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The map label for this gene is nuoL [H]

Identifier: 222110097

GI number: 222110097

Start: 905998

End: 908013

Strand: Direct

Name: nuoL [H]

Synonym: Dtpsy_0883

Alternate gene names: 222110097

Gene position: 905998-908013 (Clockwise)

Preceding gene: 222110096

Following gene: 222110098

Centisome position: 23.86

GC content: 59.77

Gene sequence:

>2016_bases
ATGAGTCAAACCCTTTCTGCTTCGACGCTGCTGGCGGTGCCCCTGGCGCCGCTCGTCGGCTCCGTGCTTGCGGGCATCTT
TGGCACGGCCTTCGGCGGCAACTGGTTCGGTCGCCGTGCTTCCCATTCGCTCACCATCCTGGGGGTGTTGGTCGCCTTCG
TGCTCTCGGCGATGACGCTCAAGAGCGTGGCTGTGGATGGCGCCCGTTTCAACGAGACCATCTATACGTGGATGGTGGTG
GGCGGTCTGAAGATGGAGGTGGGCTTCCTCATCGACAGCCTTACCGCCATGATGATGTGCGTGGTGACCTTCGTCTCCTT
GATGGTGCACATCTACACCATCGGCTACATGGAGGAGGACGAAGGCTATAACCGTTTCTTTGCCTACATCTCGCTGTTCA
CGTTCTCCATGCTCATGCTTGTCATGAGCAACAACCTGCTGCAACTGTTTTTTGGCTGGGAGGCGGTGGGCTTGGTGTCC
TACCTGCTGATCGGCTTCTGGTTCAACAAACAGTCGGCGATCTTCGCCAACATGAAGGCCTTTCTGGTCAACCGCGTCGG
CGACTTCGGCTTCATCCTTGGCATTGGCTTGATCGCTGCCTACGCGGGCACCTTCAACTACAGCGAGATCTTCGCCAAGT
CGGGCGAACTGGGCGCGATTGGCTTCCCCGGCACCGACTGGATGCTGATCACCGTGATCTGCATCTGCCTGTTCATCGGC
GCGATGGGCAAGTCTGCTCAGTTCCCGCTGCACGTGTGGCTGCCCGACTCGATGGAAGGCCCGACACCGATTTCGGCGCT
GATTCACGCGGCCACCATGGTGACGGCCGGCATTTTCATGGTGTCGCGCATGTCGCCGCTGTTTGAGTTGTCGGATACCG
CGCTGAACTTCATTCTGGTGATCGGCGCGATCACCGCACTGTTCATGGGTTTCCTGGGCATCATCCAGAACGACATCAAG
CGGGTGGTGGCGTATTCCACGCTGTCGCAGCTGGGTTACATGACCGTCGCCCTGGGCGCATCGGCCTATTCGGTGGCCGT
CTTCCACCTGATGACGCATGCGTTCTTCAAGGCCTTGCTGTTCCTGGGCGCCGGCTCGGTGATCATGGGCATGCACCACA
ACCAGGACATCCGCTGGATGGGAGGCGTGCGCAAATACATGCCTATCACTTGGATTACCTCGCTGTTGGGATCTCTGGCC
CTGATCGGCACGCCGCTGTTCTCAGGCTTCTATTCCAAGGACAGCATCATCGAGGCGGTGCATGCCAGCACGCTGCCGGC
TGCGGGCTTCGCCCATTTCGCCGTACTGGCCGGCGTGTTCGTGACGGCGTTCTACTCCTTCCGTATGTATTTCCTTGTGT
TCCACGGCAAGGAACGCTACGACCAGAATCCCGATGCGCACCACGGCGACCACCATGGCCACGATGACCATCATGAGCCG
CATGAGTCCCCGTGGGTGGTGACCGTGCCGCTGATTCTGTTGGCCATTCCCTCCGTACTGATCGGCTTCATGACCATCCA
GCCGATGCTGTTTGGCGATTTCTTCAAGGACGTGATCTTCGTGGACGCCGCCAAGCACCCCGCGATGGCGGAACTGGCGG
AGATCTTCCACGGTCCGTTGGCCATGGCTCTGCACGGCCTGCAGACGGCACCGTTCTGGCTGGCACTGGCTGGCGTCGCG
ATGGCGTACTACATGTACATGGTCAACCCGGCGCTGCCCGCGGCCATCAAGCGTATGTTCCAGCCGATCTATACCTTGTT
CGAAAACAAGTACTACCTCGACTGGATCAACGAGAACATCATCGCGCGTGGTGCCCGCGGCTTGGGCATTGCCCTGTGGA
AGGGCGGCGACCAAGGCGTGATCGACGGGGCCCTCGTGAACGGCTCGTGGAAGCTCGTGGGACGTATCGCAGGCCTGGTG
CGCTGGCTCCAGTCGGGCTATGTCTACCACTATGCGCTGGTGATGATCCTGGGTGTGTTCGCGCTCATGACTTATTTCGT
CTGGCTCAACAAGTAG

Upstream 100 bases:

>100_bases
CCTGGTGCTGCTGTTCCGTAACAAGACCAGCATTGATGCGGAAGATCTCAACACCCTCAAGGGTTGATGGGTCGCCCCGG
TACTTGCAAGGTTCTCAAGA

Downstream 100 bases:

>100_bases
GAGAAAAAAGAAAATGGGTTTGTTGAGTCTTGCCATCTGGGTGCCCATTGCCTTCGGCACCCTCCTGCTGGCCTTGGGGC
GCGACGAGCATGCACGCATG

Product: proton-translocating NADH-quinone oxidoreductase subunit l

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 671; Mature: 670

Protein sequence:

>671_residues
MSQTLSASTLLAVPLAPLVGSVLAGIFGTAFGGNWFGRRASHSLTILGVLVAFVLSAMTLKSVAVDGARFNETIYTWMVV
GGLKMEVGFLIDSLTAMMMCVVTFVSLMVHIYTIGYMEEDEGYNRFFAYISLFTFSMLMLVMSNNLLQLFFGWEAVGLVS
YLLIGFWFNKQSAIFANMKAFLVNRVGDFGFILGIGLIAAYAGTFNYSEIFAKSGELGAIGFPGTDWMLITVICICLFIG
AMGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALNFILVIGAITALFMGFLGIIQNDIK
RVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALLFLGAGSVIMGMHHNQDIRWMGGVRKYMPITWITSLLGSLA
LIGTPLFSGFYSKDSIIEAVHASTLPAAGFAHFAVLAGVFVTAFYSFRMYFLVFHGKERYDQNPDAHHGDHHGHDDHHEP
HESPWVVTVPLILLAIPSVLIGFMTIQPMLFGDFFKDVIFVDAAKHPAMAELAEIFHGPLAMALHGLQTAPFWLALAGVA
MAYYMYMVNPALPAAIKRMFQPIYTLFENKYYLDWINENIIARGARGLGIALWKGGDQGVIDGALVNGSWKLVGRIAGLV
RWLQSGYVYHYALVMILGVFALMTYFVWLNK

Sequences:

>Translated_671_residues
MSQTLSASTLLAVPLAPLVGSVLAGIFGTAFGGNWFGRRASHSLTILGVLVAFVLSAMTLKSVAVDGARFNETIYTWMVV
GGLKMEVGFLIDSLTAMMMCVVTFVSLMVHIYTIGYMEEDEGYNRFFAYISLFTFSMLMLVMSNNLLQLFFGWEAVGLVS
YLLIGFWFNKQSAIFANMKAFLVNRVGDFGFILGIGLIAAYAGTFNYSEIFAKSGELGAIGFPGTDWMLITVICICLFIG
AMGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALNFILVIGAITALFMGFLGIIQNDIK
RVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALLFLGAGSVIMGMHHNQDIRWMGGVRKYMPITWITSLLGSLA
LIGTPLFSGFYSKDSIIEAVHASTLPAAGFAHFAVLAGVFVTAFYSFRMYFLVFHGKERYDQNPDAHHGDHHGHDDHHEP
HESPWVVTVPLILLAIPSVLIGFMTIQPMLFGDFFKDVIFVDAAKHPAMAELAEIFHGPLAMALHGLQTAPFWLALAGVA
MAYYMYMVNPALPAAIKRMFQPIYTLFENKYYLDWINENIIARGARGLGIALWKGGDQGVIDGALVNGSWKLVGRIAGLV
RWLQSGYVYHYALVMILGVFALMTYFVWLNK
>Mature_670_residues
SQTLSASTLLAVPLAPLVGSVLAGIFGTAFGGNWFGRRASHSLTILGVLVAFVLSAMTLKSVAVDGARFNETIYTWMVVG
GLKMEVGFLIDSLTAMMMCVVTFVSLMVHIYTIGYMEEDEGYNRFFAYISLFTFSMLMLVMSNNLLQLFFGWEAVGLVSY
LLIGFWFNKQSAIFANMKAFLVNRVGDFGFILGIGLIAAYAGTFNYSEIFAKSGELGAIGFPGTDWMLITVICICLFIGA
MGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALNFILVIGAITALFMGFLGIIQNDIKR
VVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALLFLGAGSVIMGMHHNQDIRWMGGVRKYMPITWITSLLGSLAL
IGTPLFSGFYSKDSIIEAVHASTLPAAGFAHFAVLAGVFVTAFYSFRMYFLVFHGKERYDQNPDAHHGDHHGHDDHHEPH
ESPWVVTVPLILLAIPSVLIGFMTIQPMLFGDFFKDVIFVDAAKHPAMAELAEIFHGPLAMALHGLQTAPFWLALAGVAM
AYYMYMVNPALPAAIKRMFQPIYTLFENKYYLDWINENIIARGARGLGIALWKGGDQGVIDGALVNGSWKLVGRIAGLVR
WLQSGYVYHYALVMILGVFALMTYFVWLNK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=384, Percent_Identity=40.625, Blast_Score=283, Evalue=3e-76,
Organism=Escherichia coli, GI1788614, Length=577, Percent_Identity=37.9549393414211, Blast_Score=356, Evalue=3e-99,
Organism=Escherichia coli, GI1788829, Length=345, Percent_Identity=32.463768115942, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788831, Length=351, Percent_Identity=29.3447293447293, Blast_Score=134, Evalue=3e-32,
Organism=Escherichia coli, GI1788827, Length=451, Percent_Identity=28.8248337028825, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI2367154, Length=130, Percent_Identity=35.3846153846154, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788613, Length=333, Percent_Identity=25.5255255255255, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI145693160, Length=311, Percent_Identity=26.0450160771704, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 73742; Mature: 73611

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCC
>Mature Secondary Structure 
SQTLSASTLLAVPLAPLVGSVLAGIFGTAFGGNWFGRRASHSLTILGVLVAFVLSAMTL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
KSVAVDGARFNETIYTWMVVGGLKMEVGFLIDSLTAMMMCVVTFVSLMVHIYTIGYMEED
HHHHCCCCHHHHHHEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECC
EGYNRFFAYISLFTFSMLMLVMSNNLLQLFFGWEAVGLVSYLLIGFWFNKQSAIFANMKA
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
FLVNRVGDFGFILGIGLIAAYAGTFNYSEIFAKSGELGAIGFPGTDWMLITVICICLFIG
HHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AMGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALNFILV
CCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
IGAITALFMGFLGIIQNDIKRVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
FLGAGSVIMGMHHNQDIRWMGGVRKYMPITWITSLLGSLALIGTPLFSGFYSKDSIIEAV
HHCCCHHEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
HASTLPAAGFAHFAVLAGVFVTAFYSFRMYFLVFHGKERYDQNPDAHHGDHHGHDDHHEP
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHCCCCCCCCCCCCCCCCCCCCC
HESPWVVTVPLILLAIPSVLIGFMTIQPMLFGDFFKDVIFVDAAKHPAMAELAEIFHGPL
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHH
AMALHGLQTAPFWLALAGVAMAYYMYMVNPALPAAIKRMFQPIYTLFENKYYLDWINENI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHH
IARGARGLGIALWKGGDQGVIDGALVNGSWKLVGRIAGLVRWLQSGYVYHYALVMILGVF
HHCCCCCCEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ALMTYFVWLNK
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]