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The map label for this gene is fadD [H]

Identifier: 222097085

GI number: 222097085

Start: 3371759

End: 3373198

Strand: Reverse

Name: fadD [H]

Synonym: BCQ_3425

Alternate gene names: 222097085

Gene position: 3373198-3371759 (Counterclockwise)

Preceding gene: 222097086

Following gene: 222097084

Centisome position: 64.69

GC content: 34.31

Gene sequence:

>1440_bases
ATGGGTATTACAAAAGAATATAAAAAGCATGCCTCTTTACAACCAAATAAAATAGCAATTAAGGAAAATGATAGAGTTTT
AACATATGAAGATTGGTACGAGTCAGTATGTAAAGTAGCGAATTGGTTGCACGCAACAGAATCGAAGAGTAAAAGAGTAG
CAATTGTATTAGAAAATCGTATGGAGTTTTTACAACTATTTGCAGGTGCCGCTATGGCCGGATGGGTTTGTGTGCCATTA
GATATAAAATGGAAAAAGGATGAGCTAAAGGAAAGACTAGCAATCAGTAATTCAGATATGATTATTGCGGAACGATATAA
ATTAAATGATATTTCCGATGAAGAAGGAAGAATAATTGAAATTGATAAATGGAAACAAATAATAGAGAACTATCTTCCTA
CAGAGCACATTGTAGAAAGTTTACAAGATGCTCCTTTTTATATGGGATTTACATCAGGATCAACAGGAAAGGCAAAGGCA
TTTTTACGTGCGCAACAATCGTGGGTTCATAGTTTTAATTGTAATATACATGACTTTCATATGAAAAAAGAAGACTCTAT
TTTAATAGCTGGAACGCTCGTTCACTCTCTTTTCTTATACGGTGCAATAAGTGCATTATATATAGGACAAACCGTACATA
TTATGAGGAATTTTATTCCAAATCAAGTGTTAGATAAGTTAGAAACTGAAAATATTTCGGTCATGTATACCGTACCAACA
ATGCTGGAATCTTTATATAAAGAAAATAGAGTGATAGAAAATGAAATGAAAATAATTTCGTCAGGAGCGAAGTGGGAAGC
TGAAGCGAAAGAAAAAATAAAGAGTATATTTCCTTATGCGAAAAGATATGAATTTTACGGTGCATCGGAACTGAGTTTTG
TAACAGCATTAGTTGATGAAGAGAGCGAAAGAAGGCCAAATTCAGTAGGGAAACCTTGTCACAATGTGCAAGTTCGAGTA
TGTAATGAGGCAGGAAAAGAAGTACAGAAAGGAGAGATAGGAACTGTTTATGTGAAAAGTGATCAGTTTTTTATGGGATA
CATAATAGATGGGGTTTTAGCACGGGAGTTGAATGCAGATGGCTGGATGACAGTGCGAGATGTAGGTTATGAAGATGAAG
AAGGATTTATTTATATTGTCGGTAGAGAGAAGAATATGATTTTATTTGGAGGAATTAATATTTTCCCAGAAGAAATAGAA
AGCGTATTACATGAACATCCAGCTGTTGATGAAATAGTTGTAATTGGTGTGGAAGATAGTTACTGGGGTGAAAAACCTGT
CGCCATCGTAAAAGGAAGTGCTACGAAGCAACAATTAAAAAGTTTTTGCTTACAACGATTATCCTCTTTTAAAATACCGA
AAGAATGGTATTTCGTTGATGAAATACCGTATACAAATAGCGGAAAAAATCGCTCGTATGGCAGCAAAAAGTATAATTGA

Upstream 100 bases:

>100_bases
CTCTAAAGAGAAGCAAATATACAAATGCGGGATAAGAAAGAGAAGAAACACGTTCGTTGCGTGTTTCTTTTTATTATTTT
GGAAAGAAAGGACGTCTCAT

Downstream 100 bases:

>100_bases
AAACCGGGAGAAGATATATGAATAGAGCGGTTATTGTAGAGGCGAAAAGAACTCCTATCGGTAAGAAGAATGGGATGTTA
AAAAACTATGAAGTTCAGCA

Product: acyl-CoA synthetase

Products: AMP; diphosphate; acyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MGITKEYKKHASLQPNKIAIKENDRVLTYEDWYESVCKVANWLHATESKSKRVAIVLENRMEFLQLFAGAAMAGWVCVPL
DIKWKKDELKERLAISNSDMIIAERYKLNDISDEEGRIIEIDKWKQIIENYLPTEHIVESLQDAPFYMGFTSGSTGKAKA
FLRAQQSWVHSFNCNIHDFHMKKEDSILIAGTLVHSLFLYGAISALYIGQTVHIMRNFIPNQVLDKLETENISVMYTVPT
MLESLYKENRVIENEMKIISSGAKWEAEAKEKIKSIFPYAKRYEFYGASELSFVTALVDEESERRPNSVGKPCHNVQVRV
CNEAGKEVQKGEIGTVYVKSDQFFMGYIIDGVLARELNADGWMTVRDVGYEDEEGFIYIVGREKNMILFGGINIFPEEIE
SVLHEHPAVDEIVVIGVEDSYWGEKPVAIVKGSATKQQLKSFCLQRLSSFKIPKEWYFVDEIPYTNSGKNRSYGSKKYN

Sequences:

>Translated_479_residues
MGITKEYKKHASLQPNKIAIKENDRVLTYEDWYESVCKVANWLHATESKSKRVAIVLENRMEFLQLFAGAAMAGWVCVPL
DIKWKKDELKERLAISNSDMIIAERYKLNDISDEEGRIIEIDKWKQIIENYLPTEHIVESLQDAPFYMGFTSGSTGKAKA
FLRAQQSWVHSFNCNIHDFHMKKEDSILIAGTLVHSLFLYGAISALYIGQTVHIMRNFIPNQVLDKLETENISVMYTVPT
MLESLYKENRVIENEMKIISSGAKWEAEAKEKIKSIFPYAKRYEFYGASELSFVTALVDEESERRPNSVGKPCHNVQVRV
CNEAGKEVQKGEIGTVYVKSDQFFMGYIIDGVLARELNADGWMTVRDVGYEDEEGFIYIVGREKNMILFGGINIFPEEIE
SVLHEHPAVDEIVVIGVEDSYWGEKPVAIVKGSATKQQLKSFCLQRLSSFKIPKEWYFVDEIPYTNSGKNRSYGSKKYN
>Mature_478_residues
GITKEYKKHASLQPNKIAIKENDRVLTYEDWYESVCKVANWLHATESKSKRVAIVLENRMEFLQLFAGAAMAGWVCVPLD
IKWKKDELKERLAISNSDMIIAERYKLNDISDEEGRIIEIDKWKQIIENYLPTEHIVESLQDAPFYMGFTSGSTGKAKAF
LRAQQSWVHSFNCNIHDFHMKKEDSILIAGTLVHSLFLYGAISALYIGQTVHIMRNFIPNQVLDKLETENISVMYTVPTM
LESLYKENRVIENEMKIISSGAKWEAEAKEKIKSIFPYAKRYEFYGASELSFVTALVDEESERRPNSVGKPCHNVQVRVC
NEAGKEVQKGEIGTVYVKSDQFFMGYIIDGVLARELNADGWMTVRDVGYEDEEGFIYIVGREKNMILFGGINIFPEEIES
VLHEHPAVDEIVVIGVEDSYWGEKPVAIVKGSATKQQLKSFCLQRLSSFKIPKEWYFVDEIPYTNSGKNRSYGSKKYN

Specific function: May be involved in fatty acid metabolism [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=350, Percent_Identity=29.4285714285714, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI187761345, Length=518, Percent_Identity=25.0965250965251, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI187761343, Length=518, Percent_Identity=25.0965250965251, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI58082049, Length=464, Percent_Identity=24.5689655172414, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI157311624, Length=472, Percent_Identity=25.4237288135593, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI157311622, Length=472, Percent_Identity=25.4237288135593, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI122937307, Length=460, Percent_Identity=24.5652173913043, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI42544132, Length=279, Percent_Identity=27.2401433691756, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI38505220, Length=452, Percent_Identity=23.8938053097345, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI115511026, Length=464, Percent_Identity=23.7068965517241, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI13375727, Length=405, Percent_Identity=20, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI145693145, Length=506, Percent_Identity=24.703557312253, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1788107, Length=512, Percent_Identity=24.0234375, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1786810, Length=499, Percent_Identity=24.248496993988, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI221142682, Length=195, Percent_Identity=32.3076923076923, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788595, Length=309, Percent_Identity=26.537216828479, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1790505, Length=423, Percent_Identity=21.9858156028369, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17559526, Length=501, Percent_Identity=23.3532934131737, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17531443, Length=521, Percent_Identity=24.5681381957774, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32563687, Length=477, Percent_Identity=24.3186582809224, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17557194, Length=355, Percent_Identity=27.3239436619718, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17538037, Length=288, Percent_Identity=30.5555555555556, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71994694, Length=353, Percent_Identity=26.628895184136, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71994703, Length=353, Percent_Identity=26.628895184136, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71994690, Length=353, Percent_Identity=26.628895184136, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71985884, Length=424, Percent_Identity=25.7075471698113, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17558820, Length=496, Percent_Identity=24.7983870967742, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17560308, Length=361, Percent_Identity=26.0387811634349, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17560140, Length=469, Percent_Identity=25.5863539445629, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71996755, Length=488, Percent_Identity=22.7459016393443, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25141359, Length=488, Percent_Identity=21.7213114754098, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319699, Length=521, Percent_Identity=25.3358925143954, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319264, Length=551, Percent_Identity=23.5934664246824, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24581924, Length=340, Percent_Identity=27.9411764705882, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI21355181, Length=474, Percent_Identity=23.8396624472574, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18859661, Length=493, Percent_Identity=23.5294117647059, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24648253, Length=505, Percent_Identity=22.3762376237624, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21356441, Length=463, Percent_Identity=22.0302375809935, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356947, Length=220, Percent_Identity=26.8181818181818, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24648255, Length=451, Percent_Identity=22.3946784922395, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24648260, Length=331, Percent_Identity=25.0755287009063, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21358303, Length=226, Percent_Identity=26.9911504424779, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24653035, Length=192, Percent_Identity=28.6458333333333, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281365686, Length=223, Percent_Identity=27.3542600896861, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI161076582, Length=200, Percent_Identity=29, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922652, Length=350, Percent_Identity=22.8571428571429, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24656500, Length=344, Percent_Identity=24.7093023255814, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24648257, Length=146, Percent_Identity=28.0821917808219, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20130357, Length=190, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355225, Length=364, Percent_Identity=23.0769230769231, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.3

Molecular weight: Translated: 54900; Mature: 54769

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGITKEYKKHASLQPNKIAIKENDRVLTYEDWYESVCKVANWLHATESKSKRVAIVLENR
CCCCHHHHHHCCCCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHH
MEFLQLFAGAAMAGWVCVPLDIKWKKDELKERLAISNSDMIIAERYKLNDISDEEGRIIE
HHHHHHHHHHHHHCEEEEEEEEEECHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCEEE
IDKWKQIIENYLPTEHIVESLQDAPFYMGFTSGSTGKAKAFLRAQQSWVHSFNCNIHDFH
HHHHHHHHHHHCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEE
MKKEDSILIAGTLVHSLFLYGAISALYIGQTVHIMRNFIPNQVLDKLETENISVMYTVPT
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCEEEEEEHHH
MLESLYKENRVIENEMKIISSGAKWEAEAKEKIKSIFPYAKRYEFYGASELSFVTALVDE
HHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHCC
ESERRPNSVGKPCHNVQVRVCNEAGKEVQKGEIGTVYVKSDQFFMGYIIDGVLARELNAD
HHHCCCCCCCCCCCCCEEEEECHHCCHHHCCCCEEEEEECCCEEEHHHHHHHHHHHCCCC
GWMTVRDVGYEDEEGFIYIVGREKNMILFGGINIFPEEIESVLHEHPAVDEIVVIGVEDS
CCEEEEECCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCC
YWGEKPVAIVKGSATKQQLKSFCLQRLSSFKIPKEWYFVDEIPYTNSGKNRSYGSKKYN
CCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GITKEYKKHASLQPNKIAIKENDRVLTYEDWYESVCKVANWLHATESKSKRVAIVLENR
CCCHHHHHHCCCCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHH
MEFLQLFAGAAMAGWVCVPLDIKWKKDELKERLAISNSDMIIAERYKLNDISDEEGRIIE
HHHHHHHHHHHHHCEEEEEEEEEECHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCEEE
IDKWKQIIENYLPTEHIVESLQDAPFYMGFTSGSTGKAKAFLRAQQSWVHSFNCNIHDFH
HHHHHHHHHHHCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEE
MKKEDSILIAGTLVHSLFLYGAISALYIGQTVHIMRNFIPNQVLDKLETENISVMYTVPT
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCEEEEEEHHH
MLESLYKENRVIENEMKIISSGAKWEAEAKEKIKSIFPYAKRYEFYGASELSFVTALVDE
HHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHCC
ESERRPNSVGKPCHNVQVRVCNEAGKEVQKGEIGTVYVKSDQFFMGYIIDGVLARELNAD
HHHCCCCCCCCCCCCCEEEEECHHCCHHHCCCCEEEEEECCCEEEHHHHHHHHHHHCCCC
GWMTVRDVGYEDEEGFIYIVGREKNMILFGGINIFPEEIESVLHEHPAVDEIVVIGVEDS
CCEEEEECCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCC
YWGEKPVAIVKGSATKQQLKSFCLQRLSSFKIPKEWYFVDEIPYTNSGKNRSYGSKKYN
CCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; long-chain carboxylic acid; CoA

Specific reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]