Click here to switch to the map view.

The map label for this gene is glmS [H]

Identifier: 222109836

GI number: 222109836

Start: 638521

End: 640431

Strand: Direct

Name: glmS [H]

Synonym: Dtpsy_0620

Alternate gene names: 222109836

Gene position: 638521-640431 (Clockwise)

Preceding gene: 222109832

Following gene: 222109838

Centisome position: 16.82

GC content: 68.03

Gene sequence:

>1911_bases
ATGTGCGGCATCGTCGGCGCGGTATCCACCCGCAATATCGTTCCCATCCTGGTGCAAGGCCTGCAGCGGCTGGAGTACCG
CGGCTATGACTCCTGCGGCGTCGCCGTGCACGAGGCGAGCCTGGGCGAAATGCCCGCGGGTGGCCTGCACCGTGCGCGCA
GCACTGCCCGCGTGGCCGAATTGCTGGCGCAGGTGAACCATGAACACCTCCAAGGCGCCACGGGCATCGCCCACACCCGC
TGGGCCACGCACGGCGCCCCCGCCGTGCACAACGCCCATCCCCACTTCAGCCATGGACCCGGTGCCGCGCCGGCGCAGGC
AGAGCGCCCCGGCCGCGTCGCGCTGGTGCACAACGGCATCATCGAGAACCACGAGGAGTTGCGCGCCGAGTTGCAGGCGC
GCGGCTACGTGTTCTCCAGCCAGACCGATACCGAAGTCATCGCGCATCTGGTGGACAGCCTGTACGACGGCGACCTGTTC
CAGGCCGTGCGCGCCGCGACTGCGCGGCTGCACGGCGCATTCGCCATCGCCGTGATCCACAAGGACGAGCCGCACCGCGT
GGTGGGCGCGCGCGCGGGCTCGCCCCTGGTGCTGGGTGTCGGTGAGGGTGAGCACTTCCTGGCCAGCGATGCCATGGCCC
TGGCTGGTGTGACCGACCAGATCGTGTACCTGGAAGAGGGCGACCTGGTGGACCTGCAACTGGGCCGTTACTGGATCACC
ACGGCCGACGGCCAGCCGCTGGACGCCGGCAGCCGCCCCGTGCGCACCGTGCACGCACACAGTGGTGCGGTGGAGCTGGG
GCCCTATCGCCACTACATGCAAAAGGAAATTTTCGAGCAGCCGCGCGCCATTGCCGACACGTTGCACGGCCTGCAGGGCA
TCGTGCCCGAGCTGTTCGACGGCGTGGGCCAGCCCGGGCAGCAGGGCGCGGCAGCCTGGCGTGTGTTCAAGGAGATCGAC
TCCGTGCTCATCCTCGCCTGCGGGACCAGCTACTACAGCGGCTGCACCGCCAAGTACTGGCTGGAGGGCATCGCGGGCAT
TCCCACCCAGGTGGAAGTGGCCAGCGAATACCGCTACCGCACCAGCGTGCCCAACCCGCGCACGCTGGTGGTGACCATCA
GCCAATCCGGCGAAACCGCCGACACCCTGGCCGCACTGCGCCATGCGCAGAGCCTGGGCATGCGCCACACGCTCACCATC
TGCAACGTGGCCACCAGCGCCATGGTGCGCGAGTGCGAGCTGGCCTATGTCACCCGCGCCGGCGTGGAGATTGGCGTGGC
GTCGACCAAAGCCTTCACCGCGCAGCTGGCGGGACTGTTCCTGTTGACCCTGGCGCTGGCGCAGTCGCGCGGGCGCCTGA
CCGAGGAGGCCGAGGGCAACTACCTGAAAGCCATGCGCCATCTGCCCGCCGCACTGCAGGCCGTGCTGGCGCTGGAGCCG
CAGATCATCAGCTGGTCCGAGGACTTCGCGAAGAAGGAGAACGCCCTGTTCCTGGGCCGCGGACTGCACTACCCCATTGC
ACTGGAGGGTGCCCTCAAGCTCAAGGAGATCAGCTACATCCACGCCGAGGCGTACCCCGCGGGTGAACTCAAGCACGGCC
CGCTGGCTCTCGTCACCAGCAGCATGCCGGTGGTGACCGTGGCGCCCAACGACGCGTTGCTGGAGAAGCTCAAGAGCAAC
ATGGAAGAAGTGCGCGCCCGTGGCGGCGTGCTCTACGTGTTGGCCGATGCCGATACCCATATCGACAGCAGCGAAGGTCT
GCACGTCATCCGCATGCCAGAGCACTACGGCGCCCTGTCGCCGCTGCTGCACGTGGTGCCGCTGCAACTGCTGGCCTACC
ACACGGCCTGCGCGCGCGGAACGGATGTGGACAAGCCCCGTAACCTGGCCAAGAGCGTCACGGTGGAGTAA

Upstream 100 bases:

