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The map label for this gene is lacC [H]

Identifier: 222095654

GI number: 222095654

Start: 1973617

End: 1974552

Strand: Direct

Name: lacC [H]

Synonym: BCQ_1994

Alternate gene names: 222095654

Gene position: 1973617-1974552 (Clockwise)

Preceding gene: 222095653

Following gene: 222095655

Centisome position: 37.85

GC content: 35.26

Gene sequence:

>936_bases
ATGATTTTATCTGTCACCATGAATCCATCTGTCGATATTTCCTATTCGACTCATGAATTAAAGTTAGATGTTGTTAACCG
TGTGGAAACAGTTCACAAAACTGCTGGTGGAAAGGGATTGAATGTGGCGCGAGTGATTGCTCAAATGGAAGAAGCTGTTC
TAGCGACAGGTGTGATTGGTGGTACGATTGGCGAATACATTATTCAAGAATTAAATAAAAACAATATTCCAAATGACTTT
TTAAAAATTAAAAAAGAATCAAGAAATTGTATTGCCATTCTTCATGAAGGGATGCAAACAGAGATTTTAGAATCAGGGCC
GACATTATCCAATGAAGAAGGGATAACTTTTTTAGAAAAATTTGAATGTTTGCTTACAACAGCTTCACTTGTGACAATTT
CAGGTAGTTTGCCGAAAGGGTTACCGACTAACTTTTATTATCAAATGTTAGAAATCTGTAATAACAATGGAATTCCAGTG
ATTATAGATTCATCAGGGAAATCTTTGAAAAACGCCTTGGTGCATAAAGAAAAACCATTTGCCATCAAACCAAATAAAGC
AGAATTATCTCAGTTGTTGGGCATTAACATGGAAATGGGAATCATAGATTTGAAGCAAGCATTAAACCATGAACTATTTA
CTGGAATTGAGTGGATTATCGTGTCATTGGGTAGTGAAGGTGCCTTTGTCAGGAATGGTGAGGACTATTACCAAGTTACG
GTTCCAAAAATAGAAGTGGTCAATCCGGTTGGATCTGGTGATGCGACAGTTGCAGGGCTAGCTGTGGCATTATATCAAAA
TCAAACGGTTGAGACTGTTCTTAAAACGGCGATGACTACAGGAATATTAAATACGATGGAAGTTGGTACTGGTTATATTA
ATATAAATAAGTTTAAACAATACTTTGATCTCATTAAAATTGAAAAAATAGATTAG

Upstream 100 bases:

>100_bases
ACTTTATAGTACTGACGCCAGCGATGGATTTAGCAGCTACCTATCTTGATGGTGTGTGCCGTTTTCAAGCTTAAATATTT
TTCTGAAAGAGGGATTTCAA

Downstream 100 bases:

>100_bases
TAGAGGAGAATGTTGATGTTAGAACTAACCAAGAATAAATTGGAAGCTCTAAAACGTTTATCTGCTGAAAATGGCATAAT
TGGAGCATTGGCTATTGATC

Product: tagatose-6-phosphate kinase, phosphofructokinase i

Products: NA

Alternate protein names: Phosphotagatokinase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MILSVTMNPSVDISYSTHELKLDVVNRVETVHKTAGGKGLNVARVIAQMEEAVLATGVIGGTIGEYIIQELNKNNIPNDF
LKIKKESRNCIAILHEGMQTEILESGPTLSNEEGITFLEKFECLLTTASLVTISGSLPKGLPTNFYYQMLEICNNNGIPV
IIDSSGKSLKNALVHKEKPFAIKPNKAELSQLLGINMEMGIIDLKQALNHELFTGIEWIIVSLGSEGAFVRNGEDYYQVT
VPKIEVVNPVGSGDATVAGLAVALYQNQTVETVLKTAMTTGILNTMEVGTGYININKFKQYFDLIKIEKID

Sequences:

>Translated_311_residues
MILSVTMNPSVDISYSTHELKLDVVNRVETVHKTAGGKGLNVARVIAQMEEAVLATGVIGGTIGEYIIQELNKNNIPNDF
LKIKKESRNCIAILHEGMQTEILESGPTLSNEEGITFLEKFECLLTTASLVTISGSLPKGLPTNFYYQMLEICNNNGIPV
IIDSSGKSLKNALVHKEKPFAIKPNKAELSQLLGINMEMGIIDLKQALNHELFTGIEWIIVSLGSEGAFVRNGEDYYQVT
VPKIEVVNPVGSGDATVAGLAVALYQNQTVETVLKTAMTTGILNTMEVGTGYININKFKQYFDLIKIEKID
>Mature_311_residues
MILSVTMNPSVDISYSTHELKLDVVNRVETVHKTAGGKGLNVARVIAQMEEAVLATGVIGGTIGEYIIQELNKNNIPNDF
LKIKKESRNCIAILHEGMQTEILESGPTLSNEEGITFLEKFECLLTTASLVTISGSLPKGLPTNFYYQMLEICNNNGIPV
IIDSSGKSLKNALVHKEKPFAIKPNKAELSQLLGINMEMGIIDLKQALNHELFTGIEWIIVSLGSEGAFVRNGEDYYQVT
VPKIEVVNPVGSGDATVAGLAVALYQNQTVETVLKTAMTTGILNTMEVGTGYININKFKQYFDLIKIEKID

Specific function: Key control step of glycolysis. [C]

COG id: COG1105

COG function: function code G; Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carbohydrate kinase pfkB family. LacC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788017, Length=293, Percent_Identity=29.6928327645051, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788493, Length=277, Percent_Identity=28.8808664259928, Blast_Score=104, Evalue=9e-24,

Paralogues:

None

Copy number: 496 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR005926
- InterPro:   IPR017583 [H]

Pfam domain/function: PF00294 PfkB [H]

EC number: =2.7.1.144 [H]

Molecular weight: Translated: 33993; Mature: 33993

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00584 PFKB_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILSVTMNPSVDISYSTHELKLDVVNRVETVHKTAGGKGLNVARVIAQMEEAVLATGVIG
CEEEEECCCCEEEEECCCEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
GTIGEYIIQELNKNNIPNDFLKIKKESRNCIAILHEGMQTEILESGPTLSNEEGITFLEK
HHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCCCCCCCHHHHH
FECLLTTASLVTISGSLPKGLPTNFYYQMLEICNNNGIPVIIDSSGKSLKNALVHKEKPF
HHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHCCCCCC
AIKPNKAELSQLLGINMEMGIIDLKQALNHELFTGIEWIIVSLGSEGAFVRNGEDYYQVT
EECCCHHHHHHHHCCCCCCCHHHHHHHHCHHHHHCCEEEEEEECCCCCEEECCCCEEEEE
VPKIEVVNPVGSGDATVAGLAVALYQNQTVETVLKTAMTTGILNTMEVGTGYININKFKQ
ECEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHH
YFDLIKIEKID
HHHHHEEEECC
>Mature Secondary Structure
MILSVTMNPSVDISYSTHELKLDVVNRVETVHKTAGGKGLNVARVIAQMEEAVLATGVIG
CEEEEECCCCEEEEECCCEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
GTIGEYIIQELNKNNIPNDFLKIKKESRNCIAILHEGMQTEILESGPTLSNEEGITFLEK
HHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCCCCCCCHHHHH
FECLLTTASLVTISGSLPKGLPTNFYYQMLEICNNNGIPVIIDSSGKSLKNALVHKEKPF
HHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHCCCCCC
AIKPNKAELSQLLGINMEMGIIDLKQALNHELFTGIEWIIVSLGSEGAFVRNGEDYYQVT
EECCCHHHHHHHHCCCCCCCHHHHHHHHCHHHHHCCEEEEEEECCCCCEEECCCCEEEEE
VPKIEVVNPVGSGDATVAGLAVALYQNQTVETVLKTAMTTGILNTMEVGTGYININKFKQ
ECEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHH
YFDLIKIEKID
HHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA