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The map label for this gene is nuoE [H]

Identifier: 222110090

GI number: 222110090

Start: 899354

End: 899845

Strand: Direct

Name: nuoE [H]

Synonym: Dtpsy_0876

Alternate gene names: 222110090

Gene position: 899354-899845 (Clockwise)

Preceding gene: 222110089

Following gene: 222110091

Centisome position: 23.69

GC content: 60.77

Gene sequence:

>492_bases
ATGATTACCGAAGCGACCAAGCAACGTTTTGCCCGCGAAGTGGCGAAATACCCCGCAGACCAGAAACAGTCGGCGGTGAT
GGCGTGCCTGTCCATCGTCCAGCAGGAACAGGGCTGGGTCAGCGCCGAGAGCGAGGCCGTGATCGCCGAGTACCTGGGCA
TGCCCCAGATCGCCGTGCATGAGGTCACCACGTTCTACAACATGTACAACCAGCAGCCGGTGGGCAAGTACAAGCTGGCC
GTCTGCACCAATTTGCCGTGTCAGCTGCGCCGTGGGCAGGATGCGCTGCACCACCTTGAGAAGAAGCTGGGCATTTCCAT
GGGCGAAACCACCGCCGATGGCCTTTTCACCTTGCAGCAATGCGAATGCCTGGGGGCCTGCGCCGACGCGCCCGTGATGC
TGGTCAATGACCGCAACATGTGCAGTTTCATGGACGACGACAAGCTCGACCAGATGGTGGATGGCCTGCGCGCTGCGGAG
GGCAAACAATGA

Upstream 100 bases:

>100_bases
CGCATCTGGCCACACTCGACGAAATGGCGCGGGGCCACATGCTGGCCGACGCCGTGGCCATCATCGGCACCATGGATATC
GTGTTCGGAGAGATTGACCG

Downstream 100 bases:

>100_bases
CCACGGCTGCACAAGTGCTGTCGCAGTTTCAGGCGACGGGCGTACAGACCTGCTTCCATGACCGCCATATCAATCCGCAG
ATCTATGCGGGCTTGAACGG

Product: NADH-quinone oxidoreductase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MITEATKQRFAREVAKYPADQKQSAVMACLSIVQQEQGWVSAESEAVIAEYLGMPQIAVHEVTTFYNMYNQQPVGKYKLA
VCTNLPCQLRRGQDALHHLEKKLGISMGETTADGLFTLQQCECLGACADAPVMLVNDRNMCSFMDDDKLDQMVDGLRAAE
GKQ

Sequences:

>Translated_163_residues
MITEATKQRFAREVAKYPADQKQSAVMACLSIVQQEQGWVSAESEAVIAEYLGMPQIAVHEVTTFYNMYNQQPVGKYKLA
VCTNLPCQLRRGQDALHHLEKKLGISMGETTADGLFTLQQCECLGACADAPVMLVNDRNMCSFMDDDKLDQMVDGLRAAE
GKQ
>Mature_163_residues
MITEATKQRFAREVAKYPADQKQSAVMACLSIVQQEQGWVSAESEAVIAEYLGMPQIAVHEVTTFYNMYNQQPVGKYKLA
VCTNLPCQLRRGQDALHHLEKKLGISMGETTADGLFTLQQCECLGACADAPVMLVNDRNMCSFMDDDKLDQMVDGLRAAE
GKQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=159, Percent_Identity=41.5094339622642, Blast_Score=140, Evalue=6e-34,
Organism=Escherichia coli, GI1788621, Length=136, Percent_Identity=35.2941176470588, Blast_Score=89, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17561328, Length=158, Percent_Identity=39.873417721519, Blast_Score=133, Evalue=4e-32,
Organism=Drosophila melanogaster, GI18859877, Length=159, Percent_Identity=37.1069182389937, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21355353, Length=156, Percent_Identity=34.6153846153846, Blast_Score=109, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 18084; Mature: 18084

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
9.8 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
9.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITEATKQRFAREVAKYPADQKQSAVMACLSIVQQEQGWVSAESEAVIAEYLGMPQIAVH
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHH
EVTTFYNMYNQQPVGKYKLAVCTNLPCQLRRGQDALHHLEKKLGISMGETTADGLFTLQQ
HHHHHHHHHCCCCCCCEEEEEECCCCHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHH
CECLGACADAPVMLVNDRNMCSFMDDDKLDQMVDGLRAAEGKQ
HHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MITEATKQRFAREVAKYPADQKQSAVMACLSIVQQEQGWVSAESEAVIAEYLGMPQIAVH
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHH
EVTTFYNMYNQQPVGKYKLAVCTNLPCQLRRGQDALHHLEKKLGISMGETTADGLFTLQQ
HHHHHHHHHCCCCCCCEEEEEECCCCHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHH
CECLGACADAPVMLVNDRNMCSFMDDDKLDQMVDGLRAAEGKQ
HHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]