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The map label for this gene is phoR [H]

Identifier: 222095608

GI number: 222095608

Start: 1928655

End: 1929710

Strand: Direct

Name: phoR [H]

Synonym: BCQ_1948

Alternate gene names: 222095608

Gene position: 1928655-1929710 (Clockwise)

Preceding gene: 222095607

Following gene: 222095609

Centisome position: 36.99

GC content: 34.66

Gene sequence:

>1056_bases
ATGAATAAGGTGAAGATACTGAAAGTGATTGGAGCGGTACTAGCTCTCTTTTCTTTTCTCACAATAATTTGGTCTATAGC
CTTTTATGTATCATCAAGTGTAATAAATGCTCTTGAAATACGAGTATCACCTTTTGTTACTTTTTTAATTAGTGATATGG
TCGGCTTTGTATTTATTGTTCTTATTTGGGTGTTGATTGGAGTATTAATGAGACCGAAGCGAGAGGCGATGATTTGGACT
ATTATTGAACCGATAAAAAAAATTGCAAAAGGGGACTTCTCCGTAAAAATACGAAATGAAGAGAAATATAATGGAGAAAT
TGGTGTGCTCGTAAAAAGTATAAATGATATGACAGATGAACTAAATGCGATGGAGAAAATGCGCCAGGAATTTGTATCGA
ATGTTTCTCATGAAATACAGTCACCATTAACTTCTATAAAAGGATTTGCTAGAGCGCTACAAGATAACAATCTTTCCGAG
GAAAAGAGAGAGCATTACCTGACCATTATTGAAACGGAAACGACGAGATTATCTAAACTAAGTCAAAATTTACTGAAGCT
TACCCTTTTAGAGTCGGAAGAATATACACCAGAAAGAGTAACTTATCGATTAGATCAACAGTTAAAACAAATTGTATTAA
ATAGTGAACCGCTTTGGGCTGAGAAAGAAATTGAATTAGACCTTGATTTAGAAAAAGTGCATATAACTGCTGACCAAGAA
AGTATGAGTCAAGTTTGGATTAATTTAATTCATAATAGTATTAAATTTACTCCAAGTAGCGGTACGATTTCAATCAAGCT
AAAAGAATATGAGACATTAGTAGAAGTACGTATACGTGATACGGGAATTGGTATATCCGAAGAACAGAAGCAACATATTT
TTGAGCGTTTTTATAAAGCAGACTCTTCACGAAATCGTGCTTATGGAGGGAGTGGCTTAGGTTTGGCTATCGTAAAAAAA
GTACTCGACCTTCATCAAGGAGAAATAAAAGTCGAGAGTGAGGAAGGCAGTGGTACGGAATTTATTGTACGTATTCCGAA
TCATGAAGAGAAATAG

Upstream 100 bases:

>100_bases
TACGTGAGAAGTTCCAAGAAGAGAAGTCGAAATTTAGTATTAAAACGATAAGAGGCTTAGGATATCGCTTAGAGGTAAGT
AAATGAGAAGAAGAGAGCGA

Downstream 100 bases:

>100_bases
TGTTAGAAGGGGGAACCTTCTAACACTATTTTTCTTTAAAAATACATTTCCCATTACTGCAACTATATTGATAAGCTTTT
CCTTCATTATTCATACCGTA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MNKVKILKVIGAVLALFSFLTIIWSIAFYVSSSVINALEIRVSPFVTFLISDMVGFVFIVLIWVLIGVLMRPKREAMIWT
IIEPIKKIAKGDFSVKIRNEEKYNGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDNNLSE
EKREHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQE
SMSQVWINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKK
VLDLHQGEIKVESEEGSGTEFIVRIPNHEEK

Sequences:

>Translated_351_residues
MNKVKILKVIGAVLALFSFLTIIWSIAFYVSSSVINALEIRVSPFVTFLISDMVGFVFIVLIWVLIGVLMRPKREAMIWT
IIEPIKKIAKGDFSVKIRNEEKYNGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDNNLSE
EKREHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQE
SMSQVWINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKK
VLDLHQGEIKVESEEGSGTEFIVRIPNHEEK
>Mature_351_residues
MNKVKILKVIGAVLALFSFLTIIWSIAFYVSSSVINALEIRVSPFVTFLISDMVGFVFIVLIWVLIGVLMRPKREAMIWT
IIEPIKKIAKGDFSVKIRNEEKYNGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDNNLSE
EKREHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQE
SMSQVWINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKK
VLDLHQGEIKVESEEGSGTEFIVRIPNHEEK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=272, Percent_Identity=27.5735294117647, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1786783, Length=329, Percent_Identity=27.6595744680851, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI145693157, Length=263, Percent_Identity=30.4182509505703, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1789149, Length=224, Percent_Identity=32.1428571428571, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786600, Length=234, Percent_Identity=29.9145299145299, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788549, Length=265, Percent_Identity=27.1698113207547, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=27.6679841897233, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1787894, Length=310, Percent_Identity=25.8064516129032, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1790861, Length=281, Percent_Identity=28.8256227758007, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=26.9230769230769, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI48994928, Length=239, Percent_Identity=28.0334728033473, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87082128, Length=243, Percent_Identity=27.1604938271605, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790346, Length=238, Percent_Identity=27.3109243697479, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789403, Length=291, Percent_Identity=25.4295532646048, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=27.7777777777778, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788279, Length=324, Percent_Identity=24.0740740740741, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1790551, Length=247, Percent_Identity=25.5060728744939, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789808, Length=262, Percent_Identity=22.9007633587786, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081816, Length=230, Percent_Identity=26.0869565217391, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790300, Length=241, Percent_Identity=27.3858921161826, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322044, Length=79, Percent_Identity=32.9113924050633, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 40159; Mature: 40159

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVKILKVIGAVLALFSFLTIIWSIAFYVSSSVINALEIRVSPFVTFLISDMVGFVFIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIWVLIGVLMRPKREAMIWTIIEPIKKIAKGDFSVKIRNEEKYNGEIGVLVKSINDMTDE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
LNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDNNLSEEKREHYLTIIETETTRLSKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEECCHHHHHHH
SQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQE
HHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECEEEEEEECCHH
SMSQVWINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGIGISEEQKQHIFERFYKA
HHHHHHHHHHHCCCEEECCCCEEEEEEHHHHEEEHEEEECCCCCCCHHHHHHHHHHHHHC
DSSRNRAYGGSGLGLAIVKKVLDLHQGEIKVESEEGSGTEFIVRIPNHEEK
CCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MNKVKILKVIGAVLALFSFLTIIWSIAFYVSSSVINALEIRVSPFVTFLISDMVGFVFIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIWVLIGVLMRPKREAMIWTIIEPIKKIAKGDFSVKIRNEEKYNGEIGVLVKSINDMTDE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
LNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDNNLSEEKREHYLTIIETETTRLSKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEECCHHHHHHH
SQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQE
HHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECEEEEEEECCHH
SMSQVWINLIHNSIKFTPSSGTISIKLKEYETLVEVRIRDTGIGISEEQKQHIFERFYKA
HHHHHHHHHHHCCCEEECCCCEEEEEEHHHHEEEHEEEECCCCCCCHHHHHHHHHHHHHC
DSSRNRAYGGSGLGLAIVKKVLDLHQGEIKVESEEGSGTEFIVRIPNHEEK
CCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]