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The map label for this gene is ptxR [H]

Identifier: 222109838

GI number: 222109838

Start: 641348

End: 642250

Strand: Direct

Name: ptxR [H]

Synonym: Dtpsy_0622

Alternate gene names: 222109838

Gene position: 641348-642250 (Clockwise)

Preceding gene: 222109836

Following gene: 222109840

Centisome position: 16.89

GC content: 63.79

Gene sequence:

>903_bases
ATGCCATCCCCCGTGGGCGATCTCAACCTGTTGCGCGCTTTCCTGGCCGTCGCCGATGCGCGCAGCTTCACGGCCGCCGC
CGAACGTCTGCACATTGCGCGTCCGCAGGTGAGTCTTCAGATTCGCCGTCTGGAGAACGTGCTGGGCGCGGCCCTGTTCC
ACCGTACGACGCGCACGGTTACGCTCACCGATGCGGGGCAACGGTTGTTCGAAGAAAGCGCGCCTCTCATGCAGGGGCTT
GAGCAAGTGCTGCAACACGCCGGATCGCGTGGATCGGGTCTGCGTGGCCGCTTGCGTGTCAGTGCGCCTGTTGAATATGC
CGTTCAGGTCATGTCGCCGGTGGTGGCGGAGTTCGCTGTCCGCCATCCCGAGGTCAGTTTGGAACTTGTGGTCAGTGACA
AGGTGCAAGACCTCGTTGGCGAGGGCATCGACGTGAGCATCCGTGTGGGGTGGTTACGCAATTCAAGTGCGCGGGTTGCG
AAACTGGGGGAATTTGGGCAGGCGGTCCTGGCGTCACCCGAGTATCTGGCCCGCTGTCCGCGTCCGGAGGCTCCCGAGGA
CCTGGCGCATCACCGGTGGATCGCGCTGACCTTGCTGCCGGCGCCCCTCACATGGTCATTCACCAACGGGACAAAGGACA
TCACGGTGCGCATGGCGCCCAAGCTGCGCACCGATTCCGCTGTTGCCTTGCGCGCCTTGCTGCTCAATGGCGCAGGCGTT
TCGGTTGGCAGTTTGCTTCACTTGGAGAGTGACATCCGCAGTGGAGCGCTGGTTCGGCTGCTCCCGGAATGGACATTGCC
CAAAGGAGGCGTCTATGCCGTGTATCCGCCCGGCACAGCCATCGCACCTGCGGCGCGCGCCTTCGTCGAGCTTCTGAAGG
GCGAAATGCTCCGGAGGGCTTGA

Upstream 100 bases:

>100_bases
TTGACCCGCGGATTCGGGGTGCGGGGTCAATGATCCTCTTGCCGCATCGTCAGAAAAAGAGGACAAAAAGAACAATACTG
GTATCTAATTCGAACCAATC

Downstream 100 bases:

>100_bases
TGCAGGCCGCAGGCAAGAAGTGGGGGCACTGCGGCAACGCCCGGCAGCGTGGTCTCGGCCACCGGCGAGGAAGCACGGCG
GGTGGCGGTGCGGCCTAGAC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MPSPVGDLNLLRAFLAVADARSFTAAAERLHIARPQVSLQIRRLENVLGAALFHRTTRTVTLTDAGQRLFEESAPLMQGL
EQVLQHAGSRGSGLRGRLRVSAPVEYAVQVMSPVVAEFAVRHPEVSLELVVSDKVQDLVGEGIDVSIRVGWLRNSSARVA
KLGEFGQAVLASPEYLARCPRPEAPEDLAHHRWIALTLLPAPLTWSFTNGTKDITVRMAPKLRTDSAVALRALLLNGAGV
SVGSLLHLESDIRSGALVRLLPEWTLPKGGVYAVYPPGTAIAPAARAFVELLKGEMLRRA

Sequences:

>Translated_300_residues
MPSPVGDLNLLRAFLAVADARSFTAAAERLHIARPQVSLQIRRLENVLGAALFHRTTRTVTLTDAGQRLFEESAPLMQGL
EQVLQHAGSRGSGLRGRLRVSAPVEYAVQVMSPVVAEFAVRHPEVSLELVVSDKVQDLVGEGIDVSIRVGWLRNSSARVA
KLGEFGQAVLASPEYLARCPRPEAPEDLAHHRWIALTLLPAPLTWSFTNGTKDITVRMAPKLRTDSAVALRALLLNGAGV
SVGSLLHLESDIRSGALVRLLPEWTLPKGGVYAVYPPGTAIAPAARAFVELLKGEMLRRA
>Mature_299_residues
PSPVGDLNLLRAFLAVADARSFTAAAERLHIARPQVSLQIRRLENVLGAALFHRTTRTVTLTDAGQRLFEESAPLMQGLE
QVLQHAGSRGSGLRGRLRVSAPVEYAVQVMSPVVAEFAVRHPEVSLELVVSDKVQDLVGEGIDVSIRVGWLRNSSARVAK
LGEFGQAVLASPEYLARCPRPEAPEDLAHHRWIALTLLPAPLTWSFTNGTKDITVRMAPKLRTDSAVALRALLLNGAGVS
VGSLLHLESDIRSGALVRLLPEWTLPKGGVYAVYPPGTAIAPAARAFVELLKGEMLRRA

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786401, Length=284, Percent_Identity=32.3943661971831, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI87081978, Length=287, Percent_Identity=30.6620209059233, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1787589, Length=287, Percent_Identity=28.2229965156794, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787128, Length=286, Percent_Identity=28.6713286713287, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789639, Length=277, Percent_Identity=29.6028880866426, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI145693193, Length=291, Percent_Identity=27.4914089347079, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1789440, Length=285, Percent_Identity=25.6140350877193, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1789173, Length=269, Percent_Identity=30.1115241635688, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1786448, Length=294, Percent_Identity=29.5918367346939, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI157672245, Length=140, Percent_Identity=35, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1788748, Length=136, Percent_Identity=36.0294117647059, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI2367136, Length=121, Percent_Identity=40.495867768595, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790208, Length=127, Percent_Identity=34.6456692913386, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI145693105, Length=154, Percent_Identity=29.8701298701299, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1788706, Length=300, Percent_Identity=26.3333333333333, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788887, Length=124, Percent_Identity=35.4838709677419, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788297, Length=260, Percent_Identity=29.2307692307692, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787879, Length=157, Percent_Identity=32.484076433121, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787601, Length=123, Percent_Identity=28.4552845528455, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786713, Length=147, Percent_Identity=31.9727891156463, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789204, Length=259, Percent_Identity=25.8687258687259, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32428; Mature: 32297

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSPVGDLNLLRAFLAVADARSFTAAAERLHIARPQVSLQIRRLENVLGAALFHRTTRTV
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEE
TLTDAGQRLFEESAPLMQGLEQVLQHAGSRGSGLRGRLRVSAPVEYAVQVMSPVVAEFAV
EEEHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHH
RHPEVSLELVVSDKVQDLVGEGIDVSIRVGWLRNSSARVAKLGEFGQAVLASPEYLARCP
CCCCCEEEEEECHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHCC
RPEAPEDLAHHRWIALTLLPAPLTWSFTNGTKDITVRMAPKLRTDSAVALRALLLNGAGV
CCCCCHHHHHCCEEEEEEECCCEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCC
SVGSLLHLESDIRSGALVRLLPEWTLPKGGVYAVYPPGTAIAPAARAFVELLKGEMLRRA
CHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PSPVGDLNLLRAFLAVADARSFTAAAERLHIARPQVSLQIRRLENVLGAALFHRTTRTV
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEE
TLTDAGQRLFEESAPLMQGLEQVLQHAGSRGSGLRGRLRVSAPVEYAVQVMSPVVAEFAV
EEEHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHH
RHPEVSLELVVSDKVQDLVGEGIDVSIRVGWLRNSSARVAKLGEFGQAVLASPEYLARCP
CCCCCEEEEEECHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHCC
RPEAPEDLAHHRWIALTLLPAPLTWSFTNGTKDITVRMAPKLRTDSAVALRALLLNGAGV
CCCCCHHHHHCCEEEEEEECCCEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCC
SVGSLLHLESDIRSGALVRLLPEWTLPKGGVYAVYPPGTAIAPAARAFVELLKGEMLRRA
CHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]