Click here to switch to the map view.

The map label for this gene is atpA [H]

Identifier: 222109521

GI number: 222109521

Start: 308717

End: 310276

Strand: Direct

Name: atpA [H]

Synonym: Dtpsy_0301

Alternate gene names: 222109521

Gene position: 308717-310276 (Clockwise)

Preceding gene: 222109520

Following gene: 222109522

Centisome position: 8.13

GC content: 63.91

Gene sequence:

>1560_bases
ATGCAACTCAATCCCGCAGAAATTTCTGAACTGATCAAGAGCCGCATCGAAGGTCTGGCAGCCAGCAGCGACATCCGCAA
CCAGGGCACCGTGGTGTCCGTGACCGACGGTATCGTGCGCGTCCACGGCCTGTCGGACGTGATGCAGGGCGAAATGCTCG
AATTCCCTGCCGCGGCAGACGGTCAGCCCTCCTTCGGCCTGGCCCTGAACCTCGAGCGCGACTCCGTCGGCGCCGTGATT
CTGGGCGAGTACGAACACATTTCTGAAGGCGACACCGTGAAGTGCACGGGCCGCATTCTGGAAGTGCCGGTGGGCCCGGA
ACTGATCGGCCGCGTGGTGAACGCTCTCGGCCAGCCGATCGACGGCAAGGGTCCGATCAACGCCAAGATGACGGACGTGA
TCGAGAAGGTCGCTCCCGGCGTGATCGCGCGCCAGTCCGTGGACCAGCCGCTGCAAACCGGCCTGAAGTCCATCGACTCC
ATGGTGCCAATCGGCCGTGGCCAGCGTGAGCTGATCATCGGCGACCGCCAGACTGGCAAGACGGCAGTGGCCATCGACGC
CATCATCAACCAGAAGGGCCAGGGCGTGACGTGTATCTACGTCGCCATCGGCCAGAAGGCATCGTCGATCAAGAACGTGG
TGCGCGCCCTGGAACAAGCCGGCGCAATGGAATACACCATCGTCGTGGCGGCTTCGGCTTCCGAGTCCGCCGCCATGCAG
TACGTGTCGGCCTACTCCGGCTGCACGATGGGCGAGTACTTCCGCGACCGTGGCGAAGACGCGCTGATCGTGTACGACGA
CCTGTCCAAGCAAGCTGTGGCCTACCGCCAGGTTTCGCTGCTGTTGCGCCGCCCGCCAGGCCGCGAAGCCTTCCCCGGCG
ACGTGTTCTATCTCCACAGCCGCCTGCTGGAGCGTGCAGCCCGTGTGAATGCCGACTATGTGGAAGCCTTCACCAAGGGC
GAGGTCAAGGGCAAGACGGGTTCGCTGACCGCACTGCCCGTGATCGAAACGCAGGCCGGCGACGTGTCTGCCTTCGTTCC
AACCAACGTGATCTCGATCACCGACGGCCAGATCTTCCTGGAAACCAGCCTGTTCAACGCTGGTATCCGCCCCGCCATCA
ACGCCGGTATCTCGGTGTCGCGCGTGGGTGGTGCCGCCCAGACCAAGCTGATCAAGGGCCTGTCCGGCGGTATCCGTACC
GACCTGGCCCAGTACCGTGAACTCGCGGCGTTCGCGCAGTTCGCCTCCGACCTGGACGAAGCCACGCGCAAGCAGCTGGA
TCGCGGCGCTCGCGTGACGGAACTGCTCAAGCAGCCCCAGTACAGCCCGCTGAGCACGGCCCTGATGGGCGCGACGCTCT
TCACGGTGAACAAGGGCTTCCTGGACGACGTGGACGTGAAGAAGGTGCTGGCCTTCGAAGCCGGCCTGCACCAGTACCTG
AAGACGAGCCACGGTGCGCTGCTGGACCGCCTGCAGCAGAACCGCGCGTTCGACAAGGAAGGCAAGGACGAGGCCGAACT
GACGCAAGCCATCACGGCGTTCAAGAAGTCGTTCGTTTAA

Upstream 100 bases:

>100_bases
CGACACTTCCGTCAAAGCCCGTCTGGAACAAATGAAAGCTGCCCTCACCGCCTGATGGGCATGAGGTCTCGGCTATACCC
CAAGAAAGAAGGAAAGAGTC

Downstream 100 bases:

>100_bases
ATCGGACGAGGAACCATCATGGCAGCAGGTAAGGAAATACGCGGCAAGATCAAATCGGTGGAAAACACCAAGAAGATCAC
CAAGGCCATGGAAATGGTGG

Product: f0f1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha [H]

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MQLNPAEISELIKSRIEGLAASSDIRNQGTVVSVTDGIVRVHGLSDVMQGEMLEFPAAADGQPSFGLALNLERDSVGAVI
LGEYEHISEGDTVKCTGRILEVPVGPELIGRVVNALGQPIDGKGPINAKMTDVIEKVAPGVIARQSVDQPLQTGLKSIDS
MVPIGRGQRELIIGDRQTGKTAVAIDAIINQKGQGVTCIYVAIGQKASSIKNVVRALEQAGAMEYTIVVAASASESAAMQ
YVSAYSGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQVSLLLRRPPGREAFPGDVFYLHSRLLERAARVNADYVEAFTKG
EVKGKTGSLTALPVIETQAGDVSAFVPTNVISITDGQIFLETSLFNAGIRPAINAGISVSRVGGAAQTKLIKGLSGGIRT
DLAQYRELAAFAQFASDLDEATRKQLDRGARVTELLKQPQYSPLSTALMGATLFTVNKGFLDDVDVKKVLAFEAGLHQYL
KTSHGALLDRLQQNRAFDKEGKDEAELTQAITAFKKSFV

Sequences:

>Translated_519_residues
MQLNPAEISELIKSRIEGLAASSDIRNQGTVVSVTDGIVRVHGLSDVMQGEMLEFPAAADGQPSFGLALNLERDSVGAVI
LGEYEHISEGDTVKCTGRILEVPVGPELIGRVVNALGQPIDGKGPINAKMTDVIEKVAPGVIARQSVDQPLQTGLKSIDS
MVPIGRGQRELIIGDRQTGKTAVAIDAIINQKGQGVTCIYVAIGQKASSIKNVVRALEQAGAMEYTIVVAASASESAAMQ
YVSAYSGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQVSLLLRRPPGREAFPGDVFYLHSRLLERAARVNADYVEAFTKG
EVKGKTGSLTALPVIETQAGDVSAFVPTNVISITDGQIFLETSLFNAGIRPAINAGISVSRVGGAAQTKLIKGLSGGIRT
DLAQYRELAAFAQFASDLDEATRKQLDRGARVTELLKQPQYSPLSTALMGATLFTVNKGFLDDVDVKKVLAFEAGLHQYL
KTSHGALLDRLQQNRAFDKEGKDEAELTQAITAFKKSFV
>Mature_519_residues
MQLNPAEISELIKSRIEGLAASSDIRNQGTVVSVTDGIVRVHGLSDVMQGEMLEFPAAADGQPSFGLALNLERDSVGAVI
LGEYEHISEGDTVKCTGRILEVPVGPELIGRVVNALGQPIDGKGPINAKMTDVIEKVAPGVIARQSVDQPLQTGLKSIDS
MVPIGRGQRELIIGDRQTGKTAVAIDAIINQKGQGVTCIYVAIGQKASSIKNVVRALEQAGAMEYTIVVAASASESAAMQ
YVSAYSGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQVSLLLRRPPGREAFPGDVFYLHSRLLERAARVNADYVEAFTKG
EVKGKTGSLTALPVIETQAGDVSAFVPTNVISITDGQIFLETSLFNAGIRPAINAGISVSRVGGAAQTKLIKGLSGGIRT
DLAQYRELAAFAQFASDLDEATRKQLDRGARVTELLKQPQYSPLSTALMGATLFTVNKGFLDDVDVKKVLAFEAGLHQYL
KTSHGALLDRLQQNRAFDKEGKDEAELTQAITAFKKSFV

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=521, Percent_Identity=56.6218809980806, Blast_Score=571, Evalue=1e-163,
Organism=Homo sapiens, GI4757810, Length=521, Percent_Identity=56.6218809980806, Blast_Score=571, Evalue=1e-163,
Organism=Homo sapiens, GI32189394, Length=410, Percent_Identity=25.1219512195122, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI19913428, Length=312, Percent_Identity=26.9230769230769, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI19913426, Length=318, Percent_Identity=27.3584905660377, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI19913424, Length=262, Percent_Identity=27.0992366412214, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1790172, Length=517, Percent_Identity=69.6324951644101, Blast_Score=739, Evalue=0.0,
Organism=Escherichia coli, GI1790170, Length=377, Percent_Identity=25.1989389920424, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788251, Length=291, Percent_Identity=27.4914089347079, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71988063, Length=521, Percent_Identity=54.3186180422265, Blast_Score=552, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI71988080, Length=521, Percent_Identity=54.3186180422265, Blast_Score=552, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI71988074, Length=521, Percent_Identity=50.4798464491363, Blast_Score=501, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17510931, Length=378, Percent_Identity=25.6613756613757, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17570191, Length=340, Percent_Identity=26.1764705882353, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25144756, Length=368, Percent_Identity=24.7282608695652, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17565854, Length=254, Percent_Identity=27.9527559055118, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=56, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=522, Percent_Identity=53.448275862069, Blast_Score=551, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6322581, Length=430, Percent_Identity=25.5813953488372, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6319603, Length=309, Percent_Identity=27.5080906148867, Blast_Score=113, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6320016, Length=164, Percent_Identity=31.0975609756098, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24658560, Length=521, Percent_Identity=56.4299424184261, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI281361666, Length=305, Percent_Identity=27.2131147540984, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24646341, Length=305, Percent_Identity=27.2131147540984, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI17136796, Length=305, Percent_Identity=27.2131147540984, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24638766, Length=387, Percent_Identity=24.2894056847545, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28574560, Length=323, Percent_Identity=25.6965944272446, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24583988, Length=255, Percent_Identity=27.843137254902, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583986, Length=255, Percent_Identity=27.843137254902, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583984, Length=255, Percent_Identity=27.843137254902, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583992, Length=326, Percent_Identity=26.3803680981595, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20129479, Length=245, Percent_Identity=27.7551020408163, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 55532; Mature: 55532

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLNPAEISELIKSRIEGLAASSDIRNQGTVVSVTDGIVRVHGLSDVMQGEMLEFPAAAD
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECCHHHHHCCHHHCCCCCCC
GQPSFGLALNLERDSVGAVILGEYEHISEGDTVKCTGRILEVPVGPELIGRVVNALGQPI
CCCCCCEEEEECCCCCCEEEEECCHHCCCCCEEEEECEEEECCCCHHHHHHHHHHHCCCC
DGKGPINAKMTDVIEKVAPGVIARQSVDQPLQTGLKSIDSMVPIGRGQRELIIGDRQTGK
CCCCCCCCHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
TAVAIDAIINQKGQGVTCIYVAIGQKASSIKNVVRALEQAGAMEYTIVVAASASESAAMQ
CEEEHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHH
YVSAYSGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQVSLLLRRPPGREAFPGDVFYLHS
HHHHHCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
RLLERAARVNADYVEAFTKGEVKGKTGSLTALPVIETQAGDVSAFVPTNVISITDGQIFL
HHHHHHHHCCHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEE
ETSLFNAGIRPAINAGISVSRVGGAAQTKLIKGLSGGIRTDLAQYRELAAFAQFASDLDE
EEHHHCCCCCHHHHCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ATRKQLDRGARVTELLKQPQYSPLSTALMGATLFTVNKGFLDDVDVKKVLAFEAGLHQYL
HHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHH
KTSHGALLDRLQQNRAFDKEGKDEAELTQAITAFKKSFV
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQLNPAEISELIKSRIEGLAASSDIRNQGTVVSVTDGIVRVHGLSDVMQGEMLEFPAAAD
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECCHHHHHCCHHHCCCCCCC
GQPSFGLALNLERDSVGAVILGEYEHISEGDTVKCTGRILEVPVGPELIGRVVNALGQPI
CCCCCCEEEEECCCCCCEEEEECCHHCCCCCEEEEECEEEECCCCHHHHHHHHHHHCCCC
DGKGPINAKMTDVIEKVAPGVIARQSVDQPLQTGLKSIDSMVPIGRGQRELIIGDRQTGK
CCCCCCCCHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
TAVAIDAIINQKGQGVTCIYVAIGQKASSIKNVVRALEQAGAMEYTIVVAASASESAAMQ
CEEEHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHH
YVSAYSGCTMGEYFRDRGEDALIVYDDLSKQAVAYRQVSLLLRRPPGREAFPGDVFYLHS
HHHHHCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
RLLERAARVNADYVEAFTKGEVKGKTGSLTALPVIETQAGDVSAFVPTNVISITDGQIFL
HHHHHHHHCCHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEE
ETSLFNAGIRPAINAGISVSRVGGAAQTKLIKGLSGGIRTDLAQYRELAAFAQFASDLDE
EEHHHCCCCCHHHHCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ATRKQLDRGARVTELLKQPQYSPLSTALMGATLFTVNKGFLDDVDVKKVLAFEAGLHQYL
HHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHH
KTSHGALLDRLQQNRAFDKEGKDEAELTQAITAFKKSFV
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA