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The map label for this gene is fabG [H]

Identifier: 222109345

GI number: 222109345

Start: 140029

End: 140796

Strand: Direct

Name: fabG [H]

Synonym: Dtpsy_0123

Alternate gene names: 222109345

Gene position: 140029-140796 (Clockwise)

Preceding gene: 222109344

Following gene: 222109346

Centisome position: 3.69

GC content: 68.36

Gene sequence:

>768_bases
ATGAAGCTGCAACAAGGAATGACCGCCCTCGTCACCGGCGGGGTCTCGGGCCTGGGCGAGGCCACGGCCCTCCAGCTGCT
GGAGCGCGGCCTGAACGTGGTGGTCGTGGACCTGAACGACGAGCGCGGCCAGGCCATGGAACAGCAGTACGCCGGCCGGC
TGCGCTATGTGAAGGCCGATGTATCGGACGCCGAGCAGATGGCCCCGGCCATCGCCGCGGCCCAGGCCTTCGGCAACTTC
CGCGCGCTGGTGCACTGCGCCGGCATCGGCGGCCCGCTGCGCCTGATCGAGAAGGACGGCAGCCCCGGCTCGCTGGAAAA
ATACGTCAACATCATCCGCGTCAACCTCATCGGCACGTTCAACGTGCTGCGCCTGGCGGCCGTGAGCATGGCGGGGAACG
AGCCCATCGATGGCGAGCGCGGCGCCTGCGTGCTCACCGCATCGGTGGCGGGCTATGAGGGGCAGATCGGCCAGATTCCG
TACGCCTCCTCCAAGGCGGGCGTGATCGGCCTGACCCTCGTGGCCGCACGCGACCTGGCGTCCAAGTTCATCCGCGTGTG
CACCATCGCGCCGGGCCTGTTCGATACGCCCATCCTGGCCAAGCTGCCCGAGAACGTGCGCCAGTCGCTGTCGGCCTCGG
TGCCCCACCCTGCACGCCTGGGCTACCCCTCGGAGTACGCCATGACCGCGCTGCACATCCTGGAGAACCCCATGCTCAAT
GGCGAGACCATCCGCCTGGATGGGGCCATTCGCATGGCGCCTAGATGA

Upstream 100 bases:

>100_bases
CGGCATGGCCAACGCCACCATCATCGAACGTTTGTAACTATCAATTTAATAGCAAAAAACGCCCTGTGATTGCGCACTTG
AGGGCAAAAAGGACAGAAAC

Downstream 100 bases:

>100_bases
CGCCCCCCTGAGGCGCTGCGCCCCCCCCGCTCTCGCGTCGCTGCGCTACGCGGGCAGGGGGACGCAGCCCTCGCTGCGGG
GCGGCCCTTGCGCGGCCGCC

Product: short-chain dehydrogenase/reductase sdr

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MKLQQGMTALVTGGVSGLGEATALQLLERGLNVVVVDLNDERGQAMEQQYAGRLRYVKADVSDAEQMAPAIAAAQAFGNF
RALVHCAGIGGPLRLIEKDGSPGSLEKYVNIIRVNLIGTFNVLRLAAVSMAGNEPIDGERGACVLTASVAGYEGQIGQIP
YASSKAGVIGLTLVAARDLASKFIRVCTIAPGLFDTPILAKLPENVRQSLSASVPHPARLGYPSEYAMTALHILENPMLN
GETIRLDGAIRMAPR

Sequences:

>Translated_255_residues
MKLQQGMTALVTGGVSGLGEATALQLLERGLNVVVVDLNDERGQAMEQQYAGRLRYVKADVSDAEQMAPAIAAAQAFGNF
RALVHCAGIGGPLRLIEKDGSPGSLEKYVNIIRVNLIGTFNVLRLAAVSMAGNEPIDGERGACVLTASVAGYEGQIGQIP
YASSKAGVIGLTLVAARDLASKFIRVCTIAPGLFDTPILAKLPENVRQSLSASVPHPARLGYPSEYAMTALHILENPMLN
GETIRLDGAIRMAPR
>Mature_255_residues
MKLQQGMTALVTGGVSGLGEATALQLLERGLNVVVVDLNDERGQAMEQQYAGRLRYVKADVSDAEQMAPAIAAAQAFGNF
RALVHCAGIGGPLRLIEKDGSPGSLEKYVNIIRVNLIGTFNVLRLAAVSMAGNEPIDGERGACVLTASVAGYEGQIGQIP
YASSKAGVIGLTLVAARDLASKFIRVCTIAPGLFDTPILAKLPENVRQSLSASVPHPARLGYPSEYAMTALHILENPMLN
GETIRLDGAIRMAPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=253, Percent_Identity=48.2213438735178, Blast_Score=221, Evalue=5e-58,
Organism=Homo sapiens, GI83715985, Length=253, Percent_Identity=45.4545454545455, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI15277342, Length=258, Percent_Identity=32.1705426356589, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=27.1604938271605, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI22507405, Length=241, Percent_Identity=30.2904564315353, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI31542939, Length=256, Percent_Identity=27.34375, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4504505, Length=223, Percent_Identity=29.5964125560538, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=253, Percent_Identity=30.8300395256917, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI87082100, Length=261, Percent_Identity=29.5019157088123, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=28.6852589641434, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=255, Percent_Identity=43.5294117647059, Blast_Score=200, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI25147288, Length=253, Percent_Identity=30.8300395256917, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17555706, Length=249, Percent_Identity=31.7269076305221, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17567345, Length=214, Percent_Identity=28.0373831775701, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17737361, Length=249, Percent_Identity=47.7911646586345, Blast_Score=231, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24639444, Length=257, Percent_Identity=33.852140077821, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24663911, Length=222, Percent_Identity=29.2792792792793, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 26895; Mature: 26895

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLQQGMTALVTGGVSGLGEATALQLLERGLNVVVVDLNDERGQAMEQQYAGRLRYVKAD
CCCHHCCHHEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCEEEEECC
VSDAEQMAPAIAAAQAFGNFRALVHCAGIGGPLRLIEKDGSPGSLEKYVNIIRVNLIGTF
CCCHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHEEEEHHHH
NVLRLAAVSMAGNEPIDGERGACVLTASVAGYEGQIGQIPYASSKAGVIGLTLVAARDLA
HHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
SKFIRVCTIAPGLFDTPILAKLPENVRQSLSASVPHPARLGYPSEYAMTALHILENPMLN
HHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
GETIRLDGAIRMAPR
CCEEEECCEEEECCC
>Mature Secondary Structure
MKLQQGMTALVTGGVSGLGEATALQLLERGLNVVVVDLNDERGQAMEQQYAGRLRYVKAD
CCCHHCCHHEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCEEEEECC
VSDAEQMAPAIAAAQAFGNFRALVHCAGIGGPLRLIEKDGSPGSLEKYVNIIRVNLIGTF
CCCHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHEEEEHHHH
NVLRLAAVSMAGNEPIDGERGACVLTASVAGYEGQIGQIPYASSKAGVIGLTLVAARDLA
HHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
SKFIRVCTIAPGLFDTPILAKLPENVRQSLSASVPHPARLGYPSEYAMTALHILENPMLN
HHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
GETIRLDGAIRMAPR
CCEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]