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The map label for this gene is yqeC [H]

Identifier: 222102841

GI number: 222102841

Start: 515995

End: 517008

Strand: Reverse

Name: yqeC [H]

Synonym: Avi_7571

Alternate gene names: 222102841

Gene position: 517008-515995 (Counterclockwise)

Preceding gene: 222102842

Following gene: 222102840

Centisome position: 81.83

GC content: 59.96

Gene sequence:

>1014_bases
ATGCAATTGGGAATGGTCGGCCTCGGTCGTATGGGCGCGAACATGGTGCGGCGTCTGATAAAGGCGGGGCATGAATGCGT
TGTCTATGACGTCAATCCGCAAAACGTTGCTTCTCTTGAGGCCGAAGGCGCTGTCGGCGCGGCGAGCTACGCCGATTTTC
TCGCCAAATTGGCGACGCCCCGTGCTGTCTGGCTGATGCTGCCAGCCGCTATCACGGGAAAGGTAGCCCGCGACCTGGCT
GGCGAAATGACGAGCGGCGATATTCTGATCGATGGCGGAAACTCCTATTACCGCGACGCGGTCGATCTCGGAACTGAGCT
TGGTTCTCAAGGTATTTCCTTCGTTGACGTCGGGACCAGTGGCGGGGTCTGGGGGATCGATCGTGGCTATAGCCTGATGA
TCGGCGGTGAGAAGAAAGCCGCGCAGCATCTCGACCCCATCTTTGCGGCGCTTGCTCCCGGAAAAGACGGCGCAGGGGCC
ACGGGCGGCACGGCCGACGCGGGAACGGAAGGCTACCTGCACTGCGGTCCGCCCGGTGCCGGTCACTTCGTCAAGATGGT
GCATAATGGTATCGAATATGGAATCATGGCCGCCTATGCCGAAGGGCTGAACATCCTGAAGGCTGCTGATGCAGGCAGCG
AGGCGCGTGACGCCGATGCCGAAACCGCGCCATTGCGGGATCCGCAATACTACCGTTTCAATCTTGATCTGGTGGCTGTG
ACAGAAGTCTGGCGCCATGGCAGTGTCATTGGCTCCTGGTTGCTTGATCTCACGGCATCCGCGTTGAAGCAGGATCCGCA
ATTGTCAAACTATGGTGGTCGCGTGTCGGATTCAGGCGAAGGCCGTTGGACATTGCAGGCGGCGGTCGAGACTGGAGTAC
CGGCTCCGGTCCTGTCTTCTGCCTTGTTCGGACGCTTCACCTCGCGCGACAACGATGAGTTTGCCAACAAGCTGCTCTCG
GCCATGCGGCACGCCTTTGGCGGTCATGTGGAGAAGCCGGAGAGCACGTCATGA

Upstream 100 bases:

>100_bases
CCAGGAACTGGTGTTCACCTTCTTCTGGGAGGAGGCGGATCTCTGGGAAAATGCCAATTTCAAAGTTCAGATCATAGCTT
AACGTTTGACGGAGATAGAC

Downstream 100 bases:

>100_bases
TGCAAGGCAGATCCGATGCACTCGTCGTGTTCGGCGTGACCGGTGATCTCGCCTATAAGATGATCCTCCCGTCACTTTAC
CAGATGGTGAGGCGAGGCCA

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MQLGMVGLGRMGANMVRRLIKAGHECVVYDVNPQNVASLEAEGAVGAASYADFLAKLATPRAVWLMLPAAITGKVARDLA
GEMTSGDILIDGGNSYYRDAVDLGTELGSQGISFVDVGTSGGVWGIDRGYSLMIGGEKKAAQHLDPIFAALAPGKDGAGA
TGGTADAGTEGYLHCGPPGAGHFVKMVHNGIEYGIMAAYAEGLNILKAADAGSEARDADAETAPLRDPQYYRFNLDLVAV
TEVWRHGSVIGSWLLDLTASALKQDPQLSNYGGRVSDSGEGRWTLQAAVETGVPAPVLSSALFGRFTSRDNDEFANKLLS
AMRHAFGGHVEKPESTS

Sequences:

