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The map label for this gene is hpcE [H]

Identifier: 222102740

GI number: 222102740

Start: 393954

End: 394808

Strand: Direct

Name: hpcE [H]

Synonym: Avi_7423

Alternate gene names: 222102740

Gene position: 393954-394808 (Clockwise)

Preceding gene: 222102739

Following gene: 222102743

Centisome position: 62.36

GC content: 53.8

Gene sequence:

>855_bases
ATGAAACTACTGAGTTTTGAAATCCAGAACCGTAAAAGCTTCGGCGCTGTCATTGATGACGGCGTTATCGATCTTGGGCG
CAAGTTTGAAGGGCGCTATGCAGATCTTCTGGCGGTCCTTGAAGCAGATGCCCTCCGTGAAGTTGAAGCTGCATGTGTCG
GGGTAAAGCCGGACTATGCGTTAACGGATATTACGTTTCTTCCGGTCATCCCCAACCCGCCGAAAATCATCTGTATTGGC
GTGAATTATGAGGCGCACCGCTCTGAAATTGGCAGAGACCCCAGCAAGAAGCCGATGGTTTTTGCGCGGTTCCCAGCCAG
CCAGATTGGCCACATGCAGCCTTTGGTGGCTCCGCCCGAGTCCCATACATTTGACTATGAAGGGGAGATCGCAATCATCA
TCGGCAAACCCGGCCGCCGGATCTCGCAAGCCGATTCTTGGAGCCATATTGCCGGCTATGCGCCTTATAATGACGGCAGT
ATTCGCGAATGGCAGGGGCACACCGGGCAATGGACGCCGGGCAAGAACTGGTATCAAACGGGTGGTTTTGGCCCCTGGAT
GTCAACGCGCGGCGAAATTCCTGACAACGCGCCGCTGCATCTCAAGACCCGCGTCAACGGACAAGAAGTCCAAAGTGCGG
ACGCCAGCCAGATGATTTTCTCTATTCCGGAAATTATCGAGTATTGCTCGATCTTTACCCCGTTGGAAGCGGGCGATGTG
ATCGTTACGGGAACGCCCGGTGGCGTCGGCGTTCGCCGCAACCCGCAACTGTTCCTTAAGGATGGAGACATTGTTGAAGT
TGAGATCTCCGAAATTGGCATCTTGCGTAATTCGATCAAGGCAGAGCAGCTATAA

Upstream 100 bases:

>100_bases
TCCTGCAGGAGTTTCCACTCCCCGGGACGGGAAGACTTTGATTGCCGGTCAACGGTGAATGCTCAATCCCAGAACCGGTA
CAAACAGGAGTGCTTAAGAC

Downstream 100 bases:

>100_bases
AAATCCTATGAGGACAATGATCGGATACGGCTTTATGGCCGTGTTCGATGCCTCCTGAGCAAGGCTTATCTGTTTTCTAT
TATAGCGTTGTGCACCATCG

Product: fumarylacetoacetate (FAA) hydrolase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MKLLSFEIQNRKSFGAVIDDGVIDLGRKFEGRYADLLAVLEADALREVEAACVGVKPDYALTDITFLPVIPNPPKIICIG
VNYEAHRSEIGRDPSKKPMVFARFPASQIGHMQPLVAPPESHTFDYEGEIAIIIGKPGRRISQADSWSHIAGYAPYNDGS
IREWQGHTGQWTPGKNWYQTGGFGPWMSTRGEIPDNAPLHLKTRVNGQEVQSADASQMIFSIPEIIEYCSIFTPLEAGDV
IVTGTPGGVGVRRNPQLFLKDGDIVEVEISEIGILRNSIKAEQL

Sequences:

>Translated_284_residues
MKLLSFEIQNRKSFGAVIDDGVIDLGRKFEGRYADLLAVLEADALREVEAACVGVKPDYALTDITFLPVIPNPPKIICIG
VNYEAHRSEIGRDPSKKPMVFARFPASQIGHMQPLVAPPESHTFDYEGEIAIIIGKPGRRISQADSWSHIAGYAPYNDGS
IREWQGHTGQWTPGKNWYQTGGFGPWMSTRGEIPDNAPLHLKTRVNGQEVQSADASQMIFSIPEIIEYCSIFTPLEAGDV
IVTGTPGGVGVRRNPQLFLKDGDIVEVEISEIGILRNSIKAEQL
>Mature_284_residues
MKLLSFEIQNRKSFGAVIDDGVIDLGRKFEGRYADLLAVLEADALREVEAACVGVKPDYALTDITFLPVIPNPPKIICIG
VNYEAHRSEIGRDPSKKPMVFARFPASQIGHMQPLVAPPESHTFDYEGEIAIIIGKPGRRISQADSWSHIAGYAPYNDGS
IREWQGHTGQWTPGKNWYQTGGFGPWMSTRGEIPDNAPLHLKTRVNGQEVQSADASQMIFSIPEIIEYCSIFTPLEAGDV
IVTGTPGGVGVRRNPQLFLKDGDIVEVEISEIGILRNSIKAEQL

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=225, Percent_Identity=38.6666666666667, Blast_Score=175, Evalue=3e-44,
Organism=Homo sapiens, GI40786394, Length=225, Percent_Identity=38.2222222222222, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI13654274, Length=212, Percent_Identity=30.6603773584906, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI215422413, Length=187, Percent_Identity=32.0855614973262, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI66348062, Length=187, Percent_Identity=32.0855614973262, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1787428, Length=183, Percent_Identity=34.9726775956284, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17557057, Length=204, Percent_Identity=33.8235294117647, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6324161, Length=237, Percent_Identity=28.2700421940928, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28572127, Length=256, Percent_Identity=35.546875, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24663695, Length=250, Percent_Identity=30, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28571789, Length=221, Percent_Identity=31.6742081447964, Blast_Score=100, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 31243; Mature: 31243

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLSFEIQNRKSFGAVIDDGVIDLGRKFEGRYADLLAVLEADALREVEAACVGVKPDYA
CCEEEEEECCCCCCCCEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCE
LTDITFLPVIPNPPKIICIGVNYEAHRSEIGRDPSKKPMVFARFPASQIGHMQPLVAPPE
EEEEEEEEECCCCCEEEEEECCCHHHHHHHCCCCCCCCEEEEECCHHHHCCCCCCCCCCC
SHTFDYEGEIAIIIGKPGRRISQADSWSHIAGYAPYNDGSIREWQGHTGQWTPGKNWYQT
CCCCCCCCCEEEEECCCCCCCCCCCCCCHHCCCCCCCCCCCEECCCCCCCCCCCCCCEEC
GGFGPWMSTRGEIPDNAPLHLKTRVNGQEVQSADASQMIFSIPEIIEYCSIFTPLEAGDV
CCCCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCE
IVTGTPGGVGVRRNPQLFLKDGDIVEVEISEIGILRNSIKAEQL
EEECCCCCCCCCCCCEEEEECCCEEEEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLLSFEIQNRKSFGAVIDDGVIDLGRKFEGRYADLLAVLEADALREVEAACVGVKPDYA
CCEEEEEECCCCCCCCEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCE
LTDITFLPVIPNPPKIICIGVNYEAHRSEIGRDPSKKPMVFARFPASQIGHMQPLVAPPE
EEEEEEEEECCCCCEEEEEECCCHHHHHHHCCCCCCCCEEEEECCHHHHCCCCCCCCCCC
SHTFDYEGEIAIIIGKPGRRISQADSWSHIAGYAPYNDGSIREWQGHTGQWTPGKNWYQT
CCCCCCCCCEEEEECCCCCCCCCCCCCCHHCCCCCCCCCCCEECCCCCCCCCCCCCCEEC
GGFGPWMSTRGEIPDNAPLHLKTRVNGQEVQSADASQMIFSIPEIIEYCSIFTPLEAGDV
CCCCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCE
IVTGTPGGVGVRRNPQLFLKDGDIVEVEISEIGILRNSIKAEQL
EEECCCCCCCCCCCCEEEEECCCEEEEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]