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The map label for this gene is mdtA [H]

Identifier: 222102630

GI number: 222102630

Start: 239488

End: 240621

Strand: Direct

Name: mdtA [H]

Synonym: Avi_7282

Alternate gene names: 222102630

Gene position: 239488-240621 (Clockwise)

Preceding gene: 222102629

Following gene: 222102631

Centisome position: 37.91

GC content: 54.41

Gene sequence:

>1134_bases
TTGATGCGCAAATTTTCTACCAGGTCTCTCGCGACAGTGCTCGCCTTGGGGTCGTTTTTCATGGTCGCCTTCGCCGCCCG
AAGCCAGGATGGTGAACAAAAGACGGATCAAGCGGCCGCACTGAGCGTGAGCTTGGTCAAGCCGGCGGTTTTGCTGTGGC
CTGTTATTATTCCCGCAAGTGGTCGACTTGCCGCCTGGCATGAAGCGACAATTGCAGCAGAGACCAGCGGTATGAAGGTC
ACCGAAGTTAAAGCAGATGTTGGCGCACACGTAAAAAAGGGCGATTTGCTGGTGCAGTTTGCGCCGGAATCTGCCCAGGC
TGACCTGGAGCAACAACAAGCGAACGTTGAAAAAGCGGAAGCCGATCTTGATCAAGCAATAGCGAATGGTGACCGCGCCC
GAGGATTGACAAGTTCTGGCGCATTATCAAGCCAACAGATAAAGGAATATCTGATTACCGAGCGTAAAGCGAAAGCCTCC
CTCTTTTCGGCAAAGGCTGCGTTGGCTTCATCTCAGCTCACCTTGGACAGGACCAAGGTTTACGCAGTGGACGACGGGGT
CATATCCGAGCGCTCCGCATCTCTTGGTGATGTGGTGACCGCCGGTGGCGAGTTGTTCAAGCTGATCCGACAAAATCGTA
TCGAATGGAAAGCGGAATTGCCATTTAATCGGCTGGCTGACGTCAAGGTCGGAACAAAAGCTGTCATCCCAACGCCGCGC
GGCGACGTGCACGGTGAGGTCAGGATGGTGGCACCTTCGATGTCAACCGACAATGGTCGCGTGATCGTCTACGTGACGCT
GAATCCCACTCCAGGGATGGATGCCCCAAAGATCGGCATCCTGGCCAGCGGCTACTTTGAATTCAACAACACGGATGCGC
TCACAGTGCCCGCTGCTGCCGTCACCCTCAAGGACGGCTTCTCATATGTGTTCATTTTGAACTCGGCAGACAAAAAAACG
GTGACACGCAAGCGGGTAAAGCCTGGACGGCGGCAGGACGATCGTGTTGAAATCATTTCAGGAATTGAGAAGACTGACGA
CGTTGTTGCGTCAGGCGGCGTCTTCCTTGCAGATGGCTCTGTAGTCCATGTTGTCGACAGCAATGATGCGGCAACGACGG
AGGAATCGAAGTGA

Upstream 100 bases:

>100_bases
TCAAGCGCGACATCGTCCGCTACTGGGTCGCACCCCGCACGTCTTCAGGAGGCGGATTCTCCGCCCCGGTGGGTGCCCCG
ACCTCCGCAAAGGGAATTTA

Downstream 100 bases:

>100_bases
ATTTCTCCTCTTGGTCTATTCGCAACCCTGTCCCCCCGTTGCTGCTATTTGCATTGTTGACGGCCTGTGGCCTTTGGGCG
TTCAATCGTCTCGACATACA

Product: HlyD family secretion protein

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MMRKFSTRSLATVLALGSFFMVAFAARSQDGEQKTDQAAALSVSLVKPAVLLWPVIIPASGRLAAWHEATIAAETSGMKV
TEVKADVGAHVKKGDLLVQFAPESAQADLEQQQANVEKAEADLDQAIANGDRARGLTSSGALSSQQIKEYLITERKAKAS
LFSAKAALASSQLTLDRTKVYAVDDGVISERSASLGDVVTAGGELFKLIRQNRIEWKAELPFNRLADVKVGTKAVIPTPR
GDVHGEVRMVAPSMSTDNGRVIVYVTLNPTPGMDAPKIGILASGYFEFNNTDALTVPAAAVTLKDGFSYVFILNSADKKT
VTRKRVKPGRRQDDRVEIISGIEKTDDVVASGGVFLADGSVVHVVDSNDAATTEESK

Sequences:

>Translated_377_residues
MMRKFSTRSLATVLALGSFFMVAFAARSQDGEQKTDQAAALSVSLVKPAVLLWPVIIPASGRLAAWHEATIAAETSGMKV
TEVKADVGAHVKKGDLLVQFAPESAQADLEQQQANVEKAEADLDQAIANGDRARGLTSSGALSSQQIKEYLITERKAKAS
LFSAKAALASSQLTLDRTKVYAVDDGVISERSASLGDVVTAGGELFKLIRQNRIEWKAELPFNRLADVKVGTKAVIPTPR
GDVHGEVRMVAPSMSTDNGRVIVYVTLNPTPGMDAPKIGILASGYFEFNNTDALTVPAAAVTLKDGFSYVFILNSADKKT
VTRKRVKPGRRQDDRVEIISGIEKTDDVVASGGVFLADGSVVHVVDSNDAATTEESK
>Mature_377_residues
MMRKFSTRSLATVLALGSFFMVAFAARSQDGEQKTDQAAALSVSLVKPAVLLWPVIIPASGRLAAWHEATIAAETSGMKV
TEVKADVGAHVKKGDLLVQFAPESAQADLEQQQANVEKAEADLDQAIANGDRARGLTSSGALSSQQIKEYLITERKAKAS
LFSAKAALASSQLTLDRTKVYAVDDGVISERSASLGDVVTAGGELFKLIRQNRIEWKAELPFNRLADVKVGTKAVIPTPR
GDVHGEVRMVAPSMSTDNGRVIVYVTLNPTPGMDAPKIGILASGYFEFNNTDALTVPAAAVTLKDGFSYVFILNSADKKT
VTRKRVKPGRRQDDRVEIISGIEKTDDVVASGGVFLADGSVVHVVDSNDAATTEESK

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=335, Percent_Identity=24.4776119402985, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081796, Length=331, Percent_Identity=25.3776435045317, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40205; Mature: 40205

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRKFSTRSLATVLALGSFFMVAFAARSQDGEQKTDQAAALSVSLVKPAVLLWPVIIPAS
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEHHHHCCHHHEEHEEECCC
GRLAAWHEATIAAETSGMKVTEVKADVGAHVKKGDLLVQFAPESAQADLEQQQANVEKAE
CCEEEEECEEEEECCCCCEEEEEECCCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHHH
ADLDQAIANGDRARGLTSSGALSSQQIKEYLITERKAKASLFSAKAALASSQLTLDRTKV
HHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECEEE
YAVDDGVISERSASLGDVVTAGGELFKLIRQNRIEWKAELPFNRLADVKVGTKAVIPTPR
EEECCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCEEECCCHHHHCCCCCCCEEECCCCC
GDVHGEVRMVAPSMSTDNGRVIVYVTLNPTPGMDAPKIGILASGYFEFNNTDALTVPAAA
CCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCEEEEEECEEEECCCCEEEECEEE
VTLKDGFSYVFILNSADKKTVTRKRVKPGRRQDDRVEIISGIEKTDDVVASGGVFLADGS
EEEECCCEEEEEEECCCCHHHHHHHCCCCCCCCCHHHHHHCCCHHCHHEECCCEEEECCC
VVHVVDSNDAATTEESK
EEEEEECCCCCCCCCCC
>Mature Secondary Structure
MMRKFSTRSLATVLALGSFFMVAFAARSQDGEQKTDQAAALSVSLVKPAVLLWPVIIPAS
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEHHHHCCHHHEEHEEECCC
GRLAAWHEATIAAETSGMKVTEVKADVGAHVKKGDLLVQFAPESAQADLEQQQANVEKAE
CCEEEEECEEEEECCCCCEEEEEECCCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHHH
ADLDQAIANGDRARGLTSSGALSSQQIKEYLITERKAKASLFSAKAALASSQLTLDRTKV
HHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECEEE
YAVDDGVISERSASLGDVVTAGGELFKLIRQNRIEWKAELPFNRLADVKVGTKAVIPTPR
EEECCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCEEECCCHHHHCCCCCCCEEECCCCC
GDVHGEVRMVAPSMSTDNGRVIVYVTLNPTPGMDAPKIGILASGYFEFNNTDALTVPAAA
CCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCEEEEEECEEEECCCCEEEECEEE
VTLKDGFSYVFILNSADKKTVTRKRVKPGRRQDDRVEIISGIEKTDDVVASGGVFLADGS
EEEECCCEEEEEEECCCCHHHHHHHCCCCCCCCCHHHHHHCCCHHCHHEECCCEEEECCC
VVHVVDSNDAATTEESK
EEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA