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The map label for this gene is zwf2 [H]

Identifier: 222102840

GI number: 222102840

Start: 514622

End: 515998

Strand: Reverse

Name: zwf2 [H]

Synonym: Avi_7570

Alternate gene names: 222102840

Gene position: 515998-514622 (Counterclockwise)

Preceding gene: 222102841

Following gene: 222102839

Centisome position: 81.67

GC content: 59.33

Gene sequence:

>1377_bases
ATGATGCAAGGCAGATCCGATGCACTCGTCGTGTTCGGCGTGACCGGTGATCTCGCCTATAAGATGATCCTCCCGTCACT
TTACCAGATGGTGAGGCGAGGCCAGTTGAACGAGCCTGTCATCGGTGTGGCGCTCGACGACTGGGATATTGACCGCCTGG
CAGCCCGCGCTCACGATGGCATCAGCAAGCAGTTCGGCACGGTTGACGAGGCCGTTTTTGCCAGGCTGAAGGGATTGCTG
CGCTATGTCAGTGGCGATTACAAAAGCCCGGCCACCTTCGATCGGCTGCGCGAGGCGCTTGGCCCCGCAACGCACCCGCT
TTACTATCTGGCCATCCCGCCTTCGCTTTTCGAGACAGTCATCAAGGCATCGAAGGCGGCTGGCCTTGCTGAGAACGCCC
GGCTGATGGTGGAAAAGCCCTTCGGGCGGGATCTTGCCTCCGCCCAGGCACTCGATAGTGTCTTGCACTCCGTGTTCGAG
GAGGACGCGGTGTTCCGCATCGACCATTTCCTGGGCAAGGAAGCGGTGCAGAACTTGATCTATTTCCGCTTTGCCAACGC
TTTTCTGGAACCGGTGTGGAACCGCACCCACGTCGAAAGCGTGCAGATCACCATGGCTGAGGATTTTGGAATTGCTGGCC
GTGGCAAGTTCTATGACGAGGTTGGATGCATTCGTGACGTCATCCAGAACCACCTGATCAATATTCTCCTGCTGTTGACG
ATTGAACCGCCTGTCAACAACGGTTCTGATGAACTTAGTGACGAAAAGGTCCAGGTTCTCCGGGCCATTCGCCCGCTCTC
GACGCATGACCTCGTCAGGGGACAGTTCCAGGGCTATCACGACGAACCGGGTGTTGCGCCCGGCTCACCTGTCGAGACAT
TTGCCGCCGTGCGCCTGTTCGTGGATACGTGGCGATGGAAGGATGTGCCCTTTTTTATCAGAGCCGGCAAGCACCTGCCG
GTCCGTGCGACAGAAGTTGTCGTGCGGTTTCGCCGCCCGCCCGTTGCTCTTTTCGACGAAGTTACCGCAGCCGAAGCCAA
TTATTTGCGGTTCCGTGTTGGACCGCAGGTGGCAATCGGCATCGGTACGCGCCGTAAAGCGCCGGGCGAGGGGATGGTCG
GTGAATGTGTCGAACTTGGTGCGCTTGATGATACGACCGACGACATGATGCCCTACGAGCGGTTGATCGGCGATGCCCTG
AACGGCAGGCGCCAGCTCTTCACCCGGCAGGACGCGGCTGAGCTGGCCTGGCGCGTGGTGGATCCTGTGCTTGATCTGAG
GGAACAGCCAGACGTCTATCTGCCTGGCACCTGGGGGCCTGCGGATGCCATGAAAGATTTCGCCCCTCCCGGTGGCTGGG
TCGATCCGCAACCATAA

Upstream 100 bases:

>100_bases
GACGCTTCACCTCGCGCGACAACGATGAGTTTGCCAACAAGCTGCTCTCGGCCATGCGGCACGCCTTTGGCGGTCATGTG
GAGAAGCCGGAGAGCACGTC

Downstream 100 bases:

>100_bases
GGAAGACATCTATGGATGAGAAGCCACAGATCGTGCTTGCCGTTGATGTCGGCGGGTCGCATGTGAAAATCATGAACAGT
GTTGACGGCGTGGAAAGCAA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MMQGRSDALVVFGVTGDLAYKMILPSLYQMVRRGQLNEPVIGVALDDWDIDRLAARAHDGISKQFGTVDEAVFARLKGLL
RYVSGDYKSPATFDRLREALGPATHPLYYLAIPPSLFETVIKASKAAGLAENARLMVEKPFGRDLASAQALDSVLHSVFE
EDAVFRIDHFLGKEAVQNLIYFRFANAFLEPVWNRTHVESVQITMAEDFGIAGRGKFYDEVGCIRDVIQNHLINILLLLT
IEPPVNNGSDELSDEKVQVLRAIRPLSTHDLVRGQFQGYHDEPGVAPGSPVETFAAVRLFVDTWRWKDVPFFIRAGKHLP
VRATEVVVRFRRPPVALFDEVTAAEANYLRFRVGPQVAIGIGTRRKAPGEGMVGECVELGALDDTTDDMMPYERLIGDAL
NGRRQLFTRQDAAELAWRVVDPVLDLREQPDVYLPGTWGPADAMKDFAPPGGWVDPQP

Sequences:

>Translated_458_residues
MMQGRSDALVVFGVTGDLAYKMILPSLYQMVRRGQLNEPVIGVALDDWDIDRLAARAHDGISKQFGTVDEAVFARLKGLL
RYVSGDYKSPATFDRLREALGPATHPLYYLAIPPSLFETVIKASKAAGLAENARLMVEKPFGRDLASAQALDSVLHSVFE
EDAVFRIDHFLGKEAVQNLIYFRFANAFLEPVWNRTHVESVQITMAEDFGIAGRGKFYDEVGCIRDVIQNHLINILLLLT
IEPPVNNGSDELSDEKVQVLRAIRPLSTHDLVRGQFQGYHDEPGVAPGSPVETFAAVRLFVDTWRWKDVPFFIRAGKHLP
VRATEVVVRFRRPPVALFDEVTAAEANYLRFRVGPQVAIGIGTRRKAPGEGMVGECVELGALDDTTDDMMPYERLIGDAL
NGRRQLFTRQDAAELAWRVVDPVLDLREQPDVYLPGTWGPADAMKDFAPPGGWVDPQP
>Mature_458_residues
MMQGRSDALVVFGVTGDLAYKMILPSLYQMVRRGQLNEPVIGVALDDWDIDRLAARAHDGISKQFGTVDEAVFARLKGLL
RYVSGDYKSPATFDRLREALGPATHPLYYLAIPPSLFETVIKASKAAGLAENARLMVEKPFGRDLASAQALDSVLHSVFE
EDAVFRIDHFLGKEAVQNLIYFRFANAFLEPVWNRTHVESVQITMAEDFGIAGRGKFYDEVGCIRDVIQNHLINILLLLT
IEPPVNNGSDELSDEKVQVLRAIRPLSTHDLVRGQFQGYHDEPGVAPGSPVETFAAVRLFVDTWRWKDVPFFIRAGKHLP
VRATEVVVRFRRPPVALFDEVTAAEANYLRFRVGPQVAIGIGTRRKAPGEGMVGECVELGALDDTTDDMMPYERLIGDAL
NGRRQLFTRQDAAELAWRVVDPVLDLREQPDVYLPGTWGPADAMKDFAPPGGWVDPQP

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=493, Percent_Identity=36.3083164300203, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI108773793, Length=493, Percent_Identity=36.3083164300203, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI52145310, Length=472, Percent_Identity=29.4491525423729, Blast_Score=169, Evalue=6e-42,
Organism=Escherichia coli, GI1788158, Length=465, Percent_Identity=36.989247311828, Blast_Score=294, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17538218, Length=494, Percent_Identity=35.2226720647773, Blast_Score=271, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6324088, Length=483, Percent_Identity=35.8178053830228, Blast_Score=287, Evalue=3e-78,
Organism=Drosophila melanogaster, GI24643350, Length=465, Percent_Identity=36.989247311828, Blast_Score=271, Evalue=8e-73,
Organism=Drosophila melanogaster, GI24643352, Length=465, Percent_Identity=36.989247311828, Blast_Score=271, Evalue=1e-72,
Organism=Drosophila melanogaster, GI221513548, Length=482, Percent_Identity=28.0082987551867, Blast_Score=178, Evalue=7e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 50997; Mature: 50997

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQGRSDALVVFGVTGDLAYKMILPSLYQMVRRGQLNEPVIGVALDDWDIDRLAARAHDG
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHCC
ISKQFGTVDEAVFARLKGLLRYVSGDYKSPATFDRLREALGPATHPLYYLAIPPSLFETV
HHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEECHHHHHHH
IKASKAAGLAENARLMVEKPFGRDLASAQALDSVLHSVFEEDAVFRIDHFLGKEAVQNLI
HHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
YFRFANAFLEPVWNRTHVESVQITMAEDFGIAGRGKFYDEVGCIRDVIQNHLINILLLLT
HHHHHHHHHHHHCCCCEECEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEE
IEPPVNNGSDELSDEKVQVLRAIRPLSTHDLVRGQFQGYHDEPGVAPGSPVETFAAVRLF
ECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
VDTWRWKDVPFFIRAGKHLPVRATEVVVRFRRPPVALFDEVTAAEANYLRFRVGPQVAIG
HHHHCCCCCCHHEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCEEEEE
IGTRRKAPGEGMVGECVELGALDDTTDDMMPYERLIGDALNGRRQLFTRQDAAELAWRVV
CCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
DPVLDLREQPDVYLPGTWGPADAMKDFAPPGGWVDPQP
HHHHHHCCCCCEEECCCCCHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MMQGRSDALVVFGVTGDLAYKMILPSLYQMVRRGQLNEPVIGVALDDWDIDRLAARAHDG
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHCC
ISKQFGTVDEAVFARLKGLLRYVSGDYKSPATFDRLREALGPATHPLYYLAIPPSLFETV
HHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEECHHHHHHH
IKASKAAGLAENARLMVEKPFGRDLASAQALDSVLHSVFEEDAVFRIDHFLGKEAVQNLI
HHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
YFRFANAFLEPVWNRTHVESVQITMAEDFGIAGRGKFYDEVGCIRDVIQNHLINILLLLT
HHHHHHHHHHHHCCCCEECEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEE
IEPPVNNGSDELSDEKVQVLRAIRPLSTHDLVRGQFQGYHDEPGVAPGSPVETFAAVRLF
ECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
VDTWRWKDVPFFIRAGKHLPVRATEVVVRFRRPPVALFDEVTAAEANYLRFRVGPQVAIG
HHHHCCCCCCHHEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCEEEEE
IGTRRKAPGEGMVGECVELGALDDTTDDMMPYERLIGDALNGRRQLFTRQDAAELAWRVV
CCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
DPVLDLREQPDVYLPGTWGPADAMKDFAPPGGWVDPQP
HHHHHHCCCCCEEECCCCCHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]