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The map label for this gene is accC [H]

Identifier: 222102905

GI number: 222102905

Start: 590544

End: 591917

Strand: Direct

Name: accC [H]

Synonym: Avi_7655

Alternate gene names: 222102905

Gene position: 590544-591917 (Clockwise)

Preceding gene: 222102904

Following gene: 222102906

Centisome position: 93.47

GC content: 58.3

Gene sequence:

>1374_bases
ATGACATCGGACACGAAACGCCCCTTTGATACGGTTCTGATTGCCAATCGTGGCGAGATTGCCCTGCGCATCCAGCGCGC
CTGCCGGGAACTTGGCCTGCGCACCGTGATGATCTGCTCTGAGGCCGACCGCGATGCGCCCTATGGCGCAACCGGGGATG
AATTCATCTGTATCGGCCCTTCTGCGCCGGGTCGCAGCTATTTCAATCAATCCGCAATTCTTCTGGCCATGCGGGCATCT
GGTGCGGGTGCGGTGCATCCGGGCTACGGCTTCCTGTCGGAAAACGCTGATTTTGCCGAAGCTGTTGAGCAGGCCGGGCT
GACCTTCATAGGCCCACCAGCCTCTGCCATTCGCATTATGGGTGATAAAATCGCCGCCAAGCGGGCAATGATCGAGGCAG
GCGTGCCTTGCGTGCCGGGACCAGACACGGCCCTTGGCGAAGACATGGCTGATATTGCCGAGATCGCCGCCAAAATTGGC
TATCCAGTGATTATCAAGGCCGCGGGCGGCGGCGGTGGACGCGGCATGCGCATTGTGCGCGATGCGGCGGCGCTTGCTGA
TGCCGTTTCCATCACCCGTGAGGAAGCGCGGCGGGCTTTTGGCAATCCCGAGCTTTACATGGAAAAGTTTCTTGAGAAGC
CACGCCATGTGGAAATTCAGGTGTTGTGCGATAATTTCGGCAATGCCGTTTGGCTTGGCCATCGCGATTGCTCCATGCAG
CGCCGCCACCAGAAAGTGGTGGAAGAAGCGCCATCACCCGGTATTCCCGCCGATGTTGCGGCGACTGTGGGTGCACGTTG
CGTGGCGGCCTGCCAGCGGATTGGCTATCGCGGCGTCGGCACGTTTGAGTTTCTCTATGAGAATGGCGAATTCTATTTCA
TTGAAATGAACACCCGCCTTCAGGTGGAACATCCCGTGACCGAGATGACCAGCGGGTTGGATATTGTCTGTGAGCAATTG
CGCGTGGCGCTTGGCCTGCCGATGATGCTGACCCAAGCGGATATTCAAACCAACGGCCATTCGTTTGAATGCCGGATCAA
TGCCGAAGACCCTTACACCTTTGCCGGATCACCGGGCAAGATCACCGCTTTACAGCTTCCCTCCGGCGAGGGCGTGCGGG
TCGATACCCATGTTGTGGAAGGCTATACCGTGCCTGCCCATTATGACTCCCTGATTGCCAAGCTGATTGTGCATGCCCCA
ACCCGCGACGAGGCCATAGTGCGCATGCGCGCAGCTCTGGACGCACTCAAGATCGACGGGATCACCACCAATATCGCGCT
GCATAAGGCGATTTTTGAAGATGCGGGCTTTTGCGCGGGTGGGGCCGATATCCACCATCTTGAAAAATGGTTGAGCAAGC
GGAGCGCAGCATGA

Upstream 100 bases:

>100_bases
TCAACACCATTACGGCAGAGCGCGCAGGCAAGGTTGTTCGTTTGCTTGTTGAGGACGGCCAAGAGGTGGATGCCGGGCAG
CCCATGCTGGAGATTGCCGG

Downstream 100 bases:

>100_bases
CAACACGCACTCGTTCCAAATCCCGATCCGCCGCGGATTTCACCAGTCCAGAGGTGATCGCAACGCTCACAGCATGGTTG
GAGCAGGCCGGTGTCAGCAC

Product: acetyl-CoA carboxylase biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTSDTKRPFDTVLIANRGEIALRIQRACRELGLRTVMICSEADRDAPYGATGDEFICIGPSAPGRSYFNQSAILLAMRAS
GAGAVHPGYGFLSENADFAEAVEQAGLTFIGPPASAIRIMGDKIAAKRAMIEAGVPCVPGPDTALGEDMADIAEIAAKIG
YPVIIKAAGGGGGRGMRIVRDAAALADAVSITREEARRAFGNPELYMEKFLEKPRHVEIQVLCDNFGNAVWLGHRDCSMQ
RRHQKVVEEAPSPGIPADVAATVGARCVAACQRIGYRGVGTFEFLYENGEFYFIEMNTRLQVEHPVTEMTSGLDIVCEQL
RVALGLPMMLTQADIQTNGHSFECRINAEDPYTFAGSPGKITALQLPSGEGVRVDTHVVEGYTVPAHYDSLIAKLIVHAP
TRDEAIVRMRAALDALKIDGITTNIALHKAIFEDAGFCAGGADIHHLEKWLSKRSAA

Sequences:

>Translated_457_residues
MTSDTKRPFDTVLIANRGEIALRIQRACRELGLRTVMICSEADRDAPYGATGDEFICIGPSAPGRSYFNQSAILLAMRAS
GAGAVHPGYGFLSENADFAEAVEQAGLTFIGPPASAIRIMGDKIAAKRAMIEAGVPCVPGPDTALGEDMADIAEIAAKIG
YPVIIKAAGGGGGRGMRIVRDAAALADAVSITREEARRAFGNPELYMEKFLEKPRHVEIQVLCDNFGNAVWLGHRDCSMQ
RRHQKVVEEAPSPGIPADVAATVGARCVAACQRIGYRGVGTFEFLYENGEFYFIEMNTRLQVEHPVTEMTSGLDIVCEQL
RVALGLPMMLTQADIQTNGHSFECRINAEDPYTFAGSPGKITALQLPSGEGVRVDTHVVEGYTVPAHYDSLIAKLIVHAP
TRDEAIVRMRAALDALKIDGITTNIALHKAIFEDAGFCAGGADIHHLEKWLSKRSAA
>Mature_456_residues
TSDTKRPFDTVLIANRGEIALRIQRACRELGLRTVMICSEADRDAPYGATGDEFICIGPSAPGRSYFNQSAILLAMRASG
AGAVHPGYGFLSENADFAEAVEQAGLTFIGPPASAIRIMGDKIAAKRAMIEAGVPCVPGPDTALGEDMADIAEIAAKIGY
PVIIKAAGGGGGRGMRIVRDAAALADAVSITREEARRAFGNPELYMEKFLEKPRHVEIQVLCDNFGNAVWLGHRDCSMQR
RHQKVVEEAPSPGIPADVAATVGARCVAACQRIGYRGVGTFEFLYENGEFYFIEMNTRLQVEHPVTEMTSGLDIVCEQLR
VALGLPMMLTQADIQTNGHSFECRINAEDPYTFAGSPGKITALQLPSGEGVRVDTHVVEGYTVPAHYDSLIAKLIVHAPT
RDEAIVRMRAALDALKIDGITTNIALHKAIFEDAGFCAGGADIHHLEKWLSKRSAA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=466, Percent_Identity=45.9227467811159, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI189095269, Length=440, Percent_Identity=46.8181818181818, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI65506442, Length=440, Percent_Identity=46.5909090909091, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI295821183, Length=440, Percent_Identity=46.5909090909091, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI106049528, Length=450, Percent_Identity=42.6666666666667, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI106049295, Length=450, Percent_Identity=42.6666666666667, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI106049292, Length=450, Percent_Identity=42.6666666666667, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI38679960, Length=510, Percent_Identity=30, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI38679971, Length=510, Percent_Identity=30, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI38679977, Length=510, Percent_Identity=30, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI38679967, Length=510, Percent_Identity=30, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI38679974, Length=510, Percent_Identity=30, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI134142062, Length=513, Percent_Identity=29.8245614035088, Blast_Score=205, Evalue=7e-53,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=60.7223476297968, Blast_Score=530, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI71987519, Length=440, Percent_Identity=47.9545454545455, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17567343, Length=444, Percent_Identity=44.3693693693694, Blast_Score=380, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17562816, Length=453, Percent_Identity=41.280353200883, Blast_Score=318, Evalue=4e-87,
Organism=Caenorhabditis elegans, GI71997168, Length=518, Percent_Identity=28.3783783783784, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71997163, Length=518, Percent_Identity=28.3783783783784, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI133931226, Length=497, Percent_Identity=28.3702213279678, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=38.6516853932584, Blast_Score=332, Evalue=7e-92,
Organism=Saccharomyces cerevisiae, GI6319695, Length=440, Percent_Identity=42.0454545454545, Blast_Score=306, Evalue=5e-84,
Organism=Saccharomyces cerevisiae, GI6321376, Length=440, Percent_Identity=41.8181818181818, Blast_Score=295, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6324343, Length=507, Percent_Identity=31.5581854043393, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6323863, Length=426, Percent_Identity=31.924882629108, Blast_Score=202, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24651757, Length=425, Percent_Identity=45.4117647058823, Blast_Score=367, Evalue=1e-102,
Organism=Drosophila melanogaster, GI281363050, Length=450, Percent_Identity=43.3333333333333, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24652224, Length=450, Percent_Identity=43.3333333333333, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24652222, Length=450, Percent_Identity=43.3333333333333, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24652220, Length=450, Percent_Identity=43.3333333333333, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24652218, Length=450, Percent_Identity=43.3333333333333, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24652212, Length=450, Percent_Identity=43.3333333333333, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24652210, Length=450, Percent_Identity=43.3333333333333, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24652214, Length=450, Percent_Identity=43.3333333333333, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI19921944, Length=450, Percent_Identity=43.3333333333333, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24652216, Length=450, Percent_Identity=43.3333333333333, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24651759, Length=379, Percent_Identity=45.646437994723, Blast_Score=328, Evalue=6e-90,
Organism=Drosophila melanogaster, GI161076407, Length=506, Percent_Identity=29.2490118577075, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24586460, Length=506, Percent_Identity=29.2490118577075, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI161076409, Length=505, Percent_Identity=28.9108910891089, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24586458, Length=505, Percent_Identity=28.9108910891089, Blast_Score=195, Evalue=4e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49143; Mature: 49012

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSDTKRPFDTVLIANRGEIALRIQRACRELGLRTVMICSEADRDAPYGATGDEFICIGP
CCCCCCCCCEEEEEECCCCEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEECC
SAPGRSYFNQSAILLAMRASGAGAVHPGYGFLSENADFAEAVEQAGLTFIGPPASAIRIM
CCCCHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCHHHHHHH
GDKIAAKRAMIEAGVPCVPGPDTALGEDMADIAEIAAKIGYPVIIKAAGGGGGRGMRIVR
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHH
DAAALADAVSITREEARRAFGNPELYMEKFLEKPRHVEIQVLCDNFGNAVWLGHRDCSMQ
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCHHHH
RRHQKVVEEAPSPGIPADVAATVGARCVAACQRIGYRGVGTFEFLYENGEFYFIEMNTRL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEE
QVEHPVTEMTSGLDIVCEQLRVALGLPMMLTQADIQTNGHSFECRINAEDPYTFAGSPGK
EECCCHHHHHCCHHHHHHHHHHHHCCCHHEEECHHCCCCCEEEEEECCCCCEEECCCCCE
ITALQLPSGEGVRVDTHVVEGYTVPAHYDSLIAKLIVHAPTRDEAIVRMRAALDALKIDG
EEEEECCCCCCEEEEEEEEECEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECC
ITTNIALHKAIFEDAGFCAGGADIHHLEKWLSKRSAA
EEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSDTKRPFDTVLIANRGEIALRIQRACRELGLRTVMICSEADRDAPYGATGDEFICIGP
CCCCCCCCEEEEEECCCCEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEECC
SAPGRSYFNQSAILLAMRASGAGAVHPGYGFLSENADFAEAVEQAGLTFIGPPASAIRIM
CCCCHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCHHHHHHH
GDKIAAKRAMIEAGVPCVPGPDTALGEDMADIAEIAAKIGYPVIIKAAGGGGGRGMRIVR
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHH
DAAALADAVSITREEARRAFGNPELYMEKFLEKPRHVEIQVLCDNFGNAVWLGHRDCSMQ
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCHHHH
RRHQKVVEEAPSPGIPADVAATVGARCVAACQRIGYRGVGTFEFLYENGEFYFIEMNTRL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEE
QVEHPVTEMTSGLDIVCEQLRVALGLPMMLTQADIQTNGHSFECRINAEDPYTFAGSPGK
EECCCHHHHHCCHHHHHHHHHHHHCCCHHEEECHHCCCCCEEEEEECCCCCEEECCCCCE
ITALQLPSGEGVRVDTHVVEGYTVPAHYDSLIAKLIVHAPTRDEAIVRMRAALDALKIDG
EEEEECCCCCCEEEEEEEEECEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECC
ITTNIALHKAIFEDAGFCAGGADIHHLEKWLSKRSAA
EEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]