKGRYDTIHPNDHVNASQSTNDAY
PTALKIATYFGIETLLKALSALRGAFEAKAEEFKGILKIGRTQLQDAVPMTLGQEFAAFAAMIADDERRLRESAYLMTEV
NMGGTAIGTGINAPVGYVDVVIPELARLSGVPVKAAANLIAATSDTGAFVDISGVLKRIAAKLSKISNDLRLLSSGPQAG
VGDIQLPARQAGSSIMPGKVNPVIPEVMNQVCFEVIGNDAAITMAAEAGQLQLNAFEPLMGWALHKSLHHLAKACHTLQV
NCVEGIVANQGLLTERIAASVTLVTALNPLIGYEEAAAIAKSAIATGKPIAVVAEDLGIMTQAEMHKLLVAERLTQAGAI
QAAD
>Mature_484_residues
MFPFCLFHFARKQIDHASRTEHDFIGIKTIPPDAYWGVHTARAVENFPITGHTVAHMPELIRAFVFVKKAAAHANLQLGA
INATQARAIAQACDDLIAGQLHDQFVVDVIQGGAGTSTNMNANEVIANRALEHLGLPKGRYDTIHPNDHVNASQSTNDAY
PTALKIATYFGIETLLKALSALRGAFEAKAEEFKGILKIGRTQLQDAVPMTLGQEFAAFAAMIADDERRLRESAYLMTEV
NMGGTAIGTGINAPVGYVDVVIPELARLSGVPVKAAANLIAATSDTGAFVDISGVLKRIAAKLSKISNDLRLLSSGPQAG
VGDIQLPARQAGSSIMPGKVNPVIPEVMNQVCFEVIGNDAAITMAAEAGQLQLNAFEPLMGWALHKSLHHLAKACHTLQV
NCVEGIVANQGLLTERIAASVTLVTALNPLIGYEEAAAIAKSAIATGKPIAVVAEDLGIMTQAEMHKLLVAERLTQAGAI
QAAD

Specific function: Unknown

COG id: COG1027

COG function: function code E; Aspartate ammonia-lyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=453, Percent_Identity=42.8256070640177, Blast_Score=345, Evalue=6e-95,
Organism=Escherichia coli, GI87082375, Length=457, Percent_Identity=52.5164113785558, Blast_Score=473, Evalue=1e-134,
Organism=Escherichia coli, GI1787896, Length=466, Percent_Identity=40.5579399141631, Blast_Score=338, Evalue=4e-94,
Organism=Caenorhabditis elegans, GI17553882, Length=470, Percent_Identity=41.9148936170213, Blast_Score=352, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI32565146, Length=323, Percent_Identity=41.1764705882353, Blast_Score=246, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6324993, Length=465, Percent_Identity=42.1505376344086, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24662684, Length=460, Percent_Identity=40.8695652173913, Blast_Score=360, Evalue=2e-99,
Organism=Drosophila melanogaster, GI24640179, Length=459, Percent_Identity=42.0479302832244, Blast_Score=357, Evalue=7e-99,
Organism=Drosophila melanogaster, GI24640177, Length=459, Percent_Identity=42.0479302832244, Blast_Score=357, Evalue=9e-99,
Organism=Drosophila melanogaster, GI78710009, Length=429, Percent_Identity=43.3566433566434, Blast_Score=349, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24583245, Length=448, Percent_Identity=38.8392857142857, Blast_Score=319, Evalue=3e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004708
- InterPro:   IPR003031
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.3.1.1 [H]

Molecular weight: Translated: 51289; Mature: 51289

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00356 HTH_LACI_1 ; PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPFCLFHFARKQIDHASRTEHDFIGIKTIPPDAYWGVHTARAVENFPITGHTVAHMPEL
CCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCHHHHHHHH
IRAFVFVKKAAAHANLQLGAINATQARAIAQACDDLIAGQLHDQFVVDVIQGGAGTSTNM
HHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NANEVIANRALEHLGLPKGRYDTIHPNDHVNASQSTNDAYPTALKIATYFGIETLLKALS
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ALRGAFEAKAEEFKGILKIGRTQLQDAVPMTLGQEFAAFAAMIADDERRLRESAYLMTEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
NMGGTAIGTGINAPVGYVDVVIPELARLSGVPVKAAANLIAATSDTGAFVDISGVLKRIA
CCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCEEEHHHHHHHHH
AKLSKISNDLRLLSSGPQAGVGDIQLPARQAGSSIMPGKVNPVIPEVMNQVCFEVIGNDA
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
AITMAAEAGQLQLNAFEPLMGWALHKSLHHLAKACHTLQVNCVEGIVANQGLLTERIAAS
EEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCCHHHHHHHHH
VTLVTALNPLIGYEEAAAIAKSAIATGKPIAVVAEDLGIMTQAEMHKLLVAERLTQAGAI
HHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEHHHCHHHHHHHHHHHHHHHHHHCCCC
QAAD
CCCC
>Mature Secondary Structure
MFPFCLFHFARKQIDHASRTEHDFIGIKTIPPDAYWGVHTARAVENFPITGHTVAHMPEL
CCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCHHHHHHHH
IRAFVFVKKAAAHANLQLGAINATQARAIAQACDDLIAGQLHDQFVVDVIQGGAGTSTNM
HHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NANEVIANRALEHLGLPKGRYDTIHPNDHVNASQSTNDAYPTALKIATYFGIETLLKALS
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ALRGAFEAKAEEFKGILKIGRTQLQDAVPMTLGQEFAAFAAMIADDERRLRESAYLMTEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
NMGGTAIGTGINAPVGYVDVVIPELARLSGVPVKAAANLIAATSDTGAFVDISGVLKRIA
CCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCEEEHHHHHHHHH
AKLSKISNDLRLLSSGPQAGVGDIQLPARQAGSSIMPGKVNPVIPEVMNQVCFEVIGNDA
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
AITMAAEAGQLQLNAFEPLMGWALHKSLHHLAKACHTLQVNCVEGIVANQGLLTERIAAS
EEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCCHHHHHHHHH
VTLVTALNPLIGYEEAAAIAKSAIATGKPIAVVAEDLGIMTQAEMHKLLVAERLTQAGAI
HHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEHHHCHHHHHHHHHHHHHHHHHHCCCC
QAAD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]