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The map label for this gene is moeA-2 [H]

Identifier: 222097020

GI number: 222097020

Start: 3302834

End: 3304141

Strand: Reverse

Name: moeA-2 [H]

Synonym: BCQ_3360

Alternate gene names: 222097020

Gene position: 3304141-3302834 (Counterclockwise)

Preceding gene: 222097021

Following gene: 222097019

Centisome position: 63.37

GC content: 39.07

Gene sequence:

>1308_bases
ATGGAAAGAAGAGTACCAATCACAGTTGAAGAGGCTGTTCGTAAAGTGATGGGATTTGCTCATAACGGCTTAAAGGAGCT
ACTACCTATTGAATTAGCTTACGGACGTATATTAGCAGAGGATTTAGTAGCTGACCATGATGTGCCGTCATTTAATCGTT
CACCGTATGACGGGTTTGCTATTAGAGCAGAAGATACGAATTTAGCAAGTTATGAAACGCCAATTGTATTTGAAGTAGTG
GGTGAAATTGGTGCAGGATCGCTATTCGATGAGAAAGTAGGTCCGTTTCAAGCAGTTCGAATTATGACGGGAGCACAGAT
TCCGAGTGGATGTGATGCAGTTGTTATGCTAGAGCTGACTCGTCAATATGAGGAGGCTGGCAGTAAGTATATGGAATTGA
AACGGTCATTCAAAACGGGCGATAATATTTCTTTTCAAGGTGAAGATGCTCGTAAAGGAACGGTTCTTGCAAAGAAAGGA
ACATACATTCATCCAGGTATTTCAGCTCTTCTTGCTACGTTCGGGTATAGCGAGGTGCCAGTTGCGAGAAAGCCTGTAGT
TGGACTATTAGCGACTGGCAGTGAATTACTGGATGTAAACGATTCATTACAGCCAGGGAAAATCCGAAATAGTAATACGT
ATATGATATTGTCTCAAATCCGAAGAGCAGGCGGAAGAGTAAAATATTTTGGGAAGTTTAGCGATGATTTTTATACGTGT
TTTACGGCTGTAAAAGAAGCATTAAGCCAAGTAGATATGCTCATTACAACAGGTGGTGTATCAGTAGGGGATTACGATTA
TTTGCCAGCTATATATGAAAAATTAGGTGCATCAGTTCTTTTCAATAAAGTTGCAATGAGGCCAGGAAGTGTTACGACTG
TAGCGCAATTAAATGGCAAGTTATTATTCGGTTTATCAGGAAATCCATCTGCTTGTTACGTAGGGTTTGAATTATTTGTA
AGACCTTGTATTCGGACGTATATGTTTAGTGAAAAAGCACATGTAAAAAGAGAAAAAGCGTTATTAGGAGAAGACTTTTT
AAAGCCAAATCCATTTACAAGATTTGTACGAGGAAAACTAACATATAACGAAGGGCAGTTAATCGCTTATCCGTCAGGGT
TTGATAAATCTAGTTCAGTTTCTTCTCTAGCAGAGACAAATATATTTATTGTACTTCCAGGTGGTACGAGAGGGTATAAA
AAAGATATGTTCGTAGATGTTCTCTTGTTGGAAGATAACGAAGGTAGTGAATGGCCTTGGACATTTTATAAAGTGAGAGG
TGATTCTAATGGGACAAGTGCTATTTGA

Upstream 100 bases:

>100_bases
TTTTCGGGATGGTCGTGTTTTTATTCATGGCACAAATGATATTTCGAAAGCGAAACAACTATATTATTGCGTATTCGGCT
AATAGAAAGGGTTGTCAACA

Downstream 100 bases:

>100_bases
GATTGTTGATATACCGATTGTAGTTGAAGAAGTAACGAATAAAGTTGCAAGAAGAGAGGCAGGTGCGATTACAACTTTTA
TTGGTACAGTGAGAGAATTA

Product: molybdopterin biosynthesis protein moea

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MERRVPITVEEAVRKVMGFAHNGLKELLPIELAYGRILAEDLVADHDVPSFNRSPYDGFAIRAEDTNLASYETPIVFEVV
GEIGAGSLFDEKVGPFQAVRIMTGAQIPSGCDAVVMLELTRQYEEAGSKYMELKRSFKTGDNISFQGEDARKGTVLAKKG
TYIHPGISALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFYTC
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYK
KDMFVDVLLLEDNEGSEWPWTFYKVRGDSNGTSAI

Sequences:

>Translated_435_residues
MERRVPITVEEAVRKVMGFAHNGLKELLPIELAYGRILAEDLVADHDVPSFNRSPYDGFAIRAEDTNLASYETPIVFEVV
GEIGAGSLFDEKVGPFQAVRIMTGAQIPSGCDAVVMLELTRQYEEAGSKYMELKRSFKTGDNISFQGEDARKGTVLAKKG
TYIHPGISALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFYTC
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYK
KDMFVDVLLLEDNEGSEWPWTFYKVRGDSNGTSAI
>Mature_435_residues
MERRVPITVEEAVRKVMGFAHNGLKELLPIELAYGRILAEDLVADHDVPSFNRSPYDGFAIRAEDTNLASYETPIVFEVV
GEIGAGSLFDEKVGPFQAVRIMTGAQIPSGCDAVVMLELTRQYEEAGSKYMELKRSFKTGDNISFQGEDARKGTVLAKKG
TYIHPGISALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFYTC
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYK
KDMFVDVLLLEDNEGSEWPWTFYKVRGDSNGTSAI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=390, Percent_Identity=35.1282051282051, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI66932975, Length=391, Percent_Identity=35.0383631713555, Blast_Score=200, Evalue=3e-51,
Organism=Escherichia coli, GI1787049, Length=370, Percent_Identity=35.1351351351351, Blast_Score=182, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI25147659, Length=398, Percent_Identity=28.643216080402, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=359, Percent_Identity=28.6908077994429, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17136978, Length=369, Percent_Identity=28.9972899728997, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24638841, Length=369, Percent_Identity=28.9972899728997, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 47819; Mature: 47819

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERRVPITVEEAVRKVMGFAHNGLKELLPIELAYGRILAEDLVADHDVPSFNRSPYDGFA
CCCCCCEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
IRAEDTNLASYETPIVFEVVGEIGAGSLFDEKVGPFQAVRIMTGAQIPSGCDAVVMLELT
EEECCCCCCCCCCCCCEEEHHCCCCCCCCHHCCCCHHEEEEEECCCCCCCCCEEEHHHHH
RQYEEAGSKYMELKRSFKTGDNISFQGEDARKGTVLAKKGTYIHPGISALLATFGYSEVP
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECCCEECCCHHHHHHHCCCCCCC
VARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFYTC
CCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCEEHHHHHHHCCCCEEEEECCCCHHHHH
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGK
HHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCEEEEEECCCE
LLFGLSGNPSACYVGFELFVRPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKL
EEEEECCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHEEEEE
TYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYKKDMFVDVLLLEDNEGSEWPW
EECCCEEEEECCCCCCCCHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCE
TFYKVRGDSNGTSAI
EEEEEECCCCCCCCC
>Mature Secondary Structure
MERRVPITVEEAVRKVMGFAHNGLKELLPIELAYGRILAEDLVADHDVPSFNRSPYDGFA
CCCCCCEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
IRAEDTNLASYETPIVFEVVGEIGAGSLFDEKVGPFQAVRIMTGAQIPSGCDAVVMLELT
EEECCCCCCCCCCCCCEEEHHCCCCCCCCHHCCCCHHEEEEEECCCCCCCCCEEEHHHHH
RQYEEAGSKYMELKRSFKTGDNISFQGEDARKGTVLAKKGTYIHPGISALLATFGYSEVP
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECCCEECCCHHHHHHHCCCCCCC
VARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFYTC
CCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCEEHHHHHHHCCCCEEEEECCCCHHHHH
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGK
HHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCEEEEEECCCE
LLFGLSGNPSACYVGFELFVRPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKL
EEEEECCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHEEEEE
TYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYKKDMFVDVLLLEDNEGSEWPW
EECCCEEEEECCCCCCCCHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCE
TFYKVRGDSNGTSAI
EEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]