>Translated_337_residues
MQLGMVGLGRMGANMVRRLIKAGHECVVYDVNPQNVASLEAEGAVGAASYADFLAKLATPRAVWLMLPAAITGKVARDLA
GEMTSGDILIDGGNSYYRDAVDLGTELGSQGISFVDVGTSGGVWGIDRGYSLMIGGEKKAAQHLDPIFAALAPGKDGAGA
TGGTADAGTEGYLHCGPPGAGHFVKMVHNGIEYGIMAAYAEGLNILKAADAGSEARDADAETAPLRDPQYYRFNLDLVAV
TEVWRHGSVIGSWLLDLTASALKQDPQLSNYGGRVSDSGEGRWTLQAAVETGVPAPVLSSALFGRFTSRDNDEFANKLLS
AMRHAFGGHVEKPESTS
>Mature_337_residues
MQLGMVGLGRMGANMVRRLIKAGHECVVYDVNPQNVASLEAEGAVGAASYADFLAKLATPRAVWLMLPAAITGKVARDLA
GEMTSGDILIDGGNSYYRDAVDLGTELGSQGISFVDVGTSGGVWGIDRGYSLMIGGEKKAAQHLDPIFAALAPGKDGAGA
TGGTADAGTEGYLHCGPPGAGHFVKMVHNGIEYGIMAAYAEGLNILKAADAGSEARDADAETAPLRDPQYYRFNLDLVAV
TEVWRHGSVIGSWLLDLTASALKQDPQLSNYGGRVSDSGEGRWTLQAAVETGVPAPVLSSALFGRFTSRDNDEFANKLLS
AMRHAFGGHVEKPESTS

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=343, Percent_Identity=32.9446064139942, Blast_Score=128, Evalue=7e-30,
Organism=Escherichia coli, GI1788341, Length=331, Percent_Identity=30.2114803625378, Blast_Score=147, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17542558, Length=323, Percent_Identity=33.1269349845201, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6321695, Length=331, Percent_Identity=33.8368580060423, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6321977, Length=322, Percent_Identity=31.9875776397516, Blast_Score=129, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24639279, Length=321, Percent_Identity=31.1526479750779, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24655230, Length=207, Percent_Identity=28.5024154589372, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI19922568, Length=207, Percent_Identity=28.5024154589372, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 35233; Mature: 35233

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLGMVGLGRMGANMVRRLIKAGHECVVYDVNPQNVASLEAEGAVGAASYADFLAKLATP
CCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHCCC
RAVWLMLPAAITGKVARDLAGEMTSGDILIDGGNSYYRDAVDLGTELGSQGISFVDVGTS
CEEEEEHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCC
GGVWGIDRGYSLMIGGEKKAAQHLDPIFAALAPGKDGAGATGGTADAGTEGYLHCGPPGA
CCCCEECCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCC
GHFVKMVHNGIEYGIMAAYAEGLNILKAADAGSEARDADAETAPLRDPQYYRFNLDLVAV
HHHHHHHHCCHHHHHHHHHHHCCHHEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEH
TEVWRHGSVIGSWLLDLTASALKQDPQLSNYGGRVSDSGEGRWTLQAAVETGVPAPVLSS
HHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEHHCCCCHHHHHH
ALFGRFTSRDNDEFANKLLSAMRHAFGGHVEKPESTS
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MQLGMVGLGRMGANMVRRLIKAGHECVVYDVNPQNVASLEAEGAVGAASYADFLAKLATP
CCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHCCC
RAVWLMLPAAITGKVARDLAGEMTSGDILIDGGNSYYRDAVDLGTELGSQGISFVDVGTS
CEEEEEHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCC
GGVWGIDRGYSLMIGGEKKAAQHLDPIFAALAPGKDGAGATGGTADAGTEGYLHCGPPGA
CCCCEECCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCC
GHFVKMVHNGIEYGIMAAYAEGLNILKAADAGSEARDADAETAPLRDPQYYRFNLDLVAV
HHHHHHHHCCHHHHHHHHHHHCCHHEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEH
TEVWRHGSVIGSWLLDLTASALKQDPQLSNYGGRVSDSGEGRWTLQAAVETGVPAPVLSS
HHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEHHCCCCHHHHHH
ALFGRFTSRDNDEFANKLLSAMRHAFGGHVEKPESTS
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]