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The map label for this gene is comA [H]

Identifier: 222095466

GI number: 222095466

Start: 1771757

End: 1772410

Strand: Direct

Name: comA [H]

Synonym: BCQ_1806

Alternate gene names: 222095466

Gene position: 1771757-1772410 (Clockwise)

Preceding gene: 222095465

Following gene: 222095467

Centisome position: 33.98

GC content: 29.36

Gene sequence:

>654_bases
ATGATTCAAGTACTGATTATAGATGATCACCTAGCTGTTGGTATGGGAACAAAAGTATTAATAGAGCAAGAGAATATACA
AGCCGATGTATTGTTTTACAGTGAAAAACTTCAAACACATTTGAGTAATAAAAAATATGATGTATATATGGTAGATTTAT
ATATGCCCAATTTAAATGGGTTAGAGATATCAAAAAAAATTTTAAAAGAGGATCCTAATGCAAGAATAATTATATATACT
GGGTTTGATATTGAACCGCATTTTAACTTGCTTATTGAAACTGGAGTGATGGGGATAATAAGTAAAACAGCTTCTCAAGA
ATCAATAATTAATGCCATTGAAAGTATCATGAGAAAAGAGATTGTTATTCCATATGAGTTGTTTAAACAATTACGTATCC
AAGAACGTTATTCACATATCAACATTAATAAAAATGGAGTAGTTCCTATATCGATGAATCATCGAGAAATCGAAGTTTTA
TCCTATATAGAAAAAGGGATGACAAATAAATGTATAGCTTCTACATTGAATTTAAGTCAAAGGTCAATTGAATACACGAT
AACAGAAATATTCAATAAATTGGGTGTGTATTCCCGAGTTGAAGCTGTAAAAGCTGCAAAAAAGATTGGGATAATTTCAA
AATTTGACTTGTGA

Upstream 100 bases:

>100_bases
ATAGATAGCACTCATGGTAGTGGTGTACGCATAAAGATTAAATTTAACAAGGATAGTGTATATAAATAGTACAAATGATA
GAGAAGGTGAGAATAATATA

Downstream 100 bases:

>100_bases
ATATGTCGCCACATACATTTTAAATTATATATTTTATAAAGAGAGTGTTTACAAGGCACTCTCTTTTTTGTGGTATTTTC
AATATTTTATAATCGATTCA

Product: two-component response regulator

Products: NA

Alternate protein names: Competence protein A [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MIQVLIIDDHLAVGMGTKVLIEQENIQADVLFYSEKLQTHLSNKKYDVYMVDLYMPNLNGLEISKKILKEDPNARIIIYT
GFDIEPHFNLLIETGVMGIISKTASQESIINAIESIMRKEIVIPYELFKQLRIQERYSHININKNGVVPISMNHREIEVL
SYIEKGMTNKCIASTLNLSQRSIEYTITEIFNKLGVYSRVEAVKAAKKIGIISKFDL

Sequences:

>Translated_217_residues
MIQVLIIDDHLAVGMGTKVLIEQENIQADVLFYSEKLQTHLSNKKYDVYMVDLYMPNLNGLEISKKILKEDPNARIIIYT
GFDIEPHFNLLIETGVMGIISKTASQESIINAIESIMRKEIVIPYELFKQLRIQERYSHININKNGVVPISMNHREIEVL
SYIEKGMTNKCIASTLNLSQRSIEYTITEIFNKLGVYSRVEAVKAAKKIGIISKFDL
>Mature_217_residues
MIQVLIIDDHLAVGMGTKVLIEQENIQADVLFYSEKLQTHLSNKKYDVYMVDLYMPNLNGLEISKKILKEDPNARIIIYT
GFDIEPHFNLLIETGVMGIISKTASQESIINAIESIMRKEIVIPYELFKQLRIQERYSHININKNGVVPISMNHREIEVL
SYIEKGMTNKCIASTLNLSQRSIEYTITEIFNKLGVYSRVEAVKAAKKIGIISKFDL

Specific function: Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, d

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=215, Percent_Identity=26.5116279069767, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788521, Length=203, Percent_Identity=29.5566502463054, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1786747, Length=208, Percent_Identity=23.5576923076923, Blast_Score=70, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24823; Mature: 24823

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQVLIIDDHLAVGMGTKVLIEQENIQADVLFYSEKLQTHLSNKKYDVYMVDLYMPNLNG
CEEEEEECCCEEECCCCEEEEEECCCEEEEEEHHHHHHHHHCCCCEEEEEEEEEECCCCC
LEISKKILKEDPNARIIIYTGFDIEPHFNLLIETGVMGIISKTASQESIINAIESIMRKE
HHHHHHHHHCCCCCEEEEEECCCCCCCHHEEEECCHHHHHHHCCCHHHHHHHHHHHHHHC
IVIPYELFKQLRIQERYSHININKNGVVPISMNHREIEVLSYIEKGMTNKCIASTLNLSQ
CCCCHHHHHHHHHHHHHCEEECCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHCCCH
RSIEYTITEIFNKLGVYSRVEAVKAAKKIGIISKFDL
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCEEECCC
>Mature Secondary Structure
MIQVLIIDDHLAVGMGTKVLIEQENIQADVLFYSEKLQTHLSNKKYDVYMVDLYMPNLNG
CEEEEEECCCEEECCCCEEEEEECCCEEEEEEHHHHHHHHHCCCCEEEEEEEEEECCCCC
LEISKKILKEDPNARIIIYTGFDIEPHFNLLIETGVMGIISKTASQESIINAIESIMRKE
HHHHHHHHHCCCCCEEEEEECCCCCCCHHEEEECCHHHHHHHCCCHHHHHHHHHHHHHHC
IVIPYELFKQLRIQERYSHININKNGVVPISMNHREIEVLSYIEKGMTNKCIASTLNLSQ
CCCCHHHHHHHHHHHHHCEEECCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHCCCH
RSIEYTITEIFNKLGVYSRVEAVKAAKKIGIISKFDL
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2507523; 9274030; 9384377 [H]