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The map label for this gene is pepP [H]

Identifier: 222095553

GI number: 222095553

Start: 1871436

End: 1872719

Strand: Direct

Name: pepP [H]

Synonym: BCQ_1893

Alternate gene names: 222095553

Gene position: 1871436-1872719 (Clockwise)

Preceding gene: 222095551

Following gene: 222095556

Centisome position: 35.89

GC content: 32.55

Gene sequence:

>1284_bases
ATGAAATCAACATTTTTTGCTCAAAATAGAGAACGATTAGTAAACACATTACCAGATGAATCGATTACAATTTTATTTGC
TGGTCAAGCACCTCATATGTCAGCGGATGCACATTATAAGTTTGTGCCGAATCGGAATTTTTATTATGTAACAGGAATCG
ATGAACCAAATGTTATTTTTATGCTGAAAAAGTTTGGGAATTGTGTAGAAGAGACACTTTTCATTGAAAAATCAGATCCA
GTAATGGAAAAATGGGTCGGTAAAACAGTTTCTAAAGAAGAAGCAGAGAAAATTTCTGGTATAAAGAAAGTTGTATATTT
AGATAGCTTTGAAAAGACAATGTCAAATATATTTTTTACAGAAAATGTGAAGCATCTATTTTTAGATTTAGAGCGTCGTG
AGTGGAATGGTACAGAGACAAAAACATTAGCGTTTGCTAAACATGTAAGAGAACAATACCCCCACGTAACAATTGGTAAT
ATATATCCAAATATTTGTGAATTACGAGTGTTTAAAACAGAAGAAGAAATTGAAATTATGAAAGAAGCGATTGCTGTAAC
GAAAGACGGTATTTACAACGTACTTAAGCATGCAAAAGCAGACATGATGGAGTATGAATTAGAAGCTCAATTTGATTTTA
CACTGAAATCATCTGGCATTAAGCATCATGCGTTCAATACAATTTTGGCGAGTGGGAAAAATGCTACAGTTCTTCATTAT
GAAGATAATGATGCGCAAATTCAAAATGGTGATTTAGTATTACTAGATTTAGGTGCTCAAAAAGACTACTATAACGCTGA
TATTAGTTATACATTCCCAGCAAATGGAACATTCTCTAGTCGCCAAAAACAAATTTATAATATCGTATTAAAAGCATTGA
AAGAAACAACAGAGATTATTAAGCCAGGCTTAAAGTTCGCTGCATTAAATGAGCATGCTAAAAAAGTACTTGCAGAAGGG
TGTAAAGCGGTTGGTTTAATTCAAGAAGATGAAGAGTTATCAAAATATTATTATCATGGTGTCAGCCATTTCCTTGGTTT
AGATACGCATGATGTAGGGACATACAAAGATAGAGTATTAGAAGAAGGCATGGTTATTACAATTGAACCTGGTCTTTATA
TTGAAGAAGAATCGATTGGAATTCGTATTGAAGATGATATTCTTGTAACGAAAGACGGATACGAAAACTTGTCAAAAGAT
ATCATTAGAGAAGTTGAAGAGATTGAAGCGTTTATGAGTGTAAATAATGAACATGTCAAAGGAAAACAAGCTGTAGTTAA
ATAA

Upstream 100 bases:

>100_bases
CTAAAAAGGTTAAAAATTGACGAAAAATTGTAACAATAATAAAATGAATTGATTAGATAATTATTTTTTTAATCATACAT
AGAACGCTAGGGGGATTATT

Downstream 100 bases:

>100_bases
TAAGAAAGTCATCACTAATTTATTTGAACTTTATCTCGAATCGTGGACAATTAAAAAATCCATGATTCGGGATAGGGTTC
TTTTTATCTTCGAAATACTA

Product: xaa-pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MKSTFFAQNRERLVNTLPDESITILFAGQAPHMSADAHYKFVPNRNFYYVTGIDEPNVIFMLKKFGNCVEETLFIEKSDP
VMEKWVGKTVSKEEAEKISGIKKVVYLDSFEKTMSNIFFTENVKHLFLDLERREWNGTETKTLAFAKHVREQYPHVTIGN
IYPNICELRVFKTEEEIEIMKEAIAVTKDGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNTILASGKNATVLHY
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLKALKETTEIIKPGLKFAALNEHAKKVLAEG
CKAVGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVLEEGMVITIEPGLYIEEESIGIRIEDDILVTKDGYENLSKD
IIREVEEIEAFMSVNNEHVKGKQAVVK

Sequences:

>Translated_427_residues
MKSTFFAQNRERLVNTLPDESITILFAGQAPHMSADAHYKFVPNRNFYYVTGIDEPNVIFMLKKFGNCVEETLFIEKSDP
VMEKWVGKTVSKEEAEKISGIKKVVYLDSFEKTMSNIFFTENVKHLFLDLERREWNGTETKTLAFAKHVREQYPHVTIGN
IYPNICELRVFKTEEEIEIMKEAIAVTKDGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNTILASGKNATVLHY
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLKALKETTEIIKPGLKFAALNEHAKKVLAEG
CKAVGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVLEEGMVITIEPGLYIEEESIGIRIEDDILVTKDGYENLSKD
IIREVEEIEAFMSVNNEHVKGKQAVVK
>Mature_427_residues
MKSTFFAQNRERLVNTLPDESITILFAGQAPHMSADAHYKFVPNRNFYYVTGIDEPNVIFMLKKFGNCVEETLFIEKSDP
VMEKWVGKTVSKEEAEKISGIKKVVYLDSFEKTMSNIFFTENVKHLFLDLERREWNGTETKTLAFAKHVREQYPHVTIGN
IYPNICELRVFKTEEEIEIMKEAIAVTKDGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNTILASGKNATVLHY
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLKALKETTEIIKPGLKFAALNEHAKKVLAEG
CKAVGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVLEEGMVITIEPGLYIEEESIGIRIEDDILVTKDGYENLSKD
IIREVEEIEAFMSVNNEHVKGKQAVVK

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=473, Percent_Identity=28.5412262156448, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI11559925, Length=416, Percent_Identity=28.6057692307692, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI260593665, Length=306, Percent_Identity=32.6797385620915, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI260593663, Length=472, Percent_Identity=25.8474576271186, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI264681563, Length=256, Percent_Identity=28.90625, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789275, Length=438, Percent_Identity=31.2785388127854, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1788728, Length=242, Percent_Identity=29.7520661157025, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790282, Length=291, Percent_Identity=24.0549828178694, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17508215, Length=474, Percent_Identity=30.8016877637131, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI71989583, Length=364, Percent_Identity=25.8241758241758, Blast_Score=101, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320922, Length=442, Percent_Identity=28.2805429864253, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6321118, Length=426, Percent_Identity=29.1079812206573, Blast_Score=159, Evalue=7e-40,
Organism=Drosophila melanogaster, GI21357079, Length=481, Percent_Identity=30.3534303534304, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19920384, Length=410, Percent_Identity=27.5609756097561, Blast_Score=165, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 48775; Mature: 48775

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTFFAQNRERLVNTLPDESITILFAGQAPHMSADAHYKFVPNRNFYYVTGIDEPNVIF
CCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCEEEEEECCCCCEEE
MLKKFGNCVEETLFIEKSDPVMEKWVGKTVSKEEAEKISGIKKVVYLDSFEKTMSNIFFT
EEHHHCCHHHHHEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHEEEHHHHHHHHHHEEEC
ENVKHLFLDLERREWNGTETKTLAFAKHVREQYPHVTIGNIYPNICELRVFKTEEEIEIM
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCHHHHHHH
KEAIAVTKDGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNTILASGKNATVLHY
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCHHHHHHHHCCCCCEEEEEE
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLKALKETTEII
ECCCCEEECCCEEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KPGLKFAALNEHAKKVLAEGCKAVGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVL
CCCCCEEHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EEGMVITIEPGLYIEEESIGIRIEDDILVTKDGYENLSKDIIREVEEIEAFMSVNNEHVK
HCCEEEEECCCCEEECCCCEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
GKQAVVK
CHHHCCC
>Mature Secondary Structure
MKSTFFAQNRERLVNTLPDESITILFAGQAPHMSADAHYKFVPNRNFYYVTGIDEPNVIF
CCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCEEEEEECCCCCEEE
MLKKFGNCVEETLFIEKSDPVMEKWVGKTVSKEEAEKISGIKKVVYLDSFEKTMSNIFFT
EEHHHCCHHHHHEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHEEEHHHHHHHHHHEEEC
ENVKHLFLDLERREWNGTETKTLAFAKHVREQYPHVTIGNIYPNICELRVFKTEEEIEIM
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCHHHHHHH
KEAIAVTKDGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNTILASGKNATVLHY
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCHHHHHHHHCCCCCEEEEEE
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLKALKETTEII
ECCCCEEECCCEEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KPGLKFAALNEHAKKVLAEGCKAVGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVL
CCCCCEEHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EEGMVITIEPGLYIEEESIGIRIEDDILVTKDGYENLSKDIIREVEEIEAFMSVNNEHVK
HCCEEEEECCCCEEECCCCEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
GKQAVVK
CHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]