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The map label for this gene is hssR [H]

Identifier: 222095607

GI number: 222095607

Start: 1927936

End: 1928640

Strand: Direct

Name: hssR [H]

Synonym: BCQ_1947

Alternate gene names: 222095607

Gene position: 1927936-1928640 (Clockwise)

Preceding gene: 222095606

Following gene: 222095608

Centisome position: 36.97

GC content: 33.9

Gene sequence:

>705_bases
ATGCTACGTAGAAAGGAGAGGTTTTCTTTGCTACCAAAAATTTTAATAGTAGATGACGATCCACATATTAGAGAACTTGT
TTCTGTATTTTTAGAGCGGGAAGGATTTCAAACATATGAAGCAATTGATGGTCTAGATGCACTTCAAAAAATAGATGAAG
TGAAAGTTGATATGGTTATTCTTGATATCATGATGCCGAATATGGATGGATTTGATGTATGTTTTGAATTAAGGAAATAC
TATGATATTCCGATTTTGATGTTAACTGCTAAAGGAGAAACGTCTCAAAAAGTAAAAGGATTTCATCTTGGAACGGATGA
TTATCTTGTAAAACCATTTGATCCGATAGAACTAGTAGTGAGAGTTAAGGCGTTATTGAAACGTTACCAAATTACAGTAT
CGCAATCAATTCAAGTTGGAAATGTACTGTTAAATCGTAAAACATTTGAAGTTACAATTGGAGAACAAACAGTTACGTTA
CCACTAAAAGAATTCGAATTGCTCTTTACTTTAGGCTCTAAAACGGGGAGAACTTGTTCGAGAGAGCAATTAATTGAAGA
TGTATGGGGATATGATTTTGAAGGGAATGAGCGTACACTAGACGTTCATATAAATCGGTTACGTGAGAAGTTCCAAGAAG
AGAAGTCGAAATTTAGTATTAAAACGATAAGAGGCTTAGGATATCGCTTAGAGGTAAGTAAATGA

Upstream 100 bases:

>100_bases
GCAACGCAACAATTGAAAATTAAAGAGGGCGTATTATAAAATGAATCATCAGTGGGGCTTATACTCCGCTGGTGATTCAT
TTTTAAAAGTTATATAAAAG

Downstream 100 bases:

>100_bases
GAAGAAGAGAGCGAATGAATAAGGTGAAGATACTGAAAGTGATTGGAGCGGTACTAGCTCTCTTTTCTTTTCTCACAATA
ATTTGGTCTATAGCCTTTTA

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MLRRKERFSLLPKILIVDDDPHIRELVSVFLEREGFQTYEAIDGLDALQKIDEVKVDMVILDIMMPNMDGFDVCFELRKY
YDIPILMLTAKGETSQKVKGFHLGTDDYLVKPFDPIELVVRVKALLKRYQITVSQSIQVGNVLLNRKTFEVTIGEQTVTL
PLKEFELLFTLGSKTGRTCSREQLIEDVWGYDFEGNERTLDVHINRLREKFQEEKSKFSIKTIRGLGYRLEVSK

Sequences:

>Translated_234_residues
MLRRKERFSLLPKILIVDDDPHIRELVSVFLEREGFQTYEAIDGLDALQKIDEVKVDMVILDIMMPNMDGFDVCFELRKY
YDIPILMLTAKGETSQKVKGFHLGTDDYLVKPFDPIELVVRVKALLKRYQITVSQSIQVGNVLLNRKTFEVTIGEQTVTL
PLKEFELLFTLGSKTGRTCSREQLIEDVWGYDFEGNERTLDVHINRLREKFQEEKSKFSIKTIRGLGYRLEVSK
>Mature_234_residues
MLRRKERFSLLPKILIVDDDPHIRELVSVFLEREGFQTYEAIDGLDALQKIDEVKVDMVILDIMMPNMDGFDVCFELRKY
YDIPILMLTAKGETSQKVKGFHLGTDDYLVKPFDPIELVVRVKALLKRYQITVSQSIQVGNVLLNRKTFEVTIGEQTVTL
PLKEFELLFTLGSKTGRTCSREQLIEDVWGYDFEGNERTLDVHINRLREKFQEEKSKFSIKTIRGLGYRLEVSK

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated hssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=38.2882882882883, Blast_Score=161, Evalue=3e-41,
Organism=Escherichia coli, GI87082012, Length=216, Percent_Identity=33.7962962962963, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=33.9285714285714, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=36.9369369369369, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=36.5296803652968, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=37.3333333333333, Blast_Score=133, Evalue=8e-33,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=35.2941176470588, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=33.7777777777778, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=35.6164383561644, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790863, Length=236, Percent_Identity=30.5084745762712, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=30.3571428571429, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=27.5109170305677, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=30.6306306306306, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1788550, Length=180, Percent_Identity=30.5555555555556, Blast_Score=91, Evalue=4e-20,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=28.125, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1790299, Length=143, Percent_Identity=30.7692307692308, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788713, Length=101, Percent_Identity=39.6039603960396, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI145693157, Length=100, Percent_Identity=36, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1788191, Length=110, Percent_Identity=36.3636363636364, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=34.6534653465347, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788905, Length=102, Percent_Identity=35.2941176470588, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1789149, Length=121, Percent_Identity=32.2314049586777, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27228; Mature: 27228

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRKERFSLLPKILIVDDDPHIRELVSVFLEREGFQTYEAIDGLDALQKIDEVKVDMVI
CCCCHHHHHHCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEE
LDIMMPNMDGFDVCFELRKYYDIPILMLTAKGETSQKVKGFHLGTDDYLVKPFDPIELVV
EEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEECCCCCCEECCCCHHHHHH
RVKALLKRYQITVSQSIQVGNVLLNRKTFEVTIGEQTVTLPLKEFELLFTLGSKTGRTCS
HHHHHHHHHHHHHHCCEEECCEEECCEEEEEEECCEEEEEEHHHEEEEEEECCCCCCCCC
REQLIEDVWGYDFEGNERTLDVHINRLREKFQEEKSKFSIKTIRGLGYRLEVSK
HHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHEEHHHHHCCCEEEEECC
>Mature Secondary Structure
MLRRKERFSLLPKILIVDDDPHIRELVSVFLEREGFQTYEAIDGLDALQKIDEVKVDMVI
CCCCHHHHHHCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEE
LDIMMPNMDGFDVCFELRKYYDIPILMLTAKGETSQKVKGFHLGTDDYLVKPFDPIELVV
EEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEECCCCCCEECCCCHHHHHH
RVKALLKRYQITVSQSIQVGNVLLNRKTFEVTIGEQTVTLPLKEFELLFTLGSKTGRTCS
HHHHHHHHHHHHHHCCEEECCEEECCEEEEEEECCEEEEEEHHHEEEEEEECCCCCCCCC
REQLIEDVWGYDFEGNERTLDVHINRLREKFQEEKSKFSIKTIRGLGYRLEVSK
HHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHEEHHHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA