Click here to switch to the map view.

The map label for this gene is paaF [H]

Identifier: 222109793

GI number: 222109793

Start: 598133

End: 598909

Strand: Direct

Name: paaF [H]

Synonym: Dtpsy_0577

Alternate gene names: 222109793

Gene position: 598133-598909 (Clockwise)

Preceding gene: 222109792

Following gene: 222109794

Centisome position: 15.75

GC content: 67.95

Gene sequence:

>777_bases
ATGAGTACAACGAACGCAGACATCCTGGTCCACGCCGAAGAGGGCGTGACCACCATCACCTTCAACCGCGTGGAGAAGAA
AAATTCCATCACCACGGCCATGTACGCGCAGCTGGCCGATGCGTTCGAGGCCGCGGCGCAGGACGCTTCGGTGCGTGTGG
TCGTGCTGCAGGGCGACGTGGCCATCTTCAGTGCGGGCAACGACATCGGCGACTTTTTGCAGCAGCCGCCCGCCACGCAG
GACGCGCCCGTGTTCCGCTTCCTGCGCGCCATCGCCACCTTTCCCAAGCCCGTGCTGGCTGCGGTGTGCGGCCCGGCAGT
GGGCATCGGCACGACCCTGCTGTTCCACTGCGACCTGGTGTACGCGGGGGACAATGCGGCGTTCTCGATGCCCTTCGTGA
ACCTGGGGCTGTGCCCCGAGGCCGCCTCCAGCCTGTTCGCGCCGCAGATGCTGGGCTACCACCGCGCGGCCGAGGCGCTG
CTGCTGGGCGAGCCCTTCATGGCCGAAGCGGCGTTGGAAGTCGGCTTCGTCAACCGCGTGGTGCCGCCGACCGAATGCAA
CATGGTGGCCCAGGCCCAGGCGCGCAAGCTCGCGGCCAAGCCGCTGTCGGCCCTGATCGAGACCAAGCGCCTGCTCAAGA
AGAGCCAGACCGCCGCCGTGCTGGAGCGCATGGCCGAGGAGGGCCAGAGCTTTGGCCGCATGCTGCGCGAGCCCGCCGCC
CGCGAGGCCTTCACCGCGTTCATGGACAAACGCCGCCCGGATTTCAGCGCCTGCTGA

Upstream 100 bases:

>100_bases
TTTTTCGACCAGACCGTGCAGCTGTGGAATGAGGCCGGCGCCATGCTGGCCACCAGCCACCAGATCGTTTATTACAAGGA
ATGACCCCGGAGCAACACCC

Downstream 100 bases:

>100_bases
CATCCGCCCCGCCACCGAACAGGGCGGGGCAGGGCGACGCCGGCATCCATGCCGTGTTCGCCCTACGCGCCGGTGATCAC
CGTGTCTGCTGGACCGGGTG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MSTTNADILVHAEEGVTTITFNRVEKKNSITTAMYAQLADAFEAAAQDASVRVVVLQGDVAIFSAGNDIGDFLQQPPATQ
DAPVFRFLRAIATFPKPVLAAVCGPAVGIGTTLLFHCDLVYAGDNAAFSMPFVNLGLCPEAASSLFAPQMLGYHRAAEAL
LLGEPFMAEAALEVGFVNRVVPPTECNMVAQAQARKLAAKPLSALIETKRLLKKSQTAAVLERMAEEGQSFGRMLREPAA
REAFTAFMDKRRPDFSAC

Sequences:

>Translated_258_residues
MSTTNADILVHAEEGVTTITFNRVEKKNSITTAMYAQLADAFEAAAQDASVRVVVLQGDVAIFSAGNDIGDFLQQPPATQ
DAPVFRFLRAIATFPKPVLAAVCGPAVGIGTTLLFHCDLVYAGDNAAFSMPFVNLGLCPEAASSLFAPQMLGYHRAAEAL
LLGEPFMAEAALEVGFVNRVVPPTECNMVAQAQARKLAAKPLSALIETKRLLKKSQTAAVLERMAEEGQSFGRMLREPAA
REAFTAFMDKRRPDFSAC
>Mature_257_residues
STTNADILVHAEEGVTTITFNRVEKKNSITTAMYAQLADAFEAAAQDASVRVVVLQGDVAIFSAGNDIGDFLQQPPATQD
APVFRFLRAIATFPKPVLAAVCGPAVGIGTTLLFHCDLVYAGDNAAFSMPFVNLGLCPEAASSLFAPQMLGYHRAAEALL
LGEPFMAEAALEVGFVNRVVPPTECNMVAQAQARKLAAKPLSALIETKRLLKKSQTAAVLERMAEEGQSFGRMLREPAAR
EAFTAFMDKRRPDFSAC

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI45643119, Length=244, Percent_Identity=36.4754098360656, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI260275230, Length=244, Percent_Identity=36.4754098360656, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI260274832, Length=244, Percent_Identity=36.4754098360656, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI4757966, Length=254, Percent_Identity=27.9527559055118, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI51538581, Length=254, Percent_Identity=27.9527559055118, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI25453481, Length=252, Percent_Identity=27.7777777777778, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI51538573, Length=252, Percent_Identity=27.7777777777778, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI4757968, Length=251, Percent_Identity=27.8884462151394, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI49355787, Length=251, Percent_Identity=27.8884462151394, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI116235487, Length=229, Percent_Identity=30.5676855895196, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI31542718, Length=252, Percent_Identity=27.7777777777778, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI221136756, Length=248, Percent_Identity=27.4193548387097, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI221136753, Length=248, Percent_Identity=27.4193548387097, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI221307494, Length=248, Percent_Identity=27.4193548387097, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI194097323, Length=262, Percent_Identity=27.4809160305344, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI70995211, Length=229, Percent_Identity=29.6943231441048, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI68989263, Length=187, Percent_Identity=29.9465240641711, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI1787659, Length=251, Percent_Identity=32.6693227091633, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1787660, Length=260, Percent_Identity=36.1538461538462, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1788597, Length=254, Percent_Identity=29.9212598425197, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI87082183, Length=248, Percent_Identity=28.2258064516129, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI221142681, Length=250, Percent_Identity=30, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790281, Length=175, Percent_Identity=29.1428571428571, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17535521, Length=257, Percent_Identity=32.6848249027237, Blast_Score=120, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17554946, Length=249, Percent_Identity=29.718875502008, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI25145438, Length=247, Percent_Identity=29.9595141700405, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17549921, Length=181, Percent_Identity=34.8066298342541, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17560910, Length=182, Percent_Identity=29.6703296703297, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17540714, Length=177, Percent_Identity=28.8135593220339, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=184, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17540306, Length=250, Percent_Identity=25.6, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323314, Length=213, Percent_Identity=24.8826291079812, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24654903, Length=255, Percent_Identity=30.5882352941176, Blast_Score=130, Evalue=7e-31,
Organism=Drosophila melanogaster, GI20129971, Length=244, Percent_Identity=26.6393442622951, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24653477, Length=244, Percent_Identity=26.6393442622951, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24653139, Length=257, Percent_Identity=28.7937743190661, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI19922422, Length=253, Percent_Identity=26.8774703557312, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI21357171, Length=215, Percent_Identity=29.3023255813954, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24667722, Length=242, Percent_Identity=26.0330578512397, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19920382, Length=227, Percent_Identity=26.431718061674, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27644; Mature: 27513

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTNADILVHAEEGVTTITFNRVEKKNSITTAMYAQLADAFEAAAQDASVRVVVLQGDV
CCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCE
AIFSAGNDIGDFLQQPPATQDAPVFRFLRAIATFPKPVLAAVCGPAVGIGTTLLFHCDLV
EEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHEEEE
YAGDNAAFSMPFVNLGLCPEAASSLFAPQMLGYHRAAEALLLGEPFMAEAALEVGFVNRV
EECCCCEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
VPPTECNMVAQAQARKLAAKPLSALIETKRLLKKSQTAAVLERMAEEGQSFGRMLREPAA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
REAFTAFMDKRRPDFSAC
HHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STTNADILVHAEEGVTTITFNRVEKKNSITTAMYAQLADAFEAAAQDASVRVVVLQGDV
CCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCE
AIFSAGNDIGDFLQQPPATQDAPVFRFLRAIATFPKPVLAAVCGPAVGIGTTLLFHCDLV
EEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHEEEE
YAGDNAAFSMPFVNLGLCPEAASSLFAPQMLGYHRAAEALLLGEPFMAEAALEVGFVNRV
EECCCCEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
VPPTECNMVAQAQARKLAAKPLSALIETKRLLKKSQTAAVLERMAEEGQSFGRMLREPAA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
REAFTAFMDKRRPDFSAC
HHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]