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The map label for this gene is nuoH [H]

Identifier: 222110093

GI number: 222110093

Start: 903348

End: 904424

Strand: Direct

Name: nuoH [H]

Synonym: Dtpsy_0879

Alternate gene names: 222110093

Gene position: 903348-904424 (Clockwise)

Preceding gene: 222110092

Following gene: 222110094

Centisome position: 23.79

GC content: 60.91

Gene sequence:

>1077_bases
ATGATCGATGCAATCTACAACGGCGGCCTCAATCTGGTTGCGGCCGGATGGTGGACCGGGGTGGCTTGGCCCGTACTCTG
GATCCTGGTCAAGATCGTCTGCATCGTGGGTCCCCTGATGGGTGCCGTGGCCTACCTGACGCTGTGGGAGCGCAAGCTGC
TGGGCTTCATGCAGGTGCGCATGGGGCCCAACCGCGTGGGCCCCTTCGGTTTGCTGCAACCTCTGGCTGACGGTCTGAAA
TTGCTCTCGAAGGAGTTGATCCAGCCCACGGCCGCGGCCAAGGGCTTGTTCTACCTCGGCCCGGTCATGGCCATCATGCC
TGCCCTGGCGGCCTGGGTGGCGATTCCCTTCGGACCCGATGTAGCGCTGGCCAACGTCAATGCGGGTCTGTTGCTGATCA
TGGCCATCACCTCCATCGAGGTCTACGGCGTGATCATTGCGGGGTGGGCGTCCAACTCCAAGTACGCCTTTCTGGGCGCG
CTGCGTGCGTCTGCGCAGATGGTGAGCTACGAAATTGCCATGGGTTTCTGCTTCCTGGTCGTCATCATGGTATCGGGCAG
CATGAACCTGACCGAGATCGTGCTGGGCCAAGGGCAGGGCACGATGGCGGCCATGGGCCTGAACTTCCTGTCGTGGAATT
GGCTGCCCCTGCTGCCCATCTTCTTGGTCTACCTGATCTCGGGCGTGGCCGAAGTGAACCGCCACCCGTTTGACGTGGTG
GAAGGTGAGGCGGAAATCGTCGCCGGTCACATGGTCGAGTATTCAGGCATGGGTTTCGCCATCTTCTTCCTGGCCGAATA
CGCCAGCATGTGGCTGGTTTCCATCCTGGCGGTGGTGATGTTCCTGGGCGGCTGGCTGCCGCCGATCGAAGCCCTGGGCT
TCGTTCCGGGCTGGATCTGGCTGGGCATCAAGACGTTCCTGGTGGTATCCATGTTCATCTGGATTCGCGCCACGTTCCCG
CGCTTCCGCTATGACCAGATCATGCGTCTGGGTTGGAAGATCTTTATTCCGGTCACGCTGGTATGGCTGTTGATCGTGGG
CGCCTGGTTGCTGTCGCCCTGGAACATCTGGAAATAA

Upstream 100 bases:

>100_bases
CCGTCGTGGCAGCCATCTATCAGCTCGACAGCCTGGTGCGCCGCGCACCGTCGCTGCAACTGACTGCCGACGCGCGCGCG
GCACGTGAAGGAGTCGCCGC

Downstream 100 bases:

>100_bases
GCGGGGACATCCATGGCTGCTGTTGCTGCTCCTGCATCCTTTTCAATCAAGGATTTCTTCAAGAGCTTCATGCTCTGGGA
ACTGGCGAAGGGCATGGCCC

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MIDAIYNGGLNLVAAGWWTGVAWPVLWILVKIVCIVGPLMGAVAYLTLWERKLLGFMQVRMGPNRVGPFGLLQPLADGLK
LLSKELIQPTAAAKGLFYLGPVMAIMPALAAWVAIPFGPDVALANVNAGLLLIMAITSIEVYGVIIAGWASNSKYAFLGA
LRASAQMVSYEIAMGFCFLVVIMVSGSMNLTEIVLGQGQGTMAAMGLNFLSWNWLPLLPIFLVYLISGVAEVNRHPFDVV
EGEAEIVAGHMVEYSGMGFAIFFLAEYASMWLVSILAVVMFLGGWLPPIEALGFVPGWIWLGIKTFLVVSMFIWIRATFP
RFRYDQIMRLGWKIFIPVTLVWLLIVGAWLLSPWNIWK

Sequences:

>Translated_358_residues
MIDAIYNGGLNLVAAGWWTGVAWPVLWILVKIVCIVGPLMGAVAYLTLWERKLLGFMQVRMGPNRVGPFGLLQPLADGLK
LLSKELIQPTAAAKGLFYLGPVMAIMPALAAWVAIPFGPDVALANVNAGLLLIMAITSIEVYGVIIAGWASNSKYAFLGA
LRASAQMVSYEIAMGFCFLVVIMVSGSMNLTEIVLGQGQGTMAAMGLNFLSWNWLPLLPIFLVYLISGVAEVNRHPFDVV
EGEAEIVAGHMVEYSGMGFAIFFLAEYASMWLVSILAVVMFLGGWLPPIEALGFVPGWIWLGIKTFLVVSMFIWIRATFP
RFRYDQIMRLGWKIFIPVTLVWLLIVGAWLLSPWNIWK
>Mature_358_residues
MIDAIYNGGLNLVAAGWWTGVAWPVLWILVKIVCIVGPLMGAVAYLTLWERKLLGFMQVRMGPNRVGPFGLLQPLADGLK
LLSKELIQPTAAAKGLFYLGPVMAIMPALAAWVAIPFGPDVALANVNAGLLLIMAITSIEVYGVIIAGWASNSKYAFLGA
LRASAQMVSYEIAMGFCFLVVIMVSGSMNLTEIVLGQGQGTMAAMGLNFLSWNWLPLLPIFLVYLISGVAEVNRHPFDVV
EGEAEIVAGHMVEYSGMGFAIFFLAEYASMWLVSILAVVMFLGGWLPPIEALGFVPGWIWLGIKTFLVVSMFIWIRATFP
RFRYDQIMRLGWKIFIPVTLVWLLIVGAWLLSPWNIWK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=303, Percent_Identity=42.2442244224422, Blast_Score=242, Evalue=3e-64,
Organism=Escherichia coli, GI1788618, Length=327, Percent_Identity=40.6727828746177, Blast_Score=242, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 39379; Mature: 39379

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS00667 COMPLEX1_ND1_1 ; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDAIYNGGLNLVAAGWWTGVAWPVLWILVKIVCIVGPLMGAVAYLTLWERKLLGFMQVR
CCCCEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGPNRVGPFGLLQPLADGLKLLSKELIQPTAAAKGLFYLGPVMAIMPALAAWVAIPFGPD
CCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCC
VALANVNAGLLLIMAITSIEVYGVIIAGWASNSKYAFLGALRASAQMVSYEIAMGFCFLV
EEEECCCCHHHHHHHHHHHHEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VIMVSGSMNLTEIVLGQGQGTMAAMGLNFLSWNWLPLLPIFLVYLISGVAEVNRHPFDVV
HHHHCCCCCHHHHEEECCCCCHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHH
EGEAEIVAGHMVEYSGMGFAIFFLAEYASMWLVSILAVVMFLGGWLPPIEALGFVPGWIW
CCCHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHH
LGIKTFLVVSMFIWIRATFPRFRYDQIMRLGWKIFIPVTLVWLLIVGAWLLSPWNIWK
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIDAIYNGGLNLVAAGWWTGVAWPVLWILVKIVCIVGPLMGAVAYLTLWERKLLGFMQVR
CCCCEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGPNRVGPFGLLQPLADGLKLLSKELIQPTAAAKGLFYLGPVMAIMPALAAWVAIPFGPD
CCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCC
VALANVNAGLLLIMAITSIEVYGVIIAGWASNSKYAFLGALRASAQMVSYEIAMGFCFLV
EEEECCCCHHHHHHHHHHHHEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VIMVSGSMNLTEIVLGQGQGTMAAMGLNFLSWNWLPLLPIFLVYLISGVAEVNRHPFDVV
HHHHCCCCCHHHHEEECCCCCHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHH
EGEAEIVAGHMVEYSGMGFAIFFLAEYASMWLVSILAVVMFLGGWLPPIEALGFVPGWIW
CCCHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHH
LGIKTFLVVSMFIWIRATFPRFRYDQIMRLGWKIFIPVTLVWLLIVGAWLLSPWNIWK
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA