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The map label for this gene is hsaA [H]

Identifier: 222102735

GI number: 222102735

Start: 389768

End: 390919

Strand: Direct

Name: hsaA [H]

Synonym: Avi_7417

Alternate gene names: 222102735

Gene position: 389768-390919 (Clockwise)

Preceding gene: 222102733

Following gene: 222102736

Centisome position: 61.69

GC content: 58.51

Gene sequence:

>1152_bases
ATGATCGCGCGAGCTACGGGCATGATCGGCACACTCAGAGCGCGCCAGGCGGATGCCGAGGCCGGTGGGCGCTTGCTGGA
GGTTACCCATCAGGAGTTCATGCGGGCTGGATTCTATCGTGTTGTCCAGCCACGTCGCTTCGGTGGCTATGAATTTGACC
TGACCACTTACATGAAGGTGATGATGGAAATCGCCCGCGGCTGCCCTTCGAGCGGCTGGGTTCTGGCGCTTGTGTCCGGC
CATCCCATCATGCTTGCCGACTTTAGCGAACGTGCGCAGATCGAAGCCTATGGCGATGACGGTGATTATCGTTGTCCCTC
GGTTGGTTCGCCGGTTCCGGTAACGCTTGAAAAGGGCGGATTTCGTGTCAGCGGCGGGTGGGACTATGCATCGGGTTGCG
ATGTCTCCACCCACGCGATGGTCAGTGGTCTGACGCCGGAAGCCGACGGCAGCATGACGCCCCGATTGATGCTGGTTGAC
CGTTCTGATTATGAAATCGTCAATAACTGGGACATGATTGGGATGCAGGGCACCGGCTCTCGTCGGCTGGTCGTCAAGGA
TGTGTTTGTGCCGGAATACCGCACCGCTCCCATCGTTATGTGGCGGGGTGAGCGCGGCGCGGCTGTACATGCAAACCCAA
TGTATAACGGCCGTAAAGCATCCTATTTTGTCATTGAGCTGGGTGCGGTTGTCGTCGGCGCTGTGAAGGGTGCGCTGGAT
ATTTTCGAAGACATCTTGCGCAACAAGCCGATGCGTTTCTCATCAAAGCAGCGCTTGTACGAGAGCCATGAGTTCCAGCA
ATATTATGGCGATGCCCAAACCAAGATCGATTCCGCCGAAGCGCTGCTTTTGAAGGTGACGGAACGCTATCTGGAAGCGT
GCAGCCTGCACCAGGAAACTGGCGAGGGTTTTACCGAAGAGACCGACAGACGGCTCTTTGCTGCCGCCCAGGAGGCCTGC
CGCCTTGCATGGGACGGGTTGGAAATCATCTTCACCACGGCGGGCACGAGCACCGGGGCCAAGCAATCCATGCTCGCCCG
TATCTATCGAGACGCGGCCGTGCAGAAAACCCATTTTGTTCAGCAACGGTCGCGCACGGCCGTCAACGCTGCACGCCTTC
ACTTCGGGCTTGCCCCGCTCAGCCCGTTCTGA

Upstream 100 bases:

>100_bases
GGGCTCATGCGGAGGGTGAGGTGCGTTAATGGTAAATGTTGAGCGAAAGTTCGAAACTGTTGGATTGGAGCCGCCGGAGC
CGAACTTGCAGCCAGATGAG

Downstream 100 bases:

>100_bases
CTGCTATGGAGACCATCTTGACATCAGCAGGGTCGTCGCTCGATCCAGACTGGATCCGTGCGGAGTTTAAACGTCGGCGT
GGTCACTGGCATGATGACTG

Product: oxidoreductase

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MIARATGMIGTLRARQADAEAGGRLLEVTHQEFMRAGFYRVVQPRRFGGYEFDLTTYMKVMMEIARGCPSSGWVLALVSG
HPIMLADFSERAQIEAYGDDGDYRCPSVGSPVPVTLEKGGFRVSGGWDYASGCDVSTHAMVSGLTPEADGSMTPRLMLVD
RSDYEIVNNWDMIGMQGTGSRRLVVKDVFVPEYRTAPIVMWRGERGAAVHANPMYNGRKASYFVIELGAVVVGAVKGALD
IFEDILRNKPMRFSSKQRLYESHEFQQYYGDAQTKIDSAEALLLKVTERYLEACSLHQETGEGFTEETDRRLFAAAQEAC
RLAWDGLEIIFTTAGTSTGAKQSMLARIYRDAAVQKTHFVQQRSRTAVNAARLHFGLAPLSPF

Sequences:

>Translated_383_residues
MIARATGMIGTLRARQADAEAGGRLLEVTHQEFMRAGFYRVVQPRRFGGYEFDLTTYMKVMMEIARGCPSSGWVLALVSG
HPIMLADFSERAQIEAYGDDGDYRCPSVGSPVPVTLEKGGFRVSGGWDYASGCDVSTHAMVSGLTPEADGSMTPRLMLVD
RSDYEIVNNWDMIGMQGTGSRRLVVKDVFVPEYRTAPIVMWRGERGAAVHANPMYNGRKASYFVIELGAVVVGAVKGALD
IFEDILRNKPMRFSSKQRLYESHEFQQYYGDAQTKIDSAEALLLKVTERYLEACSLHQETGEGFTEETDRRLFAAAQEAC
RLAWDGLEIIFTTAGTSTGAKQSMLARIYRDAAVQKTHFVQQRSRTAVNAARLHFGLAPLSPF
>Mature_383_residues
MIARATGMIGTLRARQADAEAGGRLLEVTHQEFMRAGFYRVVQPRRFGGYEFDLTTYMKVMMEIARGCPSSGWVLALVSG
HPIMLADFSERAQIEAYGDDGDYRCPSVGSPVPVTLEKGGFRVSGGWDYASGCDVSTHAMVSGLTPEADGSMTPRLMLVD
RSDYEIVNNWDMIGMQGTGSRRLVVKDVFVPEYRTAPIVMWRGERGAAVHANPMYNGRKASYFVIELGAVVVGAVKGALD
IFEDILRNKPMRFSSKQRLYESHEFQQYYGDAQTKIDSAEALLLKVTERYLEACSLHQETGEGFTEETDRRLFAAAQEAC
RLAWDGLEIIFTTAGTSTGAKQSMLARIYRDAAVQKTHFVQQRSRTAVNAARLHFGLAPLSPF

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 42451; Mature: 42451

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIARATGMIGTLRARQADAEAGGRLLEVTHQEFMRAGFYRVVQPRRFGGYEFDLTTYMKV
CCCCCCCCHHHHHHHHCCHHHCCEEEEHHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHH
MMEIARGCPSSGWVLALVSGHPIMLADFSERAQIEAYGDDGDYRCPSVGSPVPVTLEKGG
HHHHHHCCCCCCCEEEEECCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCCEEEEECCC
FRVSGGWDYASGCDVSTHAMVSGLTPEADGSMTPRLMLVDRSDYEIVNNWDMIGMQGTGS
EEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEECCCCEEECCCEEEEECCCCC
RRLVVKDVFVPEYRTAPIVMWRGERGAAVHANPMYNGRKASYFVIELGAVVVGAVKGALD
CEEEEEEEECCCCCCCCEEEEECCCCCEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
IFEDILRNKPMRFSSKQRLYESHEFQQYYGDAQTKIDSAEALLLKVTERYLEACSLHQET
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
GEGFTEETDRRLFAAAQEACRLAWDGLEIIFTTAGTSTGAKQSMLARIYRDAAVQKTHFV
CCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
QQRSRTAVNAARLHFGLAPLSPF
HHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIARATGMIGTLRARQADAEAGGRLLEVTHQEFMRAGFYRVVQPRRFGGYEFDLTTYMKV
CCCCCCCCHHHHHHHHCCHHHCCEEEEHHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHH
MMEIARGCPSSGWVLALVSGHPIMLADFSERAQIEAYGDDGDYRCPSVGSPVPVTLEKGG
HHHHHHCCCCCCCEEEEECCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCCEEEEECCC
FRVSGGWDYASGCDVSTHAMVSGLTPEADGSMTPRLMLVDRSDYEIVNNWDMIGMQGTGS
EEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEECCCCEEECCCEEEEECCCCC
RRLVVKDVFVPEYRTAPIVMWRGERGAAVHANPMYNGRKASYFVIELGAVVVGAVKGALD
CEEEEEEEECCCCCCCCEEEEECCCCCEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
IFEDILRNKPMRFSSKQRLYESHEFQQYYGDAQTKIDSAEALLLKVTERYLEACSLHQET
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
GEGFTEETDRRLFAAAQEACRLAWDGLEIIFTTAGTSTGAKQSMLARIYRDAAVQKTHFV
CCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
QQRSRTAVNAARLHFGLAPLSPF
HHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA