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The map label for this gene is nqo13 [H]

Identifier: 222110098

GI number: 222110098

Start: 908027

End: 909502

Strand: Direct

Name: nqo13 [H]

Synonym: Dtpsy_0884

Alternate gene names: 222110098

Gene position: 908027-909502 (Clockwise)

Preceding gene: 222110097

Following gene: 222110099

Centisome position: 23.92

GC content: 60.77

Gene sequence:

>1476_bases
ATGGGTTTGTTGAGTCTTGCCATCTGGGTGCCCATTGCCTTCGGCACCCTCCTGCTGGCCTTGGGGCGCGACGAGCATGC
ACGCATGGTCCGCTGGCTGGCGCTCATCGGCGCGCTGCTGGGTTTGGCTGTCACGCTCCCGCTCATGGGCGGCTTCGACA
ACGGCAGCGCGGCTGCGCAGTTTGTCGAAAAGTCCATGTGGATCGAGCGCTTCAACGTCTACTACCACCTGGGTGTGGAC
GGCATCGCTTTCTGGTTCGTGCCGCTGACGGCGTTCATCACCGTCATCGTCGTGATTGCCTCCTGGGAATCGATCACCGA
GCGGGTGAATCAGTACATGGGCGCGTTCCTGATCCTTTCGGGTCTGATGGTCGGCGTCTTCAGCGCCATGGACGGCATGT
TGTTCTACGTGTTCTTCGAGGCCACGCTGATCCCGATGTACCTGATCATCGGTATCTGGGGCGGGCCGAACAAGATTTAC
GCGGCTTTCAAGTTTTTCCTGTACACGCTGCTGGGCTCGCTGCTCACGCTGATTGCGTTCATCTACCTGTACAACCAGTC
GGGCGGCAGCTTTGACATCGCTACGTGGCACAAGCTGCCCCTGTCGGCGACCGCGCAAACCCTGCTGTTCTTTGCCTTCT
TCGCGGCGTTTGCCGTGAAGGTGCCTATGTGGCCGGTGCATACCTGGCTGCCCGATGTGCACGTGGAAGCGCCCACGGGC
GGCTCCGCAGTGCTGGCCGCCATCATGCTGAAGCTGGGCGCGTATGGTTTCCTGCGCTTCTCGCTGCCGATCGCACCAGA
CGCTTCGCGCGAATGGGCGTGGCTGATGATCACCCTGTCGCTGGTGGCTGTGATCTACGTGGGGCTGGTGGCCATGGTGC
AAAAGGACATGAAGAAACTCGTGGCCTACTCGTCGGTTGCGCACATGGGCTTTGTCACGCTGGGCTTCTTCGTCTTCAAT
GACATGGGTGTCTCGGGTGGCCTGGTCCAGATGATTGCGCACGGCTTCGTGTCCGGCGCCATGTTCCTGTGCATTGGCGT
GCTGTACGACCGCGTGCATTCGCGCGAGATCGCTTCCTATGGCGGCGTGGTCAACACCATGCCCAAGTTCGCGGCCTTTG
CGCTGCTGTTCACCATGGCCAATTGCGGGCTGCCGGCTACGGCGGGCTTCGTCGGTGAATGGATGGTCATCATCGCCGCC
GTGAAGTTCGACTTTTGGGTCGGCCTTGGCGCGGCGTTGGCGTTGATCCTGGGCGCCAGCTATTCGCTGTGGATGTACAA
GCGCGTCTATCTGGGCCCCGTCACGAACGACAACGTGCGCGGCCTGACGGATATTGGCGGACGGGAATTCCTTGTGCTGG
GATTGCTGGCGATTGCCGTGCTGTACATGGGCGTCTATCCCAAGCCCTTCACGGACGTGATGGATGTGTCCGTGGCAGAG
TTGCTCAAGCATGTGGCGCAATCCAAGCTCAACTGA

Upstream 100 bases:

>100_bases
CAGTCGGGCTATGTCTACCACTATGCGCTGGTGATGATCCTGGGTGTGTTCGCGCTCATGACTTATTTCGTCTGGCTCAA
CAAGTAGGAGAAAAAAGAAA

Downstream 100 bases:

>100_bases
CCAGACTGAACCGAGAGATACGAGATGATTGACAACATCAGCTGGCTGGCGATTTATCCCGAGATCGTGCTGCTGGTCAT
GGCTTGCGTGATTGCCCTGG

Product: proton-translocating NADH-quinone oxidoreductase subunit m

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 13; NDH-1, chain 13 [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MGLLSLAIWVPIAFGTLLLALGRDEHARMVRWLALIGALLGLAVTLPLMGGFDNGSAAAQFVEKSMWIERFNVYYHLGVD
GIAFWFVPLTAFITVIVVIASWESITERVNQYMGAFLILSGLMVGVFSAMDGMLFYVFFEATLIPMYLIIGIWGGPNKIY
AAFKFFLYTLLGSLLTLIAFIYLYNQSGGSFDIATWHKLPLSATAQTLLFFAFFAAFAVKVPMWPVHTWLPDVHVEAPTG
GSAVLAAIMLKLGAYGFLRFSLPIAPDASREWAWLMITLSLVAVIYVGLVAMVQKDMKKLVAYSSVAHMGFVTLGFFVFN
DMGVSGGLVQMIAHGFVSGAMFLCIGVLYDRVHSREIASYGGVVNTMPKFAAFALLFTMANCGLPATAGFVGEWMVIIAA
VKFDFWVGLGAALALILGASYSLWMYKRVYLGPVTNDNVRGLTDIGGREFLVLGLLAIAVLYMGVYPKPFTDVMDVSVAE
LLKHVAQSKLN

Sequences:

>Translated_491_residues
MGLLSLAIWVPIAFGTLLLALGRDEHARMVRWLALIGALLGLAVTLPLMGGFDNGSAAAQFVEKSMWIERFNVYYHLGVD
GIAFWFVPLTAFITVIVVIASWESITERVNQYMGAFLILSGLMVGVFSAMDGMLFYVFFEATLIPMYLIIGIWGGPNKIY
AAFKFFLYTLLGSLLTLIAFIYLYNQSGGSFDIATWHKLPLSATAQTLLFFAFFAAFAVKVPMWPVHTWLPDVHVEAPTG
GSAVLAAIMLKLGAYGFLRFSLPIAPDASREWAWLMITLSLVAVIYVGLVAMVQKDMKKLVAYSSVAHMGFVTLGFFVFN
DMGVSGGLVQMIAHGFVSGAMFLCIGVLYDRVHSREIASYGGVVNTMPKFAAFALLFTMANCGLPATAGFVGEWMVIIAA
VKFDFWVGLGAALALILGASYSLWMYKRVYLGPVTNDNVRGLTDIGGREFLVLGLLAIAVLYMGVYPKPFTDVMDVSVAE
LLKHVAQSKLN
>Mature_490_residues
GLLSLAIWVPIAFGTLLLALGRDEHARMVRWLALIGALLGLAVTLPLMGGFDNGSAAAQFVEKSMWIERFNVYYHLGVDG
IAFWFVPLTAFITVIVVIASWESITERVNQYMGAFLILSGLMVGVFSAMDGMLFYVFFEATLIPMYLIIGIWGGPNKIYA
AFKFFLYTLLGSLLTLIAFIYLYNQSGGSFDIATWHKLPLSATAQTLLFFAFFAAFAVKVPMWPVHTWLPDVHVEAPTGG
SAVLAAIMLKLGAYGFLRFSLPIAPDASREWAWLMITLSLVAVIYVGLVAMVQKDMKKLVAYSSVAHMGFVTLGFFVFND
MGVSGGLVQMIAHGFVSGAMFLCIGVLYDRVHSREIASYGGVVNTMPKFAAFALLFTMANCGLPATAGFVGEWMVIIAAV
KFDFWVGLGAALALILGASYSLWMYKRVYLGPVTNDNVRGLTDIGGREFLVLGLLAIAVLYMGVYPKPFTDVMDVSVAEL
LKHVAQSKLN

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=374, Percent_Identity=34.2245989304813, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI251831117, Length=331, Percent_Identity=24.773413897281, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788613, Length=478, Percent_Identity=35.9832635983264, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI1788827, Length=285, Percent_Identity=27.719298245614, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1788831, Length=304, Percent_Identity=24.6710526315789, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1788829, Length=359, Percent_Identity=26.7409470752089, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI145693160, Length=433, Percent_Identity=24.2494226327945, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788614, Length=410, Percent_Identity=25.8536585365854, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI2367154, Length=241, Percent_Identity=26.9709543568465, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 53637; Mature: 53505

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLLSLAIWVPIAFGTLLLALGRDEHARMVRWLALIGALLGLAVTLPLMGGFDNGSAAAQ
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
FVEKSMWIERFNVYYHLGVDGIAFWFVPLTAFITVIVVIASWESITERVNQYMGAFLILS
HHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLMVGVFSAMDGMLFYVFFEATLIPMYLIIGIWGGPNKIYAAFKFFLYTLLGSLLTLIAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IYLYNQSGGSFDIATWHKLPLSATAQTLLFFAFFAAFAVKVPMWPVHTWLPDVHVEAPTG
HHHHCCCCCCEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCEEECCCC
GSAVLAAIMLKLGAYGFLRFSLPIAPDASREWAWLMITLSLVAVIYVGLVAMVQKDMKKL
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAYSSVAHMGFVTLGFFVFNDMGVSGGLVQMIAHGFVSGAMFLCIGVLYDRVHSREIASY
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGVVNTMPKFAAFALLFTMANCGLPATAGFVGEWMVIIAAVKFDFWVGLGAALALILGAS
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YSLWMYKRVYLGPVTNDNVRGLTDIGGREFLVLGLLAIAVLYMGVYPKPFTDVMDVSVAE
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LLKHVAQSKLN
HHHHHHHHCCC
>Mature Secondary Structure 
GLLSLAIWVPIAFGTLLLALGRDEHARMVRWLALIGALLGLAVTLPLMGGFDNGSAAAQ
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH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HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]