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The map label for this gene is glcR [H]

Identifier: 222096271

GI number: 222096271

Start: 2562962

End: 2563732

Strand: Reverse

Name: glcR [H]

Synonym: BCQ_2611

Alternate gene names: 222096271

Gene position: 2563732-2562962 (Counterclockwise)

Preceding gene: 222096274

Following gene: 222096270

Centisome position: 49.17

GC content: 33.59

Gene sequence:

>771_bases
ATGTTTACTGAAGAGCGTAGAGAGAAAATTTTGGAATTACTTAAGAAAAATGGAAGGGTAATTGCAAAGGATCTTGCGGA
AAGTTTCGATATGTCTATCGATTCTATAAGAAGAGATTTGTCTATTATGGAGAAGGGTGGCTTGTTAAAAAGAACACATG
GAGGAGCAATTGAACTTGCTAGAGTACGGAATTTAGCTACCAAGCCATTGAAACGTTATAGTAATGGTTCTGTATATGAA
GACGCAATTGCAAAAATCGCAGCTTCTTATATACAAGAAGGAGATTCCGTTTTTATTGGTGGAGCTTCTATTCATTATGC
CATGTTAAAATATTTACCTGAAACATCATTTACAGTTGTTACGAATGCTTTAGAAATTGCTAGTACGTTACGGGAATATA
AGAACATTGATACGTACTTAATTGGTGGAAAGGTGAAACCATCAGGAAATATGACAGATACACTTGCCTCAGAATTGATA
AGTAGACTCTCTATTGATCTGTATTTCTCTACAGGTGGTGGCATTTCATTGAATGGTATAAGTACTGCAACGCCTGAAGT
TGCTTTTTTTAGTAAAACAGTAAGTAAGATTGCTAGAAGAAATATTTGTTTAGCTCCTCACAATAAACTTGGAATAGACT
ACTTTATAAAAGGAGAGTCACTGATTGAAATTGACATTATAATAACAGATTCGGAGGCTAGTAAAGAAACAATTCAAGAA
TTTAAGAAACAAGGTAAAAAAATTATAATAGCACCAATAGACTGCATTTAA

Upstream 100 bases:

>100_bases
CTGAATAAAGAAGTATTGAAAATATTGTAAAATAGAAAAAACATGCATATAATTAAAAGATGGATAAATTTTCCGAATAT
TCAATGATGGTGGTGAGAAC

Downstream 100 bases:

>100_bases
AAGGAGTTTGAAATGATTATAAAAGGGCAAGAGTTTCACATAAATGGATTAGTTTATACAATTCGTTCTGCAGCTGAAAC
AGATGCGGAACAGTTGTCGG

Product: transcriptional regulator, deor family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MFTEERREKILELLKKNGRVIAKDLAESFDMSIDSIRRDLSIMEKGGLLKRTHGGAIELARVRNLATKPLKRYSNGSVYE
DAIAKIAASYIQEGDSVFIGGASIHYAMLKYLPETSFTVVTNALEIASTLREYKNIDTYLIGGKVKPSGNMTDTLASELI
SRLSIDLYFSTGGGISLNGISTATPEVAFFSKTVSKIARRNICLAPHNKLGIDYFIKGESLIEIDIIITDSEASKETIQE
FKKQGKKIIIAPIDCI

Sequences:

>Translated_256_residues
MFTEERREKILELLKKNGRVIAKDLAESFDMSIDSIRRDLSIMEKGGLLKRTHGGAIELARVRNLATKPLKRYSNGSVYE
DAIAKIAASYIQEGDSVFIGGASIHYAMLKYLPETSFTVVTNALEIASTLREYKNIDTYLIGGKVKPSGNMTDTLASELI
SRLSIDLYFSTGGGISLNGISTATPEVAFFSKTVSKIARRNICLAPHNKLGIDYFIKGESLIEIDIIITDSEASKETIQE
FKKQGKKIIIAPIDCI
>Mature_256_residues
MFTEERREKILELLKKNGRVIAKDLAESFDMSIDSIRRDLSIMEKGGLLKRTHGGAIELARVRNLATKPLKRYSNGSVYE
DAIAKIAASYIQEGDSVFIGGASIHYAMLKYLPETSFTVVTNALEIASTLREYKNIDTYLIGGKVKPSGNMTDTLASELI
SRLSIDLYFSTGGGISLNGISTATPEVAFFSKTVSKIARRNICLAPHNKLGIDYFIKGESLIEIDIIITDSEASKETIQE
FKKQGKKIIIAPIDCI

Specific function: Plays a role in carbon catabolite repression (CCR). Specifically required for transcriptional repression of the levanase operon by glucose but not by other sugars [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789059, Length=254, Percent_Identity=30.7086614173228, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI226510968, Length=253, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1789519, Length=253, Percent_Identity=24.5059288537549, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790635, Length=250, Percent_Identity=24, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789829, Length=247, Percent_Identity=25.1012145748988, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI87082344, Length=229, Percent_Identity=25.3275109170306, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1790753, Length=251, Percent_Identity=25.0996015936255, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1788069, Length=243, Percent_Identity=26.7489711934156, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787540, Length=191, Percent_Identity=29.3193717277487, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789170, Length=177, Percent_Identity=27.683615819209, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28234; Mature: 28234

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTEERREKILELLKKNGRVIAKDLAESFDMSIDSIRRDLSIMEKGGLLKRTHGGAIELA
CCCHHHHHHHHHHHHHCCCEEHHHHHHHHCCCHHHHHHHHHHHHCCCCEEECCCCEEHHH
RVRNLATKPLKRYSNGSVYEDAIAKIAASYIQEGDSVFIGGASIHYAMLKYLPETSFTVV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCHHHH
TNALEIASTLREYKNIDTYLIGGKVKPSGNMTDTLASELISRLSIDLYFSTGGGISLNGI
HHHHHHHHHHHHHHCCCEEEECCEECCCCCCHHHHHHHHHHHHEEEEEEECCCCEEECCC
STATPEVAFFSKTVSKIARRNICLAPHNKLGIDYFIKGESLIEIDIIITDSEASKETIQE
CCCCCHHHHHHHHHHHHHHCCCEECCCCCCCEEEEECCCCEEEEEEEEECCCCCHHHHHH
FKKQGKKIIIAPIDCI
HHHCCCEEEEEECCCC
>Mature Secondary Structure
MFTEERREKILELLKKNGRVIAKDLAESFDMSIDSIRRDLSIMEKGGLLKRTHGGAIELA
CCCHHHHHHHHHHHHHCCCEEHHHHHHHHCCCHHHHHHHHHHHHCCCCEEECCCCEEHHH
RVRNLATKPLKRYSNGSVYEDAIAKIAASYIQEGDSVFIGGASIHYAMLKYLPETSFTVV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCHHHH
TNALEIASTLREYKNIDTYLIGGKVKPSGNMTDTLASELISRLSIDLYFSTGGGISLNGI
HHHHHHHHHHHHHHCCCEEEECCEECCCCCCHHHHHHHHHHHHEEEEEEECCCCEEECCC
STATPEVAFFSKTVSKIARRNICLAPHNKLGIDYFIKGESLIEIDIIITDSEASKETIQE
CCCCCHHHHHHHHHHHHHHCCCEECCCCCCCEEEEECCCCEEEEEEEEECCCCCHHHHHH
FKKQGKKIIIAPIDCI
HHHCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]