>100_bases
TGACGGAAGAAATTTTTGTTCATATGTCATGAAAATCAGATCAAAAATTTCTGGAGAGGCCGCCTAGCATCTCGCCCATT
CTTTCATCGGAGCAGTATTT

Downstream 100 bases:

>100_bases
GGCCAGGCACGCTGGCGGCGCGGTTAACGCCGCCCGGTTGCGGTATTCCAACGATGCCTATCGCAGGCATCGGTGATTCA
CTGGTGCAGCGAAAGCCGTG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 636; Mature: 636

Protein sequence:

>636_residues
MCGIVGAVSTRNIVPILVQGLQRLEYRGYDSCGVAVHEASLGEMPAGGLHRARSTARVAELLAQVNHEHLQGATGIAHTR
WATHGAPAVHNAHPHFSHGPGAAPAQAERPGRVALVHNGIIENHEELRAELQARGYVFSSQTDTEVIAHLVDSLYDGDLF
QAVRAATARLHGAFAIAVIHKDEPHRVVGARAGSPLVLGVGEGEHFLASDAMALAGVTDQIVYLEEGDLVDLQLGRYWIT
TADGQPLDAGSRPVRTVHAHSGAVELGPYRHYMQKEIFEQPRAIADTLHGLQGIVPELFDGVGQPGQQGAAAWRVFKEID
SVLILACGTSYYSGCTAKYWLEGIAGIPTQVEVASEYRYRTSVPNPRTLVVTISQSGETADTLAALRHAQSLGMRHTLTI
CNVATSAMVRECELAYVTRAGVEIGVASTKAFTAQLAGLFLLTLALAQSRGRLTEEAEGNYLKAMRHLPAALQAVLALEP
QIISWSEDFAKKENALFLGRGLHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTSSMPVVTVAPNDALLEKLKSN
MEEVRARGGVLYVLADADTHIDSSEGLHVIRMPEHYGALSPLLHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE

Sequences:

>Translated_636_residues
MCGIVGAVSTRNIVPILVQGLQRLEYRGYDSCGVAVHEASLGEMPAGGLHRARSTARVAELLAQVNHEHLQGATGIAHTR
WATHGAPAVHNAHPHFSHGPGAAPAQAERPGRVALVHNGIIENHEELRAELQARGYVFSSQTDTEVIAHLVDSLYDGDLF
QAVRAATARLHGAFAIAVIHKDEPHRVVGARAGSPLVLGVGEGEHFLASDAMALAGVTDQIVYLEEGDLVDLQLGRYWIT
TADGQPLDAGSRPVRTVHAHSGAVELGPYRHYMQKEIFEQPRAIADTLHGLQGIVPELFDGVGQPGQQGAAAWRVFKEID
SVLILACGTSYYSGCTAKYWLEGIAGIPTQVEVASEYRYRTSVPNPRTLVVTISQSGETADTLAALRHAQSLGMRHTLTI
CNVATSAMVRECELAYVTRAGVEIGVASTKAFTAQLAGLFLLTLALAQSRGRLTEEAEGNYLKAMRHLPAALQAVLALEP
QIISWSEDFAKKENALFLGRGLHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTSSMPVVTVAPNDALLEKLKSN
MEEVRARGGVLYVLADADTHIDSSEGLHVIRMPEHYGALSPLLHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE
>Mature_636_residues
MCGIVGAVSTRNIVPILVQGLQRLEYRGYDSCGVAVHEASLGEMPAGGLHRARSTARVAELLAQVNHEHLQGATGIAHTR
WATHGAPAVHNAHPHFSHGPGAAPAQAERPGRVALVHNGIIENHEELRAELQARGYVFSSQTDTEVIAHLVDSLYDGDLF
QAVRAATARLHGAFAIAVIHKDEPHRVVGARAGSPLVLGVGEGEHFLASDAMALAGVTDQIVYLEEGDLVDLQLGRYWIT
TADGQPLDAGSRPVRTVHAHSGAVELGPYRHYMQKEIFEQPRAIADTLHGLQGIVPELFDGVGQPGQQGAAAWRVFKEID
SVLILACGTSYYSGCTAKYWLEGIAGIPTQVEVASEYRYRTSVPNPRTLVVTISQSGETADTLAALRHAQSLGMRHTLTI
CNVATSAMVRECELAYVTRAGVEIGVASTKAFTAQLAGLFLLTLALAQSRGRLTEEAEGNYLKAMRHLPAALQAVLALEP
QIISWSEDFAKKENALFLGRGLHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTSSMPVVTVAPNDALLEKLKSN
MEEVRARGGVLYVLADADTHIDSSEGLHVIRMPEHYGALSPLLHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=702, Percent_Identity=34.045584045584, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI205277386, Length=698, Percent_Identity=33.810888252149, Blast_Score=376, Evalue=1e-104,
Organism=Escherichia coli, GI1790167, Length=639, Percent_Identity=51.3302034428795, Blast_Score=610, Evalue=1e-176,
Organism=Escherichia coli, GI1788651, Length=234, Percent_Identity=26.4957264957265, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17539970, Length=730, Percent_Identity=34.5205479452055, Blast_Score=370, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17532899, Length=727, Percent_Identity=32.3246217331499, Blast_Score=321, Evalue=6e-88,
Organism=Caenorhabditis elegans, GI17532897, Length=439, Percent_Identity=36.9020501138952, Blast_Score=271, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6322745, Length=441, Percent_Identity=35.6009070294785, Blast_Score=258, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6323731, Length=436, Percent_Identity=28.8990825688073, Blast_Score=189, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6323730, Length=220, Percent_Identity=34.5454545454545, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21357745, Length=702, Percent_Identity=34.3304843304843, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI28573187, Length=214, Percent_Identity=27.5700934579439, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24659598, Length=295, Percent_Identity=26.1016949152542, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24659604, Length=275, Percent_Identity=26.5454545454545, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 68317; Mature: 68317

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVSTRNIVPILVQGLQRLEYRGYDSCGVAVHEASLGEMPAGGLHRARSTARVAE
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
LLAQVNHEHLQGATGIAHTRWATHGAPAVHNAHPHFSHGPGAAPAQAERPGRVALVHNGI
HHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
IENHEELRAELQARGYVFSSQTDTEVIAHLVDSLYDGDLFQAVRAATARLHGAFAIAVIH
CCCHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEEEE
KDEPHRVVGARAGSPLVLGVGEGEHFLASDAMALAGVTDQIVYLEEGDLVDLQLGRYWIT
CCCCCEEEECCCCCCEEEEECCCCCCHHHCHHHHCCCCCEEEEEECCCEEEEEECCEEEE
TADGQPLDAGSRPVRTVHAHSGAVELGPYRHYMQKEIFEQPRAIADTLHGLQGIVPELFD
ECCCCCCCCCCCCCEEEECCCCCEECCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
GVGQPGQQGAAAWRVFKEIDSVLILACGTSYYSGCTAKYWLEGIAGIPTQVEVASEYRYR
CCCCCCCCHHHHHHHHHHHHHEEEEEECCHHHCCCCHHHHHHHHCCCCCEEEHHHHHHHC
TSVPNPRTLVVTISQSGETADTLAALRHAQSLGMRHTLTICNVATSAMVRECELAYVTRA
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECC
GVEIGVASTKAFTAQLAGLFLLTLALAQSRGRLTEEAEGNYLKAMRHLPAALQAVLALEP
CCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
QIISWSEDFAKKENALFLGRGLHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTS
CEECCCHHHHCCCCCEEEECCCCCCEEECCCEEEHHHHEEEECCCCCCCCCCCCEEEEEC
SMPVVTVAPNDALLEKLKSNMEEVRARGGVLYVLADADTHIDSSEGLHVIRMPEHYGALS
CCCEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEECCHHHCHHH
PLLHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGAVSTRNIVPILVQGLQRLEYRGYDSCGVAVHEASLGEMPAGGLHRARSTARVAE
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
LLAQVNHEHLQGATGIAHTRWATHGAPAVHNAHPHFSHGPGAAPAQAERPGRVALVHNGI
HHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
IENHEELRAELQARGYVFSSQTDTEVIAHLVDSLYDGDLFQAVRAATARLHGAFAIAVIH
CCCHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEEEE
KDEPHRVVGARAGSPLVLGVGEGEHFLASDAMALAGVTDQIVYLEEGDLVDLQLGRYWIT
CCCCCEEEECCCCCCEEEEECCCCCCHHHCHHHHCCCCCEEEEEECCCEEEEEECCEEEE
TADGQPLDAGSRPVRTVHAHSGAVELGPYRHYMQKEIFEQPRAIADTLHGLQGIVPELFD
ECCCCCCCCCCCCCEEEECCCCCEECCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
GVGQPGQQGAAAWRVFKEIDSVLILACGTSYYSGCTAKYWLEGIAGIPTQVEVASEYRYR
CCCCCCCCHHHHHHHHHHHHHEEEEEECCHHHCCCCHHHHHHHHCCCCCEEEHHHHHHHC
TSVPNPRTLVVTISQSGETADTLAALRHAQSLGMRHTLTICNVATSAMVRECELAYVTRA
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECC
GVEIGVASTKAFTAQLAGLFLLTLALAQSRGRLTEEAEGNYLKAMRHLPAALQAVLALEP
CCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
QIISWSEDFAKKENALFLGRGLHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTS
CEECCCHHHHCCCCCEEEECCCCCCEEECCCEEEHHHHEEEECCCCCCCCCCCCEEEEEC
SMPVVTVAPNDALLEKLKSNMEEVRARGGVLYVLADADTHIDSSEGLHVIRMPEHYGALS
CCCEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEECCHHHCHHH
PLLHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]