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The map label for this gene is mmgC [H]

Identifier: 222109369

GI number: 222109369

Start: 166367

End: 167524

Strand: Direct

Name: mmgC [H]

Synonym: Dtpsy_0148

Alternate gene names: 222109369

Gene position: 166367-167524 (Clockwise)

Preceding gene: 222109368

Following gene: 222109370

Centisome position: 4.38

GC content: 66.75

Gene sequence:

>1158_bases
ATGATCCGCGACCCAGACATCTTGGAAGCCCTGCTCGACAGCGTGCGCCGCTTTGTGCGAGAACGCCTGGTGCCGGCCGA
GAACGAAGTGGCCGAGACCGATGAAATTCCCGAGTCCATCGTGCAGGAGATGCGCGAGCTGGGCCTGTTCGGCATGACCA
TTCCCGAGAAGTTCGGCGGCCTGGAGCTGACGATGGAGGAGGAGTGCCGCGTACTGTTCGAGCTGTGCCAGACGGCGCCG
GCCTTCCGCTCGATCATCGGCACCACCGTGGGCATCGGCTCGCAGGGCATCCTGATGGATGGCACGCCCGAGCAGCAGGC
CCAGTGGCTGCCCAAGCTGGCCACCGGCGAGGTCATCGCGTCGTTCGCGCTGACCGAACCCGAGGCGGGATCGGACGCCG
CATCGCTGCGCACCACGGCCATCAAGGACGGCGACCACTACATCGTCAACGGCACCAAGCGCTACATCACCAATGCGCCG
CACGCCGGCATGTTCACGCTGATGGCACGCACCAACCCGGCCGACAAGGGCGCGGGCGGCGTGTCCTCGTTCATCGTGGA
CGCCAAGACGCCCGGCATCAGCTTTGGCAAGTACGACAAAAAGATGGGCCAGCGCGGCGCCCACACCTGCGACGTGATCT
TCGACAACGTCAAGGTGCCGGCGGCCAACCTCATCGGCCTGCAGGAGGGCCGCGGCTTCAAGACCGCGATGAAGGTGCTG
GAAAAGGGCCGCATCCACATCGCCGCGGTAGCGGTGGGCGTGGCCCAGCGCATCCTGCGCGACGCACTCGCATATGCCCT
GGAGCGCAAGCAGTTCGGCCAGCCCATCTGCGACTTCCAGCTGGTGCAGGCCATGCTGGCCGACAGCCAGGCCGAGCTGT
ACGCCGCCGAGTGCATGACCATCGACGCCGCGCGCCGCCGCGACGACGGGCACAACGTCTCCACCGAGGCCTCGTGCGCC
AAGATGTTTGCCACCGAGATGTGCGGCCGCGTGGCCGACCGCGCGGTGCAGATCCTGGGCGGCGCAGGCTACATGGCCGA
GTACGGCATCGAGCGCTTTTACCGCGACGTGCGCCTGTTCCGCCTGTACGAAGGCACGACGCAGATCCAGCAGATCATCA
TCGCGCGCAACATGGTGCGTGAGGCGCGCGCCGCATGA

Upstream 100 bases:

>100_bases
CCGTGGTGCATGGCAACGGCGGCACGCTGTCCAGCCAGTCCACCGCCGTGCTCGGCACCGCCGACACCCTCTGAACCCGC
ATACCGAAGAAAGAACCCTC

Downstream 100 bases:

>100_bases
GCGGGGCTCCGCCGCTGGTGGACCGCAGCGCCTTCTTGCGCCTGATCGGCGCCGCGCAGGTGCCGGCGCCGCCGGGCAAG
GTGCAGGTGCGCCTGCCGCA

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MIRDPDILEALLDSVRRFVRERLVPAENEVAETDEIPESIVQEMRELGLFGMTIPEKFGGLELTMEEECRVLFELCQTAP
AFRSIIGTTVGIGSQGILMDGTPEQQAQWLPKLATGEVIASFALTEPEAGSDAASLRTTAIKDGDHYIVNGTKRYITNAP
HAGMFTLMARTNPADKGAGGVSSFIVDAKTPGISFGKYDKKMGQRGAHTCDVIFDNVKVPAANLIGLQEGRGFKTAMKVL
EKGRIHIAAVAVGVAQRILRDALAYALERKQFGQPICDFQLVQAMLADSQAELYAAECMTIDAARRRDDGHNVSTEASCA
KMFATEMCGRVADRAVQILGGAGYMAEYGIERFYRDVRLFRLYEGTTQIQQIIIARNMVREARAA

Sequences:

>Translated_385_residues
MIRDPDILEALLDSVRRFVRERLVPAENEVAETDEIPESIVQEMRELGLFGMTIPEKFGGLELTMEEECRVLFELCQTAP
AFRSIIGTTVGIGSQGILMDGTPEQQAQWLPKLATGEVIASFALTEPEAGSDAASLRTTAIKDGDHYIVNGTKRYITNAP
HAGMFTLMARTNPADKGAGGVSSFIVDAKTPGISFGKYDKKMGQRGAHTCDVIFDNVKVPAANLIGLQEGRGFKTAMKVL
EKGRIHIAAVAVGVAQRILRDALAYALERKQFGQPICDFQLVQAMLADSQAELYAAECMTIDAARRRDDGHNVSTEASCA
KMFATEMCGRVADRAVQILGGAGYMAEYGIERFYRDVRLFRLYEGTTQIQQIIIARNMVREARAA
>Mature_385_residues
MIRDPDILEALLDSVRRFVRERLVPAENEVAETDEIPESIVQEMRELGLFGMTIPEKFGGLELTMEEECRVLFELCQTAP
AFRSIIGTTVGIGSQGILMDGTPEQQAQWLPKLATGEVIASFALTEPEAGSDAASLRTTAIKDGDHYIVNGTKRYITNAP
HAGMFTLMARTNPADKGAGGVSSFIVDAKTPGISFGKYDKKMGQRGAHTCDVIFDNVKVPAANLIGLQEGRGFKTAMKVL
EKGRIHIAAVAVGVAQRILRDALAYALERKQFGQPICDFQLVQAMLADSQAELYAAECMTIDAARRRDDGHNVSTEASCA
KMFATEMCGRVADRAVQILGGAGYMAEYGIERFYRDVRLFRLYEGTTQIQQIIIARNMVREARAA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557235, Length=376, Percent_Identity=38.2978723404255, Blast_Score=258, Evalue=5e-69,
Organism=Homo sapiens, GI76496475, Length=376, Percent_Identity=38.2978723404255, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI4501859, Length=369, Percent_Identity=37.6693766937669, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI187960098, Length=368, Percent_Identity=38.3152173913043, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI4557231, Length=368, Percent_Identity=38.3152173913043, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI4557233, Length=380, Percent_Identity=36.8421052631579, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI21361497, Length=390, Percent_Identity=36.4102564102564, Blast_Score=251, Evalue=9e-67,
Organism=Homo sapiens, GI226958412, Length=372, Percent_Identity=32.5268817204301, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI226958414, Length=367, Percent_Identity=32.6975476839237, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI7656849, Length=372, Percent_Identity=36.2903225806452, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI4501857, Length=379, Percent_Identity=32.1899736147757, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI4503943, Length=387, Percent_Identity=30.2325581395349, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI7669494, Length=375, Percent_Identity=29.8666666666667, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI48976061, Length=390, Percent_Identity=29.4871794871795, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI211971008, Length=391, Percent_Identity=29.6675191815857, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI38505218, Length=403, Percent_Identity=27.7915632754342, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI156104866, Length=299, Percent_Identity=25.752508361204, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI156104864, Length=299, Percent_Identity=25.752508361204, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786223, Length=373, Percent_Identity=31.9034852546917, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI87081958, Length=377, Percent_Identity=30.2387267904509, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI87081702, Length=338, Percent_Identity=27.2189349112426, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87082384, Length=283, Percent_Identity=26.5017667844523, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17569725, Length=370, Percent_Identity=39.7297297297297, Blast_Score=265, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17534899, Length=368, Percent_Identity=38.5869565217391, Blast_Score=258, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI17508101, Length=367, Percent_Identity=37.3297002724796, Blast_Score=257, Evalue=7e-69,
Organism=Caenorhabditis elegans, GI17570075, Length=368, Percent_Identity=38.3152173913043, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=35.3099730458221, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71985184, Length=365, Percent_Identity=37.2602739726027, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17538396, Length=382, Percent_Identity=31.6753926701571, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17533517, Length=380, Percent_Identity=32.6315789473684, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI71990804, Length=293, Percent_Identity=36.8600682593857, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71985192, Length=299, Percent_Identity=36.7892976588629, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=37.0689655172414, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17534353, Length=369, Percent_Identity=28.4552845528455, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71982178, Length=271, Percent_Identity=34.6863468634686, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17551932, Length=374, Percent_Identity=27.807486631016, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=28.494623655914, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17531909, Length=248, Percent_Identity=34.2741935483871, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17562446, Length=369, Percent_Identity=29.2682926829268, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17531913, Length=178, Percent_Identity=30.8988764044944, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI86563383, Length=274, Percent_Identity=26.6423357664234, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=274, Percent_Identity=26.6423357664234, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24660351, Length=375, Percent_Identity=38.4, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI281363737, Length=390, Percent_Identity=38.2051282051282, Blast_Score=257, Evalue=7e-69,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=38.9784946236559, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI21356377, Length=380, Percent_Identity=37.1052631578947, Blast_Score=235, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=34.9462365591398, Blast_Score=217, Evalue=9e-57,
Organism=Drosophila melanogaster, GI21355753, Length=374, Percent_Identity=32.620320855615, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI19920834, Length=371, Percent_Identity=29.6495956873315, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24652780, Length=348, Percent_Identity=23.8505747126437, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42153; Mature: 42153

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRDPDILEALLDSVRRFVRERLVPAENEVAETDEIPESIVQEMRELGLFGMTIPEKFGG
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCC
LELTMEEECRVLFELCQTAPAFRSIIGTTVGIGSQGILMDGTPEQQAQWLPKLATGEVIA
EEEEHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEECCCCHHHHHHCCCHHHHHHHH
SFALTEPEAGSDAASLRTTAIKDGDHYIVNGTKRYITNAPHAGMFTLMARTNPADKGAGG
HHHCCCCCCCCCHHHHHHHEEECCCEEEECCHHHHHCCCCCCCEEEEEECCCCCCCCCCC
VSSFIVDAKTPGISFGKYDKKMGQRGAHTCDVIFDNVKVPAANLIGLQEGRGFKTAMKVL
HHHHEEECCCCCCCCCHHHHHHHHCCCCCHHHEECCCCCCHHHHEECCCCCCHHHHHHHH
EKGRIHIAAVAVGVAQRILRDALAYALERKQFGQPICDFQLVQAMLADSQAELYAAECMT
HCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHH
IDAARRRDDGHNVSTEASCAKMFATEMCGRVADRAVQILGGAGYMAEYGIERFYRDVRLF
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RLYEGTTQIQQIIIARNMVREARAA
HHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIRDPDILEALLDSVRRFVRERLVPAENEVAETDEIPESIVQEMRELGLFGMTIPEKFGG
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCC
LELTMEEECRVLFELCQTAPAFRSIIGTTVGIGSQGILMDGTPEQQAQWLPKLATGEVIA
EEEEHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEECCCCHHHHHHCCCHHHHHHHH
SFALTEPEAGSDAASLRTTAIKDGDHYIVNGTKRYITNAPHAGMFTLMARTNPADKGAGG
HHHCCCCCCCCCHHHHHHHEEECCCEEEECCHHHHHCCCCCCCEEEEEECCCCCCCCCCC
VSSFIVDAKTPGISFGKYDKKMGQRGAHTCDVIFDNVKVPAANLIGLQEGRGFKTAMKVL
HHHHEEECCCCCCCCCHHHHHHHHCCCCCHHHEECCCCCCHHHHEECCCCCCHHHHHHHH
EKGRIHIAAVAVGVAQRILRDALAYALERKQFGQPICDFQLVQAMLADSQAELYAAECMT
HCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHH
IDAARRRDDGHNVSTEASCAKMFATEMCGRVADRAVQILGGAGYMAEYGIERFYRDVRLF
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RLYEGTTQIQQIIIARNMVREARAA
HHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]