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The map label for this gene is zitB [H]

Identifier: 222110357

GI number: 222110357

Start: 1207187

End: 1208209

Strand: Direct

Name: zitB [H]

Synonym: Dtpsy_1148

Alternate gene names: 222110357

Gene position: 1207187-1208209 (Clockwise)

Preceding gene: 222110356

Following gene: 222110358

Centisome position: 31.8

GC content: 61.78

Gene sequence:

>1023_bases
ATGTCCCAATCCAATGCACATGACCATGGTCACGACCATGATCACGACCACACCCCCACAGTGACGAGCGCCAACGAGCG
CAAGGTTCTGGTTTCCTTCTTCCTGATCTTCGGCTTCATGCTCGTGGAAGCTGTCGGCGGCGTGCTGTCGGGCTCGCTAG
CCCTACTTGCCGATGCTGGCCACATGCTGACCGACGCCGTGGCACTTGCCCTGGCTTACGCTGCCTTCCGATTCGGTCGC
CGCGCAGCCGACAGCAAACGCACATTCGGTTACCTGCGCTTCGAGGTCATCGCCGGCTTCCTGAACGCCGTGACCCTGTT
CGCGATCGTCGCATGGATCGCCTACGAGGCGTGGGAGCGGCTGCAGGCGCCGCCCGTCATCCTCGCCGGCCCGATGATGA
TCGTCGCCGTGCTCGGCTTACTGATCAACGTCCTCGTGCTGTGGATCATGACCCGCGGCGAAACCGATCACGTCAATGTG
AAAGGTGCCATCCTCCACGTGATGGGTGACCTGCTCGGCTCTGTCGGCGCCATCGTTGCAGCGATCGTCATCTACTTCAC
CGGCTGGACTCCGATCGACCCCATCCTGTCGGTTCTAGTAGCGGCGTTGATTCTGCGCAGCGCCTGGAAGCTCCTGGCCA
AGTCGATCCATATCCTGTTGGAGGGTGCGCCAGAGGACGCTTCGCCGGAAAAGGTGGAACAAGGCCTGATGAGCACTGTG
CCCGGCCTGGCGGCTGTCAGCCATGTTCACGTGTGGCAACTCACTTCCGGTCGCACGATGGCCACGCTACACGTTCGACC
CAACGTGGACGAGGAGGCGCGAGCTGTGGTCAAGCGCGTCGAGGCGGTGCTGCGAGAGCAGTTCAGCATCGAACACGCCA
CAGTCGGAATCGACTGGAACTCGGAGGCTGACGAGAACATCTGCAGCCTGCAACCCACGACAGGCCGTCAGGACCACAGC
GGCCACGACCACAGTGAGCACAATCATGACCATGACCACTCCGCTCCCGGTCACAAGCATTGA

Upstream 100 bases:

>100_bases
GCTTCGGAGGCTGAGAAGGGTGAGCGAAAATATATCACATGAACACATATTCATGTGTTATATTTCGCCATAGTCAAACA
CTCAACCAGCAGAGGCGCCC

Downstream 100 bases:

>100_bases
GGCCGTGCTAGACGGTTCGCAGTTCACTTGAGGGTTTGAATCCATGACATCCCGCAAAACCACCAGCGCCGCTATTGTGC
AATGTTCGACCTCTAACCAC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MSQSNAHDHGHDHDHDHTPTVTSANERKVLVSFFLIFGFMLVEAVGGVLSGSLALLADAGHMLTDAVALALAYAAFRFGR
RAADSKRTFGYLRFEVIAGFLNAVTLFAIVAWIAYEAWERLQAPPVILAGPMMIVAVLGLLINVLVLWIMTRGETDHVNV
KGAILHVMGDLLGSVGAIVAAIVIYFTGWTPIDPILSVLVAALILRSAWKLLAKSIHILLEGAPEDASPEKVEQGLMSTV
PGLAAVSHVHVWQLTSGRTMATLHVRPNVDEEARAVVKRVEAVLREQFSIEHATVGIDWNSEADENICSLQPTTGRQDHS
GHDHSEHNHDHDHSAPGHKH

Sequences:

>Translated_340_residues
MSQSNAHDHGHDHDHDHTPTVTSANERKVLVSFFLIFGFMLVEAVGGVLSGSLALLADAGHMLTDAVALALAYAAFRFGR
RAADSKRTFGYLRFEVIAGFLNAVTLFAIVAWIAYEAWERLQAPPVILAGPMMIVAVLGLLINVLVLWIMTRGETDHVNV
KGAILHVMGDLLGSVGAIVAAIVIYFTGWTPIDPILSVLVAALILRSAWKLLAKSIHILLEGAPEDASPEKVEQGLMSTV
PGLAAVSHVHVWQLTSGRTMATLHVRPNVDEEARAVVKRVEAVLREQFSIEHATVGIDWNSEADENICSLQPTTGRQDHS
GHDHSEHNHDHDHSAPGHKH
>Mature_339_residues
SQSNAHDHGHDHDHDHTPTVTSANERKVLVSFFLIFGFMLVEAVGGVLSGSLALLADAGHMLTDAVALALAYAAFRFGRR
AADSKRTFGYLRFEVIAGFLNAVTLFAIVAWIAYEAWERLQAPPVILAGPMMIVAVLGLLINVLVLWIMTRGETDHVNVK
GAILHVMGDLLGSVGAIVAAIVIYFTGWTPIDPILSVLVAALILRSAWKLLAKSIHILLEGAPEDASPEKVEQGLMSTVP
GLAAVSHVHVWQLTSGRTMATLHVRPNVDEEARAVVKRVEAVLREQFSIEHATVGIDWNSEADENICSLQPTTGRQDHSG
HDHSEHNHDHDHSAPGHKH

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=330, Percent_Identity=26.6666666666667, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI21359890, Length=317, Percent_Identity=25.8675078864353, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI64762489, Length=313, Percent_Identity=26.8370607028754, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI289803013, Length=303, Percent_Identity=26.7326732673267, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI289803009, Length=303, Percent_Identity=26.7326732673267, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI289803007, Length=303, Percent_Identity=26.7326732673267, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI289803003, Length=303, Percent_Identity=26.7326732673267, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI21361112, Length=314, Percent_Identity=27.0700636942675, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI20070323, Length=303, Percent_Identity=25.4125412541254, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI52351208, Length=122, Percent_Identity=39.344262295082, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI14210520, Length=237, Percent_Identity=26.1603375527426, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI52352803, Length=132, Percent_Identity=40.1515151515151, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI222080086, Length=152, Percent_Identity=29.6052631578947, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI40255009, Length=152, Percent_Identity=29.6052631578947, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786966, Length=277, Percent_Identity=47.6534296028881, Blast_Score=212, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI193210990, Length=317, Percent_Identity=27.1293375394322, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17555794, Length=331, Percent_Identity=27.4924471299094, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17555796, Length=296, Percent_Identity=28.0405405405405, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI32564488, Length=313, Percent_Identity=29.073482428115, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320411, Length=242, Percent_Identity=35.1239669421488, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324892, Length=141, Percent_Identity=30.4964539007092, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323899, Length=181, Percent_Identity=29.2817679558011, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656728, Length=360, Percent_Identity=28.6111111111111, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24656724, Length=360, Percent_Identity=28.6111111111111, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24656720, Length=360, Percent_Identity=28.6111111111111, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24656715, Length=360, Percent_Identity=28.6111111111111, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI21357035, Length=360, Percent_Identity=28.6111111111111, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24583858, Length=361, Percent_Identity=24.0997229916898, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585900, Length=124, Percent_Identity=29.8387096774194, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24585898, Length=124, Percent_Identity=29.8387096774194, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24585896, Length=124, Percent_Identity=29.8387096774194, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921672, Length=124, Percent_Identity=29.8387096774194, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24645863, Length=110, Percent_Identity=37.2727272727273, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24584409, Length=142, Percent_Identity=31.6901408450704, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574430, Length=138, Percent_Identity=31.8840579710145, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 36911; Mature: 36780

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSNAHDHGHDHDHDHTPTVTSANERKVLVSFFLIFGFMLVEAVGGVLSGSLALLADAG
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCH
HMLTDAVALALAYAAFRFGRRAADSKRTFGYLRFEVIAGFLNAVTLFAIVAWIAYEAWER
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQAPPVILAGPMMIVAVLGLLINVLVLWIMTRGETDHVNVKGAILHVMGDLLGSVGAIVA
HCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AIVIYFTGWTPIDPILSVLVAALILRSAWKLLAKSIHILLEGAPEDASPEKVEQGLMSTV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
PGLAAVSHVHVWQLTSGRTMATLHVRPNVDEEARAVVKRVEAVLREQFSIEHATVGIDWN
CHHHHHHHHEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHEEEECCCC
SEADENICSLQPTTGRQDHSGHDHSEHNHDHDHSAPGHKH
CCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQSNAHDHGHDHDHDHTPTVTSANERKVLVSFFLIFGFMLVEAVGGVLSGSLALLADAG
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCH
HMLTDAVALALAYAAFRFGRRAADSKRTFGYLRFEVIAGFLNAVTLFAIVAWIAYEAWER
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQAPPVILAGPMMIVAVLGLLINVLVLWIMTRGETDHVNVKGAILHVMGDLLGSVGAIVA
HCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AIVIYFTGWTPIDPILSVLVAALILRSAWKLLAKSIHILLEGAPEDASPEKVEQGLMSTV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
PGLAAVSHVHVWQLTSGRTMATLHVRPNVDEEARAVVKRVEAVLREQFSIEHATVGIDWN
CHHHHHHHHEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHEEEECCCC
SEADENICSLQPTTGRQDHSGHDHSEHNHDHDHSAPGHKH
CCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]