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The map label for this gene is czrA [H]

Identifier: 222110358

GI number: 222110358

Start: 1208253

End: 1208630

Strand: Direct

Name: czrA [H]

Synonym: Dtpsy_1149

Alternate gene names: 222110358

Gene position: 1208253-1208630 (Clockwise)

Preceding gene: 222110357

Following gene: 222110359

Centisome position: 31.82

GC content: 60.05

Gene sequence:

>378_bases
ATGACATCCCGCAAAACCACCAGCGCCGCTATTGTGCAATGTTCGACCTCTAACCACGGCACGACCACTGATGTCCTCGC
ACTATCGCAAAGTGACGTCGCTGTTCTGGCAGAGACCTTCCGCCTGCTGGGCGACCAATCGCGATTGAAAATCCTGTTGC
AGTGCATGCGCGGATCGGTCGCAGTGGGCGACATTGCTGGCTCGCTAGACCTGTCGCAGTCCTTGGTCAGCCATCACCTG
CGCCTGTTGCGCGGCGCGCGCCTCGTGCGCGGCGAGCGCCAAGCCAAGCACATCTTCTACGGCATTGCCGACCAGCACGT
CAGCCAGGTACTCCAGGACATGGCGGTTCACATTTCGGAGGACAGACACGACGATTGA

Upstream 100 bases:

>100_bases
GACCACAGTGAGCACAATCATGACCATGACCACTCCGCTCCCGGTCACAAGCATTGAGGCCGTGCTAGACGGTTCGCAGT
TCACTTGAGGGTTTGAATCC

Downstream 100 bases:

>100_bases
CTGAACATGTGAGTGCGCGCCGGCCTACGCCTTCAAGGGGTAGGCTTTTTTTGGCTATTAATCTAGAGAGACACCGGCGC
GCCTTGCTGAATGCCTAGAA

Product: ArsR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 125; Mature: 124

Protein sequence:

>125_residues
MTSRKTTSAAIVQCSTSNHGTTTDVLALSQSDVAVLAETFRLLGDQSRLKILLQCMRGSVAVGDIAGSLDLSQSLVSHHL
RLLRGARLVRGERQAKHIFYGIADQHVSQVLQDMAVHISEDRHDD

Sequences:

>Translated_125_residues
MTSRKTTSAAIVQCSTSNHGTTTDVLALSQSDVAVLAETFRLLGDQSRLKILLQCMRGSVAVGDIAGSLDLSQSLVSHHL
RLLRGARLVRGERQAKHIFYGIADQHVSQVLQDMAVHISEDRHDD
>Mature_124_residues
TSRKTTSAAIVQCSTSNHGTTTDVLALSQSDVAVLAETFRLLGDQSRLKILLQCMRGSVAVGDIAGSLDLSQSLVSHHLR
LLRGARLVRGERQAKHIFYGIADQHVSQVLQDMAVHISEDRHDD

Specific function: Metal-responsive transcriptional regulator that represses transcription of cadA and the czcD-trkA operon by binding specifically to their promoter. Binding of zinc causes the repressor to dissociate from the DNA [H]

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 13634; Mature: 13502

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRKTTSAAIVQCSTSNHGTTTDVLALSQSDVAVLAETFRLLGDQSRLKILLQCMRGSV
CCCCCCCCEEEEEECCCCCCCCHHHEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCC
AVGDIAGSLDLSQSLVSHHLRLLRGARLVRGERQAKHIFYGIADQHVSQVLQDMAVHISE
EEHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DRHDD
CCCCC
>Mature Secondary Structure 
TSRKTTSAAIVQCSTSNHGTTTDVLALSQSDVAVLAETFRLLGDQSRLKILLQCMRGSV
CCCCCCCEEEEEECCCCCCCCHHHEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCC
AVGDIAGSLDLSQSLVSHHLRLLRGARLVRGERQAKHIFYGIADQHVSQVLQDMAVHISE
EEHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DRHDD
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]