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The map label for this gene is bdhA [H]

Identifier: 222102900

GI number: 222102900

Start: 584910

End: 585983

Strand: Direct

Name: bdhA [H]

Synonym: Avi_7649

Alternate gene names: 222102900

Gene position: 584910-585983 (Clockwise)

Preceding gene: 222102899

Following gene: 222102901

Centisome position: 92.58

GC content: 60.61

Gene sequence:

>1074_bases
ATGCGCGCGCTTAGATTTCATGCAGCCAAGGATTTGCGACTGGACGACATTGCCGAGCCGAAGCGACCGGGACCAGGTCA
GGTTCTGGTCCGTAATCGCTTCGTCGGGATTTGCGGCACGGATCTTCATGAATACAGCTACGGCCCGATCTTCATCCCGA
CCGAGCCACACCCCTTCACCGGCGCCCATGGCCCGCAAGTGCTCGGCCATGAATTCGGCGGCTTCGTCGAGGCGATTGGC
GAGGGCGTTACGTCCGTTGTTGTTGGCGACCGCGTATCCATCCAGCCCCTCGTCATGCCAAGGTCCGGCGACTATTTCGC
CGATCGCGGCCTTTTCCACTTAAGCACGCAGTTAGCGCTGGTGGGCTTGAGCTGGGATGGCGGCGGCATGGCCGACGCAG
CGCTCGTCAATGACTACAATGTCCAGAAAATCCCGGAGGAGATGAGCGATGAAGAGGCAGCCCTGGTCGAGCCAACGGCG
GTTGCTGTCTATGCCTGCGATCGCGGCGGCGTAACGGCTGGCACAAGCGTCCTCGTGACGGGCGCTGGTCCCATCGGCAT
GCTGACGTTGCTTGCCGCGCGCGCGGCGGGCGCCACCCAGCTTTTTGTGTCCGACCTCAATGACTCCAGGCTCGCGCTTG
CGAAAGGGGTGTTGCCCGATGTCATCACGATCAACCCGCAGCGCGACAATGTCGGTGATGTCGTTCGCTTGCAAACGGAA
GGCAACGTCGGCTGCGATGTCGCCATCGAATGCGTAGGCAACGAACATGCGCTGAAGGCCTGCGTCGACGCCGTGCGCAA
GCAGGGCGTCGTGGTCCAGACCGGGTTGCATCCGCATGAAAATCCGATCGACTGGTTCCAGGTGACATTCAAAGATCTCG
AAATCAAAGGGTCCTGGGCCTACCCGACACATTATTGGCCACGGGTCATCAGGCTGATTGCTTCCGGCCAGCTGCCGGCA
ATGAAGATCGTCACCAAGCGCGTCACCCTCGACACAGCTGTCAAAGAAGGCTTCGACGTCCTGCTCGACCCGGCGGGAGC
CCAACTCAAGATCCTGATCGATCTTTCGAAATAG

Upstream 100 bases:

>100_bases
CGCCTCGAAAACTGAATAATTCCAGTCCTTCGCCCTGCCAGGAGCCACTGGCACGGGTATTGCTCTTCTCTTGGCATCGA
CAGCAGCCAAGGGAGGAAAC

Downstream 100 bases:

>100_bases
CGTCGTGGCCAAAGCCTGTTGCGGGAGAGGAGACCGCGCAGGTGATGGCCGCTTCGAAAGGCGCCTGGAGGGGCGCTTCA
TCACCGATGACACAAGCACT

Product: zinc-binding dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MRALRFHAAKDLRLDDIAEPKRPGPGQVLVRNRFVGICGTDLHEYSYGPIFIPTEPHPFTGAHGPQVLGHEFGGFVEAIG
EGVTSVVVGDRVSIQPLVMPRSGDYFADRGLFHLSTQLALVGLSWDGGGMADAALVNDYNVQKIPEEMSDEEAALVEPTA
VAVYACDRGGVTAGTSVLVTGAGPIGMLTLLAARAAGATQLFVSDLNDSRLALAKGVLPDVITINPQRDNVGDVVRLQTE
GNVGCDVAIECVGNEHALKACVDAVRKQGVVVQTGLHPHENPIDWFQVTFKDLEIKGSWAYPTHYWPRVIRLIASGQLPA
MKIVTKRVTLDTAVKEGFDVLLDPAGAQLKILIDLSK

Sequences:

>Translated_357_residues
MRALRFHAAKDLRLDDIAEPKRPGPGQVLVRNRFVGICGTDLHEYSYGPIFIPTEPHPFTGAHGPQVLGHEFGGFVEAIG
EGVTSVVVGDRVSIQPLVMPRSGDYFADRGLFHLSTQLALVGLSWDGGGMADAALVNDYNVQKIPEEMSDEEAALVEPTA
VAVYACDRGGVTAGTSVLVTGAGPIGMLTLLAARAAGATQLFVSDLNDSRLALAKGVLPDVITINPQRDNVGDVVRLQTE
GNVGCDVAIECVGNEHALKACVDAVRKQGVVVQTGLHPHENPIDWFQVTFKDLEIKGSWAYPTHYWPRVIRLIASGQLPA
MKIVTKRVTLDTAVKEGFDVLLDPAGAQLKILIDLSK
>Mature_357_residues
MRALRFHAAKDLRLDDIAEPKRPGPGQVLVRNRFVGICGTDLHEYSYGPIFIPTEPHPFTGAHGPQVLGHEFGGFVEAIG
EGVTSVVVGDRVSIQPLVMPRSGDYFADRGLFHLSTQLALVGLSWDGGGMADAALVNDYNVQKIPEEMSDEEAALVEPTA
VAVYACDRGGVTAGTSVLVTGAGPIGMLTLLAARAAGATQLFVSDLNDSRLALAKGVLPDVITINPQRDNVGDVVRLQTE
GNVGCDVAIECVGNEHALKACVDAVRKQGVVVQTGLHPHENPIDWFQVTFKDLEIKGSWAYPTHYWPRVIRLIASGQLPA
MKIVTKRVTLDTAVKEGFDVLLDPAGAQLKILIDLSK

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=358, Percent_Identity=36.8715083798883, Blast_Score=212, Evalue=3e-55,
Organism=Escherichia coli, GI1790045, Length=344, Percent_Identity=31.6860465116279, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788073, Length=309, Percent_Identity=29.7734627831715, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1787863, Length=305, Percent_Identity=31.4754098360656, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788075, Length=380, Percent_Identity=27.6315789473684, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI226510992, Length=311, Percent_Identity=28.6173633440514, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=29.3367346938776, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788407, Length=345, Percent_Identity=26.0869565217391, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1790718, Length=280, Percent_Identity=26.7857142857143, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082125, Length=334, Percent_Identity=28.7425149700599, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87081918, Length=316, Percent_Identity=26.8987341772152, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=316, Percent_Identity=34.4936708860759, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17562878, Length=318, Percent_Identity=34.9056603773585, Blast_Score=151, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6319258, Length=373, Percent_Identity=30.0268096514745, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6319257, Length=378, Percent_Identity=29.1005291005291, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6323099, Length=341, Percent_Identity=29.9120234604106, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322619, Length=354, Percent_Identity=31.3559322033898, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319955, Length=354, Percent_Identity=31.3559322033898, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319621, Length=302, Percent_Identity=26.158940397351, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=303, Percent_Identity=27.3927392739274, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17737897, Length=358, Percent_Identity=34.0782122905028, Blast_Score=157, Evalue=8e-39,
Organism=Drosophila melanogaster, GI17137530, Length=357, Percent_Identity=31.6526610644258, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 38242; Mature: 38242

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALRFHAAKDLRLDDIAEPKRPGPGQVLVRNRFVGICGTDLHEYSYGPIFIPTEPHPFT
CCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCHHHCCCCCEEECCCCCCCC
GAHGPQVLGHEFGGFVEAIGEGVTSVVVGDRVSIQPLVMPRSGDYFADRGLFHLSTQLAL
CCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEECCCCCCHHCCCEEEEEEEEEE
VGLSWDGGGMADAALVNDYNVQKIPEEMSDEEAALVEPTAVAVYACDRGGVTAGTSVLVT
EEEECCCCCCCCEEEECCCCHHHCCHHHCCCCCEEECCCEEEEEEECCCCCCCCCEEEEE
GAGPIGMLTLLAARAAGATQLFVSDLNDSRLALAKGVLPDVITINPQRDNVGDVVRLQTE
CCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCCCEEEECCCCCCCCCEEEEEEC
GNVGCDVAIECVGNEHALKACVDAVRKQGVVVQTGLHPHENPIDWFQVTFKDLEIKGSWA
CCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEEEEEECCCC
YPTHYWPRVIRLIASGQLPAMKIVTKRVTLDTAVKEGFDVLLDPAGAQLKILIDLSK
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEECC
>Mature Secondary Structure
MRALRFHAAKDLRLDDIAEPKRPGPGQVLVRNRFVGICGTDLHEYSYGPIFIPTEPHPFT
CCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCHHHCCCCCEEECCCCCCCC
GAHGPQVLGHEFGGFVEAIGEGVTSVVVGDRVSIQPLVMPRSGDYFADRGLFHLSTQLAL
CCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEECCCCCCHHCCCEEEEEEEEEE
VGLSWDGGGMADAALVNDYNVQKIPEEMSDEEAALVEPTAVAVYACDRGGVTAGTSVLVT
EEEECCCCCCCCEEEECCCCHHHCCHHHCCCCCEEECCCEEEEEEECCCCCCCCCEEEEE
GAGPIGMLTLLAARAAGATQLFVSDLNDSRLALAKGVLPDVITINPQRDNVGDVVRLQTE
CCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCCCEEEECCCCCCCCCEEEEEEC
GNVGCDVAIECVGNEHALKACVDAVRKQGVVVQTGLHPHENPIDWFQVTFKDLEIKGSWA
CCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEEEEEECCCC
YPTHYWPRVIRLIASGQLPAMKIVTKRVTLDTAVKEGFDVLLDPAGAQLKILIDLSK
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]