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The map label for this gene is glcR [H]

Identifier: 222102616

GI number: 222102616

Start: 222521

End: 223282

Strand: Reverse

Name: glcR [H]

Synonym: Avi_7268

Alternate gene names: 222102616

Gene position: 223282-222521 (Counterclockwise)

Preceding gene: 222102617

Following gene: 222102615

Centisome position: 35.34

GC content: 56.3

Gene sequence:

>762_bases
ATGAGTTTTACGGAAAACCGCATCAAACACATTCTGGAGATGCTGAAACTGCATCAAAGAGTGACTGTTGTTGCACTGTC
CGAGCAGTTGCAGGTCAGCCACGAATCCATCCGTCGCGATTTAAAGGAGCTGGAGATCCGTGGCTATGCGCGTCGGGTCT
ATGGTGGCGCCGTAATCGACGGACATGACAGCGACCAACCGTTCGGTGAGCGTATCCGTGTCAGCGCCCGGGAAAAAGCT
CGCATCGGCGAGGCTGCGGCCTCCATGGTCGAAAACGGCATGAAGATTTTTATCGATACCGGCACCACGACACTGGCCTG
CCTGAAACATCTGGAGTCCCGCAAGGATGTGACAATTGTCAGCAACTCCATTGCGGTTGCGGCCCATTTTTTCCCCTACC
CCGATGCCAGCGTGCGGGTTCTGGGCGGGCGCATGCGACCGGAATATCAGGCGACCTACGGCCATGAGACGGTTGCGGCC
CTCAAGGAGCATTTTTTCGACCTGGCCATTATCGCTATCAGTGCCATCCACCTGGAGCGGGGCTTTATGGACTTTGGCGA
GGATGAAGCCGTACTGCGCCGCATTGCCCGTGGGCAGGCCAGCCGCTCCATCATTGTGGCGGACAGCTCAAAATTCGGGC
GGCTCGGCTCTATCCATACCTTTGGCCTGAGCGAGATTGACGCCGTGGTGACCAGCGGTGTGCTGCCGAAAGACTTTTCC
GATTATTTTTCGCAATCAAACGTGGACATCATCAATGCCTGA

Upstream 100 bases:

>100_bases
GGAACAGCGCCGGACAAAGGATCGCTTGTAGAGGCTGGCCCCTGACGAAAGACAGACTCCATATTGAAACAGGCAGAGAA
CAGCAGGAACAAACAAGCCC

Downstream 100 bases:

>100_bases
AGCGTCTTCAAAATCATCCAAAGCGCCTATTAATACCAAGAGGTTTCAGGCGATGGTCGATACATTGTCATCCTTCGGCG
GCGGTCCGGACGGTTCCATG

Product: transcriptional regulator DeoR family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MSFTENRIKHILEMLKLHQRVTVVALSEQLQVSHESIRRDLKELEIRGYARRVYGGAVIDGHDSDQPFGERIRVSAREKA
RIGEAAASMVENGMKIFIDTGTTTLACLKHLESRKDVTIVSNSIAVAAHFFPYPDASVRVLGGRMRPEYQATYGHETVAA
LKEHFFDLAIIAISAIHLERGFMDFGEDEAVLRRIARGQASRSIIVADSSKFGRLGSIHTFGLSEIDAVVTSGVLPKDFS
DYFSQSNVDIINA

Sequences:

>Translated_253_residues
MSFTENRIKHILEMLKLHQRVTVVALSEQLQVSHESIRRDLKELEIRGYARRVYGGAVIDGHDSDQPFGERIRVSAREKA
RIGEAAASMVENGMKIFIDTGTTTLACLKHLESRKDVTIVSNSIAVAAHFFPYPDASVRVLGGRMRPEYQATYGHETVAA
LKEHFFDLAIIAISAIHLERGFMDFGEDEAVLRRIARGQASRSIIVADSSKFGRLGSIHTFGLSEIDAVVTSGVLPKDFS
DYFSQSNVDIINA
>Mature_252_residues
SFTENRIKHILEMLKLHQRVTVVALSEQLQVSHESIRRDLKELEIRGYARRVYGGAVIDGHDSDQPFGERIRVSAREKAR
IGEAAASMVENGMKIFIDTGTTTLACLKHLESRKDVTIVSNSIAVAAHFFPYPDASVRVLGGRMRPEYQATYGHETVAAL
KEHFFDLAIIAISAIHLERGFMDFGEDEAVLRRIARGQASRSIIVADSSKFGRLGSIHTFGLSEIDAVVTSGVLPKDFSD
YFSQSNVDIINA

Specific function: Plays a role in carbon catabolite repression (CCR). Specifically required for transcriptional repression of the levanase operon by glucose but not by other sugars [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI226510968, Length=244, Percent_Identity=29.5081967213115, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1789519, Length=254, Percent_Identity=31.8897637795276, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789829, Length=226, Percent_Identity=30.0884955752212, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1788069, Length=249, Percent_Identity=26.9076305220884, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789059, Length=242, Percent_Identity=27.2727272727273, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI87082344, Length=255, Percent_Identity=25.4901960784314, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1789170, Length=228, Percent_Identity=28.0701754385965, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787540, Length=231, Percent_Identity=30.3030303030303, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1790753, Length=249, Percent_Identity=22.4899598393574, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787063, Length=246, Percent_Identity=23.9837398373984, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28078; Mature: 27947

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTENRIKHILEMLKLHQRVTVVALSEQLQVSHESIRRDLKELEIRGYARRVYGGAVID
CCCCHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEC
GHDSDQPFGERIRVSAREKARIGEAAASMVENGMKIFIDTGTTTLACLKHLESRKDVTIV
CCCCCCCCCHHEEECHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCEEEE
SNSIAVAAHFFPYPDASVRVLGGRMRPEYQATYGHETVAALKEHFFDLAIIAISAIHLER
ECCEEEEEEECCCCCCCEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GFMDFGEDEAVLRRIARGQASRSIIVADSSKFGRLGSIHTFGLSEIDAVVTSGVLPKDFS
CCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEECCHHHHHHHHHCCCCCCCHH
DYFSQSNVDIINA
HHHCCCCCEEECC
>Mature Secondary Structure 
SFTENRIKHILEMLKLHQRVTVVALSEQLQVSHESIRRDLKELEIRGYARRVYGGAVID
CCCHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEC
GHDSDQPFGERIRVSAREKARIGEAAASMVENGMKIFIDTGTTTLACLKHLESRKDVTIV
CCCCCCCCCHHEEECHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCEEEE
SNSIAVAAHFFPYPDASVRVLGGRMRPEYQATYGHETVAALKEHFFDLAIIAISAIHLER
ECCEEEEEEECCCCCCCEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GFMDFGEDEAVLRRIARGQASRSIIVADSSKFGRLGSIHTFGLSEIDAVVTSGVLPKDFS
CCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEECCHHHHHHHHHCCCCCCCHH
DYFSQSNVDIINA
HHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]