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The map label for this gene is mtaD [H]

Identifier: 222095526

GI number: 222095526

Start: 1842448

End: 1843719

Strand: Direct

Name: mtaD [H]

Synonym: BCQ_1866

Alternate gene names: 222095526

Gene position: 1842448-1843719 (Clockwise)

Preceding gene: 222095525

Following gene: 222095529

Centisome position: 35.34

GC content: 38.21

Gene sequence:

>1272_bases
ATGAATGAACAAAATGAAGTGATAGAAAATGGATATATCATTGTAGAAAATGATCAAATTATAGATGTGAAGAGCGGAGA
ATTCGCTAATGATTTTGAAGTAGATGAAGTAATTGACATGAAAGGAAAATGGGTTTTACCAGGGCTTGTCAATACACATA
CACACGTTGTAATGAGTCTCTTAAGAGGTATTGGTGATGATATGTTATTACAGCCGTGGCTTGAGACAAGAATTTGGCCA
CTTGAAAGTCAATTTACTCCAGAACTTGCGGTTGCTAGTACGGAATTAGGATTACTTGAAATGGTGAAAAGTGGTACAAC
ATCTTTCTCTGATATGTTTAATCCAATTGGAGTAGATCAAGATGCAATTATGGAAACGGTATCAAGGAGCGGGATGCGAG
CTGCTGTTTCAAGAACTTTATTTAGCTTCGGAACGAAAGAGGATGAAAAGAAAGCAATTGAAGAAGCTGAGAAATATGTG
AAGCGTTACTATAACGAAAGTGGTATGTTAACTACGATGGTTGCACCGCATAGTCCATATACATGCAGTACAGAACTGTT
AGAAGAGTGTGCACGTATTGCAGTAGAAAATCAAACGATGGTTCATATTCACCTTTCCGAAACAGAGCGTGAAGTACGTG
ATATTGAAGCGCAGTACGGAAAACGTCCAGTAGAATATGCGGCAAGTTGCGGATTGTTTAAACGACCAACAGTGATTGCA
CACGGTGTAGTATTAGATGACAATGAGCGTGCATTTTTAGCGGAACATGACGTTCGAGTAGCTCATAATCCGAATAGTAA
TTTAAAACTAGGGTCTGGTATAGCGAATGTAAAAGCGATGTTAGAAGCAGGAATAAAAGTAGGAATTGCAACAGATAGTG
TTGCATCTAACAATAATTTAGATATGTTTGAAGAAATGCGCATAGCGACTTTACTACAAAAAGGTATTCACCAAGATGCA
ACAGCGTTACCGGTTGAAACAGCTCTTACACTTGCAACTAAAGGAGCGGCTGAAGTAATCGGCATGAAACAAACAGGATC
ACTTGAGGTTGGAAAGTGCGCTGATTTCATTACAATTGATCCGTCTAATAAGCCCCATTTACAACCAGCAGATGAAGTAT
TATCGCATCTTGTATATGCTGCTAGTGGAAAAGATATAAGCGATGTAATTATTAACGGAAAACATGTCGTTTGGAATGGC
GAATGTAAAACGTTAGATGAAGAGCGTATTATATTTGAAGCAAGTCGATATAAACGAGGTTTGCAAAGATAG

Upstream 100 bases:

>100_bases
TAAGTTACTATAATGGTGGTAACTTATTAAAGGGGACTTCATAGAGTTGAAAGGGGAAATACTTTTGAAAACAACTTATG
TAAACGCTACAATCGTAACG

Downstream 100 bases:

>100_bases
GTATTTTCAGGATGTGGAGAAAGTCTTCTCCACATCCTTTTTTTGTGTCTGAACCTTTTTATTAATAAAAAGAAGTTAAG
AATTTAGATAAAATCATTAG

Product: chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MNEQNEVIENGYIIVENDQIIDVKSGEFANDFEVDEVIDMKGKWVLPGLVNTHTHVVMSLLRGIGDDMLLQPWLETRIWP
LESQFTPELAVASTELGLLEMVKSGTTSFSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTKEDEKKAIEEAEKYV
KRYYNESGMLTTMVAPHSPYTCSTELLEECARIAVENQTMVHIHLSETEREVRDIEAQYGKRPVEYAASCGLFKRPTVIA
HGVVLDDNERAFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVGIATDSVASNNNLDMFEEMRIATLLQKGIHQDA
TALPVETALTLATKGAAEVIGMKQTGSLEVGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISDVIINGKHVVWNG
ECKTLDEERIIFEASRYKRGLQR

Sequences:

>Translated_423_residues
MNEQNEVIENGYIIVENDQIIDVKSGEFANDFEVDEVIDMKGKWVLPGLVNTHTHVVMSLLRGIGDDMLLQPWLETRIWP
LESQFTPELAVASTELGLLEMVKSGTTSFSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTKEDEKKAIEEAEKYV
KRYYNESGMLTTMVAPHSPYTCSTELLEECARIAVENQTMVHIHLSETEREVRDIEAQYGKRPVEYAASCGLFKRPTVIA
HGVVLDDNERAFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVGIATDSVASNNNLDMFEEMRIATLLQKGIHQDA
TALPVETALTLATKGAAEVIGMKQTGSLEVGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISDVIINGKHVVWNG
ECKTLDEERIIFEASRYKRGLQR
>Mature_423_residues
MNEQNEVIENGYIIVENDQIIDVKSGEFANDFEVDEVIDMKGKWVLPGLVNTHTHVVMSLLRGIGDDMLLQPWLETRIWP
LESQFTPELAVASTELGLLEMVKSGTTSFSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTKEDEKKAIEEAEKYV
KRYYNESGMLTTMVAPHSPYTCSTELLEECARIAVENQTMVHIHLSETEREVRDIEAQYGKRPVEYAASCGLFKRPTVIA
HGVVLDDNERAFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVGIATDSVASNNNLDMFEEMRIATLLQKGIHQDA
TALPVETALTLATKGAAEVIGMKQTGSLEVGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISDVIINGKHVVWNG
ECKTLDEERIIFEASRYKRGLQR

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=381, Percent_Identity=27.5590551181102, Blast_Score=127, Evalue=3e-29,
Organism=Escherichia coli, GI1789249, Length=373, Percent_Identity=26.2734584450402, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082177, Length=426, Percent_Identity=25.5868544600939, Blast_Score=104, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17540282, Length=388, Percent_Identity=25.2577319587629, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319963, Length=351, Percent_Identity=28.2051282051282, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24643849, Length=380, Percent_Identity=26.8421052631579, Blast_Score=134, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 46798; Mature: 46798

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEQNEVIENGYIIVENDQIIDVKSGEFANDFEVDEVIDMKGKWVLPGLVNTHTHVVMSL
CCCCHHHHHCCEEEEECCEEEEECCCCCCCCCCHHHHHCCCCCEECCCHHHHHHHHHHHH
LRGIGDDMLLQPWLETRIWPLESQFTPELAVASTELGLLEMVKSGTTSFSDMFNPIGVDQ
HHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCHHHHCCCCCCCH
DAIMETVSRSGMRAAVSRTLFSFGTKEDEKKAIEEAEKYVKRYYNESGMLTTMVAPHSPY
HHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
TCSTELLEECARIAVENQTMVHIHLSETEREVRDIEAQYGKRPVEYAASCGLFKRPTVIA
CCHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEE
HGVVLDDNERAFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVGIATDSVASNNNL
EEEEEECCCCEEEEECCEEEEECCCCCCEECCCHHHHHHHHHCCCEEEEECCCCCCCCCC
DMFEEMRIATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSLEVGKCADFITID
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHEECCCCCCEECCCCCCEEEEC
PSNKPHLQPADEVLSHLVYAASGKDISDVIINGKHVVWNGECKTLDEERIIFEASRYKRG
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHEECCCEEEECCCCCCCCCHHHEEEHHHHHHC
LQR
CCC
>Mature Secondary Structure
MNEQNEVIENGYIIVENDQIIDVKSGEFANDFEVDEVIDMKGKWVLPGLVNTHTHVVMSL
CCCCHHHHHCCEEEEECCEEEEECCCCCCCCCCHHHHHCCCCCEECCCHHHHHHHHHHHH
LRGIGDDMLLQPWLETRIWPLESQFTPELAVASTELGLLEMVKSGTTSFSDMFNPIGVDQ
HHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCHHHHCCCCCCCH
DAIMETVSRSGMRAAVSRTLFSFGTKEDEKKAIEEAEKYVKRYYNESGMLTTMVAPHSPY
HHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
TCSTELLEECARIAVENQTMVHIHLSETEREVRDIEAQYGKRPVEYAASCGLFKRPTVIA
CCHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEE
HGVVLDDNERAFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVGIATDSVASNNNL
EEEEEECCCCEEEEECCEEEEECCCCCCEECCCHHHHHHHHHCCCEEEEECCCCCCCCCC
DMFEEMRIATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSLEVGKCADFITID
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHEECCCCCCEECCCCCCEEEEC
PSNKPHLQPADEVLSHLVYAASGKDISDVIINGKHVVWNGECKTLDEERIIFEASRYKRG
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHEECCCEEEECCCCCCCCCHHHEEEHHHHHHC
LQR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA