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The map label for this gene is fadA [H]

Identifier: 222109344

GI number: 222109344

Start: 138787

End: 139965

Strand: Direct

Name: fadA [H]

Synonym: Dtpsy_0122

Alternate gene names: 222109344

Gene position: 138787-139965 (Clockwise)

Preceding gene: 222109339

Following gene: 222109345

Centisome position: 3.66

GC content: 70.4

Gene sequence:

>1179_bases
ATGAAAAACCCCGTCATCGTCGACGCCATCCGCAGTCCCATGGCCCGGGCCAAGCCCGACGGCGCGCTGGCCCAAGTGCA
CCCCGTGGATCTGCTCTCGCAGGTGCTGGAGCAGCTGGTGGAGCGCAACCAGATCGACCCCGGCCAGGTGGATGACGTGA
TCTGCGGCTGCGTGAGCCAGGCTGGCGAGCAGGCCGGCACGCCCGGGCGCCTGGCCTGGCTGGCTGCGGGCCTGCCTGCG
CACGTGCCCTCCACCACCATCGACCGCAAGTGCGGCTCCAGCCAGCAGGCCGTGCACTTCGCGGCCCAGGCCATCATGGC
CGGCACGCAGGACATCGTGATCGCCTGCGGCGTGGAGTCCATGAGCCGCGTGCCCATGGGCAGCTCGCGCATGGGCCAGA
ACACCACCGGCGCACGGTTCGACGCGCGCTACGCCCCCGGCCTGGTGGGGCAGGGTGTCTCGGCCGACCTGGTGGCCGCC
CAATGGGGCCTGGACCGCACCGCGCTGGACACCTATGCCGCGCGCTCGCACCAGCGTGCCCACGCGGCGCAGTCCAGCGG
AGGCTTTGCGCGCGAGATCGTGGGCATCGACACCCCTGCCGGCCGCGTGACGGCAGACGAGACCATCCGCGCCGGCACCA
CGGTGGAAAAGCTCGCCGGCCTGAAGGCCGTGTTCGAGAACGAGGAGCTGTCCGCGCGCTTCCCGCAGATCCAGTGGGCC
ACCACGGCGGGCAATGCCTCGCAGATGACCGACGGCGCCAGCGCCATGCTCATCATGAGCGAGCAGCGTGCCCAGCAGCT
GGGCCTGCGTCCCCGTGCGCGTTTCGTGGCCTTCGACGTGGTGGGCGACGACCCGCTGTACATGCTCACCGCCCCCATCC
CGGCCACGCAGCGCGTGCTGGCCAAGGCCAAGATGAAGCTGGACGACATCCACCACTACGAGATCAACGAGGCCTTCGCC
TCCGTGCCCCTGGCCTGGCAGAAGGAACTGAAGGCCGATGGCGAGCGCCTGAACCCGCGCGGCGGCGCCATCGCCCTGGG
CCACCCGCTGGGCGCCTCGGGCATCCGCCTCATGACCACGATGCTGCACGCCCTGGAAGACAGCGGCCAGCGCTACGGCC
TGCAGTCCATGTGCGAGGCCGGCGGCATGGCCAACGCCACCATCATCGAACGTTTGTAA

Upstream 100 bases:

>100_bases
CGCGCAAAAAGCACCGGGTAAACACGGCCTTCAGCACAAACTAACCCATGAGAAATTGTTTTTAATGGATCATTGGTTCC
ACAAAACGTATGGAGCAAGC

Downstream 100 bases:

>100_bases
CTATCAATTTAATAGCAAAAAACGCCCTGTGATTGCGCACTTGAGGGCAAAAAGGACAGAAACATGAAGCTGCAACAAGG
AATGACCGCCCTCGTCACCG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKNPVIVDAIRSPMARAKPDGALAQVHPVDLLSQVLEQLVERNQIDPGQVDDVICGCVSQAGEQAGTPGRLAWLAAGLPA
HVPSTTIDRKCGSSQQAVHFAAQAIMAGTQDIVIACGVESMSRVPMGSSRMGQNTTGARFDARYAPGLVGQGVSADLVAA
QWGLDRTALDTYAARSHQRAHAAQSSGGFAREIVGIDTPAGRVTADETIRAGTTVEKLAGLKAVFENEELSARFPQIQWA
TTAGNASQMTDGASAMLIMSEQRAQQLGLRPRARFVAFDVVGDDPLYMLTAPIPATQRVLAKAKMKLDDIHHYEINEAFA
SVPLAWQKELKADGERLNPRGGAIALGHPLGASGIRLMTTMLHALEDSGQRYGLQSMCEAGGMANATIIERL

Sequences:

>Translated_392_residues
MKNPVIVDAIRSPMARAKPDGALAQVHPVDLLSQVLEQLVERNQIDPGQVDDVICGCVSQAGEQAGTPGRLAWLAAGLPA
HVPSTTIDRKCGSSQQAVHFAAQAIMAGTQDIVIACGVESMSRVPMGSSRMGQNTTGARFDARYAPGLVGQGVSADLVAA
QWGLDRTALDTYAARSHQRAHAAQSSGGFAREIVGIDTPAGRVTADETIRAGTTVEKLAGLKAVFENEELSARFPQIQWA
TTAGNASQMTDGASAMLIMSEQRAQQLGLRPRARFVAFDVVGDDPLYMLTAPIPATQRVLAKAKMKLDDIHHYEINEAFA
SVPLAWQKELKADGERLNPRGGAIALGHPLGASGIRLMTTMLHALEDSGQRYGLQSMCEAGGMANATIIERL
>Mature_392_residues
MKNPVIVDAIRSPMARAKPDGALAQVHPVDLLSQVLEQLVERNQIDPGQVDDVICGCVSQAGEQAGTPGRLAWLAAGLPA
HVPSTTIDRKCGSSQQAVHFAAQAIMAGTQDIVIACGVESMSRVPMGSSRMGQNTTGARFDARYAPGLVGQGVSADLVAA
QWGLDRTALDTYAARSHQRAHAAQSSGGFAREIVGIDTPAGRVTADETIRAGTTVEKLAGLKAVFENEELSARFPQIQWA
TTAGNASQMTDGASAMLIMSEQRAQQLGLRPRARFVAFDVVGDDPLYMLTAPIPATQRVLAKAKMKLDDIHHYEINEAFA
SVPLAWQKELKADGERLNPRGGAIALGHPLGASGIRLMTTMLHALEDSGQRYGLQSMCEAGGMANATIIERL

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=403, Percent_Identity=37.468982630273, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=37.1212121212121, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI4557237, Length=404, Percent_Identity=34.9009900990099, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI167614485, Length=403, Percent_Identity=33.7468982630273, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI4504327, Length=435, Percent_Identity=33.3333333333333, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI194353979, Length=89, Percent_Identity=44.9438202247191, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=41.3965087281795, Blast_Score=261, Evalue=8e-71,
Organism=Escherichia coli, GI1787663, Length=413, Percent_Identity=42.8571428571429, Blast_Score=257, Evalue=8e-70,
Organism=Escherichia coli, GI87082165, Length=405, Percent_Identity=40, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=39.1625615763547, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1788683, Length=419, Percent_Identity=30.5489260143198, Blast_Score=148, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI133906874, Length=359, Percent_Identity=39.5543175487465, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI25147385, Length=404, Percent_Identity=32.9207920792079, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17535921, Length=402, Percent_Identity=32.5870646766169, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=435, Percent_Identity=31.0344827586207, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=28.5353535353535, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322031, Length=391, Percent_Identity=35.2941176470588, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6325229, Length=412, Percent_Identity=32.2815533980583, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=37.8712871287129, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24640423, Length=400, Percent_Identity=34, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI17648125, Length=358, Percent_Identity=37.4301675977654, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17137578, Length=437, Percent_Identity=31.1212814645309, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41568; Mature: 41568

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNPVIVDAIRSPMARAKPDGALAQVHPVDLLSQVLEQLVERNQIDPGQVDDVICGCVSQ
CCCCEEHHHHHCCHHHCCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AGEQAGTPGRLAWLAAGLPAHVPSTTIDRKCGSSQQAVHFAAQAIMAGTQDIVIACGVES
HHHHCCCCCCCHHEECCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCHH
MSRVPMGSSRMGQNTTGARFDARYAPGLVGQGVSADLVAAQWGLDRTALDTYAARSHQRA
HHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHH
HAAQSSGGFAREIVGIDTPAGRVTADETIRAGTTVEKLAGLKAVFENEELSARFPQIQWA
HHHHCCCCCEEHEEECCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCHHCCCCCEEEE
TTAGNASQMTDGASAMLIMSEQRAQQLGLRPRARFVAFDVVGDDPLYMLTAPIPATQRVL
ECCCCHHHCCCCCCEEEEECHHHHHHHCCCCCCEEEEEEEECCCCEEEEECCCCHHHHHH
AKAKMKLDDIHHYEINEAFASVPLAWQKELKADGERLNPRGGAIALGHPLGASGIRLMTT
HHHHHHHHHCCCEEHHHHHHHCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHH
MLHALEDSGQRYGLQSMCEAGGMANATIIERL
HHHHHHHCCCCCCHHHHHHHCCCCCHHHHHCC
>Mature Secondary Structure
MKNPVIVDAIRSPMARAKPDGALAQVHPVDLLSQVLEQLVERNQIDPGQVDDVICGCVSQ
CCCCEEHHHHHCCHHHCCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AGEQAGTPGRLAWLAAGLPAHVPSTTIDRKCGSSQQAVHFAAQAIMAGTQDIVIACGVES
HHHHCCCCCCCHHEECCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCHH
MSRVPMGSSRMGQNTTGARFDARYAPGLVGQGVSADLVAAQWGLDRTALDTYAARSHQRA
HHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHH
HAAQSSGGFAREIVGIDTPAGRVTADETIRAGTTVEKLAGLKAVFENEELSARFPQIQWA
HHHHCCCCCEEHEEECCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCHHCCCCCEEEE
TTAGNASQMTDGASAMLIMSEQRAQQLGLRPRARFVAFDVVGDDPLYMLTAPIPATQRVL
ECCCCHHHCCCCCCEEEEECHHHHHHHCCCCCCEEEEEEEECCCCEEEEECCCCHHHHHH
AKAKMKLDDIHHYEINEAFASVPLAWQKELKADGERLNPRGGAIALGHPLGASGIRLMTT
HHHHHHHHHCCCEEHHHHHHHCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHH
MLHALEDSGQRYGLQSMCEAGGMANATIIERL
HHHHHHHCCCCCCHHHHHHHCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA