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The map label for this gene is proA [H]

Identifier: 222096469

GI number: 222096469

Start: 2744842

End: 2746089

Strand: Reverse

Name: proA [H]

Synonym: BCQ_2809

Alternate gene names: 222096469

Gene position: 2746089-2744842 (Counterclockwise)

Preceding gene: 222096470

Following gene: 222096467

Centisome position: 52.67

GC content: 39.18

Gene sequence:

>1248_bases
ATGAATGAAGTGTTAGCAAAGGGGAAAAGAGCGAAAGAGGTTGCTAGGGAACTTGTACTAAAATCTACACATCAAAAAAA
CGAAGCACTTGCTGCAATTGCAAATCAATTAATAAGTGAAACAGCTTATATTTTAGAGGAAAATAAGAGGGATATTGAAG
AAGGTAAGGCAAAAGGGTTTTCTGATTCTCTCCTTGATCGCCTTATGCTGAATGAACAGCGTATTGTTGATATGACAGAA
GGGATTAAGCAGCTAATTGAATTACGTGATCCTGTAGGAGAATGTGTAAGTGCATGGGAAAGGCCAAATGGACTATCTAT
TCAGGAAATGCGTGTACCACTTGGTGTTGTTGGGATGATTTACGAGGCAAGACCGAATGTAACAGTGGATGCTGCTACTA
TTTGTTTGAAGACAGGAAACGCAGTCATATTACGTGGTAGTTCTTCTGCTATTCATTCTAATAAAGCCATTGTTGCCGTT
ATTCACAGAGCGCTCAAACAAACAAGCTTACCAGAAGAAAGTGTACAGCTTATAGAAGATACAACGAGAGATAGTGCGAA
GCAGTTGTTTACAATGAATGATTATCTAGACGTTCTTATTCCAAGAGGTGGCAAACAATTAATCGATACTGTTGTGAGGG
AAGCGTCTGTTCCAGTACTTGAAACAGGTGCAGGAAATTGTCATATTTTCATTGATGAAACAGCGGATAAACAAATGGCA
TTTGATATTATTATAAATGCAAAAACGCAGCGTCCATCTGTATGTAATGCGATTGAAACGATTGTACTTCATGAGAACTG
GGCGCAGCAATATGGTAGCGAGTTGTTTTCTTCTTTGAAGGAAAGAGGCGTGGAGCTACGTGGTGATCAAAAAGCATTGG
CAATGGATTCGTCAATTGTACTTGCTTCAGAAGAAGACTGGGGGACAGAATTTTTATCTCTCACGCTAGCAGTTAAAATA
GTTTCTTCTATAGAAGAAGCGATTCACCACATAAATACGTATGGGTCTATGCATTCTGAAGCGATTATTTCAGAAAACGA
GGAAAACGTCAGCAAATTTTTCGTATCTGTTGATGCTGCTGCGCTGTATCACAATGCATCAACTCGTTTTACTGATGGAT
CTGAATTCGGATTCGGAGCTGAGATTGGCATCAGTACACAAAAGCTACACGTAAGGGGACCAATGGGACTTCCTGCATTA
ACTTCCACAAAATATATAATTCGTGGTAATGGACAAATTCGAAAATAA

Upstream 100 bases:

>100_bases
CATATTCAAGCAAGAGGCGAAAGGCATAATTATGAAGTCATCCATAGGGATCATTGGGTTTCACTTTAAGAATAGTGATG
TTAAAAAGGAGGAAATAAAA

Downstream 100 bases:

>100_bases
AAATAAAAGACACTCAATTTTCGTTTGGGTGTCTTTTATTTTAAAAATTATTTACCATACAAAAAGCCCAACAAGCATAG
CGCTTAATAAGGAAACAGCC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MNEVLAKGKRAKEVARELVLKSTHQKNEALAAIANQLISETAYILEENKRDIEEGKAKGFSDSLLDRLMLNEQRIVDMTE
GIKQLIELRDPVGECVSAWERPNGLSIQEMRVPLGVVGMIYEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAV
IHRALKQTSLPEESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHIFIDETADKQMA
FDIIINAKTQRPSVCNAIETIVLHENWAQQYGSELFSSLKERGVELRGDQKALAMDSSIVLASEEDWGTEFLSLTLAVKI
VSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAAALYHNASTRFTDGSEFGFGAEIGISTQKLHVRGPMGLPAL
TSTKYIIRGNGQIRK

Sequences:

>Translated_415_residues
MNEVLAKGKRAKEVARELVLKSTHQKNEALAAIANQLISETAYILEENKRDIEEGKAKGFSDSLLDRLMLNEQRIVDMTE
GIKQLIELRDPVGECVSAWERPNGLSIQEMRVPLGVVGMIYEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAV
IHRALKQTSLPEESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHIFIDETADKQMA
FDIIINAKTQRPSVCNAIETIVLHENWAQQYGSELFSSLKERGVELRGDQKALAMDSSIVLASEEDWGTEFLSLTLAVKI
VSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAAALYHNASTRFTDGSEFGFGAEIGISTQKLHVRGPMGLPAL
TSTKYIIRGNGQIRK
>Mature_415_residues
MNEVLAKGKRAKEVARELVLKSTHQKNEALAAIANQLISETAYILEENKRDIEEGKAKGFSDSLLDRLMLNEQRIVDMTE
GIKQLIELRDPVGECVSAWERPNGLSIQEMRVPLGVVGMIYEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAV
IHRALKQTSLPEESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHIFIDETADKQMA
FDIIINAKTQRPSVCNAIETIVLHENWAQQYGSELFSSLKERGVELRGDQKALAMDSSIVLASEEDWGTEFLSLTLAVKI
VSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAAALYHNASTRFTDGSEFGFGAEIGISTQKLHVRGPMGLPAL
TSTKYIIRGNGQIRK

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=412, Percent_Identity=31.0679611650485, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI62912457, Length=412, Percent_Identity=31.0679611650485, Blast_Score=231, Evalue=6e-61,
Organism=Escherichia coli, GI1786438, Length=411, Percent_Identity=44.7688564476886, Blast_Score=364, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17569969, Length=409, Percent_Identity=33.7408312958435, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17569967, Length=409, Percent_Identity=33.7408312958435, Blast_Score=256, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6324899, Length=427, Percent_Identity=37.2365339578454, Blast_Score=280, Evalue=4e-76,
Organism=Drosophila melanogaster, GI21357643, Length=411, Percent_Identity=34.0632603406326, Blast_Score=262, Evalue=3e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45620; Mature: 45620

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEVLAKGKRAKEVARELVLKSTHQKNEALAAIANQLISETAYILEENKRDIEEGKAKGF
CCCHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCC
SDSLLDRLMLNEQRIVDMTEGIKQLIELRDPVGECVSAWERPNGLSIQEMRVPLGVVGMI
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHCCHHHHHHE
YEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAVIHRALKQTSLPEESVQLIED
EECCCCCEEEHEEEEEECCCEEEEECCCCCHHCCCHHHHHHHHHHHHCCCCHHHHHHHHH
TTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHIFIDETADKQMA
HHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCEEECCCCCEEEEEECCCCCCEE
FDIIINAKTQRPSVCNAIETIVLHENWAQQYGSELFSSLKERGVELRGDQKALAMDSSIV
EEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEECCCCHHEEECCEEE
LASEEDWGTEFLSLTLAVKIVSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAA
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHH
ALYHNASTRFTDGSEFGFGAEIGISTQKLHVRGPMGLPALTSTKYIIRGNGQIRK
HHHCCCCCCCCCCCCCCCCCEECCCEEEEEEECCCCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MNEVLAKGKRAKEVARELVLKSTHQKNEALAAIANQLISETAYILEENKRDIEEGKAKGF
CCCHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCC
SDSLLDRLMLNEQRIVDMTEGIKQLIELRDPVGECVSAWERPNGLSIQEMRVPLGVVGMI
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHCCHHHHHHE
YEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAVIHRALKQTSLPEESVQLIED
EECCCCCEEEHEEEEEECCCEEEEECCCCCHHCCCHHHHHHHHHHHHCCCCHHHHHHHHH
TTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHIFIDETADKQMA
HHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCEEECCCCCEEEEEECCCCCCEE
FDIIINAKTQRPSVCNAIETIVLHENWAQQYGSELFSSLKERGVELRGDQKALAMDSSIV
EEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEECCCCHHEEECCEEE
LASEEDWGTEFLSLTLAVKIVSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAA
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHH
ALYHNASTRFTDGSEFGFGAEIGISTQKLHVRGPMGLPALTSTKYIIRGNGQIRK
HHHCCCCCCCCCCCCCCCCCEECCCEEEEEEECCCCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA