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The map label for this gene is nuoI [H]

Identifier: 222110094

GI number: 222110094

Start: 904437

End: 904949

Strand: Direct

Name: nuoI [H]

Synonym: Dtpsy_0880

Alternate gene names: 222110094

Gene position: 904437-904949 (Clockwise)

Preceding gene: 222110093

Following gene: 222110095

Centisome position: 23.82

GC content: 59.84

Gene sequence:

>513_bases
ATGGCTGCTGTTGCTGCTCCTGCATCCTTTTCAATCAAGGATTTCTTCAAGAGCTTCATGCTCTGGGAACTGGCGAAGGG
CATGGCCCTGACCGGTCGCTATACCTTCCGTCGCAAGGTCACTGTGCAGTTCCCCGAGGAGAAGACACCGTTGTCGCCGC
GCTTTCGCGGCCTGCACGCGCTGCGCCGTTATGACAACGGCGAAGAGCGCTGCATTGCCTGCAAGCTGTGCGAAGCGGTG
TGCCCGGCGCTGGCGATCACCATCGAGTCCGACGTGCGTGAGGACGGTTCGCGCCGTACCACCCGTTATGACATCGACCT
GACCAAGTGCATTTTTTGTGGCTTTTGCGAAGAGAGCTGCCCGGTGGATTCCATTGTGGAAACGCAGATCTTCGAATACC
ACGGCGAGAAGCGCGGTGATCTGTACTTCACCAAGGACATGCTGCTGGCCGTGGGCGACCGCTACGAGCCCGAGATCGCA
GCCGCCAAGGCGGCGGACGCCAAGTACCGTTGA

Upstream 100 bases:

>100_bases
GGGTTGGAAGATCTTTATTCCGGTCACGCTGGTATGGCTGTTGATCGTGGGCGCCTGGTTGCTGTCGCCCTGGAACATCT
GGAAATAAGCGGGGACATCC

Downstream 100 bases:

>100_bases
TCGGGTTGCCTCACCGCACCTGACTTTTTGAAAAGACCCGATTCATGGACGCCAAAACCGGTTTCTTCTACTTGTTCTCG
GTAGTGCTGCTGTACGCGGC

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MAAVAAPASFSIKDFFKSFMLWELAKGMALTGRYTFRRKVTVQFPEEKTPLSPRFRGLHALRRYDNGEERCIACKLCEAV
CPALAITIESDVREDGSRRTTRYDIDLTKCIFCGFCEESCPVDSIVETQIFEYHGEKRGDLYFTKDMLLAVGDRYEPEIA
AAKAADAKYR

Sequences:

>Translated_170_residues
MAAVAAPASFSIKDFFKSFMLWELAKGMALTGRYTFRRKVTVQFPEEKTPLSPRFRGLHALRRYDNGEERCIACKLCEAV
CPALAITIESDVREDGSRRTTRYDIDLTKCIFCGFCEESCPVDSIVETQIFEYHGEKRGDLYFTKDMLLAVGDRYEPEIA
AAKAADAKYR
>Mature_169_residues
AAVAAPASFSIKDFFKSFMLWELAKGMALTGRYTFRRKVTVQFPEEKTPLSPRFRGLHALRRYDNGEERCIACKLCEAVC
PALAITIESDVREDGSRRTTRYDIDLTKCIFCGFCEESCPVDSIVETQIFEYHGEKRGDLYFTKDMLLAVGDRYEPEIAA
AKAADAKYR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI4505371, Length=161, Percent_Identity=60.2484472049689, Blast_Score=201, Evalue=4e-52,
Organism=Escherichia coli, GI1788617, Length=148, Percent_Identity=37.8378378378378, Blast_Score=103, Evalue=6e-24,
Organism=Escherichia coli, GI1789075, Length=114, Percent_Identity=31.5789473684211, Blast_Score=60, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17555194, Length=169, Percent_Identity=53.2544378698225, Blast_Score=188, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17864306, Length=160, Percent_Identity=59.375, Blast_Score=194, Evalue=3e-50,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 19336; Mature: 19205

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVAAPASFSIKDFFKSFMLWELAKGMALTGRYTFRRKVTVQFPEEKTPLSPRFRGLHA
CCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECEEEEEEEEEEECCCCCCCCCHHHHHHHH
LRRYDNGEERCIACKLCEAVCPALAITIESDVREDGSRRTTRYDIDLTKCIFCGFCEESC
HHHCCCCCHHHHHHHHHHHHHHHHEEEECHHHHCCCCCCCEEEECCHHHHHHHHCCCCCC
PVDSIVETQIFEYHGEKRGDLYFTKDMLLAVGDRYEPEIAAAKAADAKYR
CHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHCCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure 
AAVAAPASFSIKDFFKSFMLWELAKGMALTGRYTFRRKVTVQFPEEKTPLSPRFRGLHA
CCCCCCCCCCHHHHHHHHHHHHHHCCCEEECEEEEEEEEEEECCCCCCCCCHHHHHHHH
LRRYDNGEERCIACKLCEAVCPALAITIESDVREDGSRRTTRYDIDLTKCIFCGFCEESC
HHHCCCCCHHHHHHHHHHHHHHHHEEEECHHHHCCCCCCCEEEECCHHHHHHHHCCCCCC
PVDSIVETQIFEYHGEKRGDLYFTKDMLLAVGDRYEPEIAAAKAADAKYR
CHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHCCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA