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The map label for this gene is nuoF1 [H]

Identifier: 222110091

GI number: 222110091

Start: 899842

End: 901203

Strand: Direct

Name: nuoF1 [H]

Synonym: Dtpsy_0877

Alternate gene names: 222110091

Gene position: 899842-901203 (Clockwise)

Preceding gene: 222110090

Following gene: 222110092

Centisome position: 23.7

GC content: 62.04

Gene sequence:

>1362_bases
ATGACCACGGCTGCACAAGTGCTGTCGCAGTTTCAGGCGACGGGCGTACAGACCTGCTTCCATGACCGCCATATCAATCC
GCAGATCTATGCGGGCTTGAACGGCAGCAACTGGAGCCTCAAGGATTACGAGGCCCGGGGAGGCTACCAGGCCCTGCGCA
AGCTGCTGGGCAAGGATGGTGGTGAAGGCCTGACCCAGGACCAGGTGATCGCCACCATGAAGGAATCCGGTCTGCGCGGC
CGTGGTGGTGCGGGCTTCCCGACTGGCCTGAAGTGGAGCTTCATGCCGCGTCAGTTCCCTGGCCAGAAATACTTGGTCTG
CAATTCCGACGAGGGGGAGCCGGGCACGTGCAAGGATCGCGACATCCTGATGTACAACCCGCACATCGTGATCGAGGGCA
TGATCATCGCGGCCTACGCGATGGGCATCTCTGTGGGCTACAACTACATCCACGGCGAGATCTTCCAGGTCTACGAGCGC
TTTGAAGCGGCGTTGGAAGAGGCGCGCGCTGCAGGCTATCTGGGTGACAACATCCTGGGCAGCAGCTTCAGCTTCCAACT
GCATGCGCACCATGGCTTTGGGGCGTATATCTGCGGTGAGGAAACCGCGTTGCTGGAATCGCTGGAAGGCAAGAAGGGCC
AGCCGCGCTTCAAGCCGCCATTCCCGGCCAGCTTTGGCCTGTACGGCAAACCCACCACGATCAACAACACCGAGACGTTC
GCCGCGGTGCCGTGGATCATCCGCAATGGCGGTCAGGCTTACCTTGAGTGCGGCAAGCCCAACAACGGCGGCACCAAGAT
CTTCTCGGTGTCCGGCGACGTAGAGCGTCCAGGCAACTATGAAGTGCCCTTGGGCACGCCATTTGCCAAGCTGCTGGAAC
TGGCGGGTGGCGTGCGCAAGGGTCGCCAGCTCAAGGCGGTGATTCCGGGTGGTTCTTCCGCTCCCGTGTTGCCGGCGTCC
ATCATCATGGAATGCACGATGGACTACGACTCCATCGCCAAGGCCGGCTCCATGCTGGGCTCGGGCGCCGTGATCGTGAT
GGACGATTCCCGCAACATGGTGGAGAGCCTGCTGCGTCTGTCGTATTTCTACGCGCATGAATCCTGCGGTCAGTGCACAC
CCTGCCGCGAAGGCACGGGCTGGATGTGGCGCGTGATCAATCGTATCCAGCACGAAGCCGGGCGGGAGAGCGATCTGGAC
CTGCTCAATTCCGTCGCGGACAACATTCAGGGCCGGACCATCTGCGCGCTGGGCGATGCGGCAGCCATGCCGGTGCGCGC
CATGCTCAAGCATTTCCGTCCGGAGTTTGAAGCGCTGATCCGAAACGCCCACCCATCGGGTTCCACCCCCGCCAGCGCCT
GA

Upstream 100 bases:

>100_bases
CGCCCGTGATGCTGGTCAATGACCGCAACATGTGCAGTTTCATGGACGACGACAAGCTCGACCAGATGGTGGATGGCCTG
CGCGCTGCGGAGGGCAAACA

Downstream 100 bases:

>100_bases
ACGCGAGTACAGCATATGGTTGAAATCGAACTGGACGGGAAGAAGGTAGAAGTCACCGAAGGCTGCATGGTGATGCATGC
GGCCGAGAAGGTGGGTACCT

Product: NADH-quinone oxidoreductase subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MTTAAQVLSQFQATGVQTCFHDRHINPQIYAGLNGSNWSLKDYEARGGYQALRKLLGKDGGEGLTQDQVIATMKESGLRG
RGGAGFPTGLKWSFMPRQFPGQKYLVCNSDEGEPGTCKDRDILMYNPHIVIEGMIIAAYAMGISVGYNYIHGEIFQVYER
FEAALEEARAAGYLGDNILGSSFSFQLHAHHGFGAYICGEETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETF
AAVPWIIRNGGQAYLECGKPNNGGTKIFSVSGDVERPGNYEVPLGTPFAKLLELAGGVRKGRQLKAVIPGGSSAPVLPAS
IIMECTMDYDSIAKAGSMLGSGAVIVMDDSRNMVESLLRLSYFYAHESCGQCTPCREGTGWMWRVINRIQHEAGRESDLD
LLNSVADNIQGRTICALGDAAAMPVRAMLKHFRPEFEALIRNAHPSGSTPASA

Sequences:

>Translated_453_residues
MTTAAQVLSQFQATGVQTCFHDRHINPQIYAGLNGSNWSLKDYEARGGYQALRKLLGKDGGEGLTQDQVIATMKESGLRG
RGGAGFPTGLKWSFMPRQFPGQKYLVCNSDEGEPGTCKDRDILMYNPHIVIEGMIIAAYAMGISVGYNYIHGEIFQVYER
FEAALEEARAAGYLGDNILGSSFSFQLHAHHGFGAYICGEETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETF
AAVPWIIRNGGQAYLECGKPNNGGTKIFSVSGDVERPGNYEVPLGTPFAKLLELAGGVRKGRQLKAVIPGGSSAPVLPAS
IIMECTMDYDSIAKAGSMLGSGAVIVMDDSRNMVESLLRLSYFYAHESCGQCTPCREGTGWMWRVINRIQHEAGRESDLD
LLNSVADNIQGRTICALGDAAAMPVRAMLKHFRPEFEALIRNAHPSGSTPASA
>Mature_452_residues
TTAAQVLSQFQATGVQTCFHDRHINPQIYAGLNGSNWSLKDYEARGGYQALRKLLGKDGGEGLTQDQVIATMKESGLRGR
GGAGFPTGLKWSFMPRQFPGQKYLVCNSDEGEPGTCKDRDILMYNPHIVIEGMIIAAYAMGISVGYNYIHGEIFQVYERF
EAALEEARAAGYLGDNILGSSFSFQLHAHHGFGAYICGEETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETFA
AVPWIIRNGGQAYLECGKPNNGGTKIFSVSGDVERPGNYEVPLGTPFAKLLELAGGVRKGRQLKAVIPGGSSAPVLPASI
IMECTMDYDSIAKAGSMLGSGAVIVMDDSRNMVESLLRLSYFYAHESCGQCTPCREGTGWMWRVINRIQHEAGRESDLDL
LNSVADNIQGRTICALGDAAAMPVRAMLKHFRPEFEALIRNAHPSGSTPASA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=425, Percent_Identity=47.7647058823529, Blast_Score=397, Evalue=1e-111,
Organism=Homo sapiens, GI260656005, Length=425, Percent_Identity=47.7647058823529, Blast_Score=397, Evalue=1e-110,
Organism=Escherichia coli, GI1788620, Length=405, Percent_Identity=43.2098765432099, Blast_Score=342, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI17531727, Length=448, Percent_Identity=45.7589285714286, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI19920794, Length=414, Percent_Identity=47.1014492753623, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI45550452, Length=419, Percent_Identity=45.1073985680191, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24653819, Length=417, Percent_Identity=35.9712230215827, Blast_Score=254, Evalue=7e-68,
Organism=Drosophila melanogaster, GI24653817, Length=353, Percent_Identity=36.2606232294618, Blast_Score=226, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 49068; Mature: 48937

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAAQVLSQFQATGVQTCFHDRHINPQIYAGLNGSNWSLKDYEARGGYQALRKLLGKDG
CCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCC
GEGLTQDQVIATMKESGLRGRGGAGFPTGLKWSFMPRQFPGQKYLVCNSDEGEPGTCKDR
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCC
DILMYNPHIVIEGMIIAAYAMGISVGYNYIHGEIFQVYERFEAALEEARAAGYLGDNILG
EEEEECCEEEEHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SSFSFQLHAHHGFGAYICGEETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETF
CCEEEEEEEECCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AAVPWIIRNGGQAYLECGKPNNGGTKIFSVSGDVERPGNYEVPLGTPFAKLLELAGGVRK
EECCHHEECCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
GRQLKAVIPGGSSAPVLPASIIMECTMDYDSIAKAGSMLGSGAVIVMDDSRNMVESLLRL
CCEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHH
SYFYAHESCGQCTPCREGTGWMWRVINRIQHEAGRESDLDLLNSVADNIQGRTICALGDA
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCH
AAMPVRAMLKHFRPEFEALIRNAHPSGSTPASA
HHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TTAAQVLSQFQATGVQTCFHDRHINPQIYAGLNGSNWSLKDYEARGGYQALRKLLGKDG
CHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCC
GEGLTQDQVIATMKESGLRGRGGAGFPTGLKWSFMPRQFPGQKYLVCNSDEGEPGTCKDR
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCC
DILMYNPHIVIEGMIIAAYAMGISVGYNYIHGEIFQVYERFEAALEEARAAGYLGDNILG
EEEEECCEEEEHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SSFSFQLHAHHGFGAYICGEETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETF
CCEEEEEEEECCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AAVPWIIRNGGQAYLECGKPNNGGTKIFSVSGDVERPGNYEVPLGTPFAKLLELAGGVRK
EECCHHEECCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
GRQLKAVIPGGSSAPVLPASIIMECTMDYDSIAKAGSMLGSGAVIVMDDSRNMVESLLRL
CCEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHH
SYFYAHESCGQCTPCREGTGWMWRVINRIQHEAGRESDLDLLNSVADNIQGRTICALGDA
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCH
AAMPVRAMLKHFRPEFEALIRNAHPSGSTPASA
HHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]