Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 222097268

GI number: 222097268

Start: 3570880

End: 3571512

Strand: Reverse

Name: uppS [H]

Synonym: BCQ_3608

Alternate gene names: 222097268

Gene position: 3571512-3570880 (Counterclockwise)

Preceding gene: 222097269

Following gene: 222097267

Centisome position: 68.5

GC content: 39.18

Gene sequence:

>633_bases
ATGCCTCGTATTGCGGGACATCATGAAGGCATGCAAGTTGTAAAGAAAATCACAAAATTTGCAAGCAAACTTAATGTGAA
AGTATTAACTCTTTATGCTTTTTCAACTGAGAACTGGAAAAGACCAAAAAAGGAAGTTGATTATTTAATGAAGCTTCCGG
AAGAATTTTTAGGTACATTTTTACCAGAATTGATTGAAGAGAACGTACAAGTCCGTGTAATAGGGCAACAAGATCGTCTT
CCTACGCATACACGCAGAGCGATGGAAAAGGCCATGGAAGAGACGAAAGAGAATACGGGATTAATTCTGAATTTCGCGTT
AAACTATGGAAGTCGAGATGAAATCGTTTCTGCTGTGCAACATATGATGAAAGATCGTGAGGAAGGAAAAGTTCGTGTTG
AAGATGTAAGCGAAGAAATGCTTTCTTCCTACTTAATGACGAGTTCTTTACCTGACCCAGAATTGTTAATCCGTACGAGC
GGAGAGCTACGTATTAGTAATTTCATGTTATGGCAAATTGCATATTCGGAATTTTGGTTTACAGATGTGTATTGGCCAGA
TTTTACCGAGGAACATTTGCTAAATGCGATTACAGACTTTCAGCATAGAGGGCGCAGATTCGGAGGCGTGTAG

Upstream 100 bases:

>100_bases
ATCGTTTGATCATCTCGTTGAAGAAGTGAAAAAAGGATACATCCCAGAACATATTGCCATCATTATGGATGGTAATGGAA
GGTGGGCAAAGAGGAGAGCG

Downstream 100 bases:

>100_bases
AAAGAGAGGGTTTGGTAGTGAAACAGAGAATTATTACTGGAGTGGTTGCTGCCGCGCTATTCATTCCCATCGTAATTTAC
GGTGGCGTGCCTTTTACGGT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MPRIAGHHEGMQVVKKITKFASKLNVKVLTLYAFSTENWKRPKKEVDYLMKLPEEFLGTFLPELIEENVQVRVIGQQDRL
PTHTRRAMEKAMEETKENTGLILNFALNYGSRDEIVSAVQHMMKDREEGKVRVEDVSEEMLSSYLMTSSLPDPELLIRTS
GELRISNFMLWQIAYSEFWFTDVYWPDFTEEHLLNAITDFQHRGRRFGGV

Sequences:

>Translated_210_residues
MPRIAGHHEGMQVVKKITKFASKLNVKVLTLYAFSTENWKRPKKEVDYLMKLPEEFLGTFLPELIEENVQVRVIGQQDRL
PTHTRRAMEKAMEETKENTGLILNFALNYGSRDEIVSAVQHMMKDREEGKVRVEDVSEEMLSSYLMTSSLPDPELLIRTS
GELRISNFMLWQIAYSEFWFTDVYWPDFTEEHLLNAITDFQHRGRRFGGV
>Mature_209_residues
PRIAGHHEGMQVVKKITKFASKLNVKVLTLYAFSTENWKRPKKEVDYLMKLPEEFLGTFLPELIEENVQVRVIGQQDRLP
THTRRAMEKAMEETKENTGLILNFALNYGSRDEIVSAVQHMMKDREEGKVRVEDVSEEMLSSYLMTSSLPDPELLIRTSG
ELRISNFMLWQIAYSEFWFTDVYWPDFTEEHLLNAITDFQHRGRRFGGV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=202, Percent_Identity=37.6237623762376, Blast_Score=137, Evalue=5e-33,
Organism=Homo sapiens, GI45580742, Length=202, Percent_Identity=37.6237623762376, Blast_Score=137, Evalue=5e-33,
Organism=Escherichia coli, GI1786371, Length=208, Percent_Identity=42.7884615384615, Blast_Score=181, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71993029, Length=203, Percent_Identity=34.4827586206897, Blast_Score=130, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6319474, Length=188, Percent_Identity=32.4468085106383, Blast_Score=95, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323748, Length=198, Percent_Identity=29.7979797979798, Blast_Score=92, Evalue=5e-20,
Organism=Drosophila melanogaster, GI18857969, Length=204, Percent_Identity=36.7647058823529, Blast_Score=138, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 24563; Mature: 24431

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRIAGHHEGMQVVKKITKFASKLNVKVLTLYAFSTENWKRPKKEVDYLMKLPEEFLGTF
CCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHCHHHHHHHH
LPELIEENVQVRVIGQQDRLPTHTRRAMEKAMEETKENTGLILNFALNYGSRDEIVSAVQ
HHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHH
HMMKDREEGKVRVEDVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWF
HHHHHHHCCCEEHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHE
TDVYWPDFTEEHLLNAITDFQHRGRRFGGV
EECCCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PRIAGHHEGMQVVKKITKFASKLNVKVLTLYAFSTENWKRPKKEVDYLMKLPEEFLGTF
CCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHCHHHHHHHH
LPELIEENVQVRVIGQQDRLPTHTRRAMEKAMEETKENTGLILNFALNYGSRDEIVSAVQ
HHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHH
HMMKDREEGKVRVEDVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWF
HHHHHHHCCCEEHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHE
TDVYWPDFTEEHLLNAITDFQHRGRRFGGV
EECCCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]