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The map label for this gene is pcm [H]

Identifier: 222110294

GI number: 222110294

Start: 1129173

End: 1129943

Strand: Direct

Name: pcm [H]

Synonym: Dtpsy_1081

Alternate gene names: 222110294

Gene position: 1129173-1129943 (Clockwise)

Preceding gene: 222110293

Following gene: 222110295

Centisome position: 29.74

GC content: 66.15

Gene sequence:

>771_bases
ATGCAGCGGCGTCCAGGTTTTCCTGCGCGGATCGACTGGCGCCAACCCGGTGCACCCACCGCGGCGCCACCGGTAGGCGC
GCGCCGCGAGGTGCAGCCGCCCACGCCGCACGGCGTAGGGCTGGACTCCGCTGCCGTGCGCGCACGCATGGTGCAGCGAC
TCGCAGCCTCGGGTATCTCGGCGGGGGCGGTTCTTCAGGCCATGGGAATGATTGAGCGGCATCGTTTTGTCGACACCGCC
TTGGCCAACCAAGCCTATGAGGACACCAGTCTGCCCATCGGACTGGGTCAGACCATTTCCAAACCCAGCGTGGTAGCACG
CATGATCGAATTGTTGCTAGGGGCCGAGTGCGCGCGCGGAAATGGAATGGGCCGGGTGCTGGAGATCGGCACTGGCTGCG
GCTATCAGGCAGCGGTGCTGTCGCGCGTCTCGCGCGAGGTGTATACCGTTGAACGCTTGCGCGCGTTGCATGAAAAGGCG
CGAGACCACTTGCGCCCGCTGCGCCTGGCCAATGTGCACCTGATCCTGGGCGACGGAATGTTGGGTTACCCCAGCGGCGC
GCCCTATGCGGGCATCATTGCCGCGGCGGGGGGCGATAGCCTTCCCGCCGCGTGGTGCGAGCAACTTGCCGTGGGTGGCC
GGCTGGTCGCCCCACTGGCGGGCGCCGACGGCCAGCAGATGCTGCTGGTCGTTGATAAAACTGCGCAAGGCTTGAAGCAG
GGCATTCTGGAAGCCGTGCATTTCGTCCCCCTAAAATCGGGGATCGCCTGA

Upstream 100 bases:

>100_bases
CGCCATTGAAGGTGGACCTGACCGATTACGACGGACTGGGGTATTGGGCGCAGACGGTGGCCCGTCTCGTACCAGCGCAG
GCGTCCGGCGAGGTGGCTTG

Downstream 100 bases:

>100_bases
AGGATTTGCTTATGTTGGTATCGCGTAGTCTTGTGGTTTGGGGAGTTGCCGTGCTGGCTGGCGGTTTGCTGGCGGGGTGC
AGCACCCCGATCAACAGGGC

Product: protein-l-isoaspartate o-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MQRRPGFPARIDWRQPGAPTAAPPVGARREVQPPTPHGVGLDSAAVRARMVQRLAASGISAGAVLQAMGMIERHRFVDTA
LANQAYEDTSLPIGLGQTISKPSVVARMIELLLGAECARGNGMGRVLEIGTGCGYQAAVLSRVSREVYTVERLRALHEKA
RDHLRPLRLANVHLILGDGMLGYPSGAPYAGIIAAAGGDSLPAAWCEQLAVGGRLVAPLAGADGQQMLLVVDKTAQGLKQ
GILEAVHFVPLKSGIA

Sequences:

>Translated_256_residues
MQRRPGFPARIDWRQPGAPTAAPPVGARREVQPPTPHGVGLDSAAVRARMVQRLAASGISAGAVLQAMGMIERHRFVDTA
LANQAYEDTSLPIGLGQTISKPSVVARMIELLLGAECARGNGMGRVLEIGTGCGYQAAVLSRVSREVYTVERLRALHEKA
RDHLRPLRLANVHLILGDGMLGYPSGAPYAGIIAAAGGDSLPAAWCEQLAVGGRLVAPLAGADGQQMLLVVDKTAQGLKQ
GILEAVHFVPLKSGIA
>Mature_256_residues
MQRRPGFPARIDWRQPGAPTAAPPVGARREVQPPTPHGVGLDSAAVRARMVQRLAASGISAGAVLQAMGMIERHRFVDTA
LANQAYEDTSLPIGLGQTISKPSVVARMIELLLGAECARGNGMGRVLEIGTGCGYQAAVLSRVSREVYTVERLRALHEKA
RDHLRPLRLANVHLILGDGMLGYPSGAPYAGIIAAAGGDSLPAAWCEQLAVGGRLVAPLAGADGQQMLLVVDKTAQGLKQ
GILEAVHFVPLKSGIA

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins [H]

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI226530908, Length=217, Percent_Identity=30.4147465437788, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1789100, Length=205, Percent_Identity=40.9756097560976, Blast_Score=136, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71983477, Length=220, Percent_Identity=30, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193207222, Length=137, Percent_Identity=34.3065693430657, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17981723, Length=222, Percent_Identity=30.1801801801802, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000682 [H]

Pfam domain/function: PF01135 PCMT [H]

EC number: =2.1.1.77 [H]

Molecular weight: Translated: 26867; Mature: 26867

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRRPGFPARIDWRQPGAPTAAPPVGARREVQPPTPHGVGLDSAAVRARMVQRLAASGIS
CCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
AGAVLQAMGMIERHRFVDTALANQAYEDTSLPIGLGQTISKPSVVARMIELLLGAECARG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCC
NGMGRVLEIGTGCGYQAAVLSRVSREVYTVERLRALHEKARDHLRPLRLANVHLILGDGM
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCEEEEEEECCC
LGYPSGAPYAGIIAAAGGDSLPAAWCEQLAVGGRLVAPLAGADGQQMLLVVDKTAQGLKQ
CCCCCCCCHHEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEEEECHHHHHHHH
GILEAVHFVPLKSGIA
HHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQRRPGFPARIDWRQPGAPTAAPPVGARREVQPPTPHGVGLDSAAVRARMVQRLAASGIS
CCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
AGAVLQAMGMIERHRFVDTALANQAYEDTSLPIGLGQTISKPSVVARMIELLLGAECARG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCC
NGMGRVLEIGTGCGYQAAVLSRVSREVYTVERLRALHEKARDHLRPLRLANVHLILGDGM
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCEEEEEEECCC
LGYPSGAPYAGIIAAAGGDSLPAAWCEQLAVGGRLVAPLAGADGQQMLLVVDKTAQGLKQ
CCCCCCCCHHEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEEEECHHHHHHHH
GILEAVHFVPLKSGIA
